{"title":"EGCG调节核甲醛氢化诱导的Tau磷酸化在神经元细胞","authors":"","doi":"10.46439/signaling.1.001","DOIUrl":null,"url":null,"abstract":"Tau hyperphosphorylation is one of the major causes of Alzheimer’s disease pathology. The abnormal phosphorylation curtails the physiological function of Tau of microtubule stabilization and renders it more prone to aggregation. Apart from its function in the cytoplasm, Tau is attributed to play a role in the nucleus.","PeriodicalId":72543,"journal":{"name":"Cell signaling","volume":"76 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"EGCG modulates nuclear formalde-hydeinduced Tau phosphorylation in neuronal cells\",\"authors\":\"\",\"doi\":\"10.46439/signaling.1.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Tau hyperphosphorylation is one of the major causes of Alzheimer’s disease pathology. The abnormal phosphorylation curtails the physiological function of Tau of microtubule stabilization and renders it more prone to aggregation. Apart from its function in the cytoplasm, Tau is attributed to play a role in the nucleus.\",\"PeriodicalId\":72543,\"journal\":{\"name\":\"Cell signaling\",\"volume\":\"76 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-02-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cell signaling\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.46439/signaling.1.001\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell signaling","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.46439/signaling.1.001","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
EGCG modulates nuclear formalde-hydeinduced Tau phosphorylation in neuronal cells
Tau hyperphosphorylation is one of the major causes of Alzheimer’s disease pathology. The abnormal phosphorylation curtails the physiological function of Tau of microtubule stabilization and renders it more prone to aggregation. Apart from its function in the cytoplasm, Tau is attributed to play a role in the nucleus.
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