Chemistry methods : new approaches to solving problems in chemistry最新文献

{"title":"Cover Picture: X-Ray Absorption Studies of Local Structure of Dilute Ionic Species in Molten Salts (Chem. Methods 7/2025)","authors":"Kaifeng Zheng,&nbsp;Nirmalendu Patra,&nbsp;Nicholas Marcella,&nbsp;Alexander S. Ivanov,&nbsp;James F. Wishart,&nbsp;Alejandro R. Ballesteros,&nbsp;Ruchi Gakhar,&nbsp;Sheng Dai,&nbsp;Santanu Roy,&nbsp;Vyacheslav Bryantsev,&nbsp;Simerjeet K. Gill,&nbsp;Anatoly I. Frenkel","doi":"10.1002/cmtd.70014","DOIUrl":"10.1002/cmtd.70014","url":null,"abstract":"<p><b>The Front Cover</b> symbolizes, amid crystalline salt formations and glowing pools of molten salt, the atomic complexity of molten salt systems and the advanced tools used to study them. X-ray absorption fine structure (XAFS) spectroscopy under in-situ conditions is the focus of this Review by A. I. Frenkel and co-workers (DOI: 10.1002/cmtd.202400097), which highlights recent advances and emerging synergies with machine learning—depicted as two giant pyramid-shaped networks—alongside simulations and complementary experimental techniques that illuminate these dynamic materials.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72562,"journal":{"name":"Chemistry methods : new approaches to solving problems in chemistry","volume":"5 7","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cmtd.70014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144615182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cover Feature: Synthetic Thermo-Sensitive Hydrogel Microspheres as Temperature Probes in an Optical Tweezers Setup (Chem. Methods 7/2025)","authors":"Shahar Goren,&nbsp;Nicole Edelstein-Pardo,&nbsp;Ran Glinowiecki,&nbsp;Amit Sitt,&nbsp;Raya Sorkin,&nbsp;Ayelet Lesman","doi":"10.1002/cmtd.70015","DOIUrl":"10.1002/cmtd.70015","url":null,"abstract":"<p><b>The Cover Feature</b> shows poly-<i>N</i>-isopropyl-acrylamide (PNIPAAm) microspheres on a glass slide in water. PNIPAAm is a temperature-sensitive polymer that undergoes a volume transition between 20 and 45 °C. The spheres were fluorescently labelled and imaged with confocal fluorescence microscopy at 22 °C (top left) and at 45 °C (bottom right). In their Research Article (DOI: 10.1002/cmtd.202400040), R. Sorkin, A. Lesman and co-workers explain how they used the volume transition of PNIPAAm microspheres to measure the temperature close to a powerful optical tweezers laser beam. Measuring the temperature directly by using PNIPAAm helps to conduct optical tweezers experiments, especially with biological samples, and provides an additional control variable.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72562,"journal":{"name":"Chemistry methods : new approaches to solving problems in chemistry","volume":"5 7","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cmtd.70015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144615183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Few Steps, Big Impact: Recent Advances in the Streamlined Synthesis of Multiply Chiral Heterohelicenes with Tunable Optoelectronic Properties","authors":"Mohamed S. H. Salem,&nbsp;Shinobu Takizawa","doi":"10.1002/cmtd.202500018","DOIUrl":"10.1002/cmtd.202500018","url":null,"abstract":"<p>Heterohelicenes with multiple chiral axes are promising materials due to their unique electronic and chiroptical features. However, their synthesis becomes more challenging as their structural complexity increases with multi-helical frameworks and various heteroatoms. This complexity requires lengthy synthetic steps and purification processes, often resulting in low yields and limiting practical applications. This review explores recent advancements to tackle these challenges, focusing on innovative strategies for the short-step synthesis of double and triple heterohelicenes. These strategies are categorized, highlighting how they improve the synthesis of functionalized materials and offer valuable opportunities for achieving a balance between synthetic efficiency and tunable properties with enhanced functionality. Remaining challenges and future potential are discussed, providing a comprehensive reference for researchers working on these molecules for next-generation technologies.</p>","PeriodicalId":72562,"journal":{"name":"Chemistry methods : new approaches to solving problems in chemistry","volume":"5 9","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/cmtd.202500018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144998668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Scalable L-α-Glycerophosphorylcholine Synthesis through the Automatic pH-Controlled (R)-Glycidol Ring Opening with Phosphorylcholine","authors":"Antonio Massa,&nbsp;Mauro Anibaldi,&nbsp;Lorenzo De Ferra","doi":"10.1002/cmtd.202500047","DOIUrl":"https://doi.org/10.1002/cmtd.202500047","url":null,"abstract":"<p>The investigation of epoxide ring opening of (<i>R</i>)-glycidol with phosphorylcholine in water leads to the development of an effective synthesis of L-α-glycerophosphorylcholine (L-α-GPC), a commercially available drug. The precise control of reaction pH with an automatic titrator proves to be crucial for achieving conversions of up to 98% and limiting byproduct formation. Additionally, an effective method for the synthesis of phosphocholine as inner salt is reported for the first time, which is also essential for achieving the described results.</p>","PeriodicalId":72562,"journal":{"name":"Chemistry methods : new approaches to solving problems in chemistry","volume":"5 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/cmtd.202500047","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Direct Quantification of Ammonia and Alkylamines in Aqueous Environments Using Solid-Phase Microextraction-Gas chromatography-Mass spectrometry","authors":"Doha Zidouhia,&nbsp;Etienne Grau,&nbsp;Dario M. Bassani","doi":"10.1002/cmtd.202400095","DOIUrl":"10.1002/cmtd.202400095","url":null,"abstract":"<p>The detection of ammonia in aqueous solutions using solid-phase microextraction (SPME)-GC-MS (gas chromatography-mass spectrometry) is described. This technique enables the direct detection of ammonia without the need for derivatization or the use of colorimetric methods, which can be prone to interference from transition metal ions or organic cosolvents typically used in nitrogen reduction catalysis. The use of a fused-silica SPME fiber coated with polydimethylsiloxane/divinylbenzene is found to allow fast and direct quantification of ammonia with a limit of detection = 0.17 ppm and a limit of quantification = 0.5 ppm in water. The method is straightforward to implement and can be readily automated using commercial instrumentation. It is also capable of detecting isotopically labeled ¹⁵NH₃ as well as simple alkylamines such as methylamine or ethylamine which may be produced or released during the course of a reaction.</p>","PeriodicalId":72562,"journal":{"name":"Chemistry methods : new approaches to solving problems in chemistry","volume":"5 8","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/cmtd.202400095","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144869357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cover Picture: Deuterium NMR in Chiral Polymer-Based Bimesophasic Lyotropic Mixtures: From the Demixing Process to Analytical Applications (Chem. Methods 6/2025)","authors":"Thomas Julien,&nbsp;Boris Gouilleux,&nbsp;Bernard Rousseau,&nbsp;Michael Reggelin,&nbsp;Philippe Lesot","doi":"10.1002/cmtd.202580601","DOIUrl":"10.1002/cmtd.202580601","url":null,"abstract":"<p><b>The Front Cover</b> offers Chemistry-Methods readers a futuristic view of the analytical interest of lyotropic chiral bimesophasic systems consisting of two immiscible helical polymers and, using modern NMR tools such as tailored spatially resolved 1D/2D experiments, to collect two sets of anisotropic data. Crossing new frontiers with innovative NMR spectroscopies in the space of chirality, prochirality, or 3D configurational analysis remains an exciting challenge for Chemistry. For more details, see the Research Article by Michael Reggelin, Philippe Lesot, and co-workers (10.1002/cmtd.202500011).\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":72562,"journal":{"name":"Chemistry methods : new approaches to solving problems in chemistry","volume":"5 6","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cmtd.202580601","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compression-Induced Amorphization of ZIF-62 Leading to Formation of Porous Glass: Overcoming the Limitations of Current Methods","authors":"Jaideep Mor,&nbsp;Renjith B. Nelliyil,&nbsp;Ravi Kumar,&nbsp;Amit Verma,&nbsp;Sandeep Kumar Sharma","doi":"10.1002/cmtd.202500045","DOIUrl":"https://doi.org/10.1002/cmtd.202500045","url":null,"abstract":"<p>Porous hybrid glasses-based on metal-organic frameworks (MOFs) have garnered significant interest in gas separation, due to their excellent processing ability, porosity, and grain boundary-free properties. Melt-quenching and mechanical vitrification are the currently used methods to transform crystalline MOFs into glasses. However, research is still ongoing to make the formation process of MOFs-based porous glasses easier, scalable, and energy efficient. A simple and scalable process overcoming the limitations of the existing methods to form glass of an extensively studied MOF, i.e., zeolitic imidazolate framework-62 (ZIF-62) is reported. Ball milling and melt-quenching are widely explored methods for ZIF-62 glass formation. ZIF-62 undergoes reversible amorphization (nonglassy phase) at very high hydrostatic pressure at ambient temperature. The present study demonstrates that successive nonhydrostatic compression at lower pressures irreversibly transforms crystalline ZIF-62 into an amorphous phase having glassy characteristics. The pore network characteristics and local structure of the compression-induced phase are compared with the melt-quenched ZIF-62. X-ray absorption spectroscopy confirms an identical local structure of both the glasses. Positron annihilation lifetime spectroscopy measurements show that the compression-induced glassy phase exhibits a higher number density of smaller pores compared to the melt-quenched glass which exhibits lower number density of larger pores.</p>","PeriodicalId":72562,"journal":{"name":"Chemistry methods : new approaches to solving problems in chemistry","volume":"5 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/cmtd.202500045","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145242932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Efficient Method Using Small-Sized Datasets Based upon Generative Adversarial Networks: Investigation of Cluster Configuration Space","authors":"Jintao Xie,&nbsp;Qing Lu,&nbsp;Wensheng Bian","doi":"10.1002/cmtd.202500004","DOIUrl":"10.1002/cmtd.202500004","url":null,"abstract":"<p>Cluster research plays an important role in chemistry. To explore the cluster configuration space, it is usually necessary to run a large-scale search. Yet for some instances, the desired cluster configuration may be counterintuitive, making it challenging to provide a reasonable initial guess to search for the corresponding minimum. There exist several routes to generate cluster configuration. However, they may suffer from the dimension problem or need some other prerequisite. In this work, generative adversarial networks (GANs) are employed to efficiently generate cluster configurations based on small-sized datasets. A dynamic clamp function is introduced during the training. The size of the dataset is controlled to be on the order of magnitude of dozens to hundreds of samples. Furthermore, the convex hull volume and area are established to assist in identifying unique structures. It is found that the proposed GAN architecture is not sensitive to network structures and can be used effectively to generate novel cluster configurations. The introduced dynamic clamp function significantly alleviates the mode collapse problem. Compared to the previous studies, the dataset size is much reduced to avoid large-scale training. Datasets containing fewer than 200 samples already yield satisfactory results. This method performs better than the genetic algorithm and is expected to have a wide range of chemical application scenarios.</p>","PeriodicalId":72562,"journal":{"name":"Chemistry methods : new approaches to solving problems in chemistry","volume":"5 9","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/cmtd.202500004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthetic Thermo-Sensitive Hydrogel Microspheres as Temperature Probes in an Optical Tweezers Setup","authors":"Shahar Goren,&nbsp;Nicole Edelstein-Pardo,&nbsp;Ran Glinowiecki,&nbsp;Amit Sitt,&nbsp;Raya Sorkin,&nbsp;Ayelet Lesman","doi":"10.1002/cmtd.202400040","DOIUrl":"10.1002/cmtd.202400040","url":null,"abstract":"<p>Optical tweezers have numerous applications in biochemistry and biophysics research. Many optical tweezers experiments require the use of high laser powers, having a substantial heating side effect that can influence experimental results. The degree of heating and its spatial profile, however, depends on experimental conditions and requires direct measurement. Various methods for local temperature measurement have been proposed, each with its advantages and drawbacks. Herein, the use of the temperature-sensitive poly(<i>N</i>-isopropyl-acrylamide) (PNIPAAm) microspheres to measure the local heating caused by optical tweezers is demonstrated and the temperature profile around the laser focus at varying laser powers is characterized. The main advantage of this method is its applicability to virtually any setup and experiment. Using simple image analysis, the temperature within the biologically relevant range can be determined with 1°–2° accuracy. Possible applications and limitations of this method are discussed.</p>","PeriodicalId":72562,"journal":{"name":"Chemistry methods : new approaches to solving problems in chemistry","volume":"5 7","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cmtd.202400040","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144615488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"iSELECTION: An Instrument to Study the Kinetics of Isomer-Selected Gas-Phase Ion-Molecule Reactions","authors":"Corentin Rossi,&nbsp;Anne P. Rasmussen,&nbsp;Bérenger Gans,&nbsp;Juraj Jašík,&nbsp;Jan Žabka,&nbsp;Marc Albaret,&nbsp;Hugo Bauduin,&nbsp;Christophe Charrière,&nbsp;Jean-Philippe Dugal,&nbsp;Jérôme Guigand,&nbsp;Catherine Le Bris,&nbsp;Ugo Jacovella","doi":"10.1002/cmtd.202500013","DOIUrl":"10.1002/cmtd.202500013","url":null,"abstract":"&lt;p&gt;Distinguishing the chemical reactivity of isomers is a fundamental challenge in chemistry, particularly in cluster chemistry, where the number of possible structures increases dramatically with cluster size. This study presents a novel approach for measuring the kinetics of ion-molecule reactions of laser-ablated species in an isomer-specific fashion. This is achieved by combining drift-tube ion mobility with mass spectrometry, enabling shape selection prior to investigating the chemical reactivity of species of interest. First, the capability of obtaining reaction rate coefficients by studying the nucleophilic addition reactions of small monocyclic carbon rings (&lt;span&gt;&lt;/span&gt;&lt;math&gt;\u0000 &lt;semantics&gt;\u0000 &lt;mrow&gt;\u0000 &lt;msubsup&gt;\u0000 &lt;mi&gt;C&lt;/mi&gt;\u0000 &lt;mrow&gt;\u0000 &lt;mn&gt;11&lt;/mn&gt;\u0000 &lt;/mrow&gt;\u0000 &lt;mo&gt;+&lt;/mo&gt;\u0000 &lt;/msubsup&gt;\u0000 &lt;/mrow&gt;\u0000 &lt;annotation&gt;$text{C}_{11}^{&amp;#x00026;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;plus;}$&lt;/annotation&gt;\u0000 &lt;/semantics&gt;&lt;/math&gt;, &lt;span&gt;&lt;/span&gt;&lt;math&gt;\u0000 &lt;semantics&gt;\u0000 &lt;mrow&gt;\u0000 &lt;msubsup&gt;\u0000 &lt;mi&gt;C&lt;/mi&gt;\u0000 &lt;mrow&gt;\u0000 &lt;mn&gt;15&lt;/mn&gt;\u0000 &lt;/mrow&gt;\u0000 &lt;mo&gt;+&lt;/mo&gt;\u0000 &lt;/msubsup&gt;\u0000 &lt;/mrow&gt;\u0000 &lt;annotation&gt;$text{C}_{15}^{&amp;#x00026;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;plus;}$&lt;/annotation&gt;\u0000 &lt;/semantics&gt;&lt;/math&gt;, and &lt;span&gt;&lt;/span&gt;&lt;math&gt;\u0000 &lt;semantics&gt;\u0000 &lt;mrow&gt;\u0000 &lt;msubsup&gt;\u0000 &lt;mi&gt;C&lt;/mi&gt;\u0000 &lt;mrow&gt;\u0000 &lt;mn&gt;17&lt;/mn&gt;\u0000 &lt;/mrow&gt;\u0000 &lt;mo&gt;+&lt;/mo&gt;\u0000 &lt;/msubsup&gt;\u0000 &lt;/mrow&gt;\u0000 &lt;annotation&gt;$text{C}_{17}^{&amp;#x00026;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;plus;}$&lt;/annotation&gt;\u0000 &lt;/semantics&gt;&lt;/math&gt;) with pyridine, comparing the results with previously reported values is validated. Then the ability to determine isomer-specific reaction rate coefficients using the &lt;span&gt;&lt;/span&gt;&lt;math&gt;\u0000 &lt;semantics&gt;\u0000 &lt;mrow&gt;\u0000 &lt;msubsup&gt;\u0000 &lt;mi&gt;C&lt;/mi&gt;\u0000 &lt;mrow&gt;\u0000 &lt;mn&gt;40&lt;/mn&gt;\u0000 &lt;/mrow&gt;\u0000 &lt;mo&gt;+&lt;/mo&gt;\u0000 &lt;/msubsup&gt;\u0000 &lt;/mrow&gt;\u0000 &lt;annotation&gt;$text{C}_{40}^{&amp;#x00026;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;plus;}$&lt;/annotation&gt;\u0000 &lt;/semantics&gt;&lt;/math&gt; cluster, where multiple isomers coexist is demonstrated. This highlights the potential of our new instrument for accurately characterizing isomer-specific r","PeriodicalId":72562,"journal":{"name":"Chemistry methods : new approaches to solving problems in chemistry","volume":"5 9","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/cmtd.202500013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}