阿尔茨海默病和慢性创伤性脑病的最新治疗策略。

Biomedical research and clinical reviews Pub Date : 2022-01-01 Epub Date: 2022-09-08 DOI:10.31579/2692-9406/128
Yusuf Mehkri, Brandon McDonald, Sai Sriram, Ramya Reddy, Savannah Kounelis-Wuillaume, Jeffrey Alexander Roberts, Brandon Lucke-Wold
{"title":"阿尔茨海默病和慢性创伤性脑病的最新治疗策略。","authors":"Yusuf Mehkri, Brandon McDonald, Sai Sriram, Ramya Reddy, Savannah Kounelis-Wuillaume, Jeffrey Alexander Roberts, Brandon Lucke-Wold","doi":"10.31579/2692-9406/128","DOIUrl":null,"url":null,"abstract":"<p><p>Neurotrauma has been well linked to the progression of neurodegenerative disease. Much work has been done characterizing chronic traumatic encephalopathy, but less has been done regarding the contribution to Alzheimer's Disease. This review focuses on AD and its association with neurotrauma. Emerging clinical trials are discussed as well as novel mechanisms. We then address how some of these mechanisms are shared with CTE and emerging pre-clinical studies. This paper is a user-friendly resource that summarizes the emerging findings and proposes further investigation into key areas of interest. It is intended to serve as a catalyst for both research teams and clinicians in the quest to improve effective treatment and diagnostic options.</p>","PeriodicalId":72392,"journal":{"name":"Biomedical research and clinical reviews","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Recent Treatment Strategies in Alzheimer's Disease and Chronic Traumatic Encephalopathy.\",\"authors\":\"Yusuf Mehkri, Brandon McDonald, Sai Sriram, Ramya Reddy, Savannah Kounelis-Wuillaume, Jeffrey Alexander Roberts, Brandon Lucke-Wold\",\"doi\":\"10.31579/2692-9406/128\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Neurotrauma has been well linked to the progression of neurodegenerative disease. Much work has been done characterizing chronic traumatic encephalopathy, but less has been done regarding the contribution to Alzheimer's Disease. This review focuses on AD and its association with neurotrauma. Emerging clinical trials are discussed as well as novel mechanisms. We then address how some of these mechanisms are shared with CTE and emerging pre-clinical studies. This paper is a user-friendly resource that summarizes the emerging findings and proposes further investigation into key areas of interest. It is intended to serve as a catalyst for both research teams and clinicians in the quest to improve effective treatment and diagnostic options.</p>\",\"PeriodicalId\":72392,\"journal\":{\"name\":\"Biomedical research and clinical reviews\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomedical research and clinical reviews\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.31579/2692-9406/128\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/9/8 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedical research and clinical reviews","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31579/2692-9406/128","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/9/8 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

神经创伤与神经退行性疾病的进展密切相关。关于慢性创伤性脑病的特征研究已做了大量工作,但关于其对阿尔茨海默病的影响研究较少。本综述将重点关注阿尔茨海默病及其与神经创伤的关系。我们讨论了新的临床试验和新的机制。然后,我们将讨论其中一些机制如何与 CTE 和新出现的临床前研究共享。本文是一份用户友好型资料,总结了新出现的研究结果,并建议对主要关注领域进行进一步研究。本文旨在为研究团队和临床医生提供催化剂,帮助他们改进有效的治疗和诊断方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Recent Treatment Strategies in Alzheimer's Disease and Chronic Traumatic Encephalopathy.

Neurotrauma has been well linked to the progression of neurodegenerative disease. Much work has been done characterizing chronic traumatic encephalopathy, but less has been done regarding the contribution to Alzheimer's Disease. This review focuses on AD and its association with neurotrauma. Emerging clinical trials are discussed as well as novel mechanisms. We then address how some of these mechanisms are shared with CTE and emerging pre-clinical studies. This paper is a user-friendly resource that summarizes the emerging findings and proposes further investigation into key areas of interest. It is intended to serve as a catalyst for both research teams and clinicians in the quest to improve effective treatment and diagnostic options.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信