Cerebral circulation - cognition and behavior最新文献

{"title":"CAIDE DEMENTIA RISK SCORE RELATES TO SEVERITY AND PROGRESSION OF CEREBRAL SMALL VESSEL DISEASE IN HEALTHY MIDLIFE ADULTS: THE PREVENT-DEMENTIA","authors":"Audrey Low , Maria A Prats-Sedano , James D Stefaniak , Elizabeth McKiernan , Stephen F Carter , Maria-Eleni Dounavi , Elijah Mak , Li Su , Olivia Stupart , Graciela Muniz-Terrera , Karen Ritchie , Craig W Ritchie , Hugh S Markus , John T O'Brien","doi":"10.1016/j.cccb.2022.100050","DOIUrl":"https://doi.org/10.1016/j.cccb.2022.100050","url":null,"abstract":"","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"6 ","pages":"Article 100050"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666245022000150/pdfft?md5=72a88a5269ca14607afe04e6a440da18&pid=1-s2.0-S2666245022000150-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141481129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SELF-REPORTED COGNITIVE DECLINE, EMOTIONAL SYMPTOMS, AND DAYTIME SLEEP AFTER ISCHEMIC STROKE","authors":"Elisabeth Kliem , Angela Labberton , Mathias Barra , Elise Gjestad , Bent Indredavik , Ramune Grambaite","doi":"10.1016/j.cccb.2022.100081","DOIUrl":"https://doi.org/10.1016/j.cccb.2022.100081","url":null,"abstract":"","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"6 ","pages":"Article 100081"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666245022000460/pdfft?md5=c1e4e463faa9a5852487ef07f1b2cfa6&pid=1-s2.0-S2666245022000460-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141482312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial. CCCB: The journal at age 5","authors":"Atticus H Hainsworth ,&nbsp;Riccardo Paracampo ,&nbsp;Anders Wallin","doi":"10.1016/j.cccb.2024.100368","DOIUrl":"10.1016/j.cccb.2024.100368","url":null,"abstract":"<div><div>The journal <em>Cerebral Circulation, Cognition &amp; Behavior</em> (<em>CCCB</em>) was conceived to serve at the border zone between the fields of cognition, brain vascular function, cerebrovascular disease and neurodegeneration. An umbrella term often used for this spectrum of disorders or conditions is Vascular contributions to Cognitive Impairment and Dementia (VCID). The journal was launched in 2020. Since then <em>CCCB</em> has published 146 articles and achieved listing on PubMed, Web of Science, Directory of Open Access Journals and Scopus. A Web of Science journal impact factor of 1.9 for 2023 has recently been released. The journal is online-only, with Gold Open Access. The number of full-text downloads is high, averaging 1200 per article.</div></div>","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"7 ","pages":"Article 100368"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142908006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The protocol for an observational Australian cohort study of CADASIL: The AusCADASIL study","authors":"Danit G. Saks ,&nbsp;Beata Bajorek ,&nbsp;Vibeke S. Catts ,&nbsp;Adam C. Bentvelzen ,&nbsp;Jiyang Jiang ,&nbsp;Wei Wen ,&nbsp;Karen A. Mather ,&nbsp;Anbupalam Thalamuthu ,&nbsp;Jessie Huang-Lung ,&nbsp;Lisa Nivison-Smith ,&nbsp;Lyn R. Griffiths ,&nbsp;Robert A. Smith ,&nbsp;Adrienne Sexton ,&nbsp;Paul James ,&nbsp;Tharusha Jayasena ,&nbsp;Anne Poljak ,&nbsp;Gurpreet K. Hansra ,&nbsp;Satoshi Hosoki ,&nbsp;Ashley Park ,&nbsp;Claudia M. Hillenbrand ,&nbsp;Perminder S. Sachdev","doi":"10.1016/j.cccb.2024.100225","DOIUrl":"https://doi.org/10.1016/j.cccb.2024.100225","url":null,"abstract":"<div><h3>Introduction</h3><p>Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a rare genetic condition with a broad phenotypic presentation. This study aims to establish the first Australian cohort of individuals affected by CADASIL (AusCADASIL) and examine its clinical features and longitudinal course, and to investigate neuroimaging and blood biomarkers to assist in early diagnosis and identify disease progression.</p></div><div><h3>Methods</h3><p>Participants will be recruited from six study centres across Australia for an observational study of CADASIL. We aim to recruit 150 participants with diagnosed CADASIL, family history of CADASIL or suspected CADASIL symptoms, and 150 cognitively normal <em>NOTCH3</em> negative individuals as controls. Participants will complete: 1) online questionnaires on medical and family history, mental health, and wellbeing; 2) neuropsychological evaluation; 3) neurological examination and brain MRI; 4) ocular examination and 5) blood sample donation. Participants will have annual follow-up for 4 years to assess their progression and will be asked to invite a study partner to corroborate their self-reported cognitive and functional abilities.</p><p>Primary outcomes include cognitive function and neuroimaging abnormalities. Secondary outcomes include investigation of genetics and blood and ocular biomarkers. Data from the cohort will contribute to an international consortium, and cohort participants will be invited to access future treatment/health intervention trials.</p></div><div><h3>Discussion</h3><p>AusCADASIL will be the first study of an Australian cohort of individuals with CADASIL. The study will identify common pathogenic variants in this cohort, and characterise the pattern of clinical presentation and longitudinal progression, including imaging features, blood and ocular biomarkers and cognitive profile.</p></div>","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"6 ","pages":"Article 100225"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666245024000266/pdfft?md5=d13da543f8720e9a466517825ffaa5e8&pid=1-s2.0-S2666245024000266-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141239334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What matters to people and families affected by cerebral small vessel disease (SVD)? A qualitative grounded theory investigation","authors":"Sophia Wong Ching Hwai ,&nbsp;Joanna M. Wardlaw ,&nbsp;Anna Williams ,&nbsp;Fergus N. Doubal","doi":"10.1016/j.cccb.2024.100202","DOIUrl":"10.1016/j.cccb.2024.100202","url":null,"abstract":"<div><h3>Background</h3><p>Cerebral small vessel disease (SVD) is a common neurological disorder contributing to stroke, dementia, and disability. No treatment options exist although clinical trials are ongoing. We aimed to understand what matters to people and families affected by SVD to inform future research.</p></div><div><h3>Methods</h3><p>We thematically analysed unsolicited correspondences from members of the public addressed to members of the Edinburgh SVD Research Group on a variety of subjects related to SVD. We used inductive thematic codes, categorised under concerns, requests, emotions, and contributions, to form a grounded theory that categorised and ranked concerns raised.</p></div><div><h3>Results</h3><p>101 correspondents expressed 346 concerns between August 2015 and February 2021, mostly via email. 60 correspondents (59.4 %) disclosed a SVD diagnosis, 39 (38.6 %) disclosed a previous stroke or TIA, and 40 (39.6 %) were family of people living with SVD. Primary concerns related to cognitive problems (number of correspondents (n)=43 (42.6 %)), lack of support or information from healthcare services (<em>n</em> = 41 (40.6 %)), prognosis (<em>n</em> = 37 (36.6 %)), sensory disturbances (<em>n</em> = 27 (26.7 %)), functional problems (<em>n</em> = 24, (23.8 %)), impact on daily life (<em>n</em> = 24 (23.8 %)), and causes of SVD (<em>n</em> = 19 (18.8 %)). 57 correspondents (56.4 %) expressed support for research, 43 (42.6 %) expressed an eagerness to understand SVD, 35 (34.7 %) expressed helplessness, and 19 (18.8 %) expressed frustration.</p></div><div><h3>Conclusions</h3><p>Cognitive decline was the main concern for people and families living with SVD who corresponded with the Edinburgh SVD research group. These findings also indicate a need for more accessible services and better information about SVD for patients and families.</p></div>","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"6 ","pages":"Article 100202"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666245024000035/pdfft?md5=b2f3385ad243f9fe6cf33fe58bc0f2f5&pid=1-s2.0-S2666245024000035-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139634784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What is brain health?","authors":"Philip B. Gorelick,&nbsp;Farzaneh A. Sorond","doi":"10.1016/j.cccb.2023.100190","DOIUrl":"10.1016/j.cccb.2023.100190","url":null,"abstract":"<div><p>The call to optimize brain health is now a local, regional and global priority. Organizations such as the World Health Organization, Centers for Disease Control and Prevention and Alzheimer's Association, American Academy of Neurology, World Federation of Neurology, and others have developed recommendations for the maintenance of brain health. Brain health definitions range from broad to narrow in scope and may focus on cognition or encompass broader core components such as cerebral, mental and social domains. In this manuscript we will explore various definitions of brain health and its core components, the importance of cognitive and functional domains, and briefly introduce the concept of cognitive medicine in the context of brain health.</p></div>","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"6 ","pages":"Article 100190"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266624502300034X/pdfft?md5=291223c05f9be0d0c5c9ca7d4a964f05&pid=1-s2.0-S266624502300034X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136093158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuropsychological assessment in vascular cognitive impairment: A call to lay the quest for the best test to rest","authors":"Geert Jan Biessels,&nbsp;GJ Biessels","doi":"10.1016/j.cccb.2024.100219","DOIUrl":"https://doi.org/10.1016/j.cccb.2024.100219","url":null,"abstract":"","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"6 ","pages":"Article 100219"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666245024000205/pdfft?md5=73d5ea6667ac63d1b600b976a1851ee4&pid=1-s2.0-S2666245024000205-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140296721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlates of axonal content in healthy adult span: Age, sex, myelin, and metabolic health","authors":"Agnieszka Z Burzynska ,&nbsp;Charles Anderson ,&nbsp;David B. Arciniegas ,&nbsp;Vince Calhoun ,&nbsp;In-Young Choi ,&nbsp;Andrea Mendez Colmenares ,&nbsp;Arthur F Kramer ,&nbsp;Kaigang Li ,&nbsp;Jongho Lee ,&nbsp;Phil Lee ,&nbsp;Michael L Thomas","doi":"10.1016/j.cccb.2024.100203","DOIUrl":"https://doi.org/10.1016/j.cccb.2024.100203","url":null,"abstract":"<div><p>As the emerging treatments that target grey matter pathology in Alzheimer's Disease have limited effectiveness, there is a critical need to identify new neural targets for treatments. White matter's (WM) metabolic vulnerability makes it a promising candidate for new interventions. This study examined the age and sex differences in estimates of axonal content, as well the associations of with highly prevalent modifiable health risk factors such as metabolic syndrome and adiposity. We estimated intra-axonal volume fraction (ICVF) using the Neurite Orientation Dispersion and Density Imaging (NODDI) in a sample of 89 cognitively and neurologically healthy adults (20–79 years). We showed that ICVF correlated positively with age and estimates of myelin content. The ICVF was also lower in women than men, across all ages, which difference was accounted for by intracranial volume. Finally, we found no association of metabolic risk or adiposity scores with the current estimates of ICVF. In addition, the previously observed adiposity-myelin associations (Burzynska et al., 2023) were independent of ICVF. Although our findings confirm the vulnerability of axons to aging, they suggest that metabolic dysfunction may selectively affect myelin content, at least in cognitively and neurologically healthy adults with low metabolic risk, and when using the specific MRI techniques. Future studies need to revisit our findings using larger samples and different MRI approaches, and identify modifiable factors that accelerate axonal deterioration as well as mechanisms linking peripheral metabolism with the health of myelin.</p></div>","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"6 ","pages":"Article 100203"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666245024000047/pdfft?md5=f1904373d769d3ad4b2aba8267134510&pid=1-s2.0-S2666245024000047-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139473511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Standing middle cerebral artery velocity predicts cognitive function and gait speed in older adults with cognitive impairment, and is impacted by sex differences","authors":"Laura K Fitzgibbon-Collins ,&nbsp;Geoff B Coombs ,&nbsp;Mamiko Noguchi ,&nbsp;Shashankdhwaj Parihar ,&nbsp;Richard L Hughson ,&nbsp;Michael Borrie ,&nbsp;Sue Peters ,&nbsp;J Kevin Shoemaker ,&nbsp;Jaspreet Bhangu","doi":"10.1016/j.cccb.2023.100198","DOIUrl":"https://doi.org/10.1016/j.cccb.2023.100198","url":null,"abstract":"<div><p>Upright posture challenges the cerebrovascular system, leading to changes in middle cerebral artery velocity (MCAv) dynamics which are less evident at supine rest. Chronic alterations in MCAv have been linked to hypoperfusion states and the effect that this may have on cognition remains unclear. This study aimed to determine if MCAv and oscillatory metrics of MCAv (ex. pulsatility index, PI) during upright posture are i) associated with cognitive function and gait speed (GS) to a greater extent than during supine rest, and ii) are different between sexes.</p><p>Beat-by-beat MCAv (transcranial Doppler ultrasound) and mean arterial pressure (MAP, plethysmography) were averaged for 30-seconds during supine-rest through a transition to standing for 53 participants (73±6yrs, 17 females). While controlling for age, multiple linear regressions predicting MoCA scores and GS from age, supine MCAv metrics, and standing MCAv metrics, were completed. Simple linear regressions predicting Montreal Cognitive Assessment (MoCA) score and GS from MCAv metrics were performed separately for females and males. Significance was set to <em>p</em>&lt;0.05.</p><p>Lower standing diastolic MCAv was a significant (<em>p</em> = 0.017) predictor of lower MoCA scores in participants with mild cognitive impairment, and this relationship only remained significant for males. Lower standing PI was associated with slower GS (<em>p</em> = 0.027, <em>r</em>=-0.306) in both sexes. Our results indicate a relationship between blunted MCAv and altered oscillatory flow profiles during standing, with lower MoCA scores and GS. These relationships were not observed in the supine position, indicating a unique relationship between standing measures of MCAv with cognitive and physical functions.</p></div>","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"6 ","pages":"Article 100198"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666245023000429/pdfft?md5=f91d374e99f31e53a9a484e25388be84&pid=1-s2.0-S2666245023000429-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139479978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"METABOLIC SYNDROME IS ASSOCIATED WITH POOR COGNITION: A POPULATION-BASED STUDY OF 70-YEAR-OLDS WITHOUT DEMENTIA","authors":"Anna Marseglia ,&nbsp;Alexander Darin-Mattsson ,&nbsp;Johan Skoog ,&nbsp;Lina Rydén ,&nbsp;Timothy Hadarsson-Bodin ,&nbsp;Silke Kern ,&nbsp;Therese Rydberg Sterner ,&nbsp;Ying Shang ,&nbsp;Anna Zettergren ,&nbsp;Eric Westman ,&nbsp;Ingmar Skoog","doi":"10.1016/j.cccb.2022.100095","DOIUrl":"https://doi.org/10.1016/j.cccb.2022.100095","url":null,"abstract":"","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"6 ","pages":"Article 100095"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666245022000605/pdfft?md5=ef07743ea3b39b9d0df732d07d0ec663&pid=1-s2.0-S2666245022000605-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141478824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}