Karen A. Lawrence , Elana M. Gloger , Cristina N. Pinheiro , Frederick A. Schmitt , Suzanne C. Segerstrom
{"title":"Associations between IL-1β, IL-6, and TNFα polymorphisms and longitudinal trajectories of cognitive function in non-demented older adults","authors":"Karen A. Lawrence , Elana M. Gloger , Cristina N. Pinheiro , Frederick A. Schmitt , Suzanne C. Segerstrom","doi":"10.1016/j.bbih.2024.100816","DOIUrl":"https://doi.org/10.1016/j.bbih.2024.100816","url":null,"abstract":"<div><p>Inflammation is implicated in Alzheimer's disease (AD), and specific single nucleotide polymorphisms (SNPs) in inflammatory cytokine genes are associated with increased AD risk. Whether the same polymorphisms also predict domain-specific cognitive change in cognitively healthy older adults is unclear. Specific SNPs in three cytokine genes, IL-1β (rs16944), IL-6 (rs1800795), and TNFα (rs1800629) were assessed for association with longitudinal trajectories spanning up to 16 years of global cognitive function, episodic memory, attention and working memory, and executive function in a sample of 324 non-demented older adults. Only rs1800629 (TNFα) was associated with significant change in global cognitive function over time [γ = 5.22; 95% CI: 0.61, 9.83; p = 0.027]. Despite an association with AD risk, rs16944 and rs1800795 may not predict cognitive decline in cognitively healthy older adults. The presence of an A at rs1800629 (TNFα) may have broad, protective effects on cognitive function, over time. More validation studies are needed to determine whether specific cytokine SNPs are associated with respective serum levels to further understanding of AD biomarkers that may also serve as markers of cognitive decline.</p></div>","PeriodicalId":72454,"journal":{"name":"Brain, behavior, & immunity - health","volume":"39 ","pages":"Article 100816"},"PeriodicalIF":3.7,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666354624000942/pdfft?md5=27d368287a563f3eb1b32e49154d7aa3&pid=1-s2.0-S2666354624000942-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141542482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Estimating survival in data-driven phenotypes of mental health symptoms and peripheral biomarkers: A prospective study","authors":"Santiago Allende , Peter J. Bayley","doi":"10.1016/j.bbih.2024.100815","DOIUrl":"https://doi.org/10.1016/j.bbih.2024.100815","url":null,"abstract":"<div><h3>Background</h3><p>Chronic psychological stress has widespread implications, including heightened mortality risk, mental and physical health conditions, and socioeconomic consequences. Stratified precision psychiatry shows promise in mitigating these effects by leveraging clinical heterogeneity to personalize interventions. However, little attention has been given to patient self-report.</p></div><div><h3>Methods</h3><p>We addressed this by combining stress-related self-report measures with peripheral biomarkers in a latent profile analysis and survival model. The latent profile models were estimated in a representative U.S. cohort (<em>n</em> = 1255; mean age = 57 years; 57% female) and cross-validated in Tokyo, Japan (<em>n</em> = 377; mean age = 55 years; 56% female).</p></div><div><h3>Results</h3><p>We identified three distinct groups: “Good Mental Health”, “Poor Mental Health”, and “High Inflammation”. Compared to the “Good Mental Health” group, the “High Inflammation” and “Poor Mental Health” groups had an increased risk of mortality, but did not differ in mortality risk from each other.</p></div><div><h3>Conclusions</h3><p>This study emphasizes the role of patient self-report in stratified psychiatry.</p></div>","PeriodicalId":72454,"journal":{"name":"Brain, behavior, & immunity - health","volume":"39 ","pages":"Article 100815"},"PeriodicalIF":3.7,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666354624000930/pdfft?md5=9df732907839560a6a4f7fda07b095b4&pid=1-s2.0-S2666354624000930-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141478983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Svetlina Vasileva , Chloe X. Yap , Andrew J.O. Whitehouse , Jacob Gratten , Darryl Eyles
{"title":"Absence of association between maternal adverse events and long-term gut microbiome outcomes in the Australian autism biobank","authors":"Svetlina Vasileva , Chloe X. Yap , Andrew J.O. Whitehouse , Jacob Gratten , Darryl Eyles","doi":"10.1016/j.bbih.2024.100814","DOIUrl":"https://doi.org/10.1016/j.bbih.2024.100814","url":null,"abstract":"<div><h3>Introduction</h3><p>Maternal immune activation (MIA) and prenatal maternal stress (MatS) are well-studied risk factors for psychiatric conditions such as autism and schizophrenia. Animal studies have proposed the gut microbiome as a mechanism underlying this association and have found that risk factor-related gut microbiome alterations persist in the adult offspring. In this cross-sectional study, we assessed whether maternal immune activation and prenatal maternal stress were associated with long-term gut microbiome alterations in children using shotgun metagenomics.</p></div><div><h3>Methods</h3><p>This cross-sectional study included children diagnosed with autism (N = 92), siblings without a diagnosis (N = 42), and unrelated children (N = 40) without a diagnosis who were recruited into the Australian Autism Biobank and provided a faecal sample. MIA exposure was inferred from self-reported data and included asthma/allergies, complications during pregnancy triggering an immune response, auto-immune conditions, and acute inflammation. Maternal stress included any of up to 9 stressful life events during pregnancy, such as divorce, job loss, and money problems. Data were analysed for a total of 174 children, of whom 63 (36%) were born to mothers with MIA and 84 (48%) were born to mothers who experienced maternal stress during pregnancy (where 33 [19%] experienced both). Gut microbiome data was assessed using shotgun metagenomic sequencing of the children's faecal samples.</p></div><div><h3>Results</h3><p>In our cohort, MIA, but not MatS, was associated with ASD. Variance component analysis revealed no associations between any of the gut microbiome datasets and neither MIA nor MatS. After adjusting for age, sex, diet and autism diagnosis, there was no significant difference between groups for bacterial richness, α-diversity or β-diversity. We found no significant differences in species abundance in the main analyses. However, when stratifying the cohort by age, we found that <em>Faecalibacterium prausnitzii E</em> was significantly decreased in MIA children aged 11–17.</p></div><div><h3>Discussion</h3><p>Consistent with previous findings, we found that children who were born to mothers with MIA were more likely to be diagnosed with autism. Unlike within animal studies, we found negligible microbiome differences associated with MIA and maternal stress. Given the current interest in the microbiome-gut-brain axis, researchers should exercise caution in translating microbiome findings from animal models to human contexts and the clinical setting.</p></div>","PeriodicalId":72454,"journal":{"name":"Brain, behavior, & immunity - health","volume":"39 ","pages":"Article 100814"},"PeriodicalIF":3.7,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666354624000929/pdfft?md5=f43b5b24af886c8ab55397d3170a9df9&pid=1-s2.0-S2666354624000929-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141478982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Majid Zaki-Dizaji , Mohammad Foad Abazari , Hossein Razzaghi , Irene Shkolnikov , Brian R. Christie
{"title":"GRM7 deficiency, from excitotoxicity and neuroinflammation to neurodegeneration: Systematic review of GRM7 deficient patients","authors":"Majid Zaki-Dizaji , Mohammad Foad Abazari , Hossein Razzaghi , Irene Shkolnikov , Brian R. Christie","doi":"10.1016/j.bbih.2024.100808","DOIUrl":"https://doi.org/10.1016/j.bbih.2024.100808","url":null,"abstract":"<div><p>The metabotropic glutamate receptor 7 (mGluR7) is a presynaptic G-protein-coupled glutamate receptor that modulates neurotransmitter release and synaptic plasticity at presynaptic terminals. It is encoded by GRM7, and recently variants have been identified in patients with autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), developmental delay (DD), intellectual disability (ID), and brain malformations. To gain updated insights into the function of GRM7 and the phenotypic spectrum of genetic variations within this gene, we conducted a systematic review of relevant literature utilizing PubMed, Web of Science, and Scopus databases. Among the 14 articles meeting the inclusion criteria, a total of 42 patients (from 28 families) harboring confirmed mutations in the <em>GRM7</em> gene have been documented. Specifically, there were 17 patients with heterozygous mutations, 20 patients with homozygous mutations, and 5 patients with compound heterozygous mutations. Common clinical features included intellectual behavioral disability, seizure/epilepsy, microcephaly, developmental delay, peripheral hypertonia and hypomyelination. Genotype-phenotype correlation was not clear and each variant had unique characteristics including gene dosage, mutant protein surface expression, and degradation pathway that result with a spectrum of phenotype manifestations through ASD or ADHD to severe DD/ID with brain malformations. Neuroinflammation may play a role in the development and/or progression of GRM7-related neurodegeneration along with excitotoxicity. The clinical and functional data presented here demonstrate that both autosomal dominant and recessive inheritance of GRM7 mutation can cause disease spectrum phenotypes through ASD or ADHD to severe DD/ID and seizure with brain malformations.</p></div>","PeriodicalId":72454,"journal":{"name":"Brain, behavior, & immunity - health","volume":"39 ","pages":"Article 100808"},"PeriodicalIF":3.7,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666354624000863/pdfft?md5=be8035c61f8bfb4d16933d8fc5b3e29b&pid=1-s2.0-S2666354624000863-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141435201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fernanda G.Q. Barros-Aragão , Talita P. Pinto , Victor C. Carregari , Nathane B.S. Rezende , Thaís L. Pinheiro , Guilherme Reis-de-Oliveira , Mauro J. Cabral-Castro , Daniel C. Queiroz , Paula L.C. Fonseca , Alessandro L. Gonçalves , Gabriel R. de Freitas , Felipe K. Sudo , Paulo Mattos , Fernando A. Bozza , Erika C. Rodrigues , Renato S. Aguiar , Rosana S. Rodrigues , Carlos O. Brandão , Andrea S. Souza , Daniel Martins-de-Souza , Fernanda Tovar-Moll
{"title":"Changes in neuroinflammatory biomarkers correlate with disease severity and neuroimaging alterations in patients with COVID-19 neurological complications","authors":"Fernanda G.Q. Barros-Aragão , Talita P. Pinto , Victor C. Carregari , Nathane B.S. Rezende , Thaís L. Pinheiro , Guilherme Reis-de-Oliveira , Mauro J. Cabral-Castro , Daniel C. Queiroz , Paula L.C. Fonseca , Alessandro L. Gonçalves , Gabriel R. de Freitas , Felipe K. Sudo , Paulo Mattos , Fernando A. Bozza , Erika C. Rodrigues , Renato S. Aguiar , Rosana S. Rodrigues , Carlos O. Brandão , Andrea S. Souza , Daniel Martins-de-Souza , Fernanda Tovar-Moll","doi":"10.1016/j.bbih.2024.100805","DOIUrl":"10.1016/j.bbih.2024.100805","url":null,"abstract":"<div><p>COVID-19 induces acute and persistent neurological symptoms in mild and severe cases. Proposed concomitant mechanisms include direct viral infection and strain, coagulopathy, hypoxia, and neuroinflammation. However, underlying molecular alterations associated with multiple neurological outcomes in both mild and severe cases are majorly unexplored. To illuminate possible mechanisms leading to COVID-19 neurological disease, we retrospectively investigated in detail a cohort of 35 COVID-19 mild and severe hospitalized patients presenting neurological alterations subject to clinically indicated cerebrospinal fluid (CSF) sampling. Clinical and neurological investigation, brain imaging, viral sequencing, and cerebrospinal CSF analyses were carried out. We found that COVID-19 patients presented heterogeneous neurological symptoms dissociated from lung burden. Nasal swab viral sequencing revealed a dominant strain at the time of the study, and we could not detect traces of SARS-CoV-2's spike protein in patients' CSF by multiple reaction monitoring analysis. Patients presented ubiquitous systemic hyper-inflammation and broad alterations in CSF proteomics related to inflammation, innate immunity, and hemostasis, irrespective of COVID-19 severity or neuroimaging alterations. Elevated CSF interleukin-6 (IL6) correlated with disease severity (sex-, age-, and comorbidity-adjusted mean Severe 24.5 pg/ml, 95% confidence interval (CI) 9.62–62.23 vs. Mild 3.91 pg/mL CI 1.5–10.3 patients, p = 0.019). CSF tumor necrosis factor-alpha (TNFα) and IL6 levels were higher in patients presenting pronounced neuroimaging alterations compared to those who did not (sex-, age-, and comorbidity-adjusted mean TNFα Pronounced 3.4, CI 2.4–4.4 vs. Non-Pronounced 2.0, CI 1.4–2.5, p = 0.022; IL6 Pronounced 33.11, CI 8.89–123.31 vs Non-Pronounced 6.22, CI 2.9–13.34, p = 0.046). Collectively, our findings put neuroinflammation as a possible driver of COVID-19 acute neurological disease in mild and severe cases.</p></div>","PeriodicalId":72454,"journal":{"name":"Brain, behavior, & immunity - health","volume":"39 ","pages":"Article 100805"},"PeriodicalIF":3.7,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666354624000838/pdfft?md5=6f74e24526870f18a56f81152f67da55&pid=1-s2.0-S2666354624000838-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141399820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ugne Simanaviciute , Harry G. Potter , Reinmar Hager , Jocelyn Glazier , Emma Hodson-Tole , John Gigg , Robyn Grant
{"title":"Maternal immune activation affects female offspring whisker movements during object exploration in a rat model of neurodevelopmental disorders","authors":"Ugne Simanaviciute , Harry G. Potter , Reinmar Hager , Jocelyn Glazier , Emma Hodson-Tole , John Gigg , Robyn Grant","doi":"10.1016/j.bbih.2024.100807","DOIUrl":"https://doi.org/10.1016/j.bbih.2024.100807","url":null,"abstract":"<div><p>Poly I:C rat offspring are used to investigate the effects of <em>in utero</em> exposure to maternal immune activation (MIA) and have been suggested as a model of neurodevelopmental disorders (NDD). The behavioural symptoms of this model are diverse and can vary with external factors, including the choice of background strain and husbandry practices. Measuring whisker movements provides quantitative, robust measurements of sensory, motor and cognitive behaviours in rodents. In this study, whisker movements were investigated in 50-day-old male and female offspring of MIA-exposed rat dams and compared to age-matched offspring of control (vehicle) dams. Rat offspring were filmed using high-speed videography in a sequential object exploration task with smooth and textured objects. Poly I:C treatment effects were found in female offspring that did not increase whisker mean angular position during object exploration, especially for the smooth object, indicating an attentional deficit. Whisker tracking during object exploration is demonstrated here, for the first time, as a useful, quick and non-invasive tool to identify both treatment effects and sex differences in a model of MIA-induced NDDs.</p></div>","PeriodicalId":72454,"journal":{"name":"Brain, behavior, & immunity - health","volume":"39 ","pages":"Article 100807"},"PeriodicalIF":0.0,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666354624000851/pdfft?md5=b46e9cf5a8ccfa41ba26c94d5a22e9cb&pid=1-s2.0-S2666354624000851-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141325960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Complement C4, C4A and C4a – What they do and how they differ","authors":"Meike Heurich , Melanie Föcking , David Cotter","doi":"10.1016/j.bbih.2024.100809","DOIUrl":"https://doi.org/10.1016/j.bbih.2024.100809","url":null,"abstract":"","PeriodicalId":72454,"journal":{"name":"Brain, behavior, & immunity - health","volume":"39 ","pages":"Article 100809"},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666354624000875/pdfft?md5=44757fb17c4cd668160d6f5f87d46955&pid=1-s2.0-S2666354624000875-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141325962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"In order to reliably assess nurses’ optimism, resilience and experience during the pandemic, all influencing factors must be taken into account","authors":"Josef Finsterer","doi":"10.1016/j.bbih.2024.100810","DOIUrl":"https://doi.org/10.1016/j.bbih.2024.100810","url":null,"abstract":"","PeriodicalId":72454,"journal":{"name":"Brain, behavior, & immunity - health","volume":"39 ","pages":"Article 100810"},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666354624000887/pdfft?md5=a9bcccc43fd4c0f96877b2fb6aa679a3&pid=1-s2.0-S2666354624000887-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141325958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luis Mercado , Shannon Rose , Diana Escalona-Vargas , Nafisa Dajani , Eric R. Siegel , Hubert Preissl , Hari Eswaran
{"title":"Correlating maternal and cord-blood inflammatory markers and BDNF with human fetal brain activity recorded by magnetoencephalography: An exploratory study","authors":"Luis Mercado , Shannon Rose , Diana Escalona-Vargas , Nafisa Dajani , Eric R. Siegel , Hubert Preissl , Hari Eswaran","doi":"10.1016/j.bbih.2024.100804","DOIUrl":"https://doi.org/10.1016/j.bbih.2024.100804","url":null,"abstract":"<div><h3>Background</h3><p>During gestation, the brain development of the fetus is affected by many biological markers, where inflammatory processes and neurotrophic factors have been of particular interest in the past decade.</p></div><div><h3>Aim</h3><p>This exploratory study is the first attempt to explore the relationships between biomarker levels in maternal and cord-blood samples and human fetal brain activity measured with non-invasive fetal magnetoencephalography (fMEG).</p></div><div><h3>Method</h3><p>Twenty-three women were enrolled in this study for collection of maternal serum and fMEG tracings immediately prior to their scheduled cesarean delivery. Twelve of these women had a preexisting diabetic condition. At the time of delivery, umbilical cord blood was also collected. Biomarker levels from both maternal and cord blood were measured and subsequently analyzed for correlations with fetal brain activity in four frequency bands extracted from fMEG power spectral densities.</p></div><div><h3>Results</h3><p>Relative power in the delta, alpha, and beta frequency bands exhibited moderate-sized correlations with maternal BDNF and cord-blood CRP levels before and after adjusting for confounding diabetic status. These correlations were negative for the delta band, and positive for the alpha and beta bands. Maternal CRP and cord-blood BDNF and IL-6 exhibited negligible correlations with relative power in all four bands. Diabetes did not appear to be a strong confounding factor affecting the studied biomarkers.</p></div><div><h3>Conclusions</h3><p>Maternal BDNF levels and cord-blood CRP levels appear to have a direct correlation to fetal brain activity. Our findings indicate the potential use of these biomarkers in conjunction with fetal brain electrophysiology to track fetal neurodevelopment.</p></div>","PeriodicalId":72454,"journal":{"name":"Brain, behavior, & immunity - health","volume":"39 ","pages":"Article 100804"},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666354624000826/pdfft?md5=aed15a337383ad42ecc4ecbc07d48486&pid=1-s2.0-S2666354624000826-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141328402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Johannes Keck , Celine Honekamp , Kristina Gebhardt , Svenja Nolte , Marcel Linka , Benjamin de Haas , Jörn Munzert , Karsten Krüger , Britta Krüger
{"title":"Exercise-induced inflammation alters the perception and visual exploration of emotional interactions","authors":"Johannes Keck , Celine Honekamp , Kristina Gebhardt , Svenja Nolte , Marcel Linka , Benjamin de Haas , Jörn Munzert , Karsten Krüger , Britta Krüger","doi":"10.1016/j.bbih.2024.100806","DOIUrl":"https://doi.org/10.1016/j.bbih.2024.100806","url":null,"abstract":"<div><h3>Introduction</h3><p>The study aimed to investigate whether an exercise-induced pro-inflammatory response alters the perception as well as visual exploration of emotional body language in social interactions.</p></div><div><h3>Methods</h3><p>In a within-subject design, 19 male, healthy adults aged between 19 and 33 years performed a downhill run for 45 min at 70% of their VO<sub>2max</sub> on a treadmill to induce maximal myokine blood elevations, leading to a pro-inflammatory status. Two control conditions were selected: a control run with no decline and a rest condition without physical exercise. Blood samples were taken before (T0), directly after (T1), 3 h after (T3), and 24 h after (T24) each exercise for analyzing the inflammatory response. 3 h after exercise, participants observed point-light displays (PLDs) of human interactions portraying four emotions (happiness, affection, sadness, and anger). Participants categorized the emotional content, assessed the emotional intensity of the stimuli, and indicated their confidence in their ratings. Eye movements during the entire paradigm and self-reported current mood were also recorded.</p></div><div><h3>Results</h3><p>The downhill exercise condition resulted in significant elevations of measured cytokines (IL6, CRP, MCP-1) and markers for muscle damage (Myoglobin) compared to the control running condition, indicating a pro-inflammatory state after the downhill run. Emotion recognition rates decreased significantly after the downhill run, whereas no such effect was observed after control running. Participants' sensitivity to emotion-specific cues also declined. However, the downhill run had no effect on the perceived emotional intensity or the subjective confidence in the given ratings. Visual scanning behavior was affected after the downhill run, with participants fixating more on sad stimuli, in contrast to the control conditions, where participants exhibited more fixations while observing happy stimuli.</p></div><div><h3>Conclusion</h3><p>Our study demonstrates that inflammation, induced through a downhill running model, impairs perception and emotional recognition abilities. Specifically, inflammation leads to decreased recognition rates of emotional content of social interactions, attributable to diminished discrimination capabilities across all emotional categories. Additionally, we observed alterations in visual exploration behavior. This confirms that inflammation significantly affects an individual's responsiveness to social and affective stimuli.</p></div>","PeriodicalId":72454,"journal":{"name":"Brain, behavior, & immunity - health","volume":"39 ","pages":"Article 100806"},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266635462400084X/pdfft?md5=f3b83a935665ad956f6bd4cb208e1a54&pid=1-s2.0-S266635462400084X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141325961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}