{"title":"Thiol/Disulfide Homeostasis in Pericardial Fluid and Plasma of Patients Undergoing Coronary Artery Bypass Surgery.","authors":"Reşat Dikme, Abdullah Taşkin","doi":"10.21470/1678-9741-2022-0367","DOIUrl":"10.21470/1678-9741-2022-0367","url":null,"abstract":"<p><strong>Introduction: </strong>On-pump coronary artery bypass grafting (CABG) method affect almost allbiochemicalreactions by disrupting the patient's redox homeostasis. Detection of systemic redox hemostasis in the patient is critical for the CABG method's success and the prognosis of the disease. In this study, thiol/disulfide parameters, which are indicators of redox homeostasis, and ischemia-modified albumin levels in the plasma and pericardial fluid of patients who underwent CABG were investigated.</p><p><strong>Methods: </strong>Sixty patients who underwent an on-pump CABG operation with the cardiopulmonary bypass method were included in this study. Blood samples were taken from the patients before and after cardiopulmonary bypass. Pericardia fluid samples were taken before cardiopulmonary bypass. Then, thiol/disulfide homeostasis, albumin, and ischemia-modified albumin levels in the pericardial fluid and the patients' plasma levels were compared.</p><p><strong>Results: </strong>Albumin and ischemia-modified albumin levels were significantly higher in the postoperative period compared to the preoperative one (P<0.001). Thiol/disulfide parameters were higher and statistically significant in preoperative than in postoperative examinations (P<0.001). A negative correlation was found between pericardial fluid ischemia-modified albumin and thiol-disulfide parameters (P<0.001).</p><p><strong>Conclusion: </strong>Changes in thiol/disulfide homeostasis, albumin, and ischemia-modified albumin levels at different times during the on-pump CABG may be caused by foreign non-endothelial surfaces, filters, the reperfusion process, and pharmacological effects in the extracorporeal circulation. Thiol/disulfide homeostasis, albumin, and ischemia-modified albumin levels should be monitored during the on-pump CABG and should be intervened with appropriate therapeutic strategies. In this way, secondary pathologies can be avoided by preventing cellular damage and excessive inflammatory responses.</p>","PeriodicalId":72457,"journal":{"name":"Brazilian journal of cardiovascular surgery","volume":"40 1","pages":"e20220367"},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gregory Fishberger, Blake Bulard, Leonardo Paim N da Costa, Lucian Lozonschi
{"title":"Robotic-Assisted Minimally Invasive Direct Coronary Artery Bypass Grafting with Concomitant Left Atrial Appendage Exclusion.","authors":"Gregory Fishberger, Blake Bulard, Leonardo Paim N da Costa, Lucian Lozonschi","doi":"10.21470/1678-9741-2024-0198","DOIUrl":"10.21470/1678-9741-2024-0198","url":null,"abstract":"<p><p>Off-pump robotic-assisted minimally invasive direct coronary artery bypass (MIDCAB) achieves revascularization without conventional sternotomy and provides benefit to patients that otherwise may not be ideal surgical candidates. For patients with comorbid atrial fibrillation, left atrial appendage exclusion may reduce stroke risk and is achievable via mini thoracotomy during concomitant MIDCAB. Here, we report four patients who underwent off-pump robotic-assisted MIDCAB and concurrent epicardial left atrial appendage exclusion. Intraoperative transesophageal echocardiography confirmed complete left atrial appendage exclusion in all cases. The concomitant robotic approach proved to be feasible, efficacious, and safe, with no postoperative mortality or stroke events during follow-up.</p>","PeriodicalId":72457,"journal":{"name":"Brazilian journal of cardiovascular surgery","volume":"40 3","pages":"e20240198"},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Saimir Kuci, Ermal Likaj, Alfred Ibrahimi, Marsela Goga, Romina Teliti, Jacob Zeitani
{"title":"Reentry to the Mediastinum When the Ascending Aorta Is Adherent to the Sternum: A Two-Stage Sternotomy Approach.","authors":"Saimir Kuci, Ermal Likaj, Alfred Ibrahimi, Marsela Goga, Romina Teliti, Jacob Zeitani","doi":"10.21470/1678-9741-2023-0310","DOIUrl":"10.21470/1678-9741-2023-0310","url":null,"abstract":"<p><p>Reentry to the mediastinum when the ascending aorta aneurysm is adherent to the sternum is characterized by high risk of aneurysm rupture during sternum opening. In such cases, often cardiopulmonary bypass via peripheral vessels is instituted, and reentry done in deep hypothermia and circulatory arrest. To reduce both risks of aneurysm rupture during resternotomy and those related to prolonged cardiopulmonary bypass time, we present a surgical approach consisting of a two-stage sternotomy to avoid the risky zone and extra-anatomic epiaortic vessels anastomoses.</p>","PeriodicalId":72457,"journal":{"name":"Brazilian journal of cardiovascular surgery","volume":"40 3","pages":"e20230310"},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11873817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maksim O Zhulkov, Dmitry A Sirota, Ilya S Zykov, Olga V Poveshchenko, Maria A Surovtseva, Irina A Kim, Andrey V Protopopov, Azat K Sabetov, Khava A Agaeva, Alexandr G Makaev, Aleksandr P Nadeev, Vladislav E Kliver, Evgeniy E Kliver, Alexander M Volkov, Natalya A Karmadonova, Yaroslav M Smirnov, Alexey D Limanskiy, Aleksandra R Tarkova, Aleksandr M Chernyavskiy
{"title":"Ex vivo Coronary Angiography: Safety of Iopromide in Cold Preservation of Pig Hearts.","authors":"Maksim O Zhulkov, Dmitry A Sirota, Ilya S Zykov, Olga V Poveshchenko, Maria A Surovtseva, Irina A Kim, Andrey V Protopopov, Azat K Sabetov, Khava A Agaeva, Alexandr G Makaev, Aleksandr P Nadeev, Vladislav E Kliver, Evgeniy E Kliver, Alexander M Volkov, Natalya A Karmadonova, Yaroslav M Smirnov, Alexey D Limanskiy, Aleksandra R Tarkova, Aleksandr M Chernyavskiy","doi":"10.21470/1678-9741-2024-0080","DOIUrl":"10.21470/1678-9741-2024-0080","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effects of intracoronary iopromide (Ultravist®, Germany) administration on the recovery of cardiac pump function and cardiomyocytes metabolism during ex vivo cold preservation of pig hearts in the early posttransplant period.</p><p><strong>Methods: </strong>Three-month-old mini pigs weighing 73 ± 2.8 kg were used as experimental models (n=12). Physiological parameters were obtained with the IntelliVue MP70 system (Philips, Netherlands). Blood samples were taken from the coronary sinus to evaluate myocardial ischemia markers - troponin I, creatine phosphokinase-MB, lactate dehydrogenase, and lactate - and apex biopsy was performed before and after the ischemia period according to the protocol. Myocardial samples were taken from the left ventricle and prepared according to the protocol either.</p><p><strong>Results: </strong>Twelve orthotopic heart transplantations were performed during the study. Sample size was divided into two groups with six each. Cardiac output was 5.11 (4.99; 5.41) l/min and 5.77 (4.97; 6.62) l/min (P-0.0009) after 120 minutes of cardiac activity in both groups. Change of lactate dehydrogenase, creatine phosphokinase-MB, and troponin I levels in the coronary sinus blood were significantly higher in the early reperfusion period. However, there were no statistically significant differences between the groups (P>0.05). Myocardial oxygen consumption was considerably reduced during reperfusion but returned to baseline by 60 minutes of postischemia without significant differences between groups (P>0.05).</p><p><strong>Conclusion: </strong>We observed that intracoronary iopromide administration was safe during the ex vivo stage cold preservation phase of the study. Intracoronary iopromide administration did not affect cardiac pump function and cardiomyocytes metabolism in the early posttransplant period.</p>","PeriodicalId":72457,"journal":{"name":"Brazilian journal of cardiovascular surgery","volume":"40 2","pages":"e20240080"},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11848746/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"One-stage Surgery for Intracardiac Leiomyomatosis.","authors":"Xin Luo, Xin Wen, Yiyuan Li, Jichun Zhao, Xiyang Chen, Qiang Guo, Bin Huang","doi":"10.21470/1678-9741-2023-0291","DOIUrl":"10.21470/1678-9741-2023-0291","url":null,"abstract":"<p><strong>Introduction: </strong>Intracardiac leiomyomatosis is a rare, histologically benign, but biologically aggressive tumor developed from uterus. This study aimed to summarize our experience with one-stage surgery for intracardiac leiomyomatosis.</p><p><strong>Methods: </strong>We retrospectively reviewed seven patients who underwent surgical treatment for intracardiac leiomyomatosis between May 2016 and November 2021.</p><p><strong>Results: </strong>All seven patients were female, aged 35 to 57 years. All lesions in the veins and cardiac chambers were removed entirely. Four of the seven patients received tumor thrombectomy through an abdominal approach. The other three patients received median sternotomy and cardiopulmonary bypass. No perioperative deaths or serious complications occurred during the observation period. The mean operation time in the abdominal approach group was shorter than that in the cardiopulmonary bypass group (308.9 ± 93.2 minutes vs. 486.3 ± 108.6 minutes; P=0.031). Blood loss during surgery in the abdominal approach group was less than that in the cardiopulmonary bypass group (1625 ± 216 mL vs. 2500 ± 1080 mL; P=0.148). All seven patients were free from tumor recurrence or death during the follow-up.</p><p><strong>Conclusion: </strong>For patients with intracardiac intravenous leiomyomatosis single-stage operation through an abdominal approach under the surveillance of intraoperative transesophageal echocardiography without the need for cardiopulmonary bypass for specified patients is feasible. Patients in the abdominal approach group can benefit from a shorter operation time and less blood loss. In our small series of varied presentations and tumor extent, we have been able to avoid two-stage surgery, because even short-term interval between the two operations may result in recurrence.</p>","PeriodicalId":72457,"journal":{"name":"Brazilian journal of cardiovascular surgery","volume":"40 2","pages":"e20230291"},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11848747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kyriakos Spiliopoulos, Dimitrios Magouliotis, Thanos Athanasiou, John Skoularigis, Andrew V Xanthopoulos
{"title":"Trends, Implications, and Outcomes in the Changing Landscape of Cardiac Surgery: Transcatheter Aortic Valve Implantation in Patients with Severe Aortic Stenosis and Concomitant Coronary Artery Disease.","authors":"Kyriakos Spiliopoulos, Dimitrios Magouliotis, Thanos Athanasiou, John Skoularigis, Andrew V Xanthopoulos","doi":"10.21470/1678-9741-2024-0050","DOIUrl":"10.21470/1678-9741-2024-0050","url":null,"abstract":"","PeriodicalId":72457,"journal":{"name":"Brazilian journal of cardiovascular surgery","volume":"40 2","pages":"e20240050"},"PeriodicalIF":0.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11831808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vasily I Kaleda, Mikhail A Snegirev, Vidadi U Efendiev, Aleksander V Piskun, Igor A Batukov, Kamo E Nazaryan, Oleg Y Pidanov
{"title":"Concomitant Box Lesion Ablation for Atrial Fibrillation with a Standard Non-Irrigated Bipolar Radiofrequency Clamp: Simplified Approach Without Left Atriotomy.","authors":"Vasily I Kaleda, Mikhail A Snegirev, Vidadi U Efendiev, Aleksander V Piskun, Igor A Batukov, Kamo E Nazaryan, Oleg Y Pidanov","doi":"10.21470/1678-9741-2023-0432","DOIUrl":"10.21470/1678-9741-2023-0432","url":null,"abstract":"<p><p>In this paper, the authors describe a simplified technique for concomitant left atrial posterior box isolation for atrial fibrillation using a standard non-irrigated bipolar radiofrequency clamp without opening the left atrium.</p>","PeriodicalId":72457,"journal":{"name":"Brazilian journal of cardiovascular surgery","volume":"40 2","pages":"e20230432"},"PeriodicalIF":0.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11831807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Occurrence of Acute Aortic Dissection Twice During the Same Pregnancy.","authors":"Qiulin Ran, Bin You","doi":"10.21470/1678-9741-2023-0401","DOIUrl":"10.21470/1678-9741-2023-0401","url":null,"abstract":"<p><p>Pregnancy-related aortic dissection is an uncommon and serious condition since it poses a risk to the lives of both the mother and the fetus. Here, we describe a pregnant woman who suffered from aortic dissection twice during the same pregnancy and whose fetus was safely delivered following aortic root replacement and thoracic aortic stent-graft implantation.</p>","PeriodicalId":72457,"journal":{"name":"Brazilian journal of cardiovascular surgery","volume":"40 2","pages":"e20230401"},"PeriodicalIF":0.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11831696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}