Burns open : an international open access journal for burn injuries最新文献

{"title":"Perforator flap for burn reconstruction","authors":"Kishore Kumar Das ,&nbsp;Ashrafur Rahman ,&nbsp;Esra Haroon","doi":"10.1016/j.burnso.2023.08.001","DOIUrl":"10.1016/j.burnso.2023.08.001","url":null,"abstract":"<div><h3>Background</h3><p>Majority of burn patients in Bangladesh are treated at home and tend to develop scar and scar contracture. Other than physical limitations there are also stigmatization, loss of marriageability or divorce particularly for women. Skin grafts are prone to contraction and need prolonged splintage and physiotherapy. Flaps are often too bulky. Local flaps have the advantage of increased positional comfort as compared to distant flaps like the abdominal or the groin flaps. Free flaps are technically demanding and facilities are not universally available. Advances in knowledge of blood supply of the skin have increased the potentials for perforator based skin flaps.</p></div><div><h3>Methodology</h3><p>A total of 72 patients who could complete a minimum one year follow up were included in the study. All flaps were rotated around the axis of the perforator ranging from 90 degrees to 180 degrees. Skin pedicles were kept when possible, complete island flaps were designed when rotation was maximum.</p></div><div><h3>Results</h3><p>Among the 72 cases 54 cases were electric burn wounds and18 were post burn scar contracture, 59 were male and 13 were female. 44 cases were done on leg. Smallest flap was 5 cm in length and the largest was 16 cm. Immediate complications include total flap loss, tip loss, margin loss, wound infection and hematoma under the flap was noted. In one case emergency exploration was required to control hemorrhage. Contour defect, dependent edema in legs, sensorineural deficit, limitation of joint movement was also observed.</p></div><div><h3>Conclusion</h3><p>A single perforator may safely supply its proper angiosome and up to the half of vascular territory of the adjacent perforator. This possibility is favored by vascular adoption directed toward the periphery that occurs by means of increased vascular pressure in the perforator artery after ligature of collateral subcutaneous and intramuscular arterial branches. The authors percept is, usually perforation is along the intermuscular septum, the portion of the flap that crosses beyond the adjacent intermuscular septum are at risk. Not required to go that far as residual wounds can be grafted with split thickness skin.</p></div>","PeriodicalId":72486,"journal":{"name":"Burns open : an international open access journal for burn injuries","volume":"7 4","pages":"Pages 107-113"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44132444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute care strategies to reduce burn scarring","authors":"Mengyue Zhu ,&nbsp;Zoë Edger-Lacoursière ,&nbsp;Elisabeth Marois-Pagé ,&nbsp;Bernadette Nedelec","doi":"10.1016/j.burnso.2023.09.004","DOIUrl":"https://doi.org/10.1016/j.burnso.2023.09.004","url":null,"abstract":"<div><p>Burn scars can have detrimental effects on survivors’ ability to resume their daily activities thereby impairing their quality of life. The medical advances in burn care have reduced mortality but increased morbidity since patients with larger total body surface area burns are now surviving. The combined reality of these phenomenon generates an imperative that all health care professionals across the continuum of burn care prioritized regenerative over fibrotic wound healing. The recent explosion of basic science wound healing research has advanced our understanding of the pathophysiology that culminates in the generation of two types of pathological scars, hypertrophic scar (HSc) or keloids. These findings provide opportunities to review and reiterate existing practices that augment wound healing but also to adopt novel interventions that have been experimentally substantiated. The purpose of this review is to summarize the basic science evidence that differentiates pathological scar formation from regenerative or non-pathological scar, then review the evidence-informed acute care conservative and surgical management which will optimize wound healing outcomes.</p></div>","PeriodicalId":72486,"journal":{"name":"Burns open : an international open access journal for burn injuries","volume":"7 4","pages":"Pages 159-173"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49804190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A management strategy for burns surgery in hemophilia complicated by inhibitors: A case report","authors":"L. Kearney ,&nbsp;M. Abrahams ,&nbsp;N. O'Connell ,&nbsp;O.P. Shelley","doi":"10.1016/j.burnso.2023.08.003","DOIUrl":"10.1016/j.burnso.2023.08.003","url":null,"abstract":"<div><p>Few reports exist in the literature dealing with the management of acute burns in the hemophilic patient [1–4]. Burns treatment in this population group is an obvious challenge, due to the recognized major blood loss that can result from both the burns excision and harvesting split thickness skin grafts. Recent proposed strategies have suggested structured factor replacement during multiple radical short operations [3]. We describe a particularly challenging case, a person with mild Factor VIII deficiency (Hemophilia A) with a history of a high responding inhibitor and cross-reactivity with standard Factor VIII products. We propose a management strategy to optimise care and reduce bleeding related complications in these patients.</p></div>","PeriodicalId":72486,"journal":{"name":"Burns open : an international open access journal for burn injuries","volume":"7 4","pages":"Pages 114-116"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44940344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burn injury characteristics and outcomes among pediatric and adult patients admitted to Ministry of National Guard Health Affairs (MNGHA) hospitals in Saudi Arabia","authors":"Abrar M. Al-Mutairi ,&nbsp;Safiah Labani ,&nbsp;Manar J. Alasmari ,&nbsp;Muhammed S. Alamri ,&nbsp;Abdullah S. Alqahtani ,&nbsp;Ibrahim Albabtain ,&nbsp;David G. Greenhalgh","doi":"10.1016/j.burnso.2023.09.002","DOIUrl":"https://doi.org/10.1016/j.burnso.2023.09.002","url":null,"abstract":"<div><h3>Objective</h3><p>This study aims to describe the characteristics and outcomes of burn injuries in pediatric and adult patients admitted to Ministry of National Guard Health Affairs (MNGHA) hospitals in Saudi Arabia.</p></div><div><h3>Methods</h3><p>A multicenter retrospective cohort study was conducted between 2015 and 2021 in five hospitals run by the MNGHA in<!--> <!-->Saudi Arabia. The study included 555 patients who were admitted to the hospital with burns, and data were collected from an institutional trauma registry on various aspects such as sociodemographic variables, burn clinical characteristics and burn outcomes. The differences in epidemiological data, general characteristics, and outcomes of burn patients with ≤18 and &gt;18 years of age among Saudi hospitalized patients. The associations between patient characteristics and burn outcomes were assessed using multivariable logistic regression.</p></div><div><h3>Results</h3><p>Most of the participants representing 66.1% males and females 33.9%. Flame and contact were the most common causes of burn injuries, accounting for 43.6% and 43.2% of cases, respectively; followed by chemical (6.7%), then electrical (5.4%), and friction (1.1%). The study revealed that pediatric were the most frequently admitted age group for burn injuries with most cases occurring at home (57%). Pediatric patients had a higher percentage of hot fluid injuries, accounting for 77.5 % of cases (P = 0.00). Flame injuries were more prevalent in adults, accounting for 65.3% of cases (P &lt; 0.05). The study reported that there were significant associations between age, gender, % TBSA, body region affected, and inhalation injury with admission to the ICU in patients with burn injuries. Relative to patients with third degree burns, first and second-degree burns were associated with a lower likelihood of mortality (OR 0.13, 95% CI: 0.03,0.51, p = 0.00).</p></div><div><h3>Conclusion</h3><p>The study’s findings can be utilized to aid in the implementation of different prevention programs and allocate appropriate resources for treatment to reduce the incidence and morbidity of burn injuries. It is essential to continue educating the public on fire safety in the home environment. This can help raise awareness, promote household safety precautions, and encourage early medical care seeking.</p></div>","PeriodicalId":72486,"journal":{"name":"Burns open : an international open access journal for burn injuries","volume":"7 4","pages":"Pages 146-152"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49804227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IBM Watson AI-enhanced search tool identifies novel candidate genes and provides insight into potential pathomechanisms of traumatic heterotopic ossification","authors":"Nichola Foster ,&nbsp;Fiona M. Wood ,&nbsp;Mark Fear ,&nbsp;Nathan Pavlos ,&nbsp;Edward Raby ,&nbsp;Dale W. Edgar","doi":"10.1016/j.burnso.2023.07.001","DOIUrl":"10.1016/j.burnso.2023.07.001","url":null,"abstract":"<div><h3>Background</h3><p>Traumatic heterotopic ossification (tHO) is the pathological formation of ectopic bone in soft tissues that can occur following injury to the skin, nervous system, or direct musculoskeletal trauma. Relatively high rates of tHO are expected after damage to neural structures. In clinical practice, diagnosis, prevention, and treatment of tHO are highly variable, partly due to a limited understanding of the pathophysiology. Identifying critical molecular contributors to the development of tHO remains challenging, limiting the development of effective diagnostics and treatment.</p><p>IBM Watson for Drug Discovery (WDD) uses machine learning and natural language processing to interrogate a literature repository encompassing private and public data sources. This study used WDD to identify plausible new genes and pathways that may be involved in tHO.</p></div><div><h3>Methods</h3><p>A three-stage process centred around the disease agnostic WDD repository was applied during this study. Firstly, WDD was used to pool and target search the scientific literature involving heterotopic ossification arising from burns, orthopaedic trauma, and neurological injury populations. This training of the WDD natural language processing algorithms using known entities was used to discover novel intercepts in the network of semantic relationships evident in the published literature to 2019. Indications of plausible relationships were sought by triangulating biological concepts such as genes and diseases. In this step, using the WDD predictive analytics engine, the study identified and ranked 233 candidate genes that may be associated with pathological ectopic ossification, utilising a set of 100 genes with previously defined associations with tHO. Finally, a search of the WDD-linked literature related to the top 25 genes identified from the rank product analysis was conducted to validate WDD’s predictions of potential novel candidate genes.</p></div><div><h3>Results</h3><p>Of the top 25 ranked genes, six genes (MMRN1, MSC/MyoR, ITGAM/CD11b, PDGF-D, GREM-1 and NELL-1) were identified to have evidence of likely association with tHO. These candidate genes had previously defined roles in inflammation, aberrant tissue repair and regeneration, extracellular matrix remodelling and mineralisation, endochondral or intramembranous bone formation and injury-associated bone reactions, as well as functions in WNT and BMP signalling that are known to be important in osteogenic differentiation.</p></div><div><h3>Conclusions</h3><p>Using a machine-learning approach, this study identified a novel set of plausible candidate gene targets associated with tHO. Machine-learning methods may effectively support target discovery and understanding of pathophysiology in complex disease states.</p></div>","PeriodicalId":72486,"journal":{"name":"Burns open : an international open access journal for burn injuries","volume":"7 4","pages":"Pages 126-138"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43597940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics of alcohol-flame burns and correlation with COVID-19 epidemic: A retrospective analysis from a single center","authors":"Lan Xiaodong ,&nbsp;Huang Zhenjia ,&nbsp;Zhou Tao ,&nbsp;Wang Chao ,&nbsp;Tang Yong ,&nbsp;Ma Yan ,&nbsp;Wang Dehuai ,&nbsp;Huang Yuesheng","doi":"10.1016/j.burnso.2023.08.004","DOIUrl":"10.1016/j.burnso.2023.08.004","url":null,"abstract":"<div><h3>Objective</h3><p>To analyze the clinical characteristics of alcohol-flame burns and the correlation with COVID-19 epidemic.</p></div><div><h3>Methods</h3><p>A retrospective analysis was conducted on the medical records of 134 patients with alcohol-flame burns who were admitted to the Second People's Hospital of Chengdu City from January 2015 to December 2022. Demographics, time of first hospital visit, burn size, depth and site, month and place of burn, inhalation injury, surgical intervention, length of hospital stay, hospital costs were recorded annually. Data from the COVID-19 epidemic period (2020–2022) were compared to those from the non-epidemic period (2015–2019) for analysis.</p></div><div><h3>Results</h3><p>The number of patients with alcohol-flame burns showed a consistent annual increase. During the epidemic period, the proportion of alcohol-flame burns among burn patients was significantly higher (2.43% ± 0.16%) than during the non-epidemic period (1.70% ± 0.15%) (P = 0.00). Alcohol-flame burns primarily affected adult men, occurring mainly in massage parlors and homes. The peak incidence was between May and August. Patients sought medical attention promptly, with a median time to first hospital visit of 2 h post-burn. Alcohol-flame burns mostly involved the trunk and upper extremities. Median total burn size was 7% TBSA, median full-thickness burn size was 1% TBSA. Over 20% of patients had combined inhalation injuries, and a similar proportion required surgical intervention. Alcohol burn patients had a median hospital stay of 14 days and incurred median medical costs of ¥16,600($2300). During the epidemic, the basic characteristics of patients with alcohol-flame burns did not change much. However, the time to first hospital visit was significantly shorter (2 h) during the epidemic period than non-epidemic period (3 h). Furthermore, alcohol-flame burn patients during the epidemic exhibited significantly larger total burn sizes, higher burn indices, and longer hospital stays compared to non-epidemic patients. The incidence of combined inhalation injuries was also significantly higher during the epidemic. Surgical requirements and medical costs were not significantly associated with the COVID-19 epidemic.</p></div><div><h3>Conclusion</h3><p>Alcohol-flame burns exhibit distinct clinical characteristics, including severe injuries, prolonged hospital stays, and elevated costs, particularly in the context of the COVID-19 pandemic.</p></div>","PeriodicalId":72486,"journal":{"name":"Burns open : an international open access journal for burn injuries","volume":"7 4","pages":"Pages 121-125"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42934826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidermolysis bullosa acquisita following skin graft in donor and graft sites: A case report","authors":"Joyce Xia ,&nbsp;Alice J. Tan ,&nbsp;Gunnlaugur P. Nielsen ,&nbsp;Ruth K. Foreman ,&nbsp;Mai Hoang ,&nbsp;Sean A. Hickey ,&nbsp;Daniela Kroshinsky","doi":"10.1016/j.burnso.2023.06.002","DOIUrl":"10.1016/j.burnso.2023.06.002","url":null,"abstract":"<div><p>Epidermolysis bullosa acquisita is a rare mucocutaneous autoimmune blistering disorder which usually presents in adulthood. The disease is mediated by antibodies against type VII collagen, though the precise inciting factors for autoantibody formation are unknown. Here, we present the case of a 69-year-old man who developed this condition following autograft. We highlight this case to draw attention to a rare cause of skin graft failure, with early referral to specialist care necessary for avoidance of sequelae related to scarring.</p></div>","PeriodicalId":72486,"journal":{"name":"Burns open : an international open access journal for burn injuries","volume":"7 4","pages":"Pages 99-102"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47224737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring gender disparities in burn injuries: A retrospective study at a burns centre in Karachi, Pakistan","authors":"Samia Tasleem ,&nbsp;Muhammad Abdul Wasay Zuberi ,&nbsp;Muhammad Sheheryar Hussain ,&nbsp;Syed Muhammad Moaaz Bin Sultan ,&nbsp;Ahmed Ibrahim Siddiqui ,&nbsp;Hussain Haider Shah ,&nbsp;Hasan Tariq ,&nbsp;Arqam Bin Aijaz","doi":"10.1016/j.burnso.2023.08.002","DOIUrl":"10.1016/j.burnso.2023.08.002","url":null,"abstract":"<div><h3>Introduction</h3><p>Burn is defined as any injury due to heat or acute trauma, according to the International Society of Burns Injury (ISBI). A neglected aspect of our country is the gender-specific pattern of burn injuries. This study aims to highlight the gender-based disparities of burns injuries and overcome the drastic effects of burns on an individual's life.</p></div><div><h3>Method</h3><p>The data from the burns centre of Dr Ruth.K.M.Pfau Civil Hospital Karachi from Jan 1, 2021, to Dec 31, 2021, were retrospectively analyzed to perform this study. Different variables such as aetiology, circumstances, residence, age, TBSA, degree and occupation were recorded from the patient's files. They were compared by gender to find out any existing correlation.</p></div><div><h3>Results</h3><p>The estimated sample size was 375, 180(48%) females, and 195(52%) were burned males. A significant correlation was found for gender with a degree of burns, aetiology, age, occupation, and residence. Whereas circumstances of burns and TBSA were non-significantly correlated to gender.</p></div><div><h3>Conclusion</h3><p>In conclusion, our study determined that men most commonly suffer from burn injuries. In contrast, thermal injury is the most dominant etiological factor in every age group in both genders. Several risk factors are associated with a specific gender, requiring adaptive prevention and management approaches to culminate this issue.</p></div>","PeriodicalId":72486,"journal":{"name":"Burns open : an international open access journal for burn injuries","volume":"7 4","pages":"Pages 117-120"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45228922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of burns at the University Clinical Center in Gdańsk in 2017–2022","authors":"Filip Lachowski ,&nbsp;Paulina Bernecka ,&nbsp;Agnieszka Pruska ,&nbsp;Dominika Ossowska ,&nbsp;Ada Łątkowska ,&nbsp;Agata Błażyńska-Spychalska ,&nbsp;Jerzy Jankau","doi":"10.1016/j.burnso.2023.05.003","DOIUrl":"10.1016/j.burnso.2023.05.003","url":null,"abstract":"<div><h3>Introduction</h3><p>The epidemiological trends in burns vary in different regions of the world.</p><p>There are only few population-based reports on this topic in Poland.</p><p>The aim of this study is to analyze statistics and epidemiology of burn patients. This can create a basis for improving the prevention of burns and their treatment.</p></div><div><h3>Methods</h3><p>This retrospective study analysis the data of burn patients admitted to the University Clinical Center in Gdańsk from 2017 to 2022. <strong>P</strong>atients were included if their primary or secondary diagnosis was burn, according to ICD. A descriptive statistics were used to describe demographics, injury and management.</p></div><div><h3>Results</h3><p>584 patients were included in the study. The dominant age group were patients aged 20–29 (139–23,8%), followed by patients aged 30–39 (118–20,2%) and 40–49 (100–17,1%). Men accounted for 338 cases (57,9%), women for 246 (42,1%). The most numerous were burns of thermal etiology (391–67%), followed by chemical burns (172–29,3%). Among thermal burns, scalds and flames were responsible for 297 cases. Head was the most common burn location (281–48,1%), followed by the upper limb (263–45%). It varied depending on gender. Among 355 burn cases characterized with the degree of the burn, second-degree burns were the largest group − 197 cases (60,6%). Plastic, ophthalmological and laryngological consultations are the most frequently ordered type in the Hospital Emergency Department. 163 burn patients required hospitalization.</p></div><div><h3>Conclusions</h3><p>The results obtained in our study are consistent with those of burn victims in other international studies in this field. It is crucial to conduct further epidemiological analysis to better quantify the impact of burns in Poland and to improve the treatment of burn patients.</p></div>","PeriodicalId":72486,"journal":{"name":"Burns open : an international open access journal for burn injuries","volume":"7 3","pages":"Pages 89-93"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44611514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective analysis of systemic Norepinephrine impact on tangential excision and split thickness skin graft outcomes in burn shock patients","authors":"Albin John ,&nbsp;Ilina Terziyski ,&nbsp;Annie Snitman ,&nbsp;John Garza ,&nbsp;Alan Pang ,&nbsp;Callie Adams ,&nbsp;Grant Sorensen ,&nbsp;John Griswold","doi":"10.1016/j.burnso.2023.05.001","DOIUrl":"10.1016/j.burnso.2023.05.001","url":null,"abstract":"<div><h3>Objective</h3><p>Burn shock is a serious complication that presents with profound cardiovascular suppression that may require vasopressor support for hemodynamic stability. This study aims to explore the patterns of systemic Norepinephrine use and skin graft take in patients with deep burns requiring excision and grafting.</p></div><div><h3>Methods</h3><p>Burn patients ages 18–89 years that presented to our regional burn center from January 2014–June 2020 and were treated with systemic vasopressors within the first 48 h of admission, and received at least one tangential excision and split thickness skin graft (STSG) procedure as part of their treatment were retrospectively identified. Patients receiving vasopressors were compared to a matched cohort of patients not receiving vasopressors yet with similar demographics, burn trauma, and smoke inhalation injury. Major outcomes investigated included: average overall graft take, amount of Norepinephrine received, total amount of fluids used for resuscitation, number of operations, and length of hospital stay.</p></div><div><h3>Results</h3><p>The mean graft uptake for patients treated with systemic Norepinephrine (80.0%) was significantly lower than the mean graft uptake for patients not treated with systemic Norepinephrine (91.4%, p &lt; 0.001).</p></div><div><h3>Conclusion</h3><p>Patients with burn shock should be primarily managed with fluid resuscitation with addition of vasopressors only if absolutely necessary.</p></div>","PeriodicalId":72486,"journal":{"name":"Burns open : an international open access journal for burn injuries","volume":"7 3","pages":"Pages 68-75"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47053488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}