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Approach to testicular adrenal rest tumors in children and adolescents with congenital adrenal hyperplasia 先天性肾上腺增生儿童及青少年睾丸肾上腺休息肿瘤的探讨
Cell signaling Pub Date : 2023-06-03 DOI: 10.46439/signaling.1.006
Sirmen Kızılcan Çetin, Z. Aycan
{"title":"Approach to testicular adrenal rest tumors in children and adolescents with congenital adrenal hyperplasia","authors":"Sirmen Kızılcan Çetin, Z. Aycan","doi":"10.46439/signaling.1.006","DOIUrl":"https://doi.org/10.46439/signaling.1.006","url":null,"abstract":"Testicular adrenal rest tumor (TART) is a long-standing, significant complication of congenital adrenal hyperplasia (CAH). Although it is the main reason for infertility in adult patients with CAH, little is known about the development mechanism, genotype-phenotype features, and exact treatment options of TART. However, in the literature, there are mainly case reports and only a few studies in the pediatric period on this subject. The critical point is the early detection of tumors to prevent infertility in adulthood. This paper reviews the embryological, clinical, diagnostic, genetic features, and treatment alternative of TART and discusses the early screening options.","PeriodicalId":72543,"journal":{"name":"Cell signaling","volume":"113 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91018645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Selecting ideal combined immunotherapy for treating HCC 选择理想的联合免疫疗法治疗HCC
Cell signaling Pub Date : 2023-05-04 DOI: 10.46439/signaling.1.004
{"title":"Selecting ideal combined immunotherapy for treating HCC","authors":"","doi":"10.46439/signaling.1.004","DOIUrl":"https://doi.org/10.46439/signaling.1.004","url":null,"abstract":"","PeriodicalId":72543,"journal":{"name":"Cell signaling","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88055489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radiation induced molecular signalling in the cells: A real struggle between death or breathe 辐射诱导细胞中的分子信号:死亡与呼吸之间的真正斗争
Cell signaling Pub Date : 2023-05-04 DOI: 10.46439/signaling.1.005
{"title":"Radiation induced molecular signalling in the cells: A real struggle between death or breathe","authors":"","doi":"10.46439/signaling.1.005","DOIUrl":"https://doi.org/10.46439/signaling.1.005","url":null,"abstract":"","PeriodicalId":72543,"journal":{"name":"Cell signaling","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78400423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perspective study of UPR signaling molecules as potential biomarkers in bone metabolism UPR信号分子作为骨代谢潜在生物标志物的前景研究
Cell signaling Pub Date : 2023-05-04 DOI: 10.46439/signaling.1.003
{"title":"Perspective study of UPR signaling molecules as potential biomarkers in bone metabolism","authors":"","doi":"10.46439/signaling.1.003","DOIUrl":"https://doi.org/10.46439/signaling.1.003","url":null,"abstract":"","PeriodicalId":72543,"journal":{"name":"Cell signaling","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89972223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
EGCG modulates nuclear formalde-hydeinduced Tau phosphorylation in neuronal cells EGCG调节核甲醛氢化诱导的Tau磷酸化在神经元细胞
Cell signaling Pub Date : 2023-02-19 DOI: 10.46439/signaling.1.001
{"title":"EGCG modulates nuclear formalde-hydeinduced Tau phosphorylation in neuronal cells","authors":"","doi":"10.46439/signaling.1.001","DOIUrl":"https://doi.org/10.46439/signaling.1.001","url":null,"abstract":"Tau hyperphosphorylation is one of the major causes of Alzheimer’s disease pathology. The abnormal phosphorylation curtails the physiological function of Tau of microtubule stabilization and renders it more prone to aggregation. Apart from its function in the cytoplasm, Tau is attributed to play a role in the nucleus.","PeriodicalId":72543,"journal":{"name":"Cell signaling","volume":"76 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135238873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Review of spinal dural arteriovenous fistulas: Challenges, diagnostics, management, and pathophysiology. 脊髓硬膜动静脉瘘回顾：挑战、诊断、管理和病理生理学。
Cell signaling Pub Date : 2023-01-01 DOI: 10.46439/signaling.1.002
Michael Goutnik, Ramya Reddy, Sandra Yan, Brandon Lucke-Wold
{"title":"Review of spinal dural arteriovenous fistulas: Challenges, diagnostics, management, and pathophysiology.","authors":"Michael Goutnik, Ramya Reddy, Sandra Yan, Brandon Lucke-Wold","doi":"10.46439/signaling.1.002","DOIUrl":"10.46439/signaling.1.002","url":null,"abstract":"<p><p>Spinal dural arteriovenous fistulae are rare, spinal vascular malformations that commonly present with progressive myelopathy in a specific demographic and are treatable with surgery (preferred) and/or endovascular embolization. PubMed and Google Scholar were searched with terms including but not limited to \"spinal dural arteriovenous fistula\", \"imaging\", \"management\" \"surgery vs embolization\", \"outcomes\", \"pathogenesis\" to find relevant studies, including emerging research. The purpose of this literature review is to highlight presentation, imaging characteristics, management strategies, pathophysiology, and future directions for these rare but distinct entities.</p>","PeriodicalId":72543,"journal":{"name":"Cell signaling","volume":"1 1","pages":"9-13"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9423905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Do arrestin oligomers have specific functions? 逮捕低聚物有特定的功能吗?
Cell signaling Pub Date : 2023-01-01 DOI: 10.46439/signaling.1.009
Vsevolod V Gurevich
{"title":"Do arrestin oligomers have specific functions?","authors":"Vsevolod V Gurevich","doi":"10.46439/signaling.1.009","DOIUrl":"https://doi.org/10.46439/signaling.1.009","url":null,"abstract":"<p><p>Arrestins are a small family of versatile regulators of cell signaling. Arrestins regulate signaling and trafficking of G protein-coupled receptors, regulate and direct to particular subcellular compartments numerous protein kinases, ubiquitin ligases, etc. Three out of four arrestin subtypes expressed in vertebrates self-associate, each forming oligomers of a distinct size and shape. While the structures of the solution oligomers of arrestin-1, -2, and -3 have been elucidated, no function specific for the oligomeric form of either of these three subtypes has been identified thus far. Considering how multi-functional average-sized (~45 kDa) arrestin proteins were found to be, it appears likely that certain functions are predominantly or exclusively fulfilled by monomeric and oligomeric forms of each subtype.</p>","PeriodicalId":72543,"journal":{"name":"Cell signaling","volume":"1 1","pages":"42-46"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10211282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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