Biomedical materials & devices (New York, N.Y.)最新文献

Comparative Analysis of Magnesium Oxide Nanoparticles Biosynthesized from Rubber Seed Shell and Rubber Leaf Extracts 橡胶籽壳与橡胶叶提取物生物合成氧化镁纳米颗粒的对比分析

Biomedical materials & devices (New York, N.Y.) Pub Date : 2023-11-10 DOI: 10.1007/s44174-023-00139-z

Esther U. Ikhuoria, Ita E. Uwidia, Godfrey O. Otabor, Ikhazuagbe H. Ifijen

{"title":"Comparative Analysis of Magnesium Oxide Nanoparticles Biosynthesized from Rubber Seed Shell and Rubber Leaf Extracts","authors":"Esther U. Ikhuoria, Ita E. Uwidia, Godfrey O. Otabor, Ikhazuagbe H. Ifijen","doi":"10.1007/s44174-023-00139-z","DOIUrl":"https://doi.org/10.1007/s44174-023-00139-z","url":null,"abstract":"Plant-mediated methods are increasingly favored for synthesizing magnesium oxide nanoparticles (MgONPs) due to their cost-effectiveness, ease of use, and eco-friendly nature compared to chemical and physical approaches. In this study, the potential of plant-derived phytochemicals as bio-reducing and capping agents in the synthesis of MgONPs was explored. Specifically, MgONPs were successfully synthesized using an aqueous extract obtained from rubber seed shells (RSS) and rubber leaves (RL). To validate the obtained MgONPs, various characterization techniques including FTIR, DLS, XRD and SEM were employed. The FTIR analysis confirmed the formation of magnesium oxide. According to DLS analysis, the average particle size of MgONPs derived from rubber seed shells was determined to be 1199 nm, while those derived from rubber leaves exhibited an average size of 44.57 nm. The X-ray Diffraction (XRD) analysis confirms a high level of crystallinity and validates the crystalline nature of both sets of synthesized nanoparticles. SEM examination revealed that the rubber seed shell-based MgONPs displayed irregular-shaped particles with a high degree of aggregation, whereas the MgONPs derived from rubber leaves exhibited a more uniform and spherical morphology. These findings highlight the efficacy of plant-mediated methods using rubber seed shells and rubber leaves extracts for synthesizing MgONPs. The characterization techniques employed in this study provided valuable insights into the structural properties of the nanoparticles. Such knowledge is crucial for further exploration and utilization of plant-mediated approaches in the synthesis of nanomaterials with desired sizes and morphologies, contributing to the development of cost-effective and environmentally friendly strategies in nanotechnology.","PeriodicalId":72388,"journal":{"name":"Biomedical materials & devices (New York, N.Y.)","volume":"67 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135093346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Stimuli-Responsive Biomaterials in Gynecological Cancer Therapy 刺激反应性生物材料在妇科肿瘤治疗中的作用

Biomedical materials & devices (New York, N.Y.) Pub Date : 2023-11-06 DOI: 10.1007/s44174-023-00138-0

Monalisha Debnath, Amreen Khan, Roshan Keshari, Arpita Banerjee, Rohit Srivastava

{"title":"Impact of Stimuli-Responsive Biomaterials in Gynecological Cancer Therapy","authors":"Monalisha Debnath, Amreen Khan, Roshan Keshari, Arpita Banerjee, Rohit Srivastava","doi":"10.1007/s44174-023-00138-0","DOIUrl":"https://doi.org/10.1007/s44174-023-00138-0","url":null,"abstract":"Gynecological cancers, predominantly cervical, ovarian, uterine, and vaginal, are among the most challenging cancers to treat due to their complex anatomical position. Owing to high recurrence tendency, total eradication of gynecological cancer forecasts the inclusion of enhanced biomaterials. This could be accomplished by surface modification, bio-functionalization, and binding of ligands for targeted delivery. Alternatively, conventional therapies to treat cancer fail to reach the tumor microenvironment due to non-specificity, causing severe off-target toxicity. Over the last decade, extensive molecular analysis of gynecological cancer has identified several targets for strategizing nanomedicines. Further advancement in intelligent drug delivery systems with innovative stimuli-responsive biomaterials for target-specific release is cutting-edge research. Stimuli-responsive biomaterials are the novel platform in clinics benefitting higher bioavailability of anticancer molecules in the tumor microenvironment, eliminating systemic toxicity, and enhancing biodistribution in the body. Moreover, precisely controlled release of anticancer drugs, genes, or biomolecules on a stimuli-dependent response can reduce host tissue damage and unnecessary drug or nanoparticle aggregation. Based on their physicochemical properties, such biomaterials can further be categorized as endogenous and exogenous. This review article mainly focuses on the progress of the design and development of such stimuli-responsive biomaterials in gynecological cancer therapy. The therapeutic aspects, limitations, and prospects of such biomaterials have also been summarized. We also consolidate biomaterials given during gynecological therapy, their clinical interventions, and the scope for FDA regulatory adherence to facilitate their advent for large-scale clinical application.","PeriodicalId":72388,"journal":{"name":"Biomedical materials & devices (New York, N.Y.)","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135590134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Machine Learning-Based Chronic Kidney Cancer Prediction Application: A Predictive Analytics Approach 基于机器学习的慢性肾癌预测应用:预测分析方法

Biomedical materials & devices (New York, N.Y.) Pub Date : 2023-11-02 DOI: 10.1007/s44174-023-00133-5

Khandaker Mohammad Mohi Uddin, Md. Nuzmul Hossain Nahid, Md. Mehedi Hasan Ullah, Badhan Mazumder, Md. Saikat Islam Khan, Samrat Kumar Dey

引用次数: 0

Fabrication and Characterization of Electrospunned Eprosartan-Loaded Biocompatible Polyvinyl Acetate/Povidone-Based Nanofiber Mat: A Novel Approach as Transdermal Carrier for Therapeutic Actives 电纺丝负载依泊沙坦的生物相容性聚氯乙烯/聚维酮纳米纤维垫的制备和表征:作为治疗活性透皮载体的新方法

Biomedical materials & devices (New York, N.Y.) Pub Date : 2023-11-02 DOI: 10.1007/s44174-023-00132-6

A. J. Mali, Archana Kadam, Saily Bharadwaj, C. Bothiraja, A. P. Pawar

{"title":"Fabrication and Characterization of Electrospunned Eprosartan-Loaded Biocompatible Polyvinyl Acetate/Povidone-Based Nanofiber Mat: A Novel Approach as Transdermal Carrier for Therapeutic Actives","authors":"A. J. Mali, Archana Kadam, Saily Bharadwaj, C. Bothiraja, A. P. Pawar","doi":"10.1007/s44174-023-00132-6","DOIUrl":"https://doi.org/10.1007/s44174-023-00132-6","url":null,"abstract":"Nanofiber (NF) represents one of the newest, promising, and advanced technologies in transdermal and oromucosal drug delivery due to its unique advantages. The present study aims to explore the feasibility of Kollidon® SR (K-SR) to fabricate the sustained release of Eprosartan (EPR)-loaded nanofiber (NF) by using electrospinning technology for transdermal drug delivery. The EPR-NF mat was prepared with sodium iodide (SI) along the backing membrane and compared with film casted mat. The fabricated NF mechanical and physicochemical properties were assessed. Further, NF was evaluated for in-vitro and ex-vivo diffusion study, skin irritation study, and for antihypertensive activity. The formed NF in presence of SI was attributed increased conductivity of polymer solution resulting in uniform NF. The SEM and IR elucidated the thin, uniform, smooth surface of NF without bead formation and interaction between EPR and K-SR. The PXRD and DSC revealed the molecular dispersion with less crystalline nature of the NF. The diffusion and permeation study resulted in initial burst release with gradual diffusion with zero-order kinetics. The skin irritation study revealed lack of erythema or edema reflecting its acceptability. Furthermore, the developed EPR-NF mat efficaciously controlled systolic blood pressure (SBP) in rats up to 24 h. As per the results, K-SR can be explored as a promising carrier for the fabrication of electrospunned NF mat for successful transdermal delivery of therapeutic actives.","PeriodicalId":72388,"journal":{"name":"Biomedical materials & devices (New York, N.Y.)","volume":"150 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135933426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ab-initio, Molecular Docking and MD Simulation of an Anti-HIV Drug (Lamivudine): An In-silico Approach 抗hiv药物(拉米夫定)的Ab-initio，分子对接和MD模拟:一种芯片方法

Biomedical materials & devices (New York, N.Y.) Pub Date : 2023-10-31 DOI: 10.1007/s44174-023-00131-7

Gargi Tiwari, Shiv Kumar, Madan Singh Chauhan, Dipendra Sharma

引用次数: 0

Trends in Biomedical Materials and Devices in Recent Decades 近几十年来生物医学材料和器件的发展趋势

Biomedical materials & devices (New York, N.Y.) Pub Date : 2023-10-26 DOI: 10.1007/s44174-023-00134-4

Roger J. Narayan

引用次数: 0

Evaluation of PEEK-Based Composites for Biomedical Applications by Performing Lubricated Sliding and Bone Growth Studies 通过润滑滑动和骨生长研究评估peek基复合材料在生物医学上的应用

Biomedical materials & devices (New York, N.Y.) Pub Date : 2023-10-12 DOI: 10.1007/s44174-023-00124-6

Sabah Javaid, Caleb Matzke, Maharshi Dey, Yun Ji, Surojit Gupta

{"title":"Evaluation of PEEK-Based Composites for Biomedical Applications by Performing Lubricated Sliding and Bone Growth Studies","authors":"Sabah Javaid, Caleb Matzke, Maharshi Dey, Yun Ji, Surojit Gupta","doi":"10.1007/s44174-023-00124-6","DOIUrl":"https://doi.org/10.1007/s44174-023-00124-6","url":null,"abstract":"We report the fluid lubrication properties of different Polyether ether ketone (PEEK) composites and their bone growth behavior by in vitro studies. Fluid tribological performance of PEEK- MAX (10%Cr2AlC), PEEK-(MAB)10%MoAlB, PEEK-10% DDGS500 (biochar of Distiller’s dried grains with soluble (DDGS) after pyrolysis at 500 °C), PEEK-10%Mo, and PEEK-10% Xonotlite composites were evaluated in Deionized and Distilled (DDI) water and Simulated Body Fluid (SBF) medium. The tribological performance of PEEK-10%Cr2AlC, PEEK-10%MoAlB, and PEEK-10%Mo composites against the stainless steel in both DDI water and SBF medium was better than PEEK. PEEK-10%DDGS composites showed similar wear performance under both water and SBF lubrication as compared to PEEK but it showed lower friction coefficient. This further shows that biochar can be integrated with the PEEK matrix. Detailed SEM analysis was used to document the apatite growth on the surfaces after treating them in SBF medium. By analyzing the microstructural images, we have identified DDGS500, Mo, and Xonotlite as promising additives for promoting apatite growth in SBF medium.","PeriodicalId":72388,"journal":{"name":"Biomedical materials & devices (New York, N.Y.)","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135968837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Urgent Need for Tungsten-Based Nanoparticles as Antibacterial Agents 钨基纳米颗粒作为抗菌剂的迫切需要

Biomedical materials & devices (New York, N.Y.) Pub Date : 2023-10-02 DOI: 10.1007/s44174-023-00127-3

Faithfulness O. Osazee, Kate E. Mokobia, Ikhazuagbe H. Ifijen

{"title":"The Urgent Need for Tungsten-Based Nanoparticles as Antibacterial Agents","authors":"Faithfulness O. Osazee, Kate E. Mokobia, Ikhazuagbe H. Ifijen","doi":"10.1007/s44174-023-00127-3","DOIUrl":"https://doi.org/10.1007/s44174-023-00127-3","url":null,"abstract":"In recent years, the rise of antibiotic-resistant bacteria has posed a significant challenge to public health worldwide. As traditional antibiotics become less effective, there is an urgent need to explore alternative strategies to combat bacterial infections. Tungsten-based nanoparticles have emerged as promising candidates for their potential as antibacterial agents. This article highlights the pressing need for effective antibacterial agents and discusses the potential of tungsten-based nanoparticles in addressing this urgent concern. We delve into the unique properties and mechanisms of action exhibited by these nanoparticles, including their ability to generate reactive oxygen species and induce photothermal effects, leading to bacterial cell death. Additionally, we discuss the challenges associated with utilizing tungsten-based nanoparticles, such as their potential toxicity and compatibility with human cells. Furthermore, we explore the future prospects and ongoing research efforts aimed at optimizing the synthesis, characterization, and application of tungsten-based nanoparticles as antibacterial agents. By addressing these challenges and harnessing the potential of tungsten-based nanoparticles, we can pave the way for the development of effective antibacterial strategies and contribute to combating the global threat of antibiotic resistance.","PeriodicalId":72388,"journal":{"name":"Biomedical materials & devices (New York, N.Y.)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135828643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genotoxicity Induced by Dental Implants In Vitro and In Vivo? A Systematic Review with Meta-analysis 牙种植体体外和体内的遗传毒性?荟萃分析的系统评价

Biomedical materials & devices (New York, N.Y.) Pub Date : 2023-09-27 DOI: 10.1007/s44174-023-00128-2

Ingra Tais Malacarne, Wilton Mitsunari Takeshita, Ana Claudia Muniz Renno, Daniel Araki Ribeiro

{"title":"Genotoxicity Induced by Dental Implants In Vitro and In Vivo? A Systematic Review with Meta-analysis","authors":"Ingra Tais Malacarne, Wilton Mitsunari Takeshita, Ana Claudia Muniz Renno, Daniel Araki Ribeiro","doi":"10.1007/s44174-023-00128-2","DOIUrl":"https://doi.org/10.1007/s44174-023-00128-2","url":null,"abstract":"The aim of this systematic review was designed to help further elucidate the following question: Are dental implants able to induce DNA damage in vitro or in vivo? The systematic review was conducted according to the PRISMA-P guidelines. After searching the literature, full manuscripts from 19 studies were carefully selected by the authors. Regarding the general characteristics, endosseous implant was studied in ten manuscripts, and titanium disks were researched by 4 authors; two studies evaluated more than one type of material: titanium miniplates and endosseous implants, cylinders; endosseous implants and rectangular-shaped titanium miniplates, ceramic composites and titanium particles were research objects only once. Following the parameters for evaluating the risk assessment, 7 manuscripts had strong scores, another 8 papers reached the moderate score, and another 4 scored poorly. The meta-analysis data did not reveal a statistically significant difference in the micronucleated cells of the dental implants patients compared to the control (SMD = 0.22, 95% CI − 0.12 to 0.56, p = 0.20), with a Tau2 = 0.00; Chi2 = 0.01, and p = 0.92, so that the selected manuscripts were considered homogeneous and the I2 of 0% indicated low heterogeneity. In our findings, after evaluating the works, it was observed that the results of the characteristics of the dental implants did not induce genotoxicity.","PeriodicalId":72388,"journal":{"name":"Biomedical materials & devices (New York, N.Y.)","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135535162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thermal Extraction: An Alternative Headspace GC–MS Method for Volatile Extractables from Medical Device Materials 热萃取:顶空气相色谱-质谱法对医疗器械材料中挥发性萃取物的一种替代方法

Biomedical materials & devices (New York, N.Y.) Pub Date : 2023-07-06 DOI: 10.1007/s44174-023-00103-x

Milani Wijeweera Patabandige, K. Nahan, Joshua A. Young, B. Oktem, E. M. Sussman, B. Yun, S. Wickramasekara

引用次数: 0