Brain & NeuroRehabilitation最新文献

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Erratum: Role of Intensive Inpatient Rehabilitation for Prevention of Disability after Stroke: The Korean Stroke Cohort for Functioning and Rehabilitation (KOSCO) Study. 强化住院康复对预防中风后残疾的作用:韩国卒中功能和康复队列(KOSCO)研究。
Brain & NeuroRehabilitation Pub Date : 2022-07-01 DOI: 10.12786/bn.2022.15.e22
Won Hyuk Chang, Min Kyun Sohn, Jongmin Lee, Deog Young Kim, Sam-Gyu Lee, Yong-Il Shin, Gyung-Jae Oh, Yang-Soo Lee, Min Cheol Joo, Eun Young Han, Junhee Han, Yun-Hee Kim
{"title":"Erratum: Role of Intensive Inpatient Rehabilitation for Prevention of Disability after Stroke: The Korean Stroke Cohort for Functioning and Rehabilitation (KOSCO) Study.","authors":"Won Hyuk Chang,&nbsp;Min Kyun Sohn,&nbsp;Jongmin Lee,&nbsp;Deog Young Kim,&nbsp;Sam-Gyu Lee,&nbsp;Yong-Il Shin,&nbsp;Gyung-Jae Oh,&nbsp;Yang-Soo Lee,&nbsp;Min Cheol Joo,&nbsp;Eun Young Han,&nbsp;Junhee Han,&nbsp;Yun-Hee Kim","doi":"10.12786/bn.2022.15.e22","DOIUrl":"https://doi.org/10.12786/bn.2022.15.e22","url":null,"abstract":"<p><p>[This corrects the article e4 in vol. 9.].</p>","PeriodicalId":72442,"journal":{"name":"Brain & NeuroRehabilitation","volume":"15 2","pages":"e22"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cb/1d/bn-15-e22.PMC9833474.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10654085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of Unilateral and Bilateral Parietal Transcranial Direct Current Stimulation on Right Hemispheric Stroke Patients With Neglect Symptoms: A Proof-of-Principle Study. 单侧和双侧顶叶经颅直流电刺激对右半脑卒中忽视症状患者的疗效:一项原理证明研究。
Brain & NeuroRehabilitation Pub Date : 2022-07-01 DOI: 10.12786/bn.2022.15.e19
Anna Gorsler, Ulrike Grittner, Torsten Rackoll, Nadine Külzow
{"title":"Efficacy of Unilateral and Bilateral Parietal Transcranial Direct Current Stimulation on Right Hemispheric Stroke Patients With Neglect Symptoms: A Proof-of-Principle Study.","authors":"Anna Gorsler,&nbsp;Ulrike Grittner,&nbsp;Torsten Rackoll,&nbsp;Nadine Külzow","doi":"10.12786/bn.2022.15.e19","DOIUrl":"https://doi.org/10.12786/bn.2022.15.e19","url":null,"abstract":"<p><p>Different transcranial direct current stimulation (tDCS) protocols have been tested to improve visuospatial neglect (VSN). So far, methodological heterogenity limits reliable conclusions about optimal stimualtion set-up. With this proof-of-principle study behavioral effects of two promising (uni- vs. bilateral) stimulation protocols were directly compared to gain more data for an appropriate tDCS protocol in subacute neglect patients. Notably, each tDCS set-up was combined with an identical sham condition to improve comparability. In a double-blind sham-controlled cross-over study 11 subacute post-stroke neglect patients received 20 minutes or 30 seconds (sham) tDCS (2 mA, 0.8 A/m<sup>2</sup>) parallel to neglect therapy randomized in unilateral (anode-reference: P4-Fp2 10-20 electroencephalography [EEG] system) and bilateral manner (anode-cathode: P4-P3) and 48h wash-out in-between. Before and immediately after stimulation performance were measured in cancellation task (bell test), and line bisection (deviation error). Significant difference between active and assigned sham condition was found in line bisection but not cancellation task. Particularly, deviation error was reduced after bilateral tDCS (hedges g<sup>*</sup> = 0.6) compared to bilateral sham, no such advantage were obtained for unilateral stimulation (hedges g<sup>*</sup> = 0.2). Using a direct comparison approach findings add further evidence that stimulating both hemispheres (bilateral) is superior in alleviating VSN symptoms than unilateral stimulation in subacute neglect.</p>","PeriodicalId":72442,"journal":{"name":"Brain & NeuroRehabilitation","volume":"15 2","pages":"e19"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7a/d1/bn-15-e19.PMC9833469.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10663204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Nutrition Management in Patients With Traumatic Brain Injury: A Narrative Review. 创伤性脑损伤患者的营养管理:叙述性综述。
Brain & NeuroRehabilitation Pub Date : 2022-03-28 eCollection Date: 2022-03-01 DOI: 10.12786/bn.2022.15.e4
Hoo Young Lee, Byung-Mo Oh
{"title":"Nutrition Management in Patients With Traumatic Brain Injury: A Narrative Review.","authors":"Hoo Young Lee, Byung-Mo Oh","doi":"10.12786/bn.2022.15.e4","DOIUrl":"10.12786/bn.2022.15.e4","url":null,"abstract":"<p><p>Traumatic brain injury (TBI) is a major cause of long-term physical and psychological disability and death. In patients with TBI, undernutrition is associated with an increased mortality rate, more infectious complications, and worse neurologic outcomes. Therefore, timely and effective nutritional therapy is particularly crucial in the management of TBI to improve patients' prognoses. This narrative review summarizes the issues encountered in clinical practice for patients with neurotrauma who receive acute and post-acute in-patient rehabilitation services, and it comprehensively incorporates a wide range of studies, including recent clinical practice guidelines (CPGs), with the aim of better understanding the current evidence for optimal nutritional therapy focused on TBI patients. Recent CPGs were reviewed for 6 topics: 1) hypermetabolism and variation in energy expenditure in patients with TBI, 2) delayed gastric emptying and intolerance to enteral nutrition, 3) decision-making on the route and timing of access in patients with TBI who are unable to maintain volitional intake (enteral nutrition versus parenteral nutrition), 4) decision-making on the enteral formula (standard or immune-modulating formulas), 5) glycemic control, and 6) protein support. We also identified areas that need further research in the future.</p>","PeriodicalId":72442,"journal":{"name":"Brain & NeuroRehabilitation","volume":"15 1","pages":"e4"},"PeriodicalIF":0.0,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/91/39/bn-15-e4.PMC9833460.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10667739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Percutaneous Endoscopic Gastrostomy: Procedure, Complications and Management. 经皮内镜胃造瘘术:手术、并发症和处理。
Brain & NeuroRehabilitation Pub Date : 2022-03-28 eCollection Date: 2022-03-01 DOI: 10.12786/bn.2022.15.e2
In Hyoung Choi, Yu Kyung Cho
{"title":"Percutaneous Endoscopic Gastrostomy: Procedure, Complications and Management.","authors":"In Hyoung Choi, Yu Kyung Cho","doi":"10.12786/bn.2022.15.e2","DOIUrl":"10.12786/bn.2022.15.e2","url":null,"abstract":"<p><p>Percutaneous endoscopic gastrostomy (PEG) is considered in patients with insufficient oral intake who need enteral feeding or therapeutic gastric decompression. PEG tube feeding is generally superior to nasogastric tube feeding in terms of patients' comfort, long-term use, and feeding efficiency. Patient selection for PEG, the proper endoscopic insertion technique, early recognition of complications, and appropriate management are important for patient care. During preparation, adequate management of anticoagulation and antithrombotic agents are important to prevent bleeding, and prophylactic antibiotics prevent wound infection. Most complications are minor; however, major complications that require surgical correction or are life-threatening may occur, such as wound infection, bleeding, buried bumper syndrome, colocutaneous fistula, perforation, volvulus, and injuries to other organs. This review presents practical guidelines for the selection and preparation of patients, endoscopic insertion methods, and complication management strategies.</p>","PeriodicalId":72442,"journal":{"name":"Brain & NeuroRehabilitation","volume":"15 1","pages":"e2"},"PeriodicalIF":0.0,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/41/7b/bn-15-e2.PMC9833457.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10667738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nutritional Supplementation in Stroke Rehabilitation: A Narrative Review. 中风康复中的营养补充:叙述性综述。
Brain & NeuroRehabilitation Pub Date : 2022-03-25 eCollection Date: 2022-03-01 DOI: 10.12786/bn.2022.15.e3
Sung-Hwa Ko, Yong-Il Shin
{"title":"Nutritional Supplementation in Stroke Rehabilitation: A Narrative Review.","authors":"Sung-Hwa Ko, Yong-Il Shin","doi":"10.12786/bn.2022.15.e3","DOIUrl":"10.12786/bn.2022.15.e3","url":null,"abstract":"<p><p>Malnutrition is associated with increased mortality and poor functional recovery after stroke. Most guidelines for stroke rehabilitation strongly recommend nutritional screening for malnutrition. Nutritional status after stroke is related to long-term outcomes, and nutritional supplementation is recommended for stroke patients with malnutrition and those at risk of malnutrition. However, routine nutritional supplementation in stroke patients, regardless of nutritional status, is not correlated with improved functional outcomes, and nutritional supplementation is not recommended if the nutritional status is adequate. Nutritional supplementation with protein, amino acids, vitamins, and minerals positively affects recovery after stroke, with improvements seen in motor function, cognition, activities of living, and mood. However, the evidence is insufficient due to the small number of studies and the lack of well-designed randomized controlled studies. Therefore, nutritional supplementation for stroke patients in rehabilitation should not be uniform, and individual nutritional interventions based on an assessment of the patient's nutritional status should be provided.</p>","PeriodicalId":72442,"journal":{"name":"Brain & NeuroRehabilitation","volume":"15 1","pages":"e3"},"PeriodicalIF":0.0,"publicationDate":"2022-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/08/9b/bn-15-e3.PMC9833461.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10660621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Causes and Trends of Disabilities in Community-Dwelling Stroke Survivors: A Population-Based Study. 居住在社区的中风幸存者残疾的原因和趋势:基于人口的研究。
Brain & NeuroRehabilitation Pub Date : 2022-03-17 eCollection Date: 2022-03-01 DOI: 10.12786/bn.2022.15.e5
Yeon Woo Ju, Jung Soo Lee, Young-Ah Choi, Yeo Hyung Kim
{"title":"Causes and Trends of Disabilities in Community-Dwelling Stroke Survivors: A Population-Based Study.","authors":"Yeon Woo Ju, Jung Soo Lee, Young-Ah Choi, Yeo Hyung Kim","doi":"10.12786/bn.2022.15.e5","DOIUrl":"10.12786/bn.2022.15.e5","url":null,"abstract":"<p><p>Many stroke survivors live with disabilities in the community. This study aimed to investigate the causes and trends of disabilities among community-dwelling stroke survivors. A total of 1547 community-dwelling stroke survivors ≥ 19 years were identified using the Korea National Health and Nutrition Examination Survey (KNHANES) database from 2007 to 2018. We analyzed the causes and trends of disabilities in strokes survivors using complex-samples procedures. During 2007-2018, 38.0% of stroke survivors were found to have disabilities. Stroke itself was the most common cause of disabilities (21.3%). Musculoskeletal (back or neck problems, 7.0%; arthritis, 5.7%; and leg pain excluding arthritis, 2.3%), sensory (visual problems, 3.6%; and auditory problems, 1.4%), and medical problems (diabetes 2.6%; hypertension, 2.3%; heart disease, 1.5%) accounted for the rest of the other causes of disabilities. Upon analyzing the trends, we found that both the proportion of stroke survivors with disabilities and that of stroke survivors with stroke-related disabilities decreased from KNHANES IV (2007-2009) to V (2010-2012). After 2010-2012, the proportion of both groups stayed constant. The burden of disabilities in non-hospitalized stroke survivors has decreased but still remains high. Attention is warranted because many other problems than a stroke can cause disabilities in community-dwelling stroke survivors.</p>","PeriodicalId":72442,"journal":{"name":"Brain & NeuroRehabilitation","volume":"15 1","pages":"e5"},"PeriodicalIF":0.0,"publicationDate":"2022-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a2/17/bn-15-e5.PMC9833459.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10667736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transient Anarthria in a Patient With Non-Dominant Hemispheric Lesion: A Case Report. 非显性半球病变患者的一过性无音1例报告。
Brain & NeuroRehabilitation Pub Date : 2022-03-01 DOI: 10.12786/bn.2022.15.e8
Yu Jin Im, Jihong Choi, Yun-Hee Kim, Won Hyuk Chang
{"title":"Transient Anarthria in a Patient With Non-Dominant Hemispheric Lesion: A Case Report.","authors":"Yu Jin Im,&nbsp;Jihong Choi,&nbsp;Yun-Hee Kim,&nbsp;Won Hyuk Chang","doi":"10.12786/bn.2022.15.e8","DOIUrl":"https://doi.org/10.12786/bn.2022.15.e8","url":null,"abstract":"<p><p>Anarthria is a complete loss of speech. It usually results from lesions in bilateral neural substrates that control articulation. Recently, lateralized cortical control of speech articulation in the dominant hemisphere has been reported. However, anarthria by non-dominant hemispheric lesion has not been reported yet. Here we report a rare case of transient anarthria caused by right hemispheric infarction after brain surgery in a right-handed patient. This report suggests that anarthria could be caused by a lesion not related to language lateralization. This report is expected to contribute to studies on neural correlates of anarthria lesions.</p>","PeriodicalId":72442,"journal":{"name":"Brain & NeuroRehabilitation","volume":"15 1","pages":"e8"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/95/ec/bn-15-e8.PMC9833467.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10660620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship Between Ipsilesional Upper Extremity Motor Function and Corpus Callosum Integrity in Patients With Unilateral Stroke: A Diffusion Tensor Imaging Study. 单侧脑卒中患者单侧上肢运动功能与胼胝体完整性的关系:弥散张量成像研究。
Brain & NeuroRehabilitation Pub Date : 2022-03-01 DOI: 10.12786/bn.2022.15.e7
Bo Mi Kwon, Yejin Lee, Hyun Haeng Lee, Nayeon Ko, Hyuntae Kim, Bo-Ram Kim, Won-Jin Moon, Jongmin Lee
{"title":"Relationship Between Ipsilesional Upper Extremity Motor Function and Corpus Callosum Integrity in Patients With Unilateral Stroke: A Diffusion Tensor Imaging Study.","authors":"Bo Mi Kwon,&nbsp;Yejin Lee,&nbsp;Hyun Haeng Lee,&nbsp;Nayeon Ko,&nbsp;Hyuntae Kim,&nbsp;Bo-Ram Kim,&nbsp;Won-Jin Moon,&nbsp;Jongmin Lee","doi":"10.12786/bn.2022.15.e7","DOIUrl":"https://doi.org/10.12786/bn.2022.15.e7","url":null,"abstract":"<p><p>This study aims to investigate the relationship between ipsilesional upper extremity (UE) motor function and the integrity of the subregions of the corpus callosum in hemiparetic stroke patients with motor deficits of the dominant or non-dominant ipsilesional side. Twenty participants with unilateral UE deficits after stroke were included. Each of the 10 participants had lesions on the left and right sides. The ipsilesional UE function was assessed with the Jebsen-Taylor hand function test (JHFT), the 9-hole peg test (9HPT), and grip and pinch strength tests. Fractional anisotropy (FA) was calculated for the integrity of the 5 subregions of the corpus callosum. Pearson's correlation analysis was conducted to investigate the relationship between UE function and the integrity of the callosal subregions. The results of JHFT and 9HPT showed a significant correlation with the FA value of the corpus callosum I projecting to the frontal lobe in the left lesion group (p < 0.05). There was no correlation between the ipsilesional UE motor function and the FA value of the ulnar subregion in the right lesion group (p > 0.05). These results showed that the motor deficits of the ipsilesional UE correlated with the integrity of callosal fiber projection to the prefrontal area when the ipsilesional side was non-dominant.</p>","PeriodicalId":72442,"journal":{"name":"Brain & NeuroRehabilitation","volume":"15 1","pages":"e7"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3e/e6/bn-15-e7.PMC9833466.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10667740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation of Hemispatial Neglect with White Matter Tract Integrity: A DTI Study. 脑半球忽视与脑白质束完整性的相关性:一项DTI研究。
Brain & NeuroRehabilitation Pub Date : 2022-03-01 DOI: 10.12786/bn.2022.15.e6
Bo Mi Kwon, Jin-Youn Lee, Nayeon Ko, Bo-Ram Kim, Won-Jin Moon, Dong-Hee Choi, Jongmin Lee
{"title":"Correlation of Hemispatial Neglect with White Matter Tract Integrity: A DTI Study.","authors":"Bo Mi Kwon,&nbsp;Jin-Youn Lee,&nbsp;Nayeon Ko,&nbsp;Bo-Ram Kim,&nbsp;Won-Jin Moon,&nbsp;Dong-Hee Choi,&nbsp;Jongmin Lee","doi":"10.12786/bn.2022.15.e6","DOIUrl":"https://doi.org/10.12786/bn.2022.15.e6","url":null,"abstract":"<p><p>We investigated the diffusion tensor image (DTI) parameters of superior longitudinal fasciculus (SLF) and inferior fronto-occipital fasciculus (IFOF), and their relationships with hemispatial neglect. Thirteen patients with first-ever ischemic stroke who had the right hemispheric lesion were included. Neglect was assessed using the Albert test and figure discrimination test of Motor-free Visual Perception Test 3 (MVPT-3). The SLF and IFOF were separated by diffusion tensor tractography (DTT) and tract volume (TV) was calculated. We measured the fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values in the total area, seed region of interest (ROI), and target ROI, respectively. Among thirteen patients, seven demonstrated signs of hemispatial neglect on neglect test. Tractography reconstruction showed significantly low TV of the right IFOF in patients with hemispatial neglect. FA values of the right SLF and the right IFOF were significantly lower in neglect patients. ADC values were not significantly different in two groups. This study suggests that damage of SLF and IFOF is associated with hemispatial neglect in right hemispheric stroke patients. DTI may be useful for predicting the severities of hemispatial neglect using values such as TV and FA of each tract.</p>","PeriodicalId":72442,"journal":{"name":"Brain & NeuroRehabilitation","volume":"15 1","pages":"e6"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/be/c0/bn-15-e6.PMC9833463.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10667741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Multidisciplinary Rehabilitation for Relapsing Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease: A Case Report. 髓鞘少突胶质细胞糖蛋白抗体相关疾病复发的多学科康复治疗一例报告。
Brain & NeuroRehabilitation Pub Date : 2022-03-01 DOI: 10.12786/bn.2022.15.e9
Jong Mi Park, Yongwook Kim, Soojin Choi
{"title":"Multidisciplinary Rehabilitation for Relapsing Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease: A Case Report.","authors":"Jong Mi Park,&nbsp;Yongwook Kim,&nbsp;Soojin Choi","doi":"10.12786/bn.2022.15.e9","DOIUrl":"https://doi.org/10.12786/bn.2022.15.e9","url":null,"abstract":"<p><p>Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an inflammatory central nervous system disease that is driven by antibodies of the immunoglobulin G1 class. MOGAD has recently been recognized as an autoimmune disease; therefore, little is known about its rehabilitation. Here, we present a case of MOGAD that showed significant recovery after rehabilitation. A 58-year-old woman developed weakness in all extremities, dysarthria, and dysphagia. She visited the neurology department, and early brain and spine magnetic resonance imaging showed multifocal high intensity in the subcortical and periventricular white matter and the cervical cord. The patient's serum tested positive for anti-MOG antibodies. She was diagnosed with MOGAD and received intravenous steroid pulse therapy. After pharmacologic therapy, the patient was transferred to the rehabilitation department. Initially, her Functional Independence Measure (FIM) motor score was 26, allowing her to stand independently for only a few seconds. After 5 weeks of rehabilitation involving physical therapy, occupational therapy, and balance training, her FIM motor score improved to 60. However, 4 months after discharge, the disease relapsed with symptoms of motor weakness in all extremities, and steroid treatment was initiated. On the second admission, her FIM motor score was 42, but after continuous multidisciplinary rehabilitation, it improved to 76. Computerized cognitive therapy improved her cognitive function, from a Korean version of the Mini-Mental State Examination score of 23 on the first admission to 30 on final discharge. Since MOGAD is a relapsing disease, a favorable outcome can be achieved with continuous monitoring and multidisciplinary, symptom-specific rehabilitation.</p>","PeriodicalId":72442,"journal":{"name":"Brain & NeuroRehabilitation","volume":"15 1","pages":"e9"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3f/5d/bn-15-e9.PMC9833465.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10660618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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