Mimicking scaffold membrane based electrospun polyurethane fibers with functional extracellular-like component coating for guided bone regeneration scaffolds

Q3 Biochemistry, Genetics and Molecular Biology

Biomaterials and biosystems Pub Date : 2025-08-08 DOI:10.1016/j.bbiosy.2025.100116

Nattawat Watcharajittanont , Worasak Prarokijjak , Chayada Teanchai , Kanon Jatuworapruk , Jirut Meesane

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Abstract

Mimicking scaffold membranes for guided bone regeneration were fabricated using electrospun polyurethane (PU) coated with polyvinyl alcohol (PVA) and sodium alginate. Five different proportions of PVA and sodium alginate (AGN) were compared as coating solutions for the electrospun PU membranes. Molecular organization, morphology, and physical, mechanical, and biological properties were investigated. The results demonstrated that the electro-spun PU membranes with PVA and sodium alginate coating showed molecular organization via chemical bonding. The coated membranes, especially PU/PVA:AGN (30:70), exhibited higher hydrophilicity, maximum load, and elasticity than membranes without coating, and they exhibited better cell adhesion, cell proliferation, ALP activity, and calcium deposition. In conclusion, we determined that our PU/PVA:AGN (30:70) periosteum mimicking membrane is a promising candidate for guided bone regeneration applications.

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带功能细胞外成分涂层的仿支架膜基静电纺聚氨酯纤维用于引导骨再生支架

采用静电纺聚氨酯（PU）包覆聚乙烯醇（PVA）和海藻酸钠制备了用于引导骨再生的模拟支架膜。比较了五种不同配比的聚乙烯醇（PVA）和海藻酸钠（AGN）作为静电纺PU膜的涂覆溶液。研究了分子的组织、形态、物理、机械和生物特性。结果表明，涂有PVA和海藻酸钠的静电纺PU膜通过化学键形成分子结构。包覆后的膜，特别是PU/PVA:AGN(30:70)，比未包覆的膜表现出更高的亲水性、最大负荷和弹性，并表现出更好的细胞粘附、细胞增殖、ALP活性和钙沉积。总之，我们确定我们的PU/PVA:AGN（30:70）骨膜模拟膜是引导骨再生应用的有希望的候选材料。

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