Cerebral cortex communications最新文献_第4页

Prefrontal cortical connectivity and coupling of infraslow oscillation in the resting human brain: a 2-channel broadband NIRS study. 静息人脑的前额叶皮层连接和次低振荡耦合：一项双通道宽带近红外光谱研究。

Cerebral cortex communications Pub Date : 2022-08-04 eCollection Date: 2022-01-01 DOI: 10.1093/texcom/tgac033

Sadra Shahdadian, Xinlong Wang, Shu Kang, Caroline Carter, Akhil Chaudhari, Hanli Liu

{"title":"Prefrontal cortical connectivity and coupling of infraslow oscillation in the resting human brain: a 2-channel broadband NIRS study.","authors":"Sadra Shahdadian, Xinlong Wang, Shu Kang, Caroline Carter, Akhil Chaudhari, Hanli Liu","doi":"10.1093/texcom/tgac033","DOIUrl":"10.1093/texcom/tgac033","url":null,"abstract":"The resting-state infraslow oscillation (ISO) of the cerebral cortex reflects the neurophysiological state of the human brain. ISO results from distinct vasomotion with endogenic (E), neurogenic (N), and myogenic (M) frequency bands. Quantification of prefrontal ISO in cortical hemodynamics and metabolism in the resting human brain may facilitate the identification of objective features that are characteristic of certain brain disorders. The goal of this study was to explore and quantify the prefrontal ISO of the cortical concentration changes of oxygenated hemoglobin (Δ[HbO]) and redox-state cytochrome c oxidase (Δ[CCO]) as hemodynamic and metabolic activity metrics in all 3 E/N/M bands. Two-channel broadband near-infrared spectroscopy (2-bbNIRS) enabled measurements of the forehead of 26 healthy young participants in a resting state once a week for 5 weeks. After quantifying the ISO spectral amplitude (SA) and coherence at each E/N/M band, several key and statistically reliable metrics were obtained as features: (i) SA of Δ[HbO] at all E/N/M bands, (ii) SA of Δ[CCO] in the M band, (iii) bilateral connectivity of hemodynamics and metabolism across the E and N bands, and (iv) unilateral hemodynamic-metabolic coupling in each of the E and M bands. These features have promising potential to be developed as objective biomarkers for clinical applications in the future.","PeriodicalId":72551,"journal":{"name":"Cerebral cortex communications","volume":" ","pages":"tgac033"},"PeriodicalIF":0.0,"publicationDate":"2022-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33448955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional connectivity of the medial prefrontal cortex related to mindreading abilities. 内侧前额叶皮层的功能连通性与读心术能力有关。

Cerebral cortex communications Pub Date : 2022-07-31 eCollection Date: 2022-01-01 DOI: 10.1093/texcom/tgac032

Marine Le Petit, Francis Eustache, Joy Perrier, Vincent de La Sayette, Béatrice Desgranges, Mickaël Laisney

{"title":"Functional connectivity of the medial prefrontal cortex related to mindreading abilities.","authors":"Marine Le Petit, Francis Eustache, Joy Perrier, Vincent de La Sayette, Béatrice Desgranges, Mickaël Laisney","doi":"10.1093/texcom/tgac032","DOIUrl":"https://doi.org/10.1093/texcom/tgac032","url":null,"abstract":"The medial prefrontal cortex is a key region of mindreading belonging to the mentalizing system, a set of brain areas underlying mental state inference based on reasoning on social concepts. The aim of this study was to characterize the functional connectivity between regions involved in mindreading and to highlight the processes it underpins, focusing on the dorsal and ventral parts of the medial prefrontal cortex. We analyzed resting-state functional magnetic resonance imaging of 56 healthy volunteers, to study the relationship between mindreading abilities and functional connectivity of the medial prefrontal cortex. Cognitive mindreading performances were correlated with connectivity between the medial prefrontal cortex and frontal regions involved in the regulation of the salience of one's own mental contents, with a distinction between the dorsal part connected to regions subtending inhibition processes and the ventral part to emotional regions. Affective mindreading performances were negatively correlated with negative connectivity of the ventro- and dorsomedial prefrontal cortex with sensorimotor regions belonging to the mirror neuron system subtending the simulation of mental states. These findings suggested a role of the medial prefrontal cortex to decrease the salience of one's own mental content and in the antisynchronous interaction between the mentalizing and mirror neurons systems.","PeriodicalId":72551,"journal":{"name":"Cerebral cortex communications","volume":" ","pages":"tgac032"},"PeriodicalIF":0.0,"publicationDate":"2022-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9454031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33460117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

One session of fMRI-Neurofeedback training on motor imagery modulates whole-brain effective connectivity and dynamical complexity. 一组fmri -神经反馈运动意象训练调节全脑有效连通性和动态复杂性。

Cerebral cortex communications Pub Date : 2022-07-25 eCollection Date: 2022-01-01 DOI: 10.1093/texcom/tgac027

Eleonora De Filippi, Theo Marins, Anira Escrichs, Matthieu Gilson, Jorge Moll, Fernanda Tovar-Moll, Gustavo Deco

{"title":"One session of fMRI-Neurofeedback training on motor imagery modulates whole-brain effective connectivity and dynamical complexity.","authors":"Eleonora De Filippi, Theo Marins, Anira Escrichs, Matthieu Gilson, Jorge Moll, Fernanda Tovar-Moll, Gustavo Deco","doi":"10.1093/texcom/tgac027","DOIUrl":"https://doi.org/10.1093/texcom/tgac027","url":null,"abstract":"In the past decade, several studies have shown that Neurofeedback (NFB) by functional magnetic resonance imaging can alter the functional coupling of targeted and non-targeted areas. However, the causal mechanisms underlying these changes remain uncertain. Here, we applied a whole-brain dynamical model to estimate Effective Connectivity (EC) profiles of resting-state data acquired before and immediately after a single-session NFB training for 17 participants who underwent motor imagery NFB training and 16 healthy controls who received sham feedback. Within-group and between-group classification analyses revealed that only for the NFB group it was possible to accurately discriminate between the 2 resting-state sessions. NFB training-related signatures were reflected in a support network of direct connections between areas involved in reward processing and implicit learning, together with regions belonging to the somatomotor, control, attention, and default mode networks, identified through a recursive-feature elimination procedure. By applying a data-driven approach to explore NFB-induced changes in spatiotemporal dynamics, we demonstrated that these regions also showed decreased switching between different brain states (i.e. metastability) only following real NFB training. Overall, our findings contribute to the understanding of NFB impact on the whole brain's structure and function by shedding light on the direct connections between brain areas affected by NFB training.","PeriodicalId":72551,"journal":{"name":"Cerebral cortex communications","volume":" ","pages":"tgac027"},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33448581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Personal space regulation is affected by unilateral temporal lesions beyond the amygdala. 个人空间调节受杏仁核以外的单侧颞叶病变的影响。

Cerebral cortex communications Pub Date : 2022-07-22 eCollection Date: 2022-01-01 DOI: 10.1093/texcom/tgac031

Audrey Dureux, Luca Zigiotto, Silvio Sarubbo, Clément Desoche, Alessandro Farnè, Nadia Bolognini, Fadila Hadj-Bouziane

{"title":"Personal space regulation is affected by unilateral temporal lesions beyond the amygdala.","authors":"Audrey Dureux, Luca Zigiotto, Silvio Sarubbo, Clément Desoche, Alessandro Farnè, Nadia Bolognini, Fadila Hadj-Bouziane","doi":"10.1093/texcom/tgac031","DOIUrl":"https://doi.org/10.1093/texcom/tgac031","url":null,"abstract":"We constantly face situations involving interactions with others that require us to automatically adjust our physical distances to avoid discomfort or anxiety. A previous case study has demonstrated that the integrity of both amygdalae is essential to regulate interpersonal distances. Despite unilateral lesion to the amygdala, as to other sectors of the medial temporal cortex, are known to also affect social behavior, their role in the regulation of interpersonal distances has never been investigated. Here, we sought to fill this gap by testing three patients with unilateral temporal lesions following surgical resections, including one patient with a lesion mainly centered on the amygdala and two with lesions to adjacent medial temporal cortex, on two versions of the stop distance paradigm (i.e. in a virtual reality environment and in a real setting). Our results showed that all three patients set shorter interpersonal distances compared to neurotypical controls. In addition, compared to controls, none of the patients adjusted such physical distances depending on facial emotional expressions, despite they preserved ability to categorize them. Finally, patients' heart rate responses differed from controls when viewing approaching faces. Our findings bring compelling evidence that unilateral lesions within the medial temporal cortex, not necessarily restricted to the amygdala, are sufficient to alter interpersonal distance, thus shedding new light on the neural circuitry regulating distance in social interactions.","PeriodicalId":72551,"journal":{"name":"Cerebral cortex communications","volume":" ","pages":"tgac031"},"PeriodicalIF":0.0,"publicationDate":"2022-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33448580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amygdala subnuclei volumes, functional connectivity, and social-emotional outcomes in children born very preterm. 非常早产儿童的杏仁核亚核体积、功能连通性和社会情感结局。

Cerebral cortex communications Pub Date : 2022-07-22 eCollection Date: 2022-01-01 DOI: 10.1093/texcom/tgac028

Megan Mueller, Benjamin Thompson, Tanya Poppe, Jane Alsweiler, Greg Gamble, Yannan Jiang, Myra Leung, Anna C Tottman, Trecia Wouldes, Jane E Harding, Emma G Duerden

{"title":"Amygdala subnuclei volumes, functional connectivity, and social-emotional outcomes in children born very preterm.","authors":"Megan Mueller, Benjamin Thompson, Tanya Poppe, Jane Alsweiler, Greg Gamble, Yannan Jiang, Myra Leung, Anna C Tottman, Trecia Wouldes, Jane E Harding, Emma G Duerden","doi":"10.1093/texcom/tgac028","DOIUrl":"https://doi.org/10.1093/texcom/tgac028","url":null,"abstract":"Children born very preterm can demonstrate social-cognitive impairments, which may result from limbic system dysfunction. Altered development of the subnuclei of the amygdala, stress-sensitive regions involved in emotional processing, may be key predictors of social-skill development. In a prospective cohort study, 7-year-old children born very preterm underwent neurodevelopmental testing and brain MRI. The Child Behavioral Checklist was used to assess social-emotional outcomes. Subnuclei volumes were extracted automatically from structural scans (n = 69) and functional connectivity (n = 66) was examined. General Linear Models were employed to examine the relationships between amygdala subnuclei volumes and functional connectivity values and social-emotional outcomes. Sex was a significant predictor of all social-emotional outcomes (P < 0.05), with boys having poorer social-emotional outcomes. Smaller right basal nuclei volumes (B = -0.043, P = 0.014), smaller right cortical volumes (B = -0.242, P = 0.02) and larger right central nuclei volumes (B = 0.85, P = 0.049) were associated with increased social problems. Decreased connectivity strength between thalamic and amygdala networks and smaller right basal volumes were significant predictors of greater social problems (both, P < 0.05), effects which were stronger in girls (P = 0.025). Dysregulated maturation of the amygdala subnuclei, along with altered connectivity strength in stress-sensitive regions, may reflect stress-induced dysfunction and can be predictive of social-emotional outcomes.","PeriodicalId":72551,"journal":{"name":"Cerebral cortex communications","volume":" ","pages":"tgac028"},"PeriodicalIF":0.0,"publicationDate":"2022-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9383265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40414102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Joint attention in infants at high familial risk for autism spectrum disorder and the association with thalamic and hippocampal macrostructure. 自闭症谱系障碍高家族风险婴儿的共同注意与丘脑和海马宏观结构的关系

Cerebral cortex communications Pub Date : 2022-07-22 eCollection Date: 2022-01-01 DOI: 10.1093/texcom/tgac029

Julia T P Montenegro, Diane Seguin, Emma G Duerden

{"title":"Joint attention in infants at high familial risk for autism spectrum disorder and the association with thalamic and hippocampal macrostructure.","authors":"Julia T P Montenegro, Diane Seguin, Emma G Duerden","doi":"10.1093/texcom/tgac029","DOIUrl":"https://doi.org/10.1093/texcom/tgac029","url":null,"abstract":"Autism spectrum disorder (ASD) is a heritable neurodevelopmental disorder. Infants diagnosed with ASD can show impairments in spontaneous gaze-following and will seldom engage in joint attention (JA). The ability to initiate JA (IJA) can be more significantly impaired than the ability to respond to JA (RJA). In a longitudinal study, 101 infants who had a familial risk for ASD were enrolled (62% males). Participants completed magnetic resonance imaging scans at 4 or 6 months of age. Subcortical volumes (thalamus, hippocampus, amygdala, basal ganglia, ventral diencephalon, and cerebellum) were automatically extracted. Early gaze and JA behaviors were assessed with standardized measures. The majority of infants were IJA nonresponders (n = 93, 92%), and over half were RJA nonresponders (n = 50, 52%). In the nonresponder groups, models testing the association of subcortical volumes with later ASD diagnosis accounted for age, sex, and cerebral volumes. In the nonresponder IJA group, using regression method, the left hippocampus (B = -0.009, aOR = 0.991, P = 0.025), the right thalamus (B = -0.016, aOR = 0.984, P = 0.026), as well as the left thalamus (B = 0.015, aOR = 1.015, P = 0.019), predicted later ASD diagnosis. Alterations in thalamic and hippocampal macrostructure in at-risk infants who do not engage in IJA may reflect an enhanced vulnerability and may be the key predictors of later ASD development.","PeriodicalId":72551,"journal":{"name":"Cerebral cortex communications","volume":" ","pages":"tgac029"},"PeriodicalIF":0.0,"publicationDate":"2022-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33448579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integration of allocentric and egocentric visual information in a convolutional/multilayer perceptron network model of goal-directed gaze shifts. 基于卷积/多层感知器网络模型的非中心和自我中心视觉信息整合。

Cerebral cortex communications Pub Date : 2022-07-08 eCollection Date: 2022-01-01 DOI: 10.1093/texcom/tgac026

Parisa Abedi Khoozani, Vishal Bharmauria, Adrian Schütz, Richard P Wildes, J Douglas Crawford

{"title":"Integration of allocentric and egocentric visual information in a convolutional/multilayer perceptron network model of goal-directed gaze shifts.","authors":"Parisa Abedi Khoozani, Vishal Bharmauria, Adrian Schütz, Richard P Wildes, J Douglas Crawford","doi":"10.1093/texcom/tgac026","DOIUrl":"https://doi.org/10.1093/texcom/tgac026","url":null,"abstract":"Allocentric (landmark-centered) and egocentric (eye-centered) visual codes are fundamental for spatial cognition, navigation, and goal-directed movement. Neuroimaging and neurophysiology suggest these codes are initially segregated, but then reintegrated in frontal cortex for movement control. We created and validated a theoretical framework for this process using physiologically constrained inputs and outputs. To implement a general framework, we integrated a convolutional neural network (CNN) of the visual system with a multilayer perceptron (MLP) model of the sensorimotor transformation. The network was trained on a task where a landmark shifted relative to the saccade target. These visual parameters were input to the CNN, the CNN output and initial gaze position to the MLP, and a decoder transformed MLP output into saccade vectors. Decoded saccade output replicated idealized training sets with various allocentric weightings and actual monkey data where the landmark shift had a partial influence (R 2 = 0.8). Furthermore, MLP output units accurately simulated prefrontal response field shifts recorded from monkeys during the same paradigm. In summary, our model replicated both the general properties of the visuomotor transformations for gaze and specific experimental results obtained during allocentric-egocentric integration, suggesting it can provide a general framework for understanding these and other complex visuomotor behaviors.","PeriodicalId":72551,"journal":{"name":"Cerebral cortex communications","volume":" ","pages":"tgac026"},"PeriodicalIF":0.0,"publicationDate":"2022-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334293/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40681116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Neural basis for anxiety and anxiety-related physiological responses during a driving situation: an fMRI study. 驾驶情况下焦虑和焦虑相关生理反应的神经基础:一项功能磁共振成像研究。

Cerebral cortex communications Pub Date : 2022-06-20 eCollection Date: 2022-01-01 DOI: 10.1093/texcom/tgac025

Takafumi Sasaoka, Tokiko Harada, Daichi Sato, Nanae Michida, Hironobu Yonezawa, Masatoshi Takayama, Takahide Nouzawa, Shigeto Yamawaki

{"title":"Neural basis for anxiety and anxiety-related physiological responses during a driving situation: an fMRI study.","authors":"Takafumi Sasaoka, Tokiko Harada, Daichi Sato, Nanae Michida, Hironobu Yonezawa, Masatoshi Takayama, Takahide Nouzawa, Shigeto Yamawaki","doi":"10.1093/texcom/tgac025","DOIUrl":"https://doi.org/10.1093/texcom/tgac025","url":null,"abstract":"Although the exteroceptive and interoceptive prediction of a negative event increases a person's anxiety in daily life situations, the relationship between the brain mechanism of anxiety and the anxiety-related autonomic response has not been fully understood. In this functional magnetic resonance imaging (fMRI) study, we examined the neural basis of anxiety and anxiety-related autonomic responses in a daily driving situation. Participants viewed a driving video clip in the first-person perspective. During the video clip, participants were presented with a cue to indicate whether a subsequent crash could occur (attention condition) or not (safe condition). Enhanced activities in the anterior insula, bed nucleus of the stria terminalis, thalamus, and periaqueductal gray, and higher sympathetic nerve responses (pupil dilation and peripheral arterial stiffness) were triggered by the attention condition but not with the safe condition. Autonomic response-related functional connectivity was detected in the visual cortex, cerebellum, brainstem, and MCC/PCC with the right anterior insula and its adjacent regions as seed regions. Thus, the right anterior insula and adjacent regions, in collaboration with other regions play a role in eliciting anxiety based on the prediction of negative events, by mediating anxiety-related autonomic responses according to interoceptive information.","PeriodicalId":72551,"journal":{"name":"Cerebral cortex communications","volume":" ","pages":"tgac025"},"PeriodicalIF":0.0,"publicationDate":"2022-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279323/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40520968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Brain morphometric similarity and flexibility. 脑形态相似性和灵活性。

Cerebral cortex communications Pub Date : 2022-06-16 eCollection Date: 2022-01-01 DOI: 10.1093/texcom/tgac024

Vesna Vuksanović

{"title":"Brain morphometric similarity and flexibility.","authors":"Vesna Vuksanović","doi":"10.1093/texcom/tgac024","DOIUrl":"https://doi.org/10.1093/texcom/tgac024","url":null,"abstract":"Background: The cerebral cortex is represented through multiple multilayer morphometric similarity networks to study their modular structures. The approach introduces a novel way for studying brain networks' metrics across individuals, and can quantify network properties usually not revealed using conventional network analyses.Methods: A total of 8 combinations or types of morphometric similarity networks were constructed - 4 combinations of the inter-regional cortical features on 2 brain atlases. The networks' modular structures were investigated by identifying those modular interactions that stay consistent across the combinations of inter-regional morphometric features and individuals.Results: The results provide evidence of the community structures as the property of (i) cortical lobar divisions, and also as (ii) the product of different combinations of morphometric features used for the construction of the multilayer representations of the cortex. For the first time, this study has mapped out flexible and inflexible morphometric similarity hubs, and evidence has been provided about variations of the modular network topology across the multilayers with age and IQ.Conclusions: The results contribute to understanding of intra-regional characteristics in cortical interactions, which potentially can be used to map heterogeneous neurodegeneration patterns in diseased brains.","PeriodicalId":72551,"journal":{"name":"Cerebral cortex communications","volume":" ","pages":"tgac024"},"PeriodicalIF":0.0,"publicationDate":"2022-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9283106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40520967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Cerebro-cerebellar interactions in nonhuman primates examined by optogenetic functional magnetic resonance imaging. 通过光遗传功能磁共振成像研究非人灵长类的大脑-小脑相互作用。

Cerebral cortex communications Pub Date : 2022-05-25 eCollection Date: 2022-01-01 DOI: 10.1093/texcom/tgac022

Naokazu Goda, Taku Hasegawa, Daisuke Koketsu, Satomi Chiken, Satomi Kikuta, Hiromi Sano, Kenta Kobayashi, Atsushi Nambu, Norihiro Sadato, Masaki Fukunaga

{"title":"Cerebro-cerebellar interactions in nonhuman primates examined by optogenetic functional magnetic resonance imaging.","authors":"Naokazu Goda, Taku Hasegawa, Daisuke Koketsu, Satomi Chiken, Satomi Kikuta, Hiromi Sano, Kenta Kobayashi, Atsushi Nambu, Norihiro Sadato, Masaki Fukunaga","doi":"10.1093/texcom/tgac022","DOIUrl":"10.1093/texcom/tgac022","url":null,"abstract":"Functional magnetic resonance imaging (fMRI) is a promising approach for the simultaneous and extensive scanning of whole-brain activities. Optogenetics is free from electrical and magnetic artifacts and is an ideal stimulation method for combined use with fMRI. However, the application of optogenetics in nonhuman primates (NHPs) remains limited. Recently, we developed an efficient optogenetic intracortical microstimulation method of the primary motor cortex (M1), which successfully induced forelimb movements in macaque monkeys. Here, we aimed to investigate how optogenetic M1 stimulation causes neural modulation in the local and remote brain regions in anesthetized monkeys using 7-tesla fMRI. We demonstrated that optogenetic stimulation of the M1 forelimb and hindlimb regions successfully evoked robust direct and remote fMRI activities. Prominent remote activities were detected in the anterior and posterior lobes in the contralateral cerebellum, which receive projections polysynaptically from the M1. We further demonstrated that the cerebro-cerebellar projections from these M1 regions were topographically organized, which is concordant with the somatotopic map in the cerebellar cortex previously reported in macaques and humans. The present study significantly enhances optogenetic fMRI in NHPs, resulting in profound understanding of the brain network, thereby accelerating the translation of findings from animal models to humans.","PeriodicalId":72551,"journal":{"name":"Cerebral cortex communications","volume":" ","pages":"tgac022"},"PeriodicalIF":0.0,"publicationDate":"2022-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9233902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40410725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0