Cerebral circulation - cognition and behavior最新文献

{"title":"A SYSTEMATIC REVIEW INTO THE RELATIONSHIP BETWEEN BLOOD PRESSURE VARIABILITY AND GREY AND WHITE MATTER STRUCTURES","authors":"Daria Gutteridge","doi":"10.1016/j.cccb.2022.100067","DOIUrl":"https://doi.org/10.1016/j.cccb.2022.100067","url":null,"abstract":"","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"6 ","pages":"Article 100067"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666245022000320/pdfft?md5=0789a0679521f7d1f9d262d17284f7a4&pid=1-s2.0-S2666245022000320-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141479032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CEREBROSPINAL FLUID BIOMARKERS, BRAIN STRUCTURAL AND COGNITIVE PERFORMANCES BETWEEN NORMOTENSIVE AND HYPERTENSIVE CONTROLLED, UNCONTROLLED AND UNTREATED 70-YEAR-OLD ADULTS","authors":"Atef Badji, Joana Pereira, Sara Shams, Johan Skoog, Anna Marseglia, Konstantinos Poulakis, lina Ryden, Kaj Blennow, Henrik Zetterberg, Silke Kern, Anna Wahlund, Lars-Olof Wahlund, Hélène Girouard, Ingmar Skoog, Eric Westman","doi":"10.1016/j.cccb.2022.100048","DOIUrl":"https://doi.org/10.1016/j.cccb.2022.100048","url":null,"abstract":"","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"6 ","pages":"Article 100048"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666245022000137/pdfft?md5=c31da3332c6686af0731f6024a76bed3&pid=1-s2.0-S2666245022000137-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141479033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PURE VASCULAR-ISCHEMIC DISEASE AND COGNITIVE IMPAIRMENT","authors":"Elisabet Englund, Keivan Javanshiri, Mattias Haglund","doi":"10.1016/j.cccb.2022.100063","DOIUrl":"https://doi.org/10.1016/j.cccb.2022.100063","url":null,"abstract":"","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"6 ","pages":"Article 100063"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666245022000289/pdfft?md5=1726e4e9070c0ad116aa3bb799440db6&pid=1-s2.0-S2666245022000289-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141479091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DOES WHITE MATTER HYPERINTENSITY LOCATION PREDICT COGNITIVE IMPAIRMENT IN AN ELDERLY POPULATION?","authors":"Polly Roads, Polina Emeliyanova, Laura Parkes","doi":"10.1016/j.cccb.2022.100101","DOIUrl":"https://doi.org/10.1016/j.cccb.2022.100101","url":null,"abstract":"","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"6 ","pages":"Article 100101"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666245022000666/pdfft?md5=ac4fcdb6cd3f44e46fa4a5c47287d45d&pid=1-s2.0-S2666245022000666-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141480252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ETHNIC DIFFERENCES IN THE PREVALENCE OF COGNITIVE IMPAIRMENT AND DEMENTIA: BASED ON THE EPIDEMIOLOGY OF DEMENTIA IN SINGAPORE (EDIS)STUDY","authors":"Ting Pang , Xuhao Zhao , Xin Xu","doi":"10.1016/j.cccb.2022.100068","DOIUrl":"https://doi.org/10.1016/j.cccb.2022.100068","url":null,"abstract":"","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"6 ","pages":"Article 100068"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666245022000332/pdfft?md5=0fd58c0e1b3b54aa8514ee4f9206e7d6&pid=1-s2.0-S2666245022000332-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141481119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CAIDE DEMENTIA RISK SCORE RELATES TO SEVERITY AND PROGRESSION OF CEREBRAL SMALL VESSEL DISEASE IN HEALTHY MIDLIFE ADULTS: THE PREVENT-DEMENTIA","authors":"Audrey Low , Maria A Prats-Sedano , James D Stefaniak , Elizabeth McKiernan , Stephen F Carter , Maria-Eleni Dounavi , Elijah Mak , Li Su , Olivia Stupart , Graciela Muniz-Terrera , Karen Ritchie , Craig W Ritchie , Hugh S Markus , John T O'Brien","doi":"10.1016/j.cccb.2022.100050","DOIUrl":"https://doi.org/10.1016/j.cccb.2022.100050","url":null,"abstract":"","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"6 ","pages":"Article 100050"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666245022000150/pdfft?md5=72a88a5269ca14607afe04e6a440da18&pid=1-s2.0-S2666245022000150-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141481129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SELF-REPORTED COGNITIVE DECLINE, EMOTIONAL SYMPTOMS, AND DAYTIME SLEEP AFTER ISCHEMIC STROKE","authors":"Elisabeth Kliem , Angela Labberton , Mathias Barra , Elise Gjestad , Bent Indredavik , Ramune Grambaite","doi":"10.1016/j.cccb.2022.100081","DOIUrl":"https://doi.org/10.1016/j.cccb.2022.100081","url":null,"abstract":"","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"6 ","pages":"Article 100081"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666245022000460/pdfft?md5=c1e4e463faa9a5852487ef07f1b2cfa6&pid=1-s2.0-S2666245022000460-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141482312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying factors affecting resilience in atrophy-based subtypes of vascular cognitive impairment","authors":"Vikram Venkatraghavan ,&nbsp;Betty Tijms ,&nbsp;Hugo Kuijf ,&nbsp;Alberto de Luca ,&nbsp;Esther Bron ,&nbsp;Argonde van Harten ,&nbsp;Lieza Exalto ,&nbsp;Frederik Barkhof ,&nbsp;Rik Ossenkoppele ,&nbsp;Geert Jan Biessels ,&nbsp;Wiesje van der Flier","doi":"10.1016/j.cccb.2024.100253","DOIUrl":"10.1016/j.cccb.2024.100253","url":null,"abstract":"<div><h3>Introduction</h3><p>Vascular cognitive impairment (VCI) is heterogeneous in brain atrophy patterns, clinical symptoms, and possibly in the factors affecting resilience to symptoms. The objective of this study was to investigate the heterogeneity of VCI by estimating different atrophy-driven subtypes and use those for identifying resilience factors in each subtype.</p></div><div><h3>Methods</h3><p>We used cross-sectional data from the Trace-VCI cohort comprising of memory-clinic patients with vascular brain injury on MRI (n=361 all-cause dementia, n=190 MCI, and n=188 SCD). White matter hyper-intensities (WMH) were segmented, and SLF toolbox was used to refill them on the MRIs for accurate parcellation. Freesurfer volumes were used for identifying subtypes with non-negative matrix factorization. Subtype-specific pseudo-timelines of progression were estimated using a previously validated discriminative event-based model. Severity of atrophy (SA) in patients was estimated using cross-validation based on their position on the pseudo-timeline. Using linear-regression, cognition and disability (MMSE, Global deterioration scale, disability assessment for dementia) were modelled to be dependent on SA and its interactions with genetic factors, vascular markers and risk-factors, and co-pathology independently (variables in Figure-3). Resilience factors were identified by testing if the model with the interaction explains the symptoms significantly more than the one without.</p></div><div><h3>Results</h3><p>The algorithm identified three atrophy-based VCI subtypes: Frontal, Subcortical/Temporal, and Parietal subtype. Their prevalence, vascular and clinical presentations are summarized in Figure-1. The pseudo-timelines of atrophy are shown in Figure-2. SA's interaction with education positively influenced cognition in all subtypes, but negatively influenced disability in subcortical/temporal subtype. In frontal and parietal subtypes, APOE ε4, AD co-pathology resulted in more SA without worsening symptoms. SA's interaction with smoking and microbleeds negatively influenced disability. In the subcortical/temporal subtype, SA's interaction with WMH, lacunes, infarcts negatively impacted disability. In parietal subtype, men have more cognitive resilience than women. SA's interaction with hypercholesterolemia, and smoking were significantly negative for cognition. Lacunes were associated with more SA without affecting cognition. Figure-3 summarizes the interactions for all subtypes.</p></div><div><h3>Discussion</h3><p>We identified three atrophy-based VCI subtypes where the risk-factors have different influence on atrophy and symptoms highlighting differences in resilience. These results could aid in prognosis and in personalizing patients’ intervention strategy.</p></div>","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"6 ","pages":"Article 100253"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666245024000540/pdfft?md5=98c5abd2834472a132583352cf9a5ce0&pid=1-s2.0-S2666245024000540-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142121605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of apelin-13 in ischemic stroke under high-fat diet-induced metabolic disturbances at middle- age","authors":"Maud Petrault,&nbsp;Olivier Petrault,&nbsp;Vincent Berezows Ki,&nbsp;Patrick Gele,&nbsp;Michèle Bastide","doi":"10.1016/j.cccb.2024.100244","DOIUrl":"10.1016/j.cccb.2024.100244","url":null,"abstract":"<div><h3>Introduction</h3><p>Visceral fat gain and the progressive onset of metabolic disorders in middle-aged mice induce alteration of the cerebral vascular tree in association with mild cognitive impairment. This precipitates stroke risk and might prompt the middle-aged population to cognitive decline. In this context, an endogenous peptide named apelin-13 and its receptor APJ are suspected to link metabolic disorders at middle age to the consequences of ischemic stroke on brain tissue, as well as vasomotor and cognitive functions. Apelin-13 induces neuroprotection after experimental ischemic stroke, but this action has not been examined under metabolic disturbances. The aim of our study is to evaluate the role of apelin-13 as a new therapeutic target in ischemic stroke under high-fat diet-induced metabolic disturbances at middle-age.</p></div><div><h3>Methods</h3><p>C57Bl/6 mice were fed for 6 months with normal diet (ND) or high-fat diet (HFD) before 30-minute middle cerebral artery occlusion (MCAO). Metabolic parameters, as well as circulating apelin-13 levels were evaluated every 3 months before MCAO. APJ brain expression and plasmatic apelin rate were assess at acute phase (24h post-stroke) and after behavioral (motor and cognitive) evaluation at chronic phase (10 days after MCAO).</p></div><div><h3>Results</h3><p>Mice under HFD developed overweight, hyperglycemia and hypercholesterolemia. Plasmatic apelin slowly decreased with age and was different between overweight and lean mice, but not between HFD and ND. The onset of MCAO under HFD induced 49% higher mortality than under ND. At acute phase, mice under HFD had a 25% decreased plasmatic apelin rate whereas mice under ND had a 2.5% of reduction. APJ brain expression in HFD mice was 59% reduced compared to ND. After 10 days, worsened behavioral impairment was observed in HFD mice compared to ND mice. Plasmatic apelin levels were reduced whatever the diet.</p></div><div><h3>Discussion</h3><p>These first results highlight the contribution of the apelinergic system to the influence of metabolic disturbances on stroke severity, that should be considered in therapeutic studies.</p></div>","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"6 ","pages":"Article 100244"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266624502400045X/pdfft?md5=0976ed8fbb064eaae747131d9c678082&pid=1-s2.0-S266624502400045X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142121672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular Risk Management in Persons with Dementia","authors":"Charlotte Nijskens ,&nbsp;Marieke Henstra ,&nbsp;Hanneke Rhodius-Meester ,&nbsp;Sevil Yasar ,&nbsp;Eveline van Poelgeest ,&nbsp;Mike Peters ,&nbsp;Majon Muller","doi":"10.1016/j.cccb.2024.100245","DOIUrl":"10.1016/j.cccb.2024.100245","url":null,"abstract":"<div><p>The number of people living with dementia, such as Alzheimer's disease, is increasing worldwide. Persons with dementia often have a high risk of atherosclerotic cardiovascular disease and they are therefore theoretically eligible for treatment of hypertension and hyperlipidemia. However, in this population, beneficial and harmful effects of cardiovascular risk management (CVRM) may be different compared to older persons without cognitive impairment. Current CVRM guidelines are based on trials from which persons with dementia were excluded. In this narrative review, we will discuss how current guidelines can be translated to persons with dementia and which aspects should be taken into account when treating hypertension and hyperlipidemia to prevent major adverse cardiovascular events (MACE). Survival time is significantly shorter in persons with dementia. We therefore suggest that since the main goal of CVRM is prevention of MACE, first of all, the patient's life expectancy and treatment wishes should be evaluated. Risk assessment tools are to be used with care, as they tend to overestimate the 5- and 10-year risk of MACE and benefit from CVRM in the prevention of MACE in persons with dementia. When the clinician and patient have decided that treatment is initiated or intensified, patients should be closely monitored since they are at high risk for adverse drugs events and overtreatment due to the natural course of blood pressure in persons with dementia. In the event of intolerance or side effects, medication should be switched or withdrawn. For persons with dementia and limited life expectancy, deprescribing should be part of usual care.</p></div>","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"6 ","pages":"Article 100245"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666245024000461/pdfft?md5=0d3a46a72145d86c8878a51dc912a36c&pid=1-s2.0-S2666245024000461-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142121673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}