Burns open : an international open access journal for burn injuries最新文献

{"title":"Enhancing burn management outcomes through family support: A literature review of current evidence and best practices","authors":"Deni Alia Yadi ,&nbsp;Chandra Isabella Hostanida Purba ,&nbsp;Tuti Pahria ,&nbsp;Bejo Ropii ,&nbsp;Maulidwina Bethasari ,&nbsp;Arif Tri Prasetyo","doi":"10.1016/j.burnso.2024.100375","DOIUrl":"10.1016/j.burnso.2024.100375","url":null,"abstract":"<div><div>Burns are identified as damage to the skin and organs, commonly resulting from contact with fire, electrical currents, radiation, heated liquids or surfaces, or chemical agents. It is considered as a challenging medical condition both physically and psychologically with significant morbidity and fatality rates. Optimal wound healing required not only extensive medical care such as fluid resuscitation, wound care, infection prevention, pain control, surgical interventions, but also strong emotional and social support from family member. This article presented and discussed the burden, the role of family, the challenges and strategy in improving the healing process and enhancing treatment outcomes through family engagement. Family involvement could minimize complication rates, enhance therapy adherence, and speed up patient rehabilitation. This review provide an overview of the value of family support in burn therapy while also adding fresh insights to the existing research on the role of family in improving burn patient outcomes.</div></div>","PeriodicalId":72486,"journal":{"name":"Burns open : an international open access journal for burn injuries","volume":"8 4","pages":"Article 100375"},"PeriodicalIF":0.0,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142528828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing a tertiary surgical units readiness to offer a fellowship in burn care in Africa","authors":"T. Netshiongolwe ,&nbsp;S. Znamerovskyi ,&nbsp;A. Muganza","doi":"10.1016/j.burnso.2024.100374","DOIUrl":"10.1016/j.burnso.2024.100374","url":null,"abstract":"<div><div>The number of patients presenting with burn injuries in Africa is increasing [1,2], and these injuries can have devastating outcomes [3,4]. One contributing factor to these outcomes is the lack of adequately trained staff in providing expert burn wound care. There is little emphasis on training staff in caring for burn patients in Africa. Our goal was to assess the services offered at a specialized burn unit in South Africa and compare them to the recommendations of the American Burn Association for providing fellowship training in burn care. Establishing such a fellowship program will help train experts who can improve burn care services across Africa.</div></div>","PeriodicalId":72486,"journal":{"name":"Burns open : an international open access journal for burn injuries","volume":"8 4","pages":"Article 100374"},"PeriodicalIF":0.0,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142444565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cases of burns reported to health facilities in the Volta Region of Ghana, 2019–2023","authors":"Maxwell Afetor ,&nbsp;Samuel Adolf Bosoka ,&nbsp;Williams Azumah Abanga ,&nbsp;Victor Zeng ,&nbsp;Christopher Sunkwa Tamal ,&nbsp;Gyesi Razak Issahaku ,&nbsp;Clement Tetteh Narh ,&nbsp;Frank Baiden ,&nbsp;Chrysantus Kubio","doi":"10.1016/j.burnso.2024.100373","DOIUrl":"10.1016/j.burnso.2024.100373","url":null,"abstract":"<div><h3>Introduction</h3><div>Burn injuries represent a significant public health challenge in Ghana, highlighting the need for an improved surveillance system to improve the quality of epidemiological data for an informed decision making. This study aimed to present the incidence, trends, and distribution of burns in the Volta region of Ghana from 2019 to 2023.</div></div><div><h3>Method</h3><div>A retrospective secondary data analysis of burns data from the District Health Information Management System (DHIMS-2) was conducted from 2019 to 2023. Burn injuries were retrieved from the OPD morbidity report form whiles deaths from burns were retrieved from the cause of death report. Data was analysed descriptively with Microsoft Excel and Quantum Geographical Information System (QGIS), with results presented in tables and graphs.</div></div><div><h3>Results</h3><div>A total of 4,441 cases of burn injuries were reported between 2019 and 2023 with 20 cases resulting in death. Nearly 59 % of burns involved females. About a third (33.9 %) of cases involved persons aged 0–4 years. The overall average incidence of burn injuries was 51 per 100,000 population, with the highest incidence of 80 per 100,000 population reported in 2019.</div></div><div><h3>Conclusion</h3><div>Burns are an important cause of morbidity and mortality in the Volta Region of Ghana. There is however scanty data on the epidemiology of the condition in the region.</div></div>","PeriodicalId":72486,"journal":{"name":"Burns open : an international open access journal for burn injuries","volume":"8 4","pages":"Article 100373"},"PeriodicalIF":0.0,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142438093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective, single-center 4-year review of synthetic polyurethane matrix use in burns and other complex wounds","authors":"Muntazim Mukit ,&nbsp;Payton Grande ,&nbsp;David Hill ,&nbsp;Kalyan Dadireddy ,&nbsp;Sai Velamuri ,&nbsp;Mahmoud Hassouba ,&nbsp;Xiangxia Liu","doi":"10.1016/j.burnso.2024.100372","DOIUrl":"10.1016/j.burnso.2024.100372","url":null,"abstract":"<div><p>Here we describe the use of a synthetic polyurethane matrix in the setting of burns and other complex wounds in the largest United States case series to date. A retrospective review was conducted at a verified, regional burn center. All patients greater than 18 years of age who received this matrix between January 2019 and July 2023 were included. A total of 182 patients with 250 wounds were included in this study. Thirty-seven percent were smokers, 23.6 % had diabetes and 5.5 % had peripheral vascular disease. The majority were acute burn wounds (60 %), followed by trauma (24.4 %), chronic wounds (5.6 %), infection (4 %) and donor sites (2 %). Exposed structures included fat (54 %), muscle (30 %), bone (16 %) and tendon (14.4 %). Microbial colonization was present in 143 (57.2 %) of cases: 98 (39.2 %) pre-application and 89 (35.6 %) post application. The incidence of new microbial colonisation post-application was 25.6 %. Infection was present in 117 (46.8 %) cases, 49 (19.6 %) pre-matrix application, 44 (17.6 %) post-matrix application and 24 (9.6 %) pre and post application. Eighteen patients (10 %) died. Median length of stay was 27 days. Median time to matrix implantation was 10 days. Median time from matrix placement to skin grafting was 35 days. Where documented, there were 162 wounds (83.5 %) with &gt; 95 % matrix survival and 136 wounds (82.4 %) with &gt; 95 % skin graft survival even in the setting of adverse factors such as infection, diabetes, or nicotine use. This study demonstrates the robustness of this skin substitute to achieve successful reconstruction even in the setting of adverse patient or wound characteristics.</p></div>","PeriodicalId":72486,"journal":{"name":"Burns open : an international open access journal for burn injuries","volume":"8 4","pages":"Article 100372"},"PeriodicalIF":0.0,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468912224000609/pdfft?md5=a0b243ce19c42b730541bc4c712aaba9&pid=1-s2.0-S2468912224000609-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142240522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strategies to reduce burn scarring","authors":"David G. Greenhalgh","doi":"10.1016/j.burnso.2024.100371","DOIUrl":"10.1016/j.burnso.2024.100371","url":null,"abstract":"<div><p>Scarring is the primary complication of anyone suffering a burn injury. Despite years of research, there have been few advances in the prevention and treatment of any scar. Recent studies have identified many factors that contribute to scar formation, but despite understanding mechanisms, clinicians are unable to stop the inevitable processes of scarring. The goal of this review is to describe current methods to reduce scarring in burns. At the same time, key questions that should direct future research will be presented. Like many maladies, optimal early care should reduce these complications.</p></div>","PeriodicalId":72486,"journal":{"name":"Burns open : an international open access journal for burn injuries","volume":"8 4","pages":"Article 100371"},"PeriodicalIF":0.0,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468912224000592/pdfft?md5=3a7a1b8be12cb0a1e6cc549b8dec4659&pid=1-s2.0-S2468912224000592-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142040973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute phase optimization in burn care: Online tools and comprehensive predictive models for adult and pediatric patients","authors":"Enrico Cocchi ,&nbsp;Fortunato Cassalia ,&nbsp;Stefano Palo ,&nbsp;Carmine D’Acunto ,&nbsp;Anna Belloni Fortina ,&nbsp;Marcello Stella ,&nbsp;Davide Melandri","doi":"10.1016/j.burnso.2024.100370","DOIUrl":"10.1016/j.burnso.2024.100370","url":null,"abstract":"<div><h3>Background</h3><p>Severe burn injuries significantly challenge acute medical care, particularly in resource-limited environments. Current predictive scoring systems, often impractical and adult-focused, neglect crucial aspects like mechanical ventilation and length of hospital stay (LOS).</p></div><div><h3>Methods</h3><p>This study analyzed 2,618 severe burn patients, developing new predictive models for survival, mechanical ventilation, and LOS, based on promptly accessible factors applicable in any setting.</p></div><div><h3>Results</h3><p>We observed significant seasonality and clear age- and gender-specific patterns, highlighting the necessity for targeted interventions. We developed and publicly released new predictive models for mortality, mechanical ventilation, and LOS for both adult and pediatric populations.</p></div><div><h3>Discussion</h3><p>Targeting deficiencies in existing scoring systems, this study potentially advances acute burn management, with a particular focus on resource-limited settings. It provides crucial insights into the epidemiology, etiology, and prognostic factors of severe burn injuries, encapsulated in 10 actionable points. We also present an innovative freely accessible online assessment tool: <span><span>https://burn-scores.com</span><svg><path></path></svg></span>.</p></div><div><h3>Conclusion</h3><p>By bridging gaps in current scoring methodologies and improving acute phase management, our research offers insights to improve clinical outcomes for severe burn patients globally. The integration of tailored predictive models and technology-driven solutions, especially relevant in resource-constrained settings, represents a major stride in enhancing the quality of burn care.</p></div>","PeriodicalId":72486,"journal":{"name":"Burns open : an international open access journal for burn injuries","volume":"8 4","pages":"Article 100370"},"PeriodicalIF":0.0,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468912224000580/pdfft?md5=8b83bbbd38e3e53955f98e0644dbc33c&pid=1-s2.0-S2468912224000580-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141993277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associated bacterial and fungal infections in burn wounds: Common factors, distribution in etiology, age groups, bacterial and fungal strands – Evaluation of a single burn center experience of 20 years","authors":"Christian Weinand","doi":"10.1016/j.burnso.2024.100363","DOIUrl":"10.1016/j.burnso.2024.100363","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;p&gt;Burn intensive care unit (BICU) patients suffer from reduced immunological competence. Often bacterial and fungal infections occur as single or associated infection of the burn site. However, common factors in associated infections are discussed controversially. In this study we evaluated factors common in associated occurrence of bacterial and fungal infection in the burn population.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Patients and methods&lt;/h3&gt;&lt;p&gt;In total 213 patients, admitted to the ICU of Cologne Merheim Clinical Center between 1988 and 2011, with associated infections were included in this study. Exclusion criteria were no bacterial, or no fungal infection, or incomplete data. Data evaluated were sex, age, type of burn injury, total body surface area (TBSA), abbreviated burn severity index (ABSI) score, 3rd degree burn, inhalation injury, length of BICU stay, antibiotic therapy, bacterial strand, fungal strand, incidence of bacteria and fungus infection, single or associated occurrence and bacteria species associated with fungus species. Statistical analysis comprised of univariate, Chi-square and Fischer Exact test, multivariate analysis, positive and negative predictive value, logistic regression analysis with the Nagelkerke, Cox/ Snell R-square.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;p&gt;196 patients were included into the study, 147 male and 49 female. Total mean age was 47 years, in the fire burn group 47 years, in scalding 53 years, in electrical burn 29 years and in chemical burn 62 years. 123 male and 45 female were combusted, 15 male and 3 female scalded, 9 male had an electrical burn and 1 female a chemical burn. The mean TBSA in fire burns was 41 %, in scalding 42 %, in electrical burns 46 %, and in chemical burn 16 %. The mean ABSI in fire burn and scalding was 9, in electrical burn 8 and in chemical burn 7. The 3rd degree burns were 16 % in fire burn and 13 % in scalding and electrical burn and 0 % in chemical burn. The length of BICU stay was 49 days for fire burn, 47 days for scalding, 58 days in electrical burn and 21 days in chemical burn patients.&lt;/p&gt;&lt;p&gt;The gram-positive bacterial strands most often found were Staphylococcus strands, gram negative Pseudomonas and Acinetobacter strands. Candida albicans was the most often present fungal strand. There was no difference in incidence between gram positive and gram-negative bacteria. In patients suffering from fire burns the most common bacteria were Staphylococcus and Pseudomonas, in scalding Acinetobacter, and in chemical burns Staphylococcus. In electrical burns no predominant bacterial strand was found. The associated occurrence of Staphylococcus and Candida albicans and Pseudomonas and Candida albicans was predominant. In patients with fire burn, 48% showed an associated infection, in scalding 21%, in electrical burn 33% and in chemical burn 100%.&lt;/p&gt;&lt;p&gt;Combusted patients had the highest incidence of associated infection in age group 80–89 years, in scalding 40–49, 50–59 a","PeriodicalId":72486,"journal":{"name":"Burns open : an international open access journal for burn injuries","volume":"8 4","pages":"Article 100363"},"PeriodicalIF":0.0,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468912224000518/pdfft?md5=96e6815fb038ba2f47e1b776c261c1e0&pid=1-s2.0-S2468912224000518-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142021436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Evaluation of clinical presentation and management outcome of burns, experience at secondary referral hospital in a low-income, sub-Saharan country: A cohort study” [Burns Open 8(2) (2024) 82–86]","authors":"Mohammedbabalrahma Bashier Ahmed Koko ,&nbsp;Mohamed Daffalla Awadalla Gismalla ,&nbsp;Mohammed Yousof Bakhiet ,&nbsp;Alshareef Mohamed Alshareef ,&nbsp;Mohammed Aseri ,&nbsp;Aimen Elsheikh Khalil Abuelnour","doi":"10.1016/j.burnso.2024.100369","DOIUrl":"10.1016/j.burnso.2024.100369","url":null,"abstract":"","PeriodicalId":72486,"journal":{"name":"Burns open : an international open access journal for burn injuries","volume":"8 4","pages":"Article 100369"},"PeriodicalIF":0.0,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468912224000579/pdfft?md5=a8d67f4a712fbe220b12b2ae75fa8629&pid=1-s2.0-S2468912224000579-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141978925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adapted approaches to initial fluid management of patients with major burns in resource-limited settings: A systematic review","authors":"Kai Hsun Hsiao ,&nbsp;Joseph Kalanzi ,&nbsp;Stuart B Watson ,&nbsp;Srinivas Murthy ,&nbsp;Ani Movsisyan ,&nbsp;Kavita Kothari ,&nbsp;Flavio Salio ,&nbsp;Pryanka Relan","doi":"10.1016/j.burnso.2024.100365","DOIUrl":"10.1016/j.burnso.2024.100365","url":null,"abstract":"<div><h3>Background</h3><p>Resource limitations in settings such as burn mass casualty incidents (MCIs) present challenges to the judicious fluid resuscitation required for major burns. Previous recommendations for burns care in MCIs have suggested certain adaptations from routine care, such as delaying intravenous (IV) fluid resuscitation until arrival at facility; using a fluid calculation formula that is independent of percentage of total body surface area (%TBSA) burned; or using fluid calculation formula based on time of arrival to first receiving facility rather than from time of injury, thus omitting ‘catch-up’ fluid.</p></div><div><h3>Objectives</h3><p>To synthesize and assess certainty of evidence from resource-limited settings on the three adaptations to fluid resuscitation for patients with major burns in MCIs.</p></div><div><h3>Methods</h3><p>PubMed, EMBASE, CINAHL, and Cochrane Library were searched on 8 September 2023 with an update search on 8 July 2024. Primary quantitative studies in resource-limited settings meeting eligibility criteria as assessed by two reviewers were included. Where available, outcome effects for these adaptations compared to routine burns care were calculated. Evidence certainty was determined by GRADE.</p></div><div><h3>Results</h3><p>Two eligible studies were identified from 544 search results. One study with 48 participants provided very uncertain evidence that delayed IV fluid resuscitation may increase acute kidney injury compared to prehospital resuscitation (OR 2.48, 95% CI 0.58–10.62). The other study with a cohort of 10 children provided very uncertain evidence that calculating fluid requirements based on time of arrival to first receiving facility, i.e. omitting ‘catch-up’ fluids, may maintain adequate urine output and be associated with no complications of fluid over- or under-resuscitation. There were no studies on use of a simplified %TBSA-independent fluid calculation formula.</p></div><div><h3>Conclusions</h3><p>There is very limited and uncertain evidence to inform on delayed IV fluid resuscitation, simplified %TBSA-independent formula, and omission of ‘catch up’ fluids for burns care in MCIs. Contextual factors, local values, preferences and feasibility also need to be considered.</p></div>","PeriodicalId":72486,"journal":{"name":"Burns open : an international open access journal for burn injuries","volume":"8 4","pages":"Article 100365"},"PeriodicalIF":0.0,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468912224000531/pdfft?md5=503b28a1d46468b83036d3c4961eb5b4&pid=1-s2.0-S2468912224000531-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141843090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral/enteral fluid resuscitation in the initial management of major burns: A systematic review and meta-analysis of human and animal studies","authors":"Kai Hsun Hsiao ,&nbsp;Joseph Kalanzi ,&nbsp;Stuart B. Watson ,&nbsp;Srinivas Murthy ,&nbsp;Ani Movsisyan ,&nbsp;Kavita Kothari ,&nbsp;Flavio Salio ,&nbsp;Pryanka Relan","doi":"10.1016/j.burnso.2024.100364","DOIUrl":"10.1016/j.burnso.2024.100364","url":null,"abstract":"<div><h3>Background</h3><p>Timely and safe intravenous (IV) fluid resuscitation for major burns may be difficult or impossible during mass casualty burn incidents. Oral/enteral fluid resuscitation may be an alternative.</p></div><div><h3>Objectives</h3><p>To synthesize and assess certainty of evidence on oral/enteral fluid resuscitation as compared to IV or no fluid resuscitation for major burns.</p></div><div><h3>Methods</h3><p>PubMed, EMBASE, CINAHL, and Cochrane Library were searched on 8 September 2023. Primary quantitative studies meeting criteria as assessed by two reviewers were included. Meta-analyses for outcome effects of oral/enteral versus IV and of oral/enteral versus no fluid resuscitation were conducted. Evidence certainty was assessed using GRADE.</p></div><div><h3>Results</h3><p>Seven human and eight animal studies were included. Three human RCTs totalling 100 participants contributed to estimates. Compared to IV fluid resuscitation, oral/enteral fluid resuscitation is associated with a statistically insignificant increased risk of mortality (OR 1.33, 95% CI 0.33–5.36) but the evidence is very uncertain, and no difference in urine output (SMD −0.17, 95% CI −0.65–0.31) with moderate certainty of evidence. Eight controlled animal studies totalling 212 participants contributed to estimates. From these animal studies, enteral fluid resuscitation may increase mortality (OR 36.00, 95% CI 2.72–476.28), worsen creatinine levels (MD 22 mmol/L, 95% CI 15.8–28.2), and increase urine output (MD 1 ml/kg/h, 95% CI 0.55–1.45) compared to IV, but all with very low certainty of evidence. Again, from animal studies, all the evidence is very uncertain, but compared to no fluid resuscitation, enteral resuscitation is associated with a statistically insignificant reduction in mortality (OR 0.29, 95% CI 0.08–1.09), improved creatinine levels (SMD −3.48, 95% CI −4.69 to −2.28), and increased urine output (MD 0.55 ml/kg/h, 95% CI 0.38–0.72).</p></div><div><h3>Conclusions</h3><p>Current evidence comparing oral/enteral and IV fluid resuscitation for major burns is limited and uncertain. However, where IV fluid resuscitation is unavailable or delayed, oral fluid resuscitation could be considered.</p></div>","PeriodicalId":72486,"journal":{"name":"Burns open : an international open access journal for burn injuries","volume":"8 4","pages":"Article 100364"},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S246891222400052X/pdfft?md5=cb9faeea0777563e90825b3d5295256d&pid=1-s2.0-S246891222400052X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141849379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}