发布求助
文献互助 智能选刊 最新文献

Chemistry methods : new approaches to solving problems in chemistry最新文献

筛选
英文 中文
Cover Picture: (Chem. Methods 9/2024) 封面图片：（化学方法 9/2024）
IF 6.1
Chemistry methods : new approaches to solving problems in chemistry Pub Date : 2024-09-12 DOI: 10.1002/cmtd.202480901
{"title":"Cover Picture: (Chem. Methods 9/2024)","authors":"","doi":"10.1002/cmtd.202480901","DOIUrl":"https://doi.org/10.1002/cmtd.202480901","url":null,"abstract":"<p>\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":72562,"journal":{"name":"Chemistry methods : new approaches to solving problems in chemistry","volume":"4 9","pages":""},"PeriodicalIF":6.1,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cmtd.202480901","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142233088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rescaling NMR for a Larger Deployment in Drug Discovery: Hyperpolarization and Benchtop NMR as Potential Game-Changers 调整 NMR 的规模，以便在药物发现中进行更广泛的部署：超极化和台式 NMR 可能改变游戏规则
IF 6.1
Chemistry methods : new approaches to solving problems in chemistry Pub Date : 2024-09-05 DOI: 10.1002/cmtd.202400009
Matthias Bütikofer, Gabriela R. Stadler, Dr. Felix Torres
{"title":"Rescaling NMR for a Larger Deployment in Drug Discovery: Hyperpolarization and Benchtop NMR as Potential Game-Changers","authors":"Matthias Bütikofer,&nbsp;Gabriela R. Stadler,&nbsp;Dr. Felix Torres","doi":"10.1002/cmtd.202400009","DOIUrl":"https://doi.org/10.1002/cmtd.202400009","url":null,"abstract":"<p>Nuclear magnetic resonance (NMR) is recognized as the gold standard method in fragment-based drug design for screening, hit validation, and affinity determination. However, its deployment at a large scale is limited by the cost and expertise needed to implement NMR as a routine drug discovery method. The increase in the adoption of fragment-based drug design created a need for biophysics to provide high-quality data for weak ligand-target interactions that can be implemented at scale. NMR must adapt its position in drug design operations to enter this new era. The recent development of commercially available benchtop NMR spectrometers in combination with hyperpolarization methods represents an opportunity for highly deployable and scalable systems.</p>","PeriodicalId":72562,"journal":{"name":"Chemistry methods : new approaches to solving problems in chemistry","volume":"4 10","pages":""},"PeriodicalIF":6.1,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cmtd.202400009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142429322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insights into CO2 Diffusion on Zeolite 13X via Frequency Response Technique 通过频率响应技术了解沸石 13X 上的二氧化碳扩散情况
IF 6.1
Chemistry methods : new approaches to solving problems in chemistry Pub Date : 2024-08-15 DOI: 10.1002/cmtd.202400006
Rebecca Grün, Atheer Saad Hashim, Dr.-Ing. Constantino Grau Turuelo, Prof. Dr. Cornelia Breitkopf
{"title":"Insights into CO2 Diffusion on Zeolite 13X via Frequency Response Technique","authors":"Rebecca Grün,&nbsp;Atheer Saad Hashim,&nbsp;Dr.-Ing. Constantino Grau Turuelo,&nbsp;Prof. Dr. Cornelia Breitkopf","doi":"10.1002/cmtd.202400006","DOIUrl":"https://doi.org/10.1002/cmtd.202400006","url":null,"abstract":"<p>Zeolite 13X is an excellent candidate for the capture of CO<sub>2</sub>. However, this system needs to be investigated in more detail with regard to adsorption and diffusion. For this purpose, frequency response (FR) measurements were carried out with binderless zeolite 13X (NaMSX) and CO<sub>2</sub>. The size of the particles and the sample amount were modified in order to investigate their effects on diffusion processes. Macropore diffusion was detected and the corresponding diffusion coefficients were determined. The mentioned system was additionally used to evaluate the performance of the in-house FR apparatus.</p>","PeriodicalId":72562,"journal":{"name":"Chemistry methods : new approaches to solving problems in chemistry","volume":"4 9","pages":""},"PeriodicalIF":6.1,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cmtd.202400006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142233169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cover Picture: (Chem. Methods 7-8/2024) 封面图片：（化学方法 7-8/2024）
IF 6.1
Chemistry methods : new approaches to solving problems in chemistry Pub Date : 2024-08-11 DOI: 10.1002/cmtd.202480701
{"title":"Cover Picture: (Chem. Methods 7-8/2024)","authors":"","doi":"10.1002/cmtd.202480701","DOIUrl":"https://doi.org/10.1002/cmtd.202480701","url":null,"abstract":"<p>\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":72562,"journal":{"name":"Chemistry methods : new approaches to solving problems in chemistry","volume":"4 7-8","pages":""},"PeriodicalIF":6.1,"publicationDate":"2024-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cmtd.202480701","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141967170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultraselective, Ultrahigh Resolution 1D TOCSY 超选择性、超高分辨率 1D TOCSY
IF 6.1
Chemistry methods : new approaches to solving problems in chemistry Pub Date : 2024-08-07 DOI: 10.1002/cmtd.202400013
Dr. James R. D. Montgomery, Emma L. Gates, Dr. Marshall J. Smith, Dr. Daniel A. Taylor, Dr. Jonathan P. Bradley, Dr. Daniel B. G. Berry, Dr. Peter Kiraly, Prof. Mathias Nilsson, Prof. Gareth A. Morris, Dr. Ralph W. Adams, Dr. Laura Castañar
{"title":"Ultraselective, Ultrahigh Resolution 1D TOCSY","authors":"Dr. James R. D. Montgomery,&nbsp;Emma L. Gates,&nbsp;Dr. Marshall J. Smith,&nbsp;Dr. Daniel A. Taylor,&nbsp;Dr. Jonathan P. Bradley,&nbsp;Dr. Daniel B. G. Berry,&nbsp;Dr. Peter Kiraly,&nbsp;Prof. Mathias Nilsson,&nbsp;Prof. Gareth A. Morris,&nbsp;Dr. Ralph W. Adams,&nbsp;Dr. Laura Castañar","doi":"10.1002/cmtd.202400013","DOIUrl":"https://doi.org/10.1002/cmtd.202400013","url":null,"abstract":"<p>Solution state <sup>1</sup>H NMR spectroscopy provides valuable insights into molecular structure and conformation. However, when the spectrum exhibits severe signal overlap, it hampers the extraction of key structural information. Here, an ultraselective, ultrahigh resolution TOCSY method is introduced that greatly reduces spectral complexity, allowing the extraction of previously inaccessible spectral information. It combines the recently developed GEMSTONE excitation with homonuclear decoupling to provide highly simplified through-bond correlation 1D <sup>1</sup>H NMR spectra, showing all signals within the selected spin system as singlets. The new method can greatly facilitate the analysis of mixtures, as shown here for a mixture of <i>Cinchona</i> alkaloids (popular catalysts in asymmetric synthesis) and a mixture of glucocorticoids (used for treating conditions such as asthma).</p>","PeriodicalId":72562,"journal":{"name":"Chemistry methods : new approaches to solving problems in chemistry","volume":"4 9","pages":""},"PeriodicalIF":6.1,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cmtd.202400013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142233117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Conjugation Methods in Synthetic Glycoconjugate Vaccines 合成糖结合疫苗中的结合方法
IF 6.1
Chemistry methods : new approaches to solving problems in chemistry Pub Date : 2024-07-26 DOI: 10.1002/cmtd.202300054
Zirong Huang, Prof. Sheng Chen, Prof. Xuechen Li, Dr. Han Liu
{"title":"Conjugation Methods in Synthetic Glycoconjugate Vaccines","authors":"Zirong Huang,&nbsp;Prof. Sheng Chen,&nbsp;Prof. Xuechen Li,&nbsp;Dr. Han Liu","doi":"10.1002/cmtd.202300054","DOIUrl":"10.1002/cmtd.202300054","url":null,"abstract":"<p>In the past two to three decades, synthetic glycoconjugate vaccines have shown great potential in the prevention of severe infections and protection of high-risk populations. Conjugation of synthetic oligosaccharide haptens to carrier proteins is the key step for the vaccine preparation. In this review, the conjugation methods currently used in the synthesis of glycoconjugate vaccines from synthetic/homogeneous oligosaccharide haptens are summarized with the focus on the reaction conditions (pH and sugar/protein ratio) and performance. This information can help researchers choose the appropriate conjugation methods. Further research directions toward site-specific conjugations and fully homogeneous glycoconjugate vaccines are also discussed.</p>","PeriodicalId":72562,"journal":{"name":"Chemistry methods : new approaches to solving problems in chemistry","volume":"4 7-8","pages":""},"PeriodicalIF":6.1,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cmtd.202300054","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141801191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Orbi-SIMS Mediated Metabolomics Analysis of Pathogenic Tissue up to Cellular Resolution Orbi-SIMS 介导的致病组织代谢组学分析达到细胞分辨率
IF 6.1
Chemistry methods : new approaches to solving problems in chemistry Pub Date : 2024-07-12 DOI: 10.1002/cmtd.202400008
Christine Kern, Astrid Scherer, Laura Gambs, Dr. Mariia Yuneva, Prof. Dr. Henning Walczak, Dr. Gianmaria Liccardi, Julia Saggau, Dr. Peter Kreuzaler, Prof. Dr. Marcus Rohnke
{"title":"Orbi-SIMS Mediated Metabolomics Analysis of Pathogenic Tissue up to Cellular Resolution","authors":"Christine Kern,&nbsp;Astrid Scherer,&nbsp;Laura Gambs,&nbsp;Dr. Mariia Yuneva,&nbsp;Prof. Dr. Henning Walczak,&nbsp;Dr. Gianmaria Liccardi,&nbsp;Julia Saggau,&nbsp;Dr. Peter Kreuzaler,&nbsp;Prof. Dr. Marcus Rohnke","doi":"10.1002/cmtd.202400008","DOIUrl":"10.1002/cmtd.202400008","url":null,"abstract":"<p>Tumors have a complex metabolism that differs from most metabolic processes in healthy tissues. It is highly dynamic and driven by the tumor cells themselves, as well as by the non-transformed stromal infiltrates and immune components. Each of these cell populations has a distinct metabolism that depends on both their cellular state and the availability of nutrients. Consequently, to fully understand the individual metabolic states of all tumor-forming cells, correlative mass spectrometric imaging (MSI) up to cellular resolution with minimal metabolite shift needs to be achieved. By using a secondary ion mass spectrometer (SIMS) equipped with an Orbitrap mass analyzer, we present a workflow to image primary murine tumor tissues up to cellular resolution and correlate these ion images with post acquisition immunofluorescence or histological staining. In a murine breast cancer model, we could identify metabolic profiles that clearly distinguish tumor tissue from stromal cells and immune infiltrates. We demonstrate the robustness of the classification by applying the same profiles to an independent murine model of lung cancer, which is accurately segmented by histological traits. Our pipeline allows metabolic segmentation with simultaneous cell identification, which in the future will enable the design of subpopulation-targeted metabolic interventions for therapeutic purposes.</p>","PeriodicalId":72562,"journal":{"name":"Chemistry methods : new approaches to solving problems in chemistry","volume":"4 7-8","pages":""},"PeriodicalIF":6.1,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cmtd.202400008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141655622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cover Picture: (Chem. Methods 6/2024) 封面图片：（化学方法 6/2024）
IF 6.1
Chemistry methods : new approaches to solving problems in chemistry Pub Date : 2024-06-27 DOI: 10.1002/cmtd.202480601
{"title":"Cover Picture: (Chem. Methods 6/2024)","authors":"","doi":"10.1002/cmtd.202480601","DOIUrl":"https://doi.org/10.1002/cmtd.202480601","url":null,"abstract":"<p>\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":72562,"journal":{"name":"Chemistry methods : new approaches to solving problems in chemistry","volume":"4 6","pages":""},"PeriodicalIF":6.1,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cmtd.202480601","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141488179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cover Picture: (Chem. Methods 5/2024) 封面图片：（化学方法 5/2024）
Chemistry methods : new approaches to solving problems in chemistry Pub Date : 2024-05-02 DOI: 10.1002/cmtd.202480501
{"title":"Cover Picture: (Chem. Methods 5/2024)","authors":"","doi":"10.1002/cmtd.202480501","DOIUrl":"https://doi.org/10.1002/cmtd.202480501","url":null,"abstract":"<p>\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":72562,"journal":{"name":"Chemistry methods : new approaches to solving problems in chemistry","volume":"4 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cmtd.202480501","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140820464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cover Picture:(Chem. Methods 4/2024) 封面图片：（化学方法 4/2024）
Chemistry methods : new approaches to solving problems in chemistry Pub Date : 2024-04-09 DOI: 10.1002/cmtd.202480401
{"title":"Cover Picture:(Chem. Methods 4/2024)","authors":"","doi":"10.1002/cmtd.202480401","DOIUrl":"https://doi.org/10.1002/cmtd.202480401","url":null,"abstract":"<p>\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":72562,"journal":{"name":"Chemistry methods : new approaches to solving problems in chemistry","volume":"4 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cmtd.202480401","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140541093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信