Cerebral circulation - cognition and behavior最新文献

{"title":"Gene-dose effects of APOE ε4 on age-dependent increases in Peak Width of Skeletonised Mean Diffusivity during midlife","authors":"Elijah Mak ,&nbsp;Maria-Eleni Dounavi ,&nbsp;Audrey Low ,&nbsp;Graciela Muniz Terrera ,&nbsp;Paresh Malhotra ,&nbsp;Ivan Koychev ,&nbsp;Clare Mackay ,&nbsp;Brian Lawlor ,&nbsp;Lorina Naci ,&nbsp;Katie Wells ,&nbsp;Craig Ritchie ,&nbsp;Karen Ritchie ,&nbsp;Li Su ,&nbsp;Juan Gispert ,&nbsp;John O'Brien","doi":"10.1016/j.cccb.2024.100293","DOIUrl":"10.1016/j.cccb.2024.100293","url":null,"abstract":"<div><h3>Introduction</h3><p>The mechanistic associations between small vessel disease (SVD) and dementia are still poorly understood. The APOE ε4 allele, recognised as the strongest genetic risk factor for Alzheimer's disease, has been previously implicated in SVD, although it remains unclear whether this association is gene-dose dependent. An emerging neuroimaging biomarker of SVD is Peak Width of Skeletonised Mean Diffusivity (PSMD), obtained from histogram analyses of diffusion weighted imaging (DWI) datasets. Here, we investigated the relationship between APOE ε4 gene dose and PSMD, as a surrogate marker of SVD, in a group of cognitively normal middle-aged adults.</p></div><div><h3>Methods</h3><p>The study included data from 1954 asymptomatic middle-aged adults from the ALFA (ALzheimer and FAmilies) and PREVENT-Dementia cohorts (See Table 1 for sample characteristics). PSMD was calculated from the DWI datasets using a publicly available script, and harmonised using COMBAT to account for site-related differences. Using non-parametric permutation models, our primary analyses focused on the (a) comparison of group differences (APOE ε4 heterozygotes vs homozygotes vs non-carriers) in PSMD, adjusting for age, sex, years of formal education, and sites; and (b) potential interactions between APOE ε4 gene dose and age on PSMD values. Marginal predictions were used to estimate the earliest age at which differences might emerge between the APOE ε4 groups and non-carriers.</p></div><div><h3>Results</h3><p>There were no significant differences in PSMD values across the non-carriers (n=1,197), heterozygous carriers (n=659), and homozygous APOE ε4 carriers (n=98) (p = 0.6; Figure 1). However, there was a statistically significant interaction between APOE ε4 gene dose and age on PSMD. Specifically, homozygous APOE ε4 carriers exhibited a steeper increase in PSMD with age compared to non-carriers and heterozygous carriers (T = 4.7, p&lt;0.01; Figure 2). Marginal effect analyses revealed higher PSMD values in homozygous APOE ε4 carriers at the estimated age of 57 relative to non-carriers and heterozygous carriers.</p></div><div><h3>Discussion</h3><p>Homozygosity for APOE ε4 could hasten dementia onset by accelerating age-dependent increases in PSMD. Future studies with a longitudinal design are warranted to clarify the molecular mechanisms through which the APOE ε4 allele influences PSMD and if this contributes to the contributes to the development of dementia.</p></div>","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"6 ","pages":"Article 100293"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666245024000941/pdfft?md5=cd88fe07fcbde6e9a072b363c77002c1&pid=1-s2.0-S2666245024000941-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142122121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebral Blood Flow in Mild Cognitive Impairment and Dementia: A Systematic Review and Meta- Analysis of Transcranial Doppler Studies","authors":"David Fresnais ,&nbsp;Håkon Ihle-Hansen ,&nbsp;Åsa Andersson ,&nbsp;Erik Lundström ,&nbsp;Brynjar Fure","doi":"10.1016/j.cccb.2024.100272","DOIUrl":"10.1016/j.cccb.2024.100272","url":null,"abstract":"<div><h3>Introduction</h3><p>Reduced cerebral blood flow has been associated with cognitive decline and incident dementia, with oxidative stress and reduced beta-amyloid clearance as possible mechanisms for neurodegeneration. Transcranial doppler sonography is a non-invasive tool for measuring cerebrovascular hemodynamics, including mean cerebral blood flow velocity. A systematic review and meta-analysis was performed to study mean cerebral blood flow velocity in the middle cerebral artery in persons with mild cognitive impairment and dementia compared to cognitively normal elderly.</p></div><div><h3>Methods</h3><p>We searched Pubmed, Embase, Cochrane Library, Epistemonikos, PsychINFO, and CINAHL according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. In total, 33439 titles and abstracts were screened, 86 articles were reviewed in full text, and 35 were included.</p></div><div><h3>Results</h3><p>Mean cerebral blood flow velocity in the middle cerebral artery was significantly lower in Alzheimer's disease (mean difference = 8.42; 95% confidence interval, -10.56 to -6.28), vascular dementia (mean difference = 11.75; 95% confidence interval, -14.68 to -8.82) and mild cognitive impairment (mean difference = 4.19; 95% confidence interval, -5.52 to -2.85) compared to cognitively normal elderly, see figures 1 – 3. Reduction in blood flow was equally pronounced in Alzheimer's disease and vascular dementia (mean difference = 2.79; 95% confidence interval, -0.78 to 6.35).</p></div><div><h3>Discussion</h3><p>Cerebral blood flow velocity is reduced in Alzheimer's disease, vascular dementia and MCI, with more pronounced disturbances in dementia.</p></div>","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"6 ","pages":"Article 100272"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666245024000734/pdfft?md5=3d77396ce306f550455e394a8e8f5380&pid=1-s2.0-S2666245024000734-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142122213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Under pressure: A systematic review of the association between blood pressure variability with depression and anxiety","authors":"Yuvthi Lutchman ,&nbsp;Rajiv Mahajan ,&nbsp;Suzanne M. Cosh ,&nbsp;Katie Harris ,&nbsp;Christophe Tzourio ,&nbsp;Phillip J. Tully","doi":"10.1016/j.cccb.2024.100228","DOIUrl":"https://doi.org/10.1016/j.cccb.2024.100228","url":null,"abstract":"<div><p>Blood pressure variability (BPV) impacts brain health by influencing brain structure and cerebrovascular pathologies, though the mechanisms are poorly understood. Changes in the cerebrovasculature may lead to late-onset depression, cognitive impairment, and dementia, however the relationship between BPV with depression and anxiety remains unclear, due to methodological differences and inconsistencies in past research. This review aims to clarify the association between BPV with depression and anxiety in adults to inform understandings of the mechanisms implicating BPV in cognitive health. A systematic search from inception through to January 2024 was performed on Embase, PubMed, PsycINFO, and Web of Science. Studies that assessed BPV quantified by beat-to-beat, 24-hour, or visit-to-visit were eligible if the standardised assessment of depression and/or anxiety were reported as a linear association, or mean differences across control and affect groups. A total of 14 articles reporting on 13 samples and <em>N</em> = 5055 persons met the inclusion criteria (median female proportion = 61 %, range 0 % - 76 %). A meta-analysis was not possible due to methodological heterogeneity in BPV measurements and metrics across studies. Mixed results were observed across depression studies with inconsistencies and variation in the direction, strength of association, and BPV metric. There was weak evidence from only three studies to support a linear association between systolic coefficient of variation and anxiety. Collectively, the findings contribute to understanding the association between BPV and brain health, suggesting that any relationship between BPV and brain structures critical for cognitive function are independent of depression and only modestly implicate anxiety.</p></div>","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"6 ","pages":"Article 100228"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666245024000291/pdfft?md5=d347ef9f4218320c499e7b0240f9741d&pid=1-s2.0-S2666245024000291-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141314449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SERUM PLACENTAL GROWTH FACTOR AS A MARKER OF CEREBROVASCULAR DISEASE BURDEN IN PATIENTS WITH ALZHEIMER'S DISEASE","authors":"Liu-Yun Wu ,&nbsp;Joyce Chong ,&nbsp;Bibek Gyanwali ,&nbsp;Saima Hilal ,&nbsp;Christopher Chen ,&nbsp;Mitchell Lai","doi":"10.1016/j.cccb.2022.100099","DOIUrl":"https://doi.org/10.1016/j.cccb.2022.100099","url":null,"abstract":"","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"6 ","pages":"Article 100099"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666245022000642/pdfft?md5=cd5d85f31ee6068085784cf65d4a74d5&pid=1-s2.0-S2666245022000642-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141478676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANALYZING MULTIMODAL MRI AT TRACT-LEVEL WITH NEURAL NETWORKS ENHANCES THE PREDICTION OF COGNITIVE PERFORMANCE IN MEMORY CLINIC PATIENTS WITH SMALL VESSEL DISEASE","authors":"Alberto De Luca ,&nbsp;Hugo Kuijf ,&nbsp;Lieza Exalto ,&nbsp;Geert-Jan Biessels","doi":"10.1016/j.cccb.2022.100053","DOIUrl":"https://doi.org/10.1016/j.cccb.2022.100053","url":null,"abstract":"","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"6 ","pages":"Article 100053"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666245022000186/pdfft?md5=185de1532cea30527da5735dbfab0435&pid=1-s2.0-S2666245022000186-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141478894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A SYSTEMATIC REVIEW INTO THE RELATIONSHIP BETWEEN BLOOD PRESSURE VARIABILITY AND GREY AND WHITE MATTER STRUCTURES","authors":"Daria Gutteridge","doi":"10.1016/j.cccb.2022.100067","DOIUrl":"https://doi.org/10.1016/j.cccb.2022.100067","url":null,"abstract":"","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"6 ","pages":"Article 100067"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666245022000320/pdfft?md5=0789a0679521f7d1f9d262d17284f7a4&pid=1-s2.0-S2666245022000320-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141479032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CEREBROSPINAL FLUID BIOMARKERS, BRAIN STRUCTURAL AND COGNITIVE PERFORMANCES BETWEEN NORMOTENSIVE AND HYPERTENSIVE CONTROLLED, UNCONTROLLED AND UNTREATED 70-YEAR-OLD ADULTS","authors":"Atef Badji,&nbsp;Joana Pereira,&nbsp;Sara Shams,&nbsp;Johan Skoog,&nbsp;Anna Marseglia,&nbsp;Konstantinos Poulakis,&nbsp;lina Ryden,&nbsp;Kaj Blennow,&nbsp;Henrik Zetterberg,&nbsp;Silke Kern,&nbsp;Anna Wahlund,&nbsp;Lars-Olof Wahlund,&nbsp;Hélène Girouard,&nbsp;Ingmar Skoog,&nbsp;Eric Westman","doi":"10.1016/j.cccb.2022.100048","DOIUrl":"https://doi.org/10.1016/j.cccb.2022.100048","url":null,"abstract":"","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"6 ","pages":"Article 100048"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666245022000137/pdfft?md5=c31da3332c6686af0731f6024a76bed3&pid=1-s2.0-S2666245022000137-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141479033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PURE VASCULAR-ISCHEMIC DISEASE AND COGNITIVE IMPAIRMENT","authors":"Elisabet Englund,&nbsp;Keivan Javanshiri,&nbsp;Mattias Haglund","doi":"10.1016/j.cccb.2022.100063","DOIUrl":"https://doi.org/10.1016/j.cccb.2022.100063","url":null,"abstract":"","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"6 ","pages":"Article 100063"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666245022000289/pdfft?md5=1726e4e9070c0ad116aa3bb799440db6&pid=1-s2.0-S2666245022000289-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141479091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DOES WHITE MATTER HYPERINTENSITY LOCATION PREDICT COGNITIVE IMPAIRMENT IN AN ELDERLY POPULATION?","authors":"Polly Roads,&nbsp;Polina Emeliyanova,&nbsp;Laura Parkes","doi":"10.1016/j.cccb.2022.100101","DOIUrl":"https://doi.org/10.1016/j.cccb.2022.100101","url":null,"abstract":"","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"6 ","pages":"Article 100101"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666245022000666/pdfft?md5=ac4fcdb6cd3f44e46fa4a5c47287d45d&pid=1-s2.0-S2666245022000666-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141480252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ETHNIC DIFFERENCES IN THE PREVALENCE OF COGNITIVE IMPAIRMENT AND DEMENTIA: BASED ON THE EPIDEMIOLOGY OF DEMENTIA IN SINGAPORE (EDIS)STUDY","authors":"Ting Pang ,&nbsp;Xuhao Zhao ,&nbsp;Xin Xu","doi":"10.1016/j.cccb.2022.100068","DOIUrl":"https://doi.org/10.1016/j.cccb.2022.100068","url":null,"abstract":"","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"6 ","pages":"Article 100068"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666245022000332/pdfft?md5=0fd58c0e1b3b54aa8514ee4f9206e7d6&pid=1-s2.0-S2666245022000332-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141481119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}