Biomedical research and clinical reviews最新文献_第4页

Herbal Medicine for the Treatmentof Viral Infections: A Systemic Review 中药治疗病毒感染的系统评价

Biomedical research and clinical reviews Pub Date : 2022-01-12 DOI: 10.31579/2692-9406/088

A. Krishna sailaja, Amand Alekhya

{"title":"Herbal Medicine for the Treatmentof Viral Infections: A Systemic Review","authors":"A. Krishna sailaja, Amand Alekhya","doi":"10.31579/2692-9406/088","DOIUrl":"https://doi.org/10.31579/2692-9406/088","url":null,"abstract":"The term “Antiviral agents” has been defined in very wide terms as substances other than a virus or virus containing vaccine or specific antibody which can build either a protective or therapeutic effect to the direct measurable advantage of the virus infected host. Viruses are simple in form which are very tiny germs. They comprise of genetic material inside of a protein coating. Viruses cause amicable infectious diseases like common cold, flu and warts. They also cause severe diseases such as HIV/AIDS, Ebola, avian influenzas, dengue virus and COVID-19. Viral diseases are very complex and are easily spread. Herbs and herbal medicines were the foremost in treating infections from centuries over the world in every civilization. Modern science has narrowed the importance of herbal medicine in the past two centuries. But, the side effects and new varieties of diseases creating challenges to modern science. So, usage of herbal medicines is again attaining interests these days. Herbal products for different treatments have achieved a lot of popularity in the last couple of decades. Thus, discovering novel antiviral drugs is of extremely important and natural products are an excellent source for such discoveries. There are many herbs which are excellent sources for the antiviral properties to treat viral infections. This review provides the verified data on the herbal substances with antiviral activity, and some of the herbal marketed antiviral agents like CORONIL TABLETS from Patanjali and different companies had made an attempt to treat viral infections in this pandemic situation. Therefore, herbal plants proved to be a major resort for the treatment of diseases and sickness by traditional healers in many societies.","PeriodicalId":72392,"journal":{"name":"Biomedical research and clinical reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46758646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CNS Lymphoma: Clinical Pearls and Management Considerations. 中枢神经系统淋巴瘤：临床要点和管理考虑。

Biomedical research and clinical reviews Pub Date : 2022-01-01 Epub Date: 2022-06-27

Michelot Michel, Noelle Lucke-Wold, Mohammad Reza Hosseini, Eric Panther, Ramya Reddy, Brandon Lucke-Wold

引用次数: 0

Recent Treatment Strategies in Alzheimer's Disease and Chronic Traumatic Encephalopathy. 阿尔茨海默病和慢性创伤性脑病的最新治疗策略。

Biomedical research and clinical reviews Pub Date : 2022-01-01 Epub Date: 2022-09-08 DOI: 10.31579/2692-9406/128

Yusuf Mehkri, Brandon McDonald, Sai Sriram, Ramya Reddy, Savannah Kounelis-Wuillaume, Jeffrey Alexander Roberts, Brandon Lucke-Wold

引用次数: 0

Reprint: Peculiarities of expression of apoptosis markers in the tissues of primary fallopian tubes carcinoma 转载：细胞凋亡标志物在原发性输卵管癌组织中表达的特点

Biomedical research and clinical reviews Pub Date : 2021-10-29 DOI: 10.31579/2692-9406/084

F. Unawunwa, N. Hyriavenko, A. Korobchanska, M. Lyndin, V. Sikora

{"title":"Reprint: Peculiarities of expression of apoptosis markers in the tissues of primary fallopian tubes carcinoma","authors":"F. Unawunwa, N. Hyriavenko, A. Korobchanska, M. Lyndin, V. Sikora","doi":"10.31579/2692-9406/084","DOIUrl":"https://doi.org/10.31579/2692-9406/084","url":null,"abstract":"Aim: immunohistochemical analysis of apoptosis markers in the tissue of PFTC. Introduction: Primary fallopian tubes carcinoma is a rare case among oncological diseases of female genital organs, but the mortality rate is rather high. Nowadays, the prognostic factors of this neoplasia are not fully determined. The data on the p53 and bcl2 proteins expression and their use as prognostic factors in patients with malignant tumors of many locations are contradictory. Methods: the study was conducted on 66 samples of fallopian tubes tumor tissue. To study the apoptosis peculiarities of tumor cells the mouse monoclonal antibodies for bcl-2 (clone 100/D5) and p53 (clone SP5) were used. Mathematic calculations were done using Microsoft Excel 2010 with AtteStat 12.0.5. Results: The high expression of p53 was found in patients of all clinical stages. Mutations of p53 increased with spreading of the neoplastic process. Strong correlation of p53 presence in tumor samples and clinical stage of the disease was determined (r=0.77). In contrast to the abovementioned protein the study of bcl-2 showed the moderate negative correlation between this protein and the stage of the disease (r=−0.54). Analysis of the dependence of p53 expression with the presence or absence of lymph nodes metastasis showed a direct correlation between the indicators (r=0.25). Thus the level of p53 expression in patients with N1 was 80.6±2.7% compared with the N0 group (29.7±3.6%). The stage of neoplasia differentiation is in moderate direct correlation with p53 expression (r=0.58) and in inverse with – bcl-2 (r=−0.64). Conclusion: Expression of p53 depends on neoplasia spreading and stage of tumor differentiation. The expression of p53 is an independent prognostic marker for N-status and helps to classify the patients into “risk” groups.","PeriodicalId":72392,"journal":{"name":"Biomedical research and clinical reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47991232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Re-Print: An Interesting Case of Disseminated Tuberculoma of Brain and Spinal Cord Type of Study: Case Report 重印:一例有趣的脑和脊髓弥散性结核瘤的研究类型:病例报告

Biomedical research and clinical reviews Pub Date : 2021-10-29 DOI: 10.31579/2692-9406/083

A. Sakalecha, Parameshwar Keerthi B H, Varun S, Shivaprasad G Savagave

引用次数: 0

Why do Patients with Acute Pneumonia Receive Intravenous Infusions? 为什么急性肺炎患者要接受静脉输液？

Biomedical research and clinical reviews Pub Date : 2021-10-29 DOI: 10.31579/2692-9406/085

I. Klepikov

引用次数: 0

What We Need to Do to Improve Our Immune System Despite the Use of Vaccination for COVID-19? 尽管使用了COVID-19疫苗，我们需要做些什么来改善我们的免疫系统?

Biomedical research and clinical reviews Pub Date : 2021-10-29 DOI: 10.31579/2692-9406/081

Huang Wei Ling

引用次数: 0

Diabetes Ameliorating Effect of Mushrooms 香菇对糖尿病的改善作用

Biomedical research and clinical reviews Pub Date : 2021-10-28 DOI: 10.31579/2692-9406/086

M. Azizur Rahman, Rabeya Akter

引用次数: 1

Coronavirus Variants of Concern: An Insight 冠状病毒变异毒株：一个见解

Biomedical research and clinical reviews Pub Date : 2021-09-27 DOI: 10.31579/2692-9406/080

Prabir Mandal, T. Andrews, Quinlin Bisbee, Asiah Cheek, DeLisa Davis, Jada V. Harvey, Armani B Hayes, Steven Hopkins, Jeannette Mack, Gianni Narcisse, Brianna Pendergrass, Janai Poullard, Nathaniel Schirmer, Caytlin Willis

{"title":"Coronavirus Variants of Concern: An Insight","authors":"Prabir Mandal, T. Andrews, Quinlin Bisbee, Asiah Cheek, DeLisa Davis, Jada V. Harvey, Armani B Hayes, Steven Hopkins, Jeannette Mack, Gianni Narcisse, Brianna Pendergrass, Janai Poullard, Nathaniel Schirmer, Caytlin Willis","doi":"10.31579/2692-9406/080","DOIUrl":"https://doi.org/10.31579/2692-9406/080","url":null,"abstract":"The new coronavirus, SARS-CoV-2, which causes the disease COVID-19, has had a serious worldwide impact on human health. The virus was virtually unknown at the beginning of 2020. Since then, intense research efforts have resulted in sequencing the coronavirus genome, identifying the structures of its proteins, and creating a wide range of tools to search for effective vaccines and therapies. Also, there’s a chance that the COVID-19 contraction rate could get higher than the COVID-19 vaccination rate. In other words, the virus continues to spread while very little people actually get vaccinated. This only makes the job of scientists even harder. In order to stop the spread of COVID-19, citizens must get vaccinated more frequently than citizens are contracting COVID-19. The coronavirus attacks and kills healthy cells, causing detrimental damage to the respiratory system and immune system. It was then discovered that COVID-19 can be terribly fatal for those with already fragile immune systems and preexisting health conditions. Back in March, when COVID-19 was clearly becoming a critical threat to many countries around the world, the evidence indicated that the virus spreads from person to person through small respiratory droplets produced when people cough or sneeze, or even breathe. Surfaces can serve as an intermediary for the virus when looking for a host. Instead of contracting the virus directly from a person, it is possible to receive the virus from touching an object that an infected person sneezed on. It has been discovered that the virus can last up to three 3 days on a surface. Proceeding to rub one’s eyes, mouth, or nose after such contact is also a mode of transmission.","PeriodicalId":72392,"journal":{"name":"Biomedical research and clinical reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48640317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Re-Print: Developing and then Confirming a Hypothesis Based on a Chronology of Several Clinical Trials: A Bayesian Application to Pirfenidone Mortality Results 基于几项临床试验年表的假设的发展和确认:吡非尼酮死亡率结果的贝叶斯应用

Biomedical research and clinical reviews Pub Date : 2021-09-27 DOI: 10.31579/2692-9406/066

Zhengning Lin, Donald A Berry

{"title":"Re-Print: Developing and then Confirming a Hypothesis Based on a Chronology of Several Clinical Trials: A Bayesian Application to Pirfenidone Mortality Results","authors":"Zhengning Lin, Donald A Berry","doi":"10.31579/2692-9406/066","DOIUrl":"https://doi.org/10.31579/2692-9406/066","url":null,"abstract":"Designing a study for independent confirmation of a treatment effect is sometimes not practical due to required large sample size. Post hoc pooling of studies including those for learning purposes is subject to selection bias and therefore generally not suitable for confirmation of a treatment effect. We propose a Bayesian approach which calibrates the role of prior information from historical studies for learning and confirming purposes. The amount of prior information to be combined with current study data for the purpose of hypothesis confirmation depends on the overall strength of prior information for hypothesis generation. The method is illustrated in the analysis of mortality data for the pirfenidone NDA. The Bayesian analysis provides a formal method to calibrate the role of information from historical evidence in the overall interpretation of results from both historical and concurrent clinical studies. The increased efficiency of using all available data is especially important in drug development for rare diseases with serious consequences, where limited patient source prohibits large trials, and unmet medical needs demand rapid access to treatment options.","PeriodicalId":72392,"journal":{"name":"Biomedical research and clinical reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44929802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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