Burns open : an international open access journal for burn injuries最新文献

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The impact of a residential fire on occupational engagement and performance: A reflexive narrative approach 住宅火灾对职业参与和表现的影响:反思性叙事方法
Burns open : an international open access journal for burn injuries Pub Date : 2024-04-10 DOI: 10.1016/j.burnso.2024.04.001
Gregory Chown
{"title":"The impact of a residential fire on occupational engagement and performance: A reflexive narrative approach","authors":"Gregory Chown","doi":"10.1016/j.burnso.2024.04.001","DOIUrl":"https://doi.org/10.1016/j.burnso.2024.04.001","url":null,"abstract":"<div><p>Residential fires are a devastating and stressful life event. The high number of residential fires per year and significant associated stressors impacts all aspects of daily life. This reflexive narrative approach highlights gaps in inpatient and outpatient burn care for those who have suffered a residential fire from an occupational therapy perspective. The findings show that healthcare professionals need to consider social support systems, use therapeutic listening, provide stress management techniques and be advocates throughout the recovery process.</p></div>","PeriodicalId":72486,"journal":{"name":"Burns open : an international open access journal for burn injuries","volume":"8 3","pages":"Pages 165-168"},"PeriodicalIF":0.0,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468912224000257/pdfft?md5=f3b29ce578eee9ad03dc0f9e2181524e&pid=1-s2.0-S2468912224000257-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140555343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial Board Page 编辑委员会页面
Burns open : an international open access journal for burn injuries Pub Date : 2024-04-01 DOI: 10.1016/S2468-9122(24)00026-9
{"title":"Editorial Board Page","authors":"","doi":"10.1016/S2468-9122(24)00026-9","DOIUrl":"https://doi.org/10.1016/S2468-9122(24)00026-9","url":null,"abstract":"","PeriodicalId":72486,"journal":{"name":"Burns open : an international open access journal for burn injuries","volume":"8 2","pages":"Page i"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468912224000269/pdfft?md5=451afb3838ccfedc32fe86e8eb2d2bd3&pid=1-s2.0-S2468912224000269-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140555684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Burnt out: A retrospective review of paediatric burns admissions at Chris Hani Baragwanath Academic Hospital 2015–2020 烧伤了:克里斯-哈尼-巴拉夸那思学术医院 2015-2020 年儿科烧伤收治情况回顾
Burns open : an international open access journal for burn injuries Pub Date : 2024-04-01 DOI: 10.1016/j.burnso.2024.03.007
R. Mahlaule , N. Meghraj , L. Tshuta , A. Seedat , K. Mothoane , I. Kotze , G. Miller , T. Zama , J. Scribante , N. Patel
{"title":"Burnt out: A retrospective review of paediatric burns admissions at Chris Hani Baragwanath Academic Hospital 2015–2020","authors":"R. Mahlaule ,&nbsp;N. Meghraj ,&nbsp;L. Tshuta ,&nbsp;A. Seedat ,&nbsp;K. Mothoane ,&nbsp;I. Kotze ,&nbsp;G. Miller ,&nbsp;T. Zama ,&nbsp;J. Scribante ,&nbsp;N. Patel","doi":"10.1016/j.burnso.2024.03.007","DOIUrl":"https://doi.org/10.1016/j.burnso.2024.03.007","url":null,"abstract":"<div><h3>Background</h3><p>Burn injuries in children in low- and middle-income countries are common, serious, and preventable. Despite the high burden of disease, there is a paucity of data on the profile of paediatric burns in South Africa. Such data are essential to local burn prevention strategies.</p></div><div><h3>Methods</h3><p>A retrospective review of all recorded paediatric burns admissions to the paediatric burns unit at Chris Hani Baragwanath Academic Hospital was performed from 1 January 2015 – 31 December 2020. Ethical approval was obtained. Data extracted anonymously included patient age, sex, mechanism of injury, injury severity, date of injury and residential location.</p></div><div><h3>Results</h3><p>A total of 2980 admissions occurred during the study period. Infants ≤ 1 year accounted for 42.2 % (1259/2980), males 61.4 % (1689/2751), hot water burns 79.1 % (2357/2980), and major injury 40.1 % (1201/2980) of admissions. Most burn injuries occurred in winter (28.2 %, 842/2980), and most admitted patients lived in Soweto 45.5 % (1355/2980).</p></div><div><h3>Conclusions</h3><p>Most burns admissions in the study period were characterised by male children less than one year of age, hot water burns, major burn injuries and admissions in the winter months. These results are similar to national and international data regarding age, sex, mechanism of injury and seasonality of paediatric burns. The results from the study have been utilised to inform Surgeons For Little Lives’ paediatric burns prevention campaigns in Soweto and Gauteng Province.</p></div>","PeriodicalId":72486,"journal":{"name":"Burns open : an international open access journal for burn injuries","volume":"8 2","pages":"Pages 160-163"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468912224000245/pdfft?md5=c7833984aff0a4e3165fe6d0d52c62a1&pid=1-s2.0-S2468912224000245-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140350172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Solar radiation can cause clinically relevant burns in breast reconstructed patients even after years- a rare case report 太阳辐射可导致乳房再造患者在多年后仍出现临床相关烧伤--罕见病例报告
Burns open : an international open access journal for burn injuries Pub Date : 2024-04-01 DOI: 10.1016/j.burnso.2024.03.006
Till Wagner, Anne-Sophie Kruit, Marielle Vehmeijer-Heeman, Dietmar Ulrich
{"title":"Solar radiation can cause clinically relevant burns in breast reconstructed patients even after years- a rare case report","authors":"Till Wagner,&nbsp;Anne-Sophie Kruit,&nbsp;Marielle Vehmeijer-Heeman,&nbsp;Dietmar Ulrich","doi":"10.1016/j.burnso.2024.03.006","DOIUrl":"https://doi.org/10.1016/j.burnso.2024.03.006","url":null,"abstract":"<div><p>We hereby present a rare case of a full-thickness skin burn after solar radiation by wearing a black bra. The patient underwent late 2020 a delayed bilateral autologous breast reconstruction with a bilateral DIEP flap, followed shortly after by a latissimus dorsi flap reconstruction of her left breast caused by flap necrosis of the left-sided DIEP flap and a secondary nipple reconstruction with afterward a small cosmetic correction. Shortly after she travelled for a holiday in November 2023 to Egypt. After less than 2 h sunbathing in the afternoon in her black bra, she recognized later in the evening redness and blistering of the skin of her right breast. After return and presentation to our outpatient department, we stated a 2b-3 degree burn of her right lateral breast. Under conservative treatment no progress was seen, thus we scheduled the patient for a direct resection and primary closure of the burned skin, which further healed uneventfully. This case presentation shows again the potential risk of solar burns in breast-reconstructed patients with reduced skin sensitivity even after years. Therefore patients undergoing breast reconstruction should be informed about this issue and medical professionals should be aware of this potential harm in these population groups.</p></div>","PeriodicalId":72486,"journal":{"name":"Burns open : an international open access journal for burn injuries","volume":"8 2","pages":"Pages 157-159"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468912224000233/pdfft?md5=66e44e6832b1a0418ca01488ab7d6dfd&pid=1-s2.0-S2468912224000233-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140350173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Penile burn reconstruction after self-mutilation using electrothermal device-a case report 使用电热装置自残后的阴茎烧伤重建--病例报告
Burns open : an international open access journal for burn injuries Pub Date : 2024-04-01 DOI: 10.1016/j.burnso.2024.03.004
Alica Hokynková , Petr Šín , Gabriela Michalčáková , Aleš Čermák , Andrea Pokorná
{"title":"Penile burn reconstruction after self-mutilation using electrothermal device-a case report","authors":"Alica Hokynková ,&nbsp;Petr Šín ,&nbsp;Gabriela Michalčáková ,&nbsp;Aleš Čermák ,&nbsp;Andrea Pokorná","doi":"10.1016/j.burnso.2024.03.004","DOIUrl":"10.1016/j.burnso.2024.03.004","url":null,"abstract":"<div><h3>Introduction</h3><p>Isolated genital burns are not frequent injuries; more often, they are part of larger surface-area burn injuries. Aetiology and mechanisms of genital burn injuries differ regarding country, age and patients’ socioeconomic status.</p></div><div><h3>Aim</h3><p>The aim is to describe a rare case report of a 69-year-old man who incurred a deep penile burn after using an electrothermal sexual device.</p></div><div><h3>Methods</h3><p>The patient was admitted to the Department of Urology (blinded for review) with deep penile burn a week after the injury<em>.</em> Debridement, conservative therapy, and deferred reconstruction due to extensive lymphoedema were performed<em>.</em> Due to numerous small, contracted skin scars of penile corpus arising from multiple healed burns caused by self-mutilation by repeatedly using an electrothermal sexual device, the penile defect reconstruction was performed. A local ventral foreskin skin flap in combination with a full split-thickness graft was done in order to avoid extensive scar contracture with possible penile deviation.</p></div><div><h3>Results</h3><p>There were no complications in postoperative care in the follow-up period of 26 months, with satisfactory aesthetical and functional results<em>.</em></p></div><div><h3>Conclusion</h3><p>In the case of penile wounds, the reconstruction technique depends on the injury's size, depth and localisation of the damage.</p></div>","PeriodicalId":72486,"journal":{"name":"Burns open : an international open access journal for burn injuries","volume":"8 2","pages":"Pages 143-146"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S246891222400021X/pdfft?md5=906ff7f29a11bbf59663d65326f3a7b9&pid=1-s2.0-S246891222400021X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140273839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term vitamin D insufficiency and associated risk factors for paediatric burns patients 小儿烧伤患者长期维生素 D 不足及相关风险因素
Burns open : an international open access journal for burn injuries Pub Date : 2024-04-01 DOI: 10.1016/j.burnso.2024.03.003
Donna Langley , Pawel Sadowski , Zoe Dettrick , Giorgio Stefanutti , Roy Kimble , Craig Munns , Tuo Zang , Andrew J.A. Holland , Mark W. Fear , Lisa J. Martin , Fiona M. Wood , Leila Cuttle
{"title":"Long-term vitamin D insufficiency and associated risk factors for paediatric burns patients","authors":"Donna Langley ,&nbsp;Pawel Sadowski ,&nbsp;Zoe Dettrick ,&nbsp;Giorgio Stefanutti ,&nbsp;Roy Kimble ,&nbsp;Craig Munns ,&nbsp;Tuo Zang ,&nbsp;Andrew J.A. Holland ,&nbsp;Mark W. Fear ,&nbsp;Lisa J. Martin ,&nbsp;Fiona M. Wood ,&nbsp;Leila Cuttle","doi":"10.1016/j.burnso.2024.03.003","DOIUrl":"10.1016/j.burnso.2024.03.003","url":null,"abstract":"<div><p>The most recognised role of vitamin D in the body is for calcium absorption, and sufficiency is defined as a vitamin D blood serum level greater than 20 ng/mL (50 nmol/L). In growing children, hypovitaminosis D is associated with bone and muscle weakness, fractures, and osteoporosis. Burns patients are at a greater risk of low vitamin D levels due to lack of ultraviolet rays reaching the skin during prolonged hospital admission and sun avoidance post-burn injury. This study aimed to identify any individual, seasonal or burn injury characteristics in paediatric patients that were associated with low total vitamin D levels. Three different vitamin D metabolites were analysed to identify if, and where, in the synthesis pathway any insufficiencies may be occurring. Liquid Chromatography Mass Spectrometry (LCMS) was used to concurrently assess vitamin D3 (25OHD3 or Calcifediol), its epimer (3epi-25(OH)D3), and its precursor Pre Vitamin D3 (Cholecalciferol), in the plasma from 193 Australian paediatric burn patients, compared to 46 healthy controls. The results indicated that 61 % of healthy controls and up to 76 % of all burn patients had below normal clinical ranges of Total 25OHD3 (25(OH)D3 + 3epi-25(OH)D3). However, there were no significant differences between patient groups (control, acute, scarring, and reconstructive). The season of sample collection contributed significantly to total vitamin D levels but patients who were undergoing reconstructive surgery 1–17 years post-burn had consistently low vitamin D levels across all seasons. Routine screening, dietary monitoring, and potential supplementation of vitamin D in the burns population is recommended as it may impact recovery, growth and development of the child post-burn.</p></div>","PeriodicalId":72486,"journal":{"name":"Burns open : an international open access journal for burn injuries","volume":"8 2","pages":"Pages 147-156"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468912224000208/pdfft?md5=52a9cd41ee9aee5b1bf60b8ee43e4cf9&pid=1-s2.0-S2468912224000208-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140280649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The introduction of microvascular free tissue transfer in primary burn reconstruction. Experience report of the national burn center in Chile 在原发性烧伤重建中引入微血管游离组织移植。智利国家烧伤中心的经验报告
Burns open : an international open access journal for burn injuries Pub Date : 2024-03-28 DOI: 10.1016/j.burnso.2024.03.005
Soto Carolina , Dona Jimena , Alzate Adriana , Troncoso Ekaterina , Hurtado María José , González Diego , Calcagno Manuel , Calderón María Elsa , Flores Nicolás , Ríos Marco
{"title":"The introduction of microvascular free tissue transfer in primary burn reconstruction. Experience report of the national burn center in Chile","authors":"Soto Carolina ,&nbsp;Dona Jimena ,&nbsp;Alzate Adriana ,&nbsp;Troncoso Ekaterina ,&nbsp;Hurtado María José ,&nbsp;González Diego ,&nbsp;Calcagno Manuel ,&nbsp;Calderón María Elsa ,&nbsp;Flores Nicolás ,&nbsp;Ríos Marco","doi":"10.1016/j.burnso.2024.03.005","DOIUrl":"10.1016/j.burnso.2024.03.005","url":null,"abstract":"<div><h3>Background</h3><p>Surgical debridement and split thickness graft is the most common treatment for acute burn patients that require surgery. However, there is a relevant minority that will require more complex reconstructive options. Microsurgery has evolved as a valuable tool in the acute setting allowing early closure of complex wounds in order to avoid infection, maintain function and even for limb salvage in one stage reconstruction. We present our experience in the management of severely acute burned patients with free flaps, flap survival rate and complications in Chile’s National Health service.</p></div><div><h3>Method</h3><p>We performed a retrospective analysis of all major burn patients admitted in our unit who received a microsurgical flap in the period between april 2019 and march 2023. Data was collected on patient sex, age, mechanism of injury, total burned surface area (TBSA), location of the defect, days to reconstruction, flaps used, operatory time, flap survival and complications.</p></div><div><h3>Results</h3><p>In the study period we had 925 admissions. A total of 36 patients had 42 free flaps (5,1%). All but two patients were male (95 %), mean age 46 years (range 20–––76 years). Total body surface area burned averaged 14 % (range 1–64 %). The majority of injuries were caused by high voltage electricity (59 %) and fire (33 %). 59 % compromised lower limbs and 31 % upper limbs. In 81 % of the cases anterolateral thigh flaps were used. Mean time to reconstruction was 39 days(range 1–64 days), we had 9 complications (21 %) and only one flap was lost (2,9%).</p></div><div><h3>Discussion</h3><p>The introduction of free flaps in the burn reconstruction field was first described in sequelae management. In the acute phase it has also proven to be safe and feasible with a surgical indication of 1,5% to 2% of the admissions in different series. In our unit, 5,1% of our admissions required it, with a low flap loss rate. The increased confidence for its use in the acutely burned setting allowed us to achieve complex coverage while maintaining surgical risk and an internationally acceptable rate of losses and complications. Free flaps cpnstitute an active approach in the classical treatment of this pathology pushing the boundaries in the local environment.</p></div>","PeriodicalId":72486,"journal":{"name":"Burns open : an international open access journal for burn injuries","volume":"8 3","pages":"Pages 169-174"},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468912224000221/pdfft?md5=4ae320a97fda6bb31dad126f89c8b02f&pid=1-s2.0-S2468912224000221-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140400352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tetra-combined Z-plasty for wide-scar hip contracture including the anus 治疗包括肛门在内的宽疤痕髋关节挛缩症的四联合 Z 形成形术
Burns open : an international open access journal for burn injuries Pub Date : 2024-03-08 DOI: 10.1016/j.burnso.2024.03.002
Masaki Fujioka , Kiyoko Fukui , Kazufumi Koga
{"title":"Tetra-combined Z-plasty for wide-scar hip contracture including the anus","authors":"Masaki Fujioka ,&nbsp;Kiyoko Fukui ,&nbsp;Kazufumi Koga","doi":"10.1016/j.burnso.2024.03.002","DOIUrl":"https://doi.org/10.1016/j.burnso.2024.03.002","url":null,"abstract":"<div><p>Extensive burns around the anus cause scarring and contracture, leading to difficulty in defecation due to anal stenosis and restriction of hip joint movement, which causes suffering to the patient. Conventional Z-plasty is not effective for widespread zonular scar contracture, and methods such as double combined Z-plasty and reversed Z-plasty have been developed. However, these methods are difficult to use because the position of the anus is displaced when the flap is moved.</p><p>The purpose of this study was to introduce a new technique to effectively release contracture in wide scars using tetra-combined Z-plasty, which has the following characteristics: 1. There is no deviation of the anus. 2. It prevents anal restenosis. 3. The funnel-shaped three-dimensional structure can be reconstructed.</p><p>These characteristics suggest that tetra-combined Z-plasty is also well-suited for the release of scar contracture in a wide range of skin landmark organs, including the perineum, penis, umbilicus, nipples, stoma, and tracheostomy.</p></div>","PeriodicalId":72486,"journal":{"name":"Burns open : an international open access journal for burn injuries","volume":"8 2","pages":"Pages 125-127"},"PeriodicalIF":0.0,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S246891222400018X/pdfft?md5=8c7b0506eb8da8341bc868cc8389d9c3&pid=1-s2.0-S246891222400018X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140113355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Celecoxib to improve scar quality following acute burn injury: Lessons learned after premature termination of a randomised trial 用塞来昔布改善急性烧伤后的疤痕质量:随机试验提前终止后的经验教训
Burns open : an international open access journal for burn injuries Pub Date : 2024-03-07 DOI: 10.1016/j.burnso.2024.03.001
Edward Raby , Paul Gittings , Edward Litton , Aaron Berghuber , Dale Wesley Edgar , Jo Camilleri , Kris Owen , Rosemary Kendell , Laurens Manning , Mark Fear , Fiona Melanie Wood
{"title":"Celecoxib to improve scar quality following acute burn injury: Lessons learned after premature termination of a randomised trial","authors":"Edward Raby ,&nbsp;Paul Gittings ,&nbsp;Edward Litton ,&nbsp;Aaron Berghuber ,&nbsp;Dale Wesley Edgar ,&nbsp;Jo Camilleri ,&nbsp;Kris Owen ,&nbsp;Rosemary Kendell ,&nbsp;Laurens Manning ,&nbsp;Mark Fear ,&nbsp;Fiona Melanie Wood","doi":"10.1016/j.burnso.2024.03.001","DOIUrl":"https://doi.org/10.1016/j.burnso.2024.03.001","url":null,"abstract":"<div><h3>Background</h3><p>Pre-clinical studies suggest that non-steroidal anti-inflammatory therapy may reduce acute inflammation and modulate scar formation after burn injury. The objective of this trial was to determine if celecoxib administered soon after acute burn improved scar quality.</p></div><div><h3>Methods</h3><p>A single centre, parallel group, placebo-controlled, randomised, superiority trial. Adults with non-major acute burn injury were eligible for recruitment. Participants within 48 h of admission for acute burn injury received either six weeks of celecoxib 200 mg twice daily or identically packaged placebo capsules. The primary outcome was participant-reported Patient Observer Scar Assessment Scale (POSAS) at day 42 following burn injury. The best possible score using this assessment is 7 and the worst 70. Key safety outcomes included study drug side effects.</p></div><div><h3>Results</h3><p>Restrictions imposed during the COVID-19 pandemic resulted in slow recruitment and early termination after 59 of the 150 planned participants were enrolled. The primary outcome was available for 21/30 (70 %) participants in the celecoxib arm and for 23/29 (79 %) who received placebo. There was no significant difference in the primary outcome between treatment groups with a mean POSAS of 33.4 (standard deviation 12.7) in the celecoxib arm and 36.9 (13.7) in the control arm giving a difference of −3.49 (95 % CI [-11.57, 4.59], <em>p</em> =.39). Gastrointestinal symptoms occurred in 3/30 (10 %) allocated celecoxib and in none allocated placebo. Secondary outcomes including graft loss and delayed healing were similar between groups.</p></div><div><h3>Conclusions</h3><p>Anti-inflammatory therapy did not improve scar quality. Due to early trial termination and significant loss to follow up these findings should be interpreted cautiously. To improve generalisability and to attain recruitment targets, future trials should apply different approaches to improve participant retention as well as including patients with larger burn injuries and an older population.</p><p>Trial registration: ACTRN12618000732280.</p></div>","PeriodicalId":72486,"journal":{"name":"Burns open : an international open access journal for burn injuries","volume":"8 2","pages":"Pages 128-135"},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468912224000191/pdfft?md5=94392e503be34bb4014409c0c61a626f&pid=1-s2.0-S2468912224000191-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140112942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acellular dermal matrix combined with negative pressure wound therapy in a chemical burn: Case report 细胞真皮基质结合负压疗法治疗化学烧伤:病例报告
Burns open : an international open access journal for burn injuries Pub Date : 2024-03-02 DOI: 10.1016/j.burnso.2024.02.008
Viviana Gómez-Ortega , David Camacho-Obando , Ana-María Camargo-López , Cesar Cardona-Montes
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