Cardiovascular endocrinology最新文献

{"title":"Prevalence of cardiovascular disease and evaluation of standard of care in type 2 diabetes: a nationwide study in primary care.","authors":"Jorgen Rungby,&nbsp;Morten Schou,&nbsp;Per Warrer,&nbsp;Lars Ytte,&nbsp;Gert S Andersen","doi":"10.1097/XCE.0000000000000135","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000135","url":null,"abstract":"<p><strong>Objective: </strong>Cardiovascular disease (CVD) complicates type 2 diabetes. Empagliflozin and liraglutide have demonstrated improved survival in patients with type 2 diabetes and established CVD. We assessed prevalence and standard of care of patients with type 2 diabetes and established CVD managed in primary care.</p><p><strong>Patients and methods: </strong>A total of 129 general practitioners in both rural and urban areas, responsible for 348 373 patients, identified their patients with type 2 diabetes. The identification was based on a search for International Classification of Primary Health Care 2 codes in the general practitioners' electronic patient record systems. Patients with concomitant CVD were identified and characterized.</p><p><strong>Results: </strong>A total of 17 113 (4.9%) patients were diagnosed with type 2 diabetes. Type 2 diabetes with concomitant CVD was found in 3665 (21.4%) patients, with their mean age being 72 years, and 34.6% were women. Mean estimated glomerular filtration rate was 68.2 ml/min, and 22.2% had microalbuminuria or macroalbuminuria. Standard of care was fair: mean glycated hemoglobin was 52.3 mmol/mol (Diabetes Control and Complications Trial=6.9%), mean blood pressure was 131.4/75.7 mmHg, and mean low-density lipoprotein cholesterol was 2.0 mmol/l.</p><p><strong>Conclusion: </strong>In a nationwide database survey in primary care, the prevalence of CVD in patients with type 2 diabetes was high (21.4%). Standard of care was largely in accordance with national guidelines. Identification of eligible patients is possible with existing electronic patient record systems. Identifying this high-risk subgroup of patients with type 2 diabetes and optimizing their treatment might add further cardiovascular benefits as suggested by recent cardiovascular outcome trials.</p>","PeriodicalId":72529,"journal":{"name":"Cardiovascular endocrinology","volume":"6 4","pages":"145-151"},"PeriodicalIF":0.0,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/XCE.0000000000000135","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35687114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of vitamin D status and dietary calcium intake with individual components of the metabolic syndrome: a population-based study in Victoria, Australia","authors":"Poonam K. Pannu, M. Soares, L. Piers, Yun Zhao, Z. Ansari","doi":"10.1097/XCE.0000000000000133","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000133","url":null,"abstract":"Objective This study examined the associations between 25-hydroxyvitamin D (25-OHD), dietary calcium (Ca) intake, and individual components of the metabolic syndrome (MetS). Methods We analyzed a population-based sample of 18–75-year-old adults (n=3387) from the Victorian Health Monitor survey. Results After adjustment for sociodemographic, physical, and dietary factors, as well as other MetS components, every 10 nmol/l increment in 25-OHD was associated with reduced adjusted odds ratio (AOR) of elevated triglycerides (TG) [AOR: 0.79, 95% confidence interval (CI): 0.74–0.84, P<0.001], and higher fasting plasma glucose (AOR: 0.91, 95% CI: 0.86–0.96, P=0.002). After adjustment for confounders, every 500 mg/day increment in dietary Ca intake significantly reduced the odds of elevated diastolic blood pressure (AOR: 0.80, 95% CI: 0.66–0.99, P=0.038). When nine combinations of 25-OHD and Ca tertiles were examined, certain combinations were associated with reduced AOR for elevated TG (P<0.001), when referenced against the combination of low 25-OHD (median: 33 nmol/l) and low Ca (median: 579 mg/day). At low 25-OHD, increasing Ca intake decreased the AOR for low high-density lipoprotein cholesterol in a dose-dependent manner, but at high 25-OHD; such effects of Ca were blunted. Conclusion Higher vitamin D status and Ca intake or their combination were associated with reduced odds for a number of individual MetS components.","PeriodicalId":72529,"journal":{"name":"Cardiovascular endocrinology","volume":"60 1","pages":"136–144"},"PeriodicalIF":0.0,"publicationDate":"2017-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84638075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic kidney disease-associated cardiovascular disease: scope and limitations of animal models","authors":"O. Sadeghi-Alavijeh, M. Tadayyon, B. Caplin","doi":"10.1097/XCE.0000000000000132","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000132","url":null,"abstract":"Chronic kidney disease (CKD) is a heterogeneous range of disorders affecting up to 11% of the world’s population. The majority of patients with CKD die of cardiovascular disease (CVD) before progressing to end-stage renal disease. CKD patients have an increased risk of atherosclerotic disease as well as a unique cardiovascular phenotype. There remains no clear aetiology for these issues and a better understanding of the pathophysiology of CKD-associated CVD is urgently needed. Although nonanimal studies can provide insights into the nature of disease, the whole-organism nature of CKD-associated CVD means that high-quality animal models, at least for the immediate future, are likely to remain a key tool in improving our understanding in this area. We will discuss the methods used to induce renal impairment in rodents and the methods available to assess cardiovascular phenotype and in each case describe the applicability to humans.","PeriodicalId":72529,"journal":{"name":"Cardiovascular endocrinology","volume":"25 1","pages":"120–127"},"PeriodicalIF":0.0,"publicationDate":"2017-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90205034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxford Diabetes Symposium 2017.","authors":"A. Krentz","doi":"10.1097/XCE.0000000000000137","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000137","url":null,"abstract":"The 2017 annual Oxford Diabetes Symposium was held at Keble College on 20th and 21st July. The event, which is by invitation and focused on senior diabetes specialist clinicians, was organized by Oxford physicians Dr Garry Tan and Dr Jonathan Levy. As usual, the symposium was supported by an unrestricted educational grant from Novo Nordisk (who have recently announced a major collaboration on type 2 diabetes research with the University of Oxford).","PeriodicalId":72529,"journal":{"name":"Cardiovascular endocrinology","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72896405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Androgenic alopecia, premature graying, and hair thinning as independent predictors of coronary artery disease in young Asian males","authors":"K. Sharma, Dhammdeep Humane, K. Shah, S. Patil, R. Charaniya, Jayesh Meniya","doi":"10.1097/XCE.0000000000000136","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000136","url":null,"abstract":"Introduction We herewith aimed to explore the association of premature graying, androgenic alopecia (AGA), and hair thinning with coronary artery disease (CAD) in young (⩽40 years) male individuals from Western India. Patients and methods In this prospective, case–control study, 1380 male individuals from a super speciality cardiac care center were enrolled, of which 468 were established cases of CAD and 912 were age-matched healthy male individuals not having history of any major illness including CAD. Details of demographics, cardiovascular risk factors, and cutaneous markers were collected for both the groups. Results Prevalence of hypertension (30.3 vs. 13.6%), obesity (28.8 vs. 12.2%), hair thinning (36.3 vs. 14.6%), premature graying (49.6 vs. 29.9%), AGA (49.1 vs. 27.4%), and lipid abnormalities (total cholesterol – 16.7 vs. 8.8%; low-density lipoprotein – 7.3 vs. 2.2%; and high-density lipoprotein – 92.5 vs. 88.7%) were higher in cases as compared with control. Multiple logistic regression analysis showed that AGA [5.619, 95% confidence interval (CI): 4.025–7.845, P<0.0001] is the strongest predictor of CAD among young Asian male individuals, closely followed by premature graying (5.267, 95% CI: 3.716–7.466, P<0.0001), obesity (4.133, 95% CI: 2.839–6.018, P<0.0001), and hair thinning (3.36, 95% CI: 2.452–4.621, P<0.0001). SYNTAX score, left ventricle ejection fraction, and degree of disease severity were also found to be independent associates of premature graying and AGA. Conclusion Our findings support the hypothesis that cutaneous markers are independently associated with underlying CAD irrespective of other classical cardiovascular risk factors. This, in combination with classical markers, could be effectively used for early identification and risk stratification of young patients with occult or established CAD.","PeriodicalId":72529,"journal":{"name":"Cardiovascular endocrinology","volume":"6 1","pages":"152–158"},"PeriodicalIF":0.0,"publicationDate":"2017-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75273070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ready! Aim! Fire! targeting the right medical science journal.","authors":"Timothy C Hardman, James M Serginson","doi":"10.1097/XCE.0000000000000083","DOIUrl":"10.1097/XCE.0000000000000083","url":null,"abstract":"<p><strong>Objective: </strong>Inadvertently submitting a paper to a journal that is unlikely to publish it is a waste of resources and ultimately delays dissemination of one's research. A high proportion of manuscripts are rejected by their author's first-choice journal. The aim of the present work was to review guidance provided within the literature for journal selection that might minimize the chance of manuscript rejection. We also consider papers that encompass more than one main medical science and describe the selection process that we used with a paper that was published in <i>Cardiovascular Endocrinology</i>.</p><p><strong>Methods: </strong>A database search (Embase, PubMed and Medworm) was performed for all articles published in the scientific literature providing guidance on journal selection. Articles were identified that either had journal selection as their principal topic or included journal selection as part of a broader discussion of publishing. The relative performance of four free-to-use, web-based applications that claim to provide guidance on journal selection was compared.</p><p><strong>Results: </strong>The searches identified 286 hits, of which 249 were in English. Of these papers, 16 discussed journal selection and a further 10 articles were identified from citations within the original 16 articles. Only one article described a comprehensive model for submission decision-making. Identification of appropriate candidate journals by various web-based applications was erratic, with the Jane database providing the most robust suggestions.</p><p><strong>Conclusion: </strong>Our work suggests that little attention has been focused in the scientific literature on the mechanisms that authors use to select a journal for their work. Nevertheless, scientists for the most part seem to have a good sense of where their papers are most likely to be accepted. Beyond ensuring that a manuscript fulfils all the target journal's requirements, the literature suggests that it is important to have an objective view of the scientific contribution or 'value' of your work.</p>","PeriodicalId":72529,"journal":{"name":"Cardiovascular endocrinology","volume":"6 3","pages":"95-100"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4c/79/ce-6-095.PMC5567399.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35483481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two-dimensional speckle-tracking echocardiography evaluation of left atrial function according to glycemic state in patients with coronary artery disease.","authors":"Ali Hosseinsabet,&nbsp;Reza Mohseni-Badalabadi,&nbsp;Arash Jalali","doi":"10.1097/XCE.0000000000000127","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000127","url":null,"abstract":"<p><p>Prediabetes and diabetes are dysglycemic conditions associated with increased cardiovascular risks and subtle myocardial injuries. The aim of our study was to evaluate left atrial (LA) function by two-dimensional speckle-tracking echocardiography in prediabetic and diabetic patients with coronary artery disease (CAD) and compare the results with those in euglycemic patients with CAD.</p><p><strong>Methods: </strong>The study population comprised 205 consecutive patients with CAD: 104 diabetic, 51 prediabetic, and 50 euglycemic patients. LA function was evaluated with two-dimensional speckle-tracking echocardiography and the longitudinal deformation indices of the LA were measured.</p><p><strong>Results: </strong>Our results showed that early diastolic strain was lower in the diabetic patients than in the prediabetic and euglycemic patients. The absolute value of early diastolic strain rate was reduced in the diabetic patients compared with the euglycemic patients. Late diastolic strain was increased in the diabetic patients compared with the prediabetic and euglycemic patients. The multivariate analysis showed that diabetes was a determinant of early diastolic strain and strain rate, but not late diastolic strain.</p><p><strong>Conclusion: </strong>LA conduit function, as evaluated in terms of early diastolic strain and strain rate, was impaired in the diabetic CAD patients compared with the prediabetic and euglycemic CAD patients.</p>","PeriodicalId":72529,"journal":{"name":"Cardiovascular endocrinology","volume":"6 3","pages":"101-108"},"PeriodicalIF":0.0,"publicationDate":"2017-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/XCE.0000000000000127","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41221778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic clinic for individuals with HIV/AIDS: a commitment and vision to the future of HIV services","authors":"Mohamed H. Ahmed, C. Woodward, D. Mital","doi":"10.1097/XCE.0000000000000128","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000128","url":null,"abstract":"One of the biggest current challenges in managing an ageing cohort living with the HIV is handling dyslipidaemia, diabetes, metabolic syndrome and nonalcoholic fatty liver disease. Combination antiretroviral therapy decrease mortality and morbidity in HIV patients, but lead to increase in insulin resistance, dyslipidaemia, abnormalities of fat distribution and high risk of cardiovascular disease. Therefore, a metabolic clinic was established for individuals living with HIV in the Milton Keynes University Hospital NHS Foundation Trust. The clinic meets considerable demands by service users and hence has the potential to be popular. This review focuses on the importance of the development of a metabolic clinic for the purpose of audit, research, teaching and exchange of knowledge between HIV specialists and the metabolic team in the management of complex cases. Therefore, the metabolic clinic should be an integral part of HIV services especially as the cohort of the ‘older’ HIV population increases.","PeriodicalId":72529,"journal":{"name":"Cardiovascular endocrinology","volume":"35 1","pages":"109–112"},"PeriodicalIF":0.0,"publicationDate":"2017-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91384123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Report of the European Group for the Study of Insulin Resistance annual meeting, Dublin, 4-6th May 2017.","authors":"A. Krentz, J. Petrie","doi":"10.1097/XCE.0000000000000131","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000131","url":null,"abstract":"The annual meeting of the European Group for the study of Insulin Resistance (EGIR) was held in Dublin, Ireland in May 2017. Ably organized by Dr. Mesud Hatunic, Consultant Endocrinologist at Mater Misericordiae University Hospital, the conference explored the pathophysiology and treatment of insulin resistance and extended a perspective to include aspects of clinical diabetes care including diabetic retinopathy (Dr. David Keegan, Consultant Vitreo-Retinal Surgeon, Mater University Hospital, Dublin, Ireland), monogenic forms of diabetes (Dr. Maria Byrne, Consultant in Endocrinology and Diabetes, Mater Misericordiae Hospital, Dublin, Ireland) and the impact of gastric bypass surgery (Professor Carel le Roux, Co-Director of the Metabolic Medicine Group, University College, Dublin, Ireland). The group actively welcomed the participation of members who have recently joined from the Pasteur Institute in Lille, France, including Dr. Caroline Bonner, who will co-host the Spring 2018 EGIR meeting there with Professor Francois Pattou. New members are always welcome, e-mail: egir@med.unipi.it for details.","PeriodicalId":72529,"journal":{"name":"Cardiovascular endocrinology","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84536211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of high-risk cardiovascular patients with therapy-resistant hypercholesterolemia.","authors":"Karel Kostev,&nbsp;Klaus G Parhofer,&nbsp;Franz-Werner Dippel","doi":"10.1097/XCE.0000000000000098","DOIUrl":"https://doi.org/10.1097/XCE.0000000000000098","url":null,"abstract":"Introduction Hypercholesterolemia is a causal risk factor for cardiovascular diseases, which is recommended to be treated at least in high-risk patients. Yet, currently there is a lack of epidemiological data on the number of high-risk patients in Germany who do not respond adequately to high-dose statin monotherapy or statin therapy in combination with other lipid-lowering agents. Methods Of a total of over 2.6 million patient records from general practitioners in the IMS Disease Analyzer database, all high-risk cardiovascular patients with hypercholesterolemia who did not reach target low-density lipoprotein-cholesterol (LDL-C) levels despite at least 12 months of maximum lipid-lowering therapy and optimal medication supply (medication possession rate≥80%) were selected over a defined period. Results On the basis of the practice data, a total of 602 133 patients with a high cardiovascular risk who were treated with statin monotherapy or statin combination therapy with optimal medication supply (medication possession rate≥80%) for at least 12 months were identified. Of them, 49 406 patients received high-dose statin therapy, and 51 869 patients received statin therapy in any dose in combination with another lipid-lowering agent. A total of 79 848 high-risk patients did not reach the target LDL-C level of 70 mg/dl or less despite consistent lipid-lowering therapy; of them, 12 808 had a documented LDL-C level of at least 130 mg/dl. Conclusion The prevalence of high-risk cardiovascular patients with therapy-resistant hypercholesterolemia is substantial in Germany.","PeriodicalId":72529,"journal":{"name":"Cardiovascular endocrinology","volume":"6 2","pages":"81-85"},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/XCE.0000000000000098","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35023897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}