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Probes for cancer metastasis imaging and therapeutic targeting 用于癌症转移成像和靶向治疗的探针
Cell signaling Pub Date : 2023-11-28 DOI: 10.46439/signaling.1.020
Suridh Adhikari, A. Azhdarinia, M. Kolonin
{"title":"Probes for cancer metastasis imaging and therapeutic targeting","authors":"Suridh Adhikari, A. Azhdarinia, M. Kolonin","doi":"10.46439/signaling.1.020","DOIUrl":"https://doi.org/10.46439/signaling.1.020","url":null,"abstract":"Progression to metastases remains the overriding cause of cancer-associated mortality. Metastatic cancer is not amenable to surgery and its treatment is further complicated by the development of therapy resistance often observed at advanced cancer stages. Early detection of metastases is therefore critical but has been limited by the lack of probes that can effectively localize them. Similar challenges persist with therapeutics specifically targeting metastasized cancer cells. Thus, agents that specifically target disseminating tumor cells at an early stage could produce new theranostic applications and be transformative for the survival of patients with advanced cancers. Recent studies have described new approaches for early detection and targeted eradication of metastatic cancer. Here we summarize the results from preclinical validation of the experimental probes reported to date.","PeriodicalId":72543,"journal":{"name":"Cell signaling","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139225021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pathogenic contribute of unaffected cardiac cells in female Fabry cardiomyopathy 女性法布里心肌病中未受影响心脏细胞的致病作用
Cell signaling Pub Date : 2023-11-27 DOI: 10.46439/signaling.1.019
Andrea Frustaci, R. Verardo, C. Chimenti
{"title":"Pathogenic contribute of unaffected cardiac cells in female Fabry cardiomyopathy","authors":"Andrea Frustaci, R. Verardo, C. Chimenti","doi":"10.46439/signaling.1.019","DOIUrl":"https://doi.org/10.46439/signaling.1.019","url":null,"abstract":"","PeriodicalId":72543,"journal":{"name":"Cell signaling","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139233306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Commentary: Role of estrogen receptor β in kidney disease 评论：雌激素受体β在肾病中的作用
Cell signaling Pub Date : 2023-11-24 DOI: 10.46439/signaling.1.017
Wen Su, Rong Cao, Qijun Wan, Hui-Yao Lan
{"title":"Commentary: Role of estrogen receptor β in kidney disease","authors":"Wen Su, Rong Cao, Qijun Wan, Hui-Yao Lan","doi":"10.46439/signaling.1.017","DOIUrl":"https://doi.org/10.46439/signaling.1.017","url":null,"abstract":"Recent studies have shed light on the pivotal roles of estrogen in various pathophysiological processes related to kidney diseases. However, the precise mechanisms governing the estrogen actions remain enigmatic. The downstream impacts of estrogen primarily hinge on estrogen receptors (ERs), namely ERα (NR3A1) and ERβ (NR3A2). Building upon our previous finding that ERβ participates in subcutaneous adipose tissue browning in female mice, our recent study found that ERβ functions to protect kidney from progressive renal fibrosis by inactivating transforming growth factor-β (TGF-β)/Smad3 signaling. In the normal kidney, ERβ is highly expressed by proximal tubular epithelial cells but it is lost when kidney becomes fibrotic. In contrast, activation of ERβ inhibits kidney fibrosis. Mechanistically, we uncovered that ERβ can bind to Smad3, thereby transcriptionally downregulating Smad3 and inhibiting TGF-β1/Smad3-mediated renal fibrosis. Thus, ERβ is protective in renal fibrosis and may have therapeutic potential for chronic kidney disease.","PeriodicalId":72543,"journal":{"name":"Cell signaling","volume":"26 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139241934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
GABA fluctuations driven by astrocytic Glu-GABA exchange explain synaptic acuity 由星形胶质细胞 Glu-GABA 交换驱动的 GABA 波动可解释突触的敏锐性
Cell signaling Pub Date : 2023-10-27 DOI: 10.46439/signaling.1.016
László Héja, J. Kardos
{"title":"GABA fluctuations driven by astrocytic Glu-GABA exchange explain synaptic acuity","authors":"László Héja, J. Kardos","doi":"10.46439/signaling.1.016","DOIUrl":"https://doi.org/10.46439/signaling.1.016","url":null,"abstract":"","PeriodicalId":72543,"journal":{"name":"Cell signaling","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139312602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of an authentic light-activated calcium channel 开发真正的光激活钙通道
Cell signaling Pub Date : 2023-10-17 DOI: 10.46439/signaling.1.015
Wenyu Li, Liuqing Wang, Youjun Wang, Lian He
{"title":"Development of an authentic light-activated calcium channel","authors":"Wenyu Li, Liuqing Wang, Youjun Wang, Lian He","doi":"10.46439/signaling.1.015","DOIUrl":"https://doi.org/10.46439/signaling.1.015","url":null,"abstract":"Optogenetic-based genetically encoded Ca2+ actuators (GECA) have been developed to enable remote control of Ca2+ entry into cells. However, current blue light-dependent tools either lack high calcium selectivity or exhibit crosstalk with other targets, raising concerns about potential side effects. In this commentary, we present our successful design of a single-component optogenetic Ca2+ ion channel (LOCa) that selectively elevates cytoplasmic Ca2+ concentration with high spatial and temporal resolution. Furthermore, LOCa has demonstrated promising applications in regulating Ca2+-dependent cellular physiological responses and investigating diseases through animal models.","PeriodicalId":72543,"journal":{"name":"Cell signaling","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139317889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The value of EGFR in individualized treatment for brain metastases in non-small cell lung cancer EGFR在非小细胞肺癌脑转移个体化治疗中的价值
Cell signaling Pub Date : 2023-10-03 DOI: 10.46439/signaling.1.014
Li Tan, Juan Ren
{"title":"The value of EGFR in individualized treatment for brain metastases in non-small cell lung cancer","authors":"Li Tan, Juan Ren","doi":"10.46439/signaling.1.014","DOIUrl":"https://doi.org/10.46439/signaling.1.014","url":null,"abstract":"The prognosis of brain metastases in non-small cell lung cancer (NSCLC) is poor, and patients with EGFR mutations are more likely to have brain metastases. The epidermal growth factor receptor (EGFR) gene status has changed the direction of treatment for NSCLC patients with brain metastases. The development of EGFR tyrosine kinase inhibitors (EGFR-TKI) has prolonged the survival time of NSCLC patients with brain metastases. The treatment of patients with NSCLC brain metastases should be individualized according to the clinical symptoms, tumor stage, and different gene mutation status. As cancer is heterogeneous at the molecular level, related biomarker studies looking for individualized characteristics are recommended.","PeriodicalId":72543,"journal":{"name":"Cell signaling","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135738759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A vicious cycle happened in the progress of hyperhomocysteinemia, the same may exist in the development of cancer 恶性循环发生在高同型半胱氨酸血症的发展过程中，同样可能存在于癌症的发展中
Cell signaling Pub Date : 2023-10-03 DOI: 10.46439/signaling.1.012
Chenghua Luo, Dengyu Ji, Wen Wang
{"title":"A vicious cycle happened in the progress of hyperhomocysteinemia, the same may exist in the development of cancer","authors":"Chenghua Luo, Dengyu Ji, Wen Wang","doi":"10.46439/signaling.1.012","DOIUrl":"https://doi.org/10.46439/signaling.1.012","url":null,"abstract":"","PeriodicalId":72543,"journal":{"name":"Cell signaling","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135695983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deciphering Notch signaling notch by notch 一个缺口一个缺口地破译Notch信号
Cell signaling Pub Date : 2023-08-11 DOI: 10.46439/signaling.1.011
L. Borkiewicz, A. Rivero-Müller
{"title":"Deciphering Notch signaling notch by notch","authors":"L. Borkiewicz, A. Rivero-Müller","doi":"10.46439/signaling.1.011","DOIUrl":"https://doi.org/10.46439/signaling.1.011","url":null,"abstract":"","PeriodicalId":72543,"journal":{"name":"Cell signaling","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89428503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immune-enhanced nanocomposites provide hope for drug-resistant infection treatment 免疫增强纳米复合材料为耐药感染治疗提供了希望
Cell signaling Pub Date : 2023-08-11 DOI: 10.46439/signaling.1.010
Tao Zhang, Mo Chen, S.A. Makhanov, Xianzuo Zhang, Yao Luo, Chen Zhu
{"title":"Immune-enhanced nanocomposites provide hope for drug-resistant infection treatment","authors":"Tao Zhang, Mo Chen, S.A. Makhanov, Xianzuo Zhang, Yao Luo, Chen Zhu","doi":"10.46439/signaling.1.010","DOIUrl":"https://doi.org/10.46439/signaling.1.010","url":null,"abstract":"","PeriodicalId":72543,"journal":{"name":"Cell signaling","volume":"04 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88904983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aiming for the brain: a new thermogel-based drug delivery platform 瞄准大脑:一种新的基于热凝胶的药物输送平台
Cell signaling Pub Date : 2023-06-26 DOI: 10.46439/signaling.1.007
M. Chiariello, L. Gherardini
{"title":"Aiming for the brain: a new thermogel-based drug delivery platform","authors":"M. Chiariello, L. Gherardini","doi":"10.46439/signaling.1.007","DOIUrl":"https://doi.org/10.46439/signaling.1.007","url":null,"abstract":"Glioblastoma Multiforme (GBM) is one of the most lethal human cancer types, with a 5-year survival rate of approximately 5%. A key reason for this is usually considered its poor accessibility to systemically administered drugs that only limitedly overcome the Blood Brain Barrier, ultimately causing the likely dismal appearance of recurrences. Here, we comment on our successful use, in GBM preclinical models, of novel thermogel based drug-delivery platforms for loco-regional treatment of tumor recurrences after primary surgery. The innovation as well as the pitfalls of our processes are outlined and discussed with an eye towards potential advancements in the realm of personalized medicine applications.","PeriodicalId":72543,"journal":{"name":"Cell signaling","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85313161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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