Biomaterials and biosystems最新文献

Evaluating the potential hepatotoxicity from hip implant wear products—An in-vitro and in-vivo study 评估髋关节植入物的潜在肝毒性——一项体外和体内研究

Biomaterials and biosystems Pub Date : 2025-05-18 DOI: 10.1016/j.bbiosy.2025.100113

Shriya Thakur , Hemalatha Kanniyappan , Puranjay Gupta , Govindaraj Perumal , Robert Hillwig , Vedant V. Bodke , Salman R. Khetani , Mathew T. Mathew

{"title":"Evaluating the potential hepatotoxicity from hip implant wear products—An in-vitro and in-vivo study","authors":"Shriya Thakur , Hemalatha Kanniyappan , Puranjay Gupta , Govindaraj Perumal , Robert Hillwig , Vedant V. Bodke , Salman R. Khetani , Mathew T. Mathew","doi":"10.1016/j.bbiosy.2025.100113","DOIUrl":"10.1016/j.bbiosy.2025.100113","url":null,"abstract":"<div><div>Total hip replacement (THR) is recognized as an effective treatment for patients suffering from severe arthritis or hip issues, with approximately 2.5 million hip and knee replacements recorded annually (AJJR, 2021). A significant clinical concern associated with THR is the toxicity caused by metal particles and ions released from the implant surfaces, which can damage local tissue and potentially spread to distant organs, resulting in systemic toxicity. The toxicity, influenced by the size and concentration of the particles and ions, is especially critical in the liver, the body's main metabolic organ and a primary site for implant accumulation. In this study, we aim to investigate the hepatotoxicity of increasing concentrations of cobalt-chromium-molybdenum (CoCrMo) and titanium (Ti) particles/ions (generally called wear products) in remote organs, particularly the liver. We found that these particles and ions enter cells through metal ion transporters and phagocytosis, leading to significant cellular damage, with titanium ions exhibiting the highest toxicity levels, followed by cobalt ions and CoCrMo particles. Our combined <em>in-vitro</em> and <em>in-vivo</em> research supports the hypothesis that metal particles and ions from implants pose a substantial risk of liver cell damage. This underscores the importance of addressing the systemic impacts of implant-derived metal toxicity in patients with THR.</div></div>","PeriodicalId":72379,"journal":{"name":"Biomaterials and biosystems","volume":"18 ","pages":"Article 100113"},"PeriodicalIF":0.0,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144147916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regenerative potential of biopolymers - calcium phosphate osteogenic composites in the healing of an experimental defect of the parietal bone 生物聚合物-磷酸钙成骨复合材料在实验性顶骨缺损愈合中的再生潜力

Biomaterials and biosystems Pub Date : 2025-05-04 DOI: 10.1016/j.bbiosy.2025.100112

Leonid Sukhodub, Oleksii Korenkov, Liudmyla Sukhodub, Mariia Kumeda

{"title":"Regenerative potential of biopolymers - calcium phosphate osteogenic composites in the healing of an experimental defect of the parietal bone","authors":"Leonid Sukhodub, Oleksii Korenkov, Liudmyla Sukhodub, Mariia Kumeda","doi":"10.1016/j.bbiosy.2025.100112","DOIUrl":"10.1016/j.bbiosy.2025.100112","url":null,"abstract":"<div><div>Given the problem of healing defects of the skull vault, this work is designed to compare in vivo on experimental animals the regenerative potential of osteogenic composite materials different in composition and properties: a) modified with nanostructured hydroxyapatite (HA) and Zn<sup>2+</sup> ions biopolymer alginate (Alg) matrix (Alg_HA), and b) loaded with nanoparticles (NPs) brushite (dicalcium phosphate dihydrate, DCPD) biopolymer chitosan (CS) matrix (CS_DCPD). Regeneration of the parietal bone defect in rats was studied on the 90th and 140th day using light and electron microscopy. Starting from the 90th day, mature lamellar bone tissue formation was observed in the peripheral parts of both implants, which was not yet detected in animals of the control group (healing under the blood clot). The materials underwent resorption during the experiment and were replaced by regenerated tissues. The complete biocompatibility of both materials and the absence of signs of inflammation have been proven. Alg_HA implantation contributed to faster formation and maturation of bone tissue compared to CS_DCPD.</div></div>","PeriodicalId":72379,"journal":{"name":"Biomaterials and biosystems","volume":"18 ","pages":"Article 100112"},"PeriodicalIF":0.0,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143928235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Arterial Junctional Hemostasis without Compression: Evaluation of Visco-liquid Hemostats in Male Swine✰ 无压迫的动脉结缔组织止血：粘液止血剂在雄性猪✰中的应用评价

Biomaterials and biosystems Pub Date : 2025-04-11 DOI: 10.1016/j.bbiosy.2025.100111

Michelle A. Tucci , Joseph D. Lichtenhan , Hamad A. Benghuzzi , Drew A. Hildebrandt

{"title":"Arterial Junctional Hemostasis without Compression: Evaluation of Visco-liquid Hemostats in Male Swine✰","authors":"Michelle A. Tucci , Joseph D. Lichtenhan , Hamad A. Benghuzzi , Drew A. Hildebrandt","doi":"10.1016/j.bbiosy.2025.100111","DOIUrl":"10.1016/j.bbiosy.2025.100111","url":null,"abstract":"<div><div>Trimethylpentyl polysilsesquioxane (POSS) gels containing kaolin and chitin promote clotting and stabilize and strengthen thrombi in vitro, and may offer a potential solution for treating non-compressible wounds. This study was designed to determine if the gels could stop bleeding in a junctional arterial hemorrhage model. Anesthetized male swine were instrumented for systemic arterial pressure (MAP) measurement and saline infusion. A femoral artery was punctured (2 × 6 mm), allowed to bleed freely for 45 s, and then either QuikClot gauze bandage (QC; <em>n</em> = 7), POSS-Kaolin (PK) or POSS-Chitin (PC) (40 ml; <em>n</em> = 7/group) applied with no external compression. Blood loss (BL) at 60 min post-treatment was greater in QC (1166±79 ml) than PK (188±74 ml; <em>p</em> < 0.0001) or PC (523±116 ml; <em>p</em> = 0.0001); BL in PC was greater than in PK (<em>p</em> = 0.03). Total BL (180 min) was higher in QC (1210±93 ml) than PK (475±85 ml, <em>p</em> < 0.001) or PC (632±133 ml; <em>p</em> = 0.002) and in PC vs PK (<em>p</em> = 0.008). Time to clot was not different between PK (3 ± 1) or PC (10±3 min), but was longer in QC (44±9 min) than PK or PC (<em>p</em> < 0.0001 vs PK, <em>p</em> < 0.0003 vs PC). MAP fell 40±3 mmHg in QC by 10 min post-injury (<em>p</em> < 0.0003), and remained below control. PC MAP fell 41±5 mmHg, but returned to control, and MAP did not change in PK. POSS in combination with kaolin or chitin provided hemorrhage control and systemic hemodynamic stability without compression. These results support the treatment concept that this new approach to hemostasis can be efficacious in treating non-compressible trauma wounds.</div></div>","PeriodicalId":72379,"journal":{"name":"Biomaterials and biosystems","volume":"18 ","pages":"Article 100111"},"PeriodicalIF":0.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143917638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “In vitro and in vivo assessment of a non-animal sourced chitosan scaffold loaded with xeno-free umbilical cord mesenchymal stromal cells cultured under macromolecular crowding conditions” [Biomaterials and Biosystems, Volume 16, December 2024, 100102] “在大分子拥挤条件下负载无异种脐带间充质间质细胞的非动物源壳聚糖支架的体外和体内评估”的更正[生物材料和生物系统，第16卷，2024年12月，100102]

Biomaterials and biosystems Pub Date : 2025-03-01 DOI: 10.1016/j.bbiosy.2025.100106

Alessia Di Nubila , Meletios-Nikolaos Doulgkeroglou , Mehmet Gurdal , Stefanie H. Korntner , Dimitrios I. Zeugolis

引用次数: 0

State-of the-art and future perspective in co-culture systems for tendon engineering 肌腱工程共培养系统的现状与未来展望

Biomaterials and biosystems Pub Date : 2025-03-01 DOI: 10.1016/j.bbiosy.2025.100110

Salomé Guillaumin , Andrea Rossoni , Dimitrios Zeugolis

{"title":"State-of the-art and future perspective in co-culture systems for tendon engineering","authors":"Salomé Guillaumin , Andrea Rossoni , Dimitrios Zeugolis","doi":"10.1016/j.bbiosy.2025.100110","DOIUrl":"10.1016/j.bbiosy.2025.100110","url":null,"abstract":"<div><div>Tendon is a connective tissue that links bone to muscle, allowing for maintenance of skeleton posture, joint movement, energy storage and transmission of muscle force to bone. Tendon is a hypocellular and hypovascular tissue of poor self-regeneration capacity. Current surgical treatments are of limited success, frequently resulting in reinjury. Upcoming cell therapies are primarily based on tenocytes, a cell population of limited self-renewal capacity in vitro or mesenchymal stromal cells, a cell population prone to ectopic bone formation in vivo. Over the years mono- or multi- factorial cell culture technologies have failed to effectively maintain tenocyte phenotype in culture during expansion or to prime mesenchymal stromal cells towards tenogenic lineage prior to implantation. Upon these limitations the concept of co-culture was conceived. Here, we comprehensively review and discuss tenogenic differentiation of mesenchymal stromal cells through direct or indirect culture with tenocytes in an attempt to generate a tenocyte or a tendon-like cell population for regenerative medicine purposes.</div></div>","PeriodicalId":72379,"journal":{"name":"Biomaterials and biosystems","volume":"17 ","pages":"Article 100110"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143594099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dental implant prevalence and durability: A concise review of factors influencing success and failure 牙种植的流行和耐久性：影响成功和失败的因素的简要回顾

Biomaterials and biosystems Pub Date : 2025-02-15 DOI: 10.1016/j.bbiosy.2025.100109

Yoshiyasu Takefuji

引用次数: 0

Advancements in mesoporous bioactive glasses for effective bone cancer therapy: Recent developments and future perspectives 用于骨癌有效治疗的介孔生物活性玻璃的进展：最新进展和未来展望

Biomaterials and biosystems Pub Date : 2025-02-15 DOI: 10.1016/j.bbiosy.2025.100108

Laila Hussein , Mona Moaness , Mostafa Mabrouk , Mohamed G. Farahat , Hanan H. Beherei

{"title":"Advancements in mesoporous bioactive glasses for effective bone cancer therapy: Recent developments and future perspectives","authors":"Laila Hussein , Mona Moaness , Mostafa Mabrouk , Mohamed G. Farahat , Hanan H. Beherei","doi":"10.1016/j.bbiosy.2025.100108","DOIUrl":"10.1016/j.bbiosy.2025.100108","url":null,"abstract":"<div><div>This review focuses on recent advancements in the effective use of mesoporous bioactive glasses (MBG) in the treatment of bone cancer, focusing on Osteosarcoma (OS). Bone cancers are rare but are associated with significant morbidity and mortality; often, aggressive treatment is required. Conventional treatments such as surgery, radiation, and chemotherapy are often not enough. This is because surgery cannot completely remove the tumor, without creating a critical size which are defects larger than 2 cm that cannot be repaired by physiological mechanisms. As a result, patients often face the additional burden of radiation and chemotherapy. Scientists have been exploring new treatments, including hyperthermia-targeted therapy, polymeric nanoparticles, and stem cell therapy. This could potentially negatively impact healthy tissues and organs. MBG offers a promising alternative to chemotherapeutic agents and ions for disease treatment as it acts as a multifunctional drug delivery system (DDS). In addition, MBG can also be engineered into scaffolds to facilitate local delivery of growth factors and drugs, thus promoting the efficiency of bone healing and restoration. Therefore, the current review highlights various MBG types reported in the past decade and explores potential future paths to enhance their use in bone cancer treatment while also giving insight on the already commercially available BGs that are used in different bone-related disease.</div></div>","PeriodicalId":72379,"journal":{"name":"Biomaterials and biosystems","volume":"17 ","pages":"Article 100108"},"PeriodicalIF":0.0,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143453077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of fully-resorption replacement paste-like organic/inorganic artificial bones compatible with bone remodeling cycles 与骨重塑周期相适应的全吸收替代膏状有机/无机人工骨的研制

Biomaterials and biosystems Pub Date : 2025-01-26 DOI: 10.1016/j.bbiosy.2025.100107

Yuki Kamaya , Shiori Kato , Kazuaki Nakano , Masaki Nagaya , Hiroshi Nagashima , Mamoru Aizawa

{"title":"Development of fully-resorption replacement paste-like organic/inorganic artificial bones compatible with bone remodeling cycles","authors":"Yuki Kamaya , Shiori Kato , Kazuaki Nakano , Masaki Nagaya , Hiroshi Nagashima , Mamoru Aizawa","doi":"10.1016/j.bbiosy.2025.100107","DOIUrl":"10.1016/j.bbiosy.2025.100107","url":null,"abstract":"<div><div>Calcium-phosphate cement (CPC), commonly used as a bone graft substitute, sets as hydroxyapatite (HAp) and remains in the body for extended periods. To enhance bioresorbabability, we developed a chelate-setting tricalcium β-phosphate (β-TCP) cement using inositol phosphate (IP6) surface modification. By incorporating poly(lactic-co-glycolic acid) (PLGA) particles as a pore-forming agent and calcium sulfate hemihydrate (CSH) to this CPC, we created an organic/inorganic hybrid cement combining bioresorbability with favorable material properties. In this study, varying amounts of PLGA particles were added alongside CSH, and the resulting cement's properties, cytotoxicity, and <em>in vivo</em> response large animals (pigs) were assessed. The cement exhibited a compressive strength of ∼ 30 MPa and set within 15 min, making it suitable for clinical use. Cytotoxicity tests using Transwell® demonstrated cell growth in all cement specimens. In a pig tibia model, the amount of PLGA particle of 5 mass%, 10 mass%, and 20 mass% were tested to optimize material resorption and bone formation, compared with commercial HAp-based CPCs. Histological evaluations showed that higher amount of PLGA particles (10 mass% and 20 mass%) led to increased material resorption but impaired bone formation. The cement containing 5 mass% PLGA particles achieved the best balance, promoting the highest rate of bone formation. Thus, 5 mass% PLGA is the optimal amount for balancing resorption and bone regeneration in β-TCP cement. This formulation is expected to serve as a fully absorbable hybrid paste-type artificial bone supporting bone remodeling cycles.</div></div>","PeriodicalId":72379,"journal":{"name":"Biomaterials and biosystems","volume":"17 ","pages":"Article 100107"},"PeriodicalIF":0.0,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143171576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tissue-engineered fibrillar fibronectin matrices are not only lovely, but also functional for regenerative medicines and in vitro model systems 组织工程纤维连接蛋白基质不仅可爱，而且在再生药物和体外模型系统中也有功能。

Biomaterials and biosystems Pub Date : 2024-12-01 DOI: 10.1016/j.bbiosy.2024.100104

Seungkuk Ahn

引用次数: 0

Enhanced osteogenic potential of spider silk fibroin-based composite scaffolds incorporating carboxymethyl cellulose for bone tissue engineering 掺入羧甲基纤维素的蛛丝纤维素基复合支架在骨组织工程中的成骨潜力得到增强

Biomaterials and biosystems Pub Date : 2024-11-19 DOI: 10.1016/j.bbiosy.2024.100103

Woong Jin Lee , Kyoungjoo Cho , Dayoon Lee , Seungmin Lee , Hyojae Jeon , Aaron Youngjae Kim , Gyung Whan Kim

{"title":"Enhanced osteogenic potential of spider silk fibroin-based composite scaffolds incorporating carboxymethyl cellulose for bone tissue engineering","authors":"Woong Jin Lee , Kyoungjoo Cho , Dayoon Lee , Seungmin Lee , Hyojae Jeon , Aaron Youngjae Kim , Gyung Whan Kim","doi":"10.1016/j.bbiosy.2024.100103","DOIUrl":"10.1016/j.bbiosy.2024.100103","url":null,"abstract":"<div><div>This study aimed to investigate the characteristics of composite scaffolds that combine fibroin derived from spider silk and carboxymethyl cellulose (CMC) in the field of bone tissue engineering. Fibroin, obtained from spider silk, serves as a valuable biomaterial and constitutes the primary component of fibrous protein-based spider silk threads. To enhance the binding efficiency in bone formation after scaffold implantation, CMC was integrated into fibroin, aiming to improve the injectability properties of the scaffold in bone substitutes. For bone marrow mesenchymal stem cell (BMSC) tissue engineering, BMSCs isolated from mice were seeded onto the scaffold, and the rate of cell proliferation was assessed. The composite scaffold, with the addition of CMC to fibroin, exhibited superior characteristics compared to scaffolds containing only silks, including porous morphology, porosity, surface wettability, water absorption, and thermal properties. Alkaline phosphatase activity in BMSCs was significantly higher in the CMC-containing scaffold compared to the silk-only scaffold, and the CMC-containing scaffold demonstrated increased expression of osteocyte marker genes and proteins. In conclusion, the biocompatibility and hydrophilicity of CMC-containing scaffolds play essential roles in the growth and proliferation of osteocytes. Furthermore, the CMC-containing scaffold design proposed in this study is expected to have a substantial impact on promoting ossification of BMSCs.</div></div>","PeriodicalId":72379,"journal":{"name":"Biomaterials and biosystems","volume":"16 ","pages":"Article 100103"},"PeriodicalIF":0.0,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0