Chemistry methods : new approaches to solving problems in chemistry最新文献

Proton NMR Revisited: Negative Time Reconstruction Transforms Pure Shift and 2D J-Spectroscopy

IF 3.7

Chemistry methods : new approaches to solving problems in chemistry Pub Date : 2026-10-18 DOI: 10.1002/cmtd.70172

Gareth A. Morris, Ellie Davies, Ralph W. Adams, Mathias Nilsson, Soumya S. Roy

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Front Cover: Multispectral Analysis Graphical User Interface for Ratiometric Analysis and Background Correction (Chem. Methods 11/2026) 封面：多光谱分析图形用户界面比率分析和背景校正（化学）。方法11/2026)

IF 3.7

Chemistry methods : new approaches to solving problems in chemistry Pub Date : 2026-10-15 DOI: 10.1002/cmtd.70174

Grayson R. Hoy, Caitlin M. Davis

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Use of Polycyclic Aromatic Compounds as Electrophotocatalysts in Organic Reactions 多环芳香族化合物作为光电催化剂在有机反应中的应用

IF 3.7

Chemistry methods : new approaches to solving problems in chemistry Pub Date : 2026-10-14 DOI: 10.1002/cmtd.70171

Marco Manni, Jacopo Dosso, Federico Franco, Giacomo Filippini

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A Simplified Viscometric Methodology for Rapid Experimental Screening of Polymer–Solvent Affinity 一种用于快速实验筛选聚合物-溶剂亲和性的简化粘度法

IF 3.7

Chemistry methods : new approaches to solving problems in chemistry Pub Date : 2026-10-08 DOI: 10.1002/cmtd.70156

Xabier Manrique-Bernaola, Monica de la Viuda, Laura Palacio, F. Javier Carmona, Antonio Hernández, Pedro Pradanos, Alberto Tena

{"title":"A Simplified Viscometric Methodology for Rapid Experimental Screening of Polymer–Solvent Affinity","authors":"Xabier Manrique-Bernaola, Monica de la Viuda, Laura Palacio, F. Javier Carmona, Antonio Hernández, Pedro Pradanos, Alberto Tena","doi":"10.1002/cmtd.70156","DOIUrl":"https://doi.org/10.1002/cmtd.70156","url":null,"abstract":"The selection of suitable solvents for polymer processing remains largely dependent on empirical optimization and thermodynamic approaches based on Hansen solubility parameters (HSPs), which frequently require extensive solvent-screening campaigns. In this work, a simplified experimental methodology for rapid comparative polymer–solvent evaluation is proposed through dilute-solution viscometry and intrinsic-viscosity analysis. Complete Mark–Houwink–Sakurada (MHS) analysis performed for a model polyimide system revealed that the conformational exponent a remains effectively quasi-invariant within the investigated aprotic solvent family, whereas the hydrodynamic parameter K exhibits substantially stronger solvent dependence. Based on this behavior, a simplified methodology using single-point Solomon–Ciuta intrinsic-viscosity estimations was developed and experimentally validated, showing excellent agreement with complete MHS analysis while substantially reducing experimental complexity, solvent consumption, and material requirements. Comparison of the experimentally determined K values with conventional solvent descriptors revealed that dielectric constant, HSPs, Ra, and RED values do not necessarily reproduce the experimentally observed polymer–solvent interaction trends. The methodology was subsequently extended to PVDF and PES systems using literature-derived Mark–Houwink exponents, demonstrating the transferability of the approach to established polymeric systems under fixed experimental conditions.","PeriodicalId":72562,"journal":{"name":"Chemistry methods : new approaches to solving problems in chemistry","volume":"6 10","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cmtd.70156","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149146165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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CH-π Supramolecular Functionalization of Carbon Nitride Microtubes With a Ru(bda) Coordination Oligomer for Boosting Oxidative Processes Ru（bda）配位低聚物促进氧化过程的CH-π超分子功能化氮化碳微管

IF 3.7

Chemistry methods : new approaches to solving problems in chemistry Pub Date : 2026-10-08 DOI: 10.1002/cmtd.70155

Júlia Prat, Eliana S. Da Silva, Paula Tris-Marzo, Antoni Llobet, Marcos Gil-Sepulcre, Jose Muñoz

{"title":"CH-π Supramolecular Functionalization of Carbon Nitride Microtubes With a Ru(bda) Coordination Oligomer for Boosting Oxidative Processes","authors":"Júlia Prat, Eliana S. Da Silva, Paula Tris-Marzo, Antoni Llobet, Marcos Gil-Sepulcre, Jose Muñoz","doi":"10.1002/cmtd.70155","DOIUrl":"https://doi.org/10.1002/cmtd.70155","url":null,"abstract":"Efficiently interfacing molecular catalysts with nanostructured materials is critical to advance oxidative processes relevant, for example, to energy conversion and chemical sensing. Herein, we report a supramolecular functionalization approach for anchoring a Ru(II)-based coordination oligomer—namely Ru(bda)—onto carbon nitride microtubes (C3N4-MTs) via CH–π interactions, yielding hybrid Ru@C3N4-MTs. After its immobilization on fluorine-doped tin oxide electrode surfaces, the resulting electrochemical transducers were evaluated in two representative oxidative scenarios: i) the electrochemical determination of cysteamine via thiol oxidation and ii) the (photo)electrochemical water oxidation. Remarkably, Ru@C3N4-MTs outperformed benchmark C3N4-MTs and g-C3N4 counterparts, since its inherent microtubular morphology provides enhanced surface-to-volume ratio that facilitates supramolecular catalyst assembly and improves charge transport. Overall, this work establishes a general supramolecular route to engineer advanced C3N4-based electrochemical transducers, which might be tailored for task-specific catalytic applications by tailoring the molecular catalysts.","PeriodicalId":72562,"journal":{"name":"Chemistry methods : new approaches to solving problems in chemistry","volume":"6 10","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cmtd.70155","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149146168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Examining Plasma Polymer-Coated Indium Tin Oxide Slides to Enhance Analyte Detection in Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging 检测等离子体聚合物涂层氧化铟锡载玻片在基质辅助激光解吸/电离质谱成像中增强分析物检测

IF 3.7

Chemistry methods : new approaches to solving problems in chemistry Pub Date : 2026-10-07 DOI: 10.1002/cmtd.202500118

Parul Mittal, Iliana Delcheva, Jens Soltwisch, Peter Hoffmann, Melanie MacGregor, Manuela Klingler-Hoffmann

{"title":"Examining Plasma Polymer-Coated Indium Tin Oxide Slides to Enhance Analyte Detection in Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging","authors":"Parul Mittal, Iliana Delcheva, Jens Soltwisch, Peter Hoffmann, Melanie MacGregor, Manuela Klingler-Hoffmann","doi":"10.1002/cmtd.202500118","DOIUrl":"https://doi.org/10.1002/cmtd.202500118","url":null,"abstract":"Analyte delocalization is a significant challenge in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI). In this study, we present a novel approach to decrease this phenomenon and improve analyte detection by modifying the wettability of indium tin oxide (ITO)-coated glass slides, commonly used for tissue analysis, using plasma polymer coatings. These coatings are stable under vacuum conditions and during the ionization process. Surface coatings had minimal impact on the signal-to-noise ratio of peptides, proteins, and lipids in profiling experiments, where analytes were directly spotted on the surface, but it had a pronounced effect in MALDI MSI. When analyzing fresh-frozen murine brain sections, the highly hydrophobic pPFO coating reduced analyte delocalization and improved the detection of m/z features and lipids compared to uncoated ITO slides. This enhancement was likely due to better preservation of native spatial distribution during tissue-dependent extraction and retention. Notably, cholesterol, a critical analyte in brain research, was easily detected. This study marks the first application of plasma polymers to modify ITO slides for MALDI MSI, resulting in a significant enhancement of localized lipid ion intensity, particularly in the context of high-resolution MALDI-2.","PeriodicalId":72562,"journal":{"name":"Chemistry methods : new approaches to solving problems in chemistry","volume":"6 10","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cmtd.202500118","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149146384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Sustainable Recovery of Actinidin From Actinidia deliciosa Peel Using Biocompatible Cholinium-Based Ionic Liquids 利用生物相容性胆离子液体从美味猕猴桃果皮中可持续回收放线菌素

IF 3.7

Chemistry methods : new approaches to solving problems in chemistry Pub Date : 2026-10-02 DOI: 10.1002/cmtd.70169

Carolina M. Saúde, Cariny Polesca, Ana Paula M. Tavares, Mara G. Freire, Filipe Smith Buarque

{"title":"Sustainable Recovery of Actinidin From Actinidia deliciosa Peel Using Biocompatible Cholinium-Based Ionic Liquids","authors":"Carolina M. Saúde, Cariny Polesca, Ana Paula M. Tavares, Mara G. Freire, Filipe Smith Buarque","doi":"10.1002/cmtd.70169","DOIUrl":"https://doi.org/10.1002/cmtd.70169","url":null,"abstract":"Food waste valorization has emerged as an important strategy to recover high-value biomolecules from underutilized agro-industrial waste. Among them, actinidin, the major protease of Actinidia deliciosa, has attracted considerable interest due to its broad proteolytic activity and potential applications in food processing, nutrition, and biotechnology. In this work, actinidin was extracted from kiwifruit peel using aqueous solutions of cholinium-based ionic liquids (ILs). An initial solvent screening identified cholinium bitartrate [N111(2OH)][Bit] as the most effective extraction medium. Molecular docking studies revealed that the interactions between actinidin and IL ions depend strongly on ion identity, particularly the anion. Process optimization identified 500 mM [N111(2OH)][Bit], a solid-to-liquid ratio of 1:10 w/w, 600 rpm, 45°C, and 30 min as the most favorable extraction conditions, yielding a proteolytic activity of 5.388 U L−1, a protein concentration of 1115.3 mg L−1, and a specific proteolytic activity of 0.00483 U mg−1 protein. The process achieved a Path2Green score of 0.392, indicating moderate sustainability potential, and a process for IL recyclability was proposed. These results support the potential of aqueous cholinium-based ILs for the valorization of kiwifruit peel while defining solvent recovery, toxicological assessment, and technoeconomic evaluation as priorities for further process development.","PeriodicalId":72562,"journal":{"name":"Chemistry methods : new approaches to solving problems in chemistry","volume":"6 10","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cmtd.70169","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149145778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Fast Process Development Made Possible Using an Easy to Duplicate Integrated Microfluidic Platform 使用易于复制的集成微流体平台实现快速工艺开发

IF 3.7

Chemistry methods : new approaches to solving problems in chemistry Pub Date : 2026-09-24 DOI: 10.1002/cmtd.70148

Iyo Baudouy, Emilie Rolland, Gwenael Dupuis, Thomas Drouinot, Florent Malloggi, Hélène Isnard, Guillaume Zante, Jean-Christophe P. Gabriel

{"title":"Fast Process Development Made Possible Using an Easy to Duplicate Integrated Microfluidic Platform","authors":"Iyo Baudouy, Emilie Rolland, Gwenael Dupuis, Thomas Drouinot, Florent Malloggi, Hélène Isnard, Guillaume Zante, Jean-Christophe P. Gabriel","doi":"10.1002/cmtd.70148","DOIUrl":"https://doi.org/10.1002/cmtd.70148","url":null,"abstract":"Selective and efficient purification methods are needed to recover metals from wastes with highly variable and complex compositions, such as printed circuit boards (PCBs). Fast process development is a key requirement for their development due to the rapid variability in waste composition and target metal content from one batch to another. Here, we report an easy-to-replicate integrated microfluidic platform enabling rapid process development, exemplified in the case of a nanosheet-based highly silver-selective membrane. The system combines controlled microfluidic injection, a tangential-flow membrane module, and inline commercial X-ray fluorescence detection within a unified architecture, allowing real-time quantification of metal ion transport under precisely regulated flow conditions. Using a membrane incorporating phosphatoantimonic acid (H3Sb3P2O14), we demonstrate preferential silver transfer from nitric-acid leachates of real silver-rich waste electronic components. The platform enables accurate and inline permeation monitoring while drastically reducing reagent consumption and experimental time compared with conventional batch methods. Moreover, machine learning allowed predicting silver concentrations with good generalization ability to unknown flow rates, which constitutes an additional step toward autonomous process optimization. Overall, this second generation of microfluidic platforms provides an efficient tool for fast process development, accelerated material screening, and optimization of environmentally beneficial recycling pathways.","PeriodicalId":72562,"journal":{"name":"Chemistry methods : new approaches to solving problems in chemistry","volume":"6 10","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cmtd.70148","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149048112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multispectral Analysis Graphical User Interface for Ratiometric Analysis and Background Correction 多光谱分析图形用户界面比例分析和背景校正

IF 3.7

Chemistry methods : new approaches to solving problems in chemistry Pub Date : 2026-09-23 DOI: 10.1002/cmtd.70167

Grayson R. Hoy, Caitlin M. Davis

{"title":"Multispectral Analysis Graphical User Interface for Ratiometric Analysis and Background Correction","authors":"Grayson R. Hoy, Caitlin M. Davis","doi":"10.1002/cmtd.70167","DOIUrl":"https://doi.org/10.1002/cmtd.70167","url":null,"abstract":"Chemical imaging is a powerful branch of modern microscopy encumbered by a lack of flexible, high-throughput analysis tools. Bespoke analytical pipelines typically perform ratiometric analysis on two layers in a multispectral image to describe the relative composition of molecules in a sample. This strategy has been implemented across fields, spanning histopathology, cell biology, environmental science, and materials science. The commercialization of chemical imaging microscopes has facilitated the collection of large multispectral datasets, necessitating accessible ways to process them. This paper describes multispectral analysis graphical user interface (msaGUI), a desktop graphical user interface to analyze individual and batch datasets of multispectral images. Data are loaded as CSV, TSV, or TIFFs and processed through a user-defined sequence of modular image operations that can be flexibly combined, e.g., to reduce spectral crosstalk or background noise. After analysis, data are visualized as exportable images, histograms, and statistics. To yield publication-quality figures, output images are fully customizable. Written in Python with open-source libraries, the msaGUI program is packaged into an executable for Windows and Mac for a fully no-code application. Other operating systems are supported via the Python source code. In summary, msaGUI provides a rapid, graphical solution for analyzing and visualizing multispectral data.","PeriodicalId":72562,"journal":{"name":"Chemistry methods : new approaches to solving problems in chemistry","volume":"6 10","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cmtd.70167","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149048310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of the Thermal Stability of Type I Collagen Extracted From Atlantic Cod (Gadus morhua) Skin 大西洋鳕鱼（Gadus morhua）皮中I型胶原蛋白热稳定性的研究

IF 3.7

Chemistry methods : new approaches to solving problems in chemistry Pub Date : 2026-09-21 DOI: 10.1002/cmtd.70138

Abolfazl Keshmirshekan, Paulo Ribeiro-Claro, João A. P. Coutinho, Sónia P. M. Ventura

{"title":"Characterization of the Thermal Stability of Type I Collagen Extracted From Atlantic Cod (Gadus morhua) Skin","authors":"Abolfazl Keshmirshekan, Paulo Ribeiro-Claro, João A. P. Coutinho, Sónia P. M. Ventura","doi":"10.1002/cmtd.70138","DOIUrl":"https://doi.org/10.1002/cmtd.70138","url":null,"abstract":"Collagen, one of the most abundant structural proteins in vertebrates, is an important compound in biomaterials and biomedicine, with applications in musculoskeletal regeneration and tissue engineering, but also food, packaging, and cosmetics. Its excellent biocompatibility, water-binding capacity, and low cytotoxicity make it highly suitable for these purposes. The chemical structure and functional behavior of extracted collagen vary with its biological source (terrestrial, marine, or recombinant microbial systems) and are strongly influenced by the extraction method, which determines its structural integrity. This work studies the thermal stability of Type I collagen extracted from salted codfish skin at 4°C and subjected to thermal treatment at temperatures from 20°C to 80°C for 72 h. Structural stability and conformational changes were analyzed by UV–Vis, SDS–PAGE, XRD, CD, and FTIR. Results revealed that collagen retained its triple-helical structure up to 20°C, showing no significant deviation from the sample extracted at 4°C. Above 20°C, structural changes are observed, attaining their maximum at 80°C. These results provide insights into the thermal stability of marine collagen and suggest that controlled extraction at room temperature can maintain its structural integrity that can be important toward a sustainable valorization of waste marine biomass.","PeriodicalId":72562,"journal":{"name":"Chemistry methods : new approaches to solving problems in chemistry","volume":"6 10","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cmtd.70138","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149047851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0