Biomedical materials & devices (New York, N.Y.)最新文献

{"title":"Machine Learning Based Diabetes Detection Model for False Negative Reduction","authors":"Md. Ashraf Uddin, Md. Manowarul Islam, Md. Alamin Talukder, Md. Al Amin Hossain, Arnisha Akhter, Sunil Aryal, Maisha Muntaha","doi":"10.1007/s44174-023-00104-w","DOIUrl":"https://doi.org/10.1007/s44174-023-00104-w","url":null,"abstract":"Diabetes is a chronic disease characterized by the inability of the pancreas to produce enough insulin or the body’s inability to use insulin efficiently. This disease is becoming increasingly prevalent worldwide and can result in severe complications such as blindness, kidney failure, and stroke. Early detection of diabetes can potentially save millions of lives globally, making it a crucial focus of research. In this study, we propose a machine learning model to aid in predicting diabetes. The model comprises several machine learning methods: Linear Regression (LnR), Logistic Regression (LR), k-nearest neighbor (KNN), Naive Bayes (NB), Random Forest (RF), Support Vector Machine (SVM), and Decision Tree (DT). Prior to feeding the pre-processed data into the machine learning model for evaluation, we conducted several pre-processing steps, such as removing null values, standardizing data using normalization, and labeling data using the label encoding process. Imbalanced datasets can adversely affect the accuracy of machine learning algorithms, and we address this problem by balancing the datasets using the Synthetic Minority Oversampling Technique (SMOTE) method. We assessed the model’s performance on two datasets and found that the random forest algorithm produced optimal results, with 97% accuracy on the diabetes dataset 2019 and 80% accuracy on the Pima Indian dataset. However, using a balanced dataset, we can significantly reduce the number of false-negative detections.","PeriodicalId":72388,"journal":{"name":"Biomedical materials & devices (New York, N.Y.)","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136296269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Injectable Platelet-Rich Fibrin in Contact with Bone Substitutes, Porous Zirconia, or Laser-Textured Implant Surfaces: A Detailed Morphological Analysis","authors":"Miguel Noronha Oliveira, Hugo Almeida Varela, Rubens M. Nascimento, Narayan Sahoo, Oscar Carvalho, Bruno Henriques, Júlio C. M. Souza","doi":"10.1007/s44174-023-00094-9","DOIUrl":"https://doi.org/10.1007/s44174-023-00094-9","url":null,"abstract":"Abstract The aim of the present study was to perform a detailed morphological analysis of an injectable platelet rich fibrin after combination with two different particulate hydroxyapatite-based granules, a porous zirconia block, and laser-textured zirconia or titanium surfaces. Blood samples were harvested from three participants to prepare the flowable injectable PRF in contact or not with particulate hydroxyapatite (Hap), bone mineral granules (DBBM), porous zirconia blocks, laser-textured titanium or zirconia surfaces. Optical and scanning electron microscopy (SEM) were used to evaluate the fibrin network density, fibrin fibers’ diameter, blood cells, and the interaction of PRF with the biomaterials. Histomorphometry of the flowable PRF was also performed using the hematoxylin–eosin staining protocol. Specimens were independently evaluated by two blinded and well-trained researchers in histomorphometry and microscopy. Particulate Hap and DBBM shown different morphological aspects by SEM analyses since DBBM revealed macro- and micro-scale pores while Hap revealed a dense structure. Hydroxyapatite and DBBM granules were entirely embedded by the fibrin-network in the presence of leukocytes and blood platelets. The zirconia porous structured was filled with PRF and its components. Also, the laser-structured zirconia or implant surfaces were entirely coated with the PRF fibrin network embedding leukocytes and blood platelets. Laser-textured titanium surfaces revealed macro- and micro-scale irregularities that increase the surface area and retention of the injectable PRF. Histomorphometric analyses revealed complementary details on the distribution of lymphocytes, red blood cells, and fibrin associated with platelet aggregation. The flowing and viscosity of an injectable platelet rich fibrin provided an agglomeration of synthetic or xenogeneic particulate bone substitutes and the coating of porous zirconia and textured implant surfaces as inspected by scanning electron microscopy. A cross-linked 3D-fibrin network was noticed involving the particulate bone substitutes and clogging the spaces into porous blocks as well as at macro-/micro-scale valleys on laser-textured implant surfaces. On the reconstruction of larger bone defects, platelet rich fibrin should be mixed with inorganic bone substitutes and implant surfaces to speed up the early events of the bone ingrowth. In addition, the particulate bioactive ceramics, porous zirconia, and textured implant surfaces provide the mechanical stability of the bone tissues and the 3D-fibrin network for further stimulation of osteogenic cells leading to an enhanced bone healing.","PeriodicalId":72388,"journal":{"name":"Biomedical materials & devices (New York, N.Y.)","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136356176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review on Saliva-Based Health Diagnostics: Biomarker Selection and Future Directions.","authors":"Swati Kumari,&nbsp;Mesk Samara,&nbsp;Remya Ampadi Ramachandran,&nbsp;Sujoy Gosh,&nbsp;Haritha George,&nbsp;Rong Wang,&nbsp;Russell P Pesavento,&nbsp;Mathew T Mathew","doi":"10.1007/s44174-023-00090-z","DOIUrl":"10.1007/s44174-023-00090-z","url":null,"abstract":"<p><p>The human body has a unique way of saying when something is wrong with it. The molecules in the body fluids can be helpful in the early detection of diseases by enabling health and preventing disease progression. These biomarkers enabling better healthcare are becoming an extensive area of research interest. Biosensors that detect these biomarkers are becoming the future, especially Point Of Care (POC) biosensors that remove the need to be physically present in the hospital. Detection of complex and systemic diseases using biosensors has a long way to go. Saliva-based biosensors are gaining attention among body fluids due to their non-invasive collection and ability to detect periodontal disease and identify systemic diseases. The possibility of saliva-based diagnostic biosensors has gained much publicity, with companies sending home kits for ancestry prediction. Saliva-based testing for covid 19 has revealed effective clinical use and relevance of the economic collection. Based on universal biomarkers, the detection of systemic diseases is a booming research arena. Lots of research on saliva-based biosensors is available, but it still poses challenges and limitations as POC devices. This review paper talks about the relevance of saliva and its usefulness as a biosensor. Also, it has recommendations that need to be considered to enable it as a possible diagnostic tool.</p><p><strong>Graphical abstract: </strong></p>","PeriodicalId":72388,"journal":{"name":"Biomedical materials & devices (New York, N.Y.)","volume":" ","pages":"1-18"},"PeriodicalIF":0.0,"publicationDate":"2023-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10243891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10137659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Handheld Spectroscopy Tool for Detection of Lymphedema","authors":"J. Sibley, Jarren Baldwin, John R. Pamplin, Julia R. Rodrick, Charles Liu, H. Hettrick, A. Doraiswamy","doi":"10.1007/s44174-023-00070-3","DOIUrl":"https://doi.org/10.1007/s44174-023-00070-3","url":null,"abstract":"","PeriodicalId":72388,"journal":{"name":"Biomedical materials & devices (New York, N.Y.)","volume":"67 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76317560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organic-Inorganic Hybrid Nanocomposites for Nanotheranostics: Special Focus on Preventing Emerging Variants of SARS-COV-2.","authors":"Sayan Mukherjee,&nbsp;Souvik Manna,&nbsp;Nivedita Som,&nbsp;Santanu Dhara","doi":"10.1007/s44174-023-00077-w","DOIUrl":"10.1007/s44174-023-00077-w","url":null,"abstract":"<p><p>The worldwide emerging cases of various respiratory viral diseases and the current escalation of novel coronavirus disease (COVID-19) make people considerably attentive to controlling these viruses through innovative methods. Most re-emerging respiratory diseases envelop RNA viruses that employ attachment between the virus and host cell to get an entry form using the host cell machinery. Emerging variants of COVD-19 also bring about a constant threat to public health as it has wide infectivity and can quickly spread to infect humans. This review focuses on insights into the current investigations to prevent the progression of incipient variants of Severe Acute Respiratory Syndrome Coronavirus (SARS-COV-2) along with similar enveloped RNA viruses that cause respiratory illness in humans and animals. Nanotheranostics is a trailblazing arena of nanomedicine that simultaneously helps prevent or treat diseases and diagnoses. Nanoparticle coating and nanofibers were extensively explored, preventing viral contaminations. Several studies have proven the virucidal activities of metal nanoparticles like copper, silver, and titanium against respiratory viral pathogens. Worldwide many researchers have shown surfaces coated with ionic nanoparticles like zinc or titanium act as potent antiviral agents against RNA viruses. Carbon nanotubes, quantum dots, silica nanoparticles (NPs), polymeric and metallic nanoparticles have also been explored in the field of nanotheranostics in viral detection. In this review, we have comprehensively discussed different types of metallic, ionic, organic nanoparticles and their hybrids showing substantial antiviral properties to stop the progression of the novel coronavirus disease focused on three key classes: prevention, diagnostics, and treatment.</p>","PeriodicalId":72388,"journal":{"name":"Biomedical materials & devices (New York, N.Y.)","volume":" ","pages":"1-15"},"PeriodicalIF":0.0,"publicationDate":"2023-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9708707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Degradation of Plastics Waste and Its Effects on Biological Ecosystems: A Scientific Analysis and Comprehensive Review","authors":"S. Dey, G. Veerendra, P. A. Babu, A. Manoj, K. Nagarjuna","doi":"10.1007/s44174-023-00085-w","DOIUrl":"https://doi.org/10.1007/s44174-023-00085-w","url":null,"abstract":"","PeriodicalId":72388,"journal":{"name":"Biomedical materials & devices (New York, N.Y.)","volume":"5 1","pages":"1-43"},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90163370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain Computer Interface-Based Signal Processing Techniques for Feature Extraction and Classification of Motor Imagery Using EEG: A Literature Review","authors":"D. Jaipriya, K. Sriharipriya","doi":"10.1007/s44174-023-00082-z","DOIUrl":"https://doi.org/10.1007/s44174-023-00082-z","url":null,"abstract":"","PeriodicalId":72388,"journal":{"name":"Biomedical materials & devices (New York, N.Y.)","volume":"26 1","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2023-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78788323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SiNx Coating Deposition on CoCr by Plasma-Enhanced Chemical Vapor Deposition","authors":"H. Zhou, C. Persson, W. Xia, H. Engqvist","doi":"10.1007/s44174-023-00083-y","DOIUrl":"https://doi.org/10.1007/s44174-023-00083-y","url":null,"abstract":"","PeriodicalId":72388,"journal":{"name":"Biomedical materials & devices (New York, N.Y.)","volume":"23 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2023-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72525761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overcoming Challenges and Innovations in Orthopedic Prosthesis Design: An Interdisciplinary Perspective.","authors":"Pranav G Kulkarni, Namuna Paudel, Shilpa Magar, Maria Fernanda Santilli, Shubham Kashyap, Akash Kumar Baranwal, Paolo Zamboni, Priyank Vasavada, Aman Katiyar, Ajay Vikram Singh","doi":"10.1007/s44174-023-00087-8","DOIUrl":"10.1007/s44174-023-00087-8","url":null,"abstract":"<p><p>Recent advances in the orthopedic prostheses design have significantly improved the quality of life for individuals with orthopedic disabilities. However, there are still critical challenges that need to be addressed to further enhance the functionality of orthopedic prostheses improving biocompatibility to promote better integration with natural tissues, enhancing durability to withstand the demands of daily use, and improving sensory feedback for better control of movement are the most pressing issues. To address these challenges, promising emerging solutions such as smart prosthetics, 3D printing, regenerative medicine, and artificial intelligence have been developed. These innovative technologies hold the potential to significantly enhance the functionality of orthopedic prostheses. Realizing the full potential of these next-generation orthopedic prostheses requires addressing several critical factors. These include interdisciplinary collaboration between experts in orthopedics, materials science, biology, and engineering, increased investment in research and development, standardization of components to ensure quality and reliability, and improved access to prosthetics. A comprehensive review of these challenges and considerations for future orthopedic prosthesis design is s provided in this paper addressing the further advances to the field. By addressing these issues, we can continue to improve the lives of individuals with orthopedic disabilities and further enhance the field of orthopedic prosthetics.</p>","PeriodicalId":72388,"journal":{"name":"Biomedical materials & devices (New York, N.Y.)","volume":" ","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2023-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9715547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computer Simulation of the Coupling Between Recirculation Flows and Drug Release from a Coronary Drug-Eluting Stent","authors":"F. Chabi, N. Abbasnezhad, S. Champmartin, C. Sarraf, F. Bakir","doi":"10.1007/s44174-023-00081-0","DOIUrl":"https://doi.org/10.1007/s44174-023-00081-0","url":null,"abstract":"","PeriodicalId":72388,"journal":{"name":"Biomedical materials & devices (New York, N.Y.)","volume":"34 1","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2023-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72890004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}