Biomaterial investigations in dentistry最新文献

{"title":"Bond strength between titanium and polymer-based materials adhesively cemented.","authors":"Camilla Johansson,&nbsp;Aleksandra Håkansson,&nbsp;Evaggelia Papia","doi":"10.1080/26415275.2021.1937182","DOIUrl":"https://doi.org/10.1080/26415275.2021.1937182","url":null,"abstract":"<p><p>The aim was to evaluate the bond strength between titanium and polymer-based materials for prosthetic restorations, cemented with different adhesive cement systems. Eight groups with 13 specimens in each group were included. Each specimen consisted of two parts: a cylinder of titanium resembling a titanium base, and a cylinder of one of two polymer-based materials Micro Filled Hybrid (MFH) or Telio CAD and cemented with one of four adhesive cement systems, namely Multilink Hybrid Abutment, Panavia V5, RelyX Ultimate and G-Cem LinkAce. The titanium was sandblasted with 50 µm Al₂O₃ and treated according to each cement manufacturer's recommendations. The polymer-based materials were pre-treated according to the manufacturer's instructions including sandblasting for MFH. After cementation, the groups were water stored for one day before thermocycling: 5000 cycles in 5-55 °C. A shear bond strength test was performed (crosshead speed 0.5 mm/min) and data was analysed with one-way ANOVA, Tukey's test. Telio CAD cemented with Panavia V5 and G-Cem LinkAce showed significantly lower bond strength compared to all other groups, due to spontaneous debonding. The highest numerical bond strength was found in the group of MFH cemented with RelyX Ultimate or with G-Cem LinkAce. Generally, the Telio CAD groups showed lower bond strength values than the MFH groups. The conclusions are that pre-treatment methods and choice of cement system are of importance for polymer-based materials for prosthetic restorations. The bond strength is adequate for provisional cementation irrespective of cement system when pre-treating by sandblasting, but cement dependent without sandblasting.</p>","PeriodicalId":72378,"journal":{"name":"Biomaterial investigations in dentistry","volume":" ","pages":"79-86"},"PeriodicalIF":0.0,"publicationDate":"2021-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/26415275.2021.1937182","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39156764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative evaluation of penetration depth and surface microhardness of Resin Infiltrant, CPP-ACPF and Novamin on enamel demineralization after banding: an <i>in vitro</i> study.","authors":"Nishita Rana,&nbsp;Namita Singh,&nbsp;Shaila,&nbsp;Abi M Thomas,&nbsp;Rajan Jairath","doi":"10.1080/26415275.2021.1919119","DOIUrl":"https://doi.org/10.1080/26415275.2021.1919119","url":null,"abstract":"<p><strong>Background: </strong>The field of dentistry has been revolutionized by various concepts. Minimal invasive dentistry is the preferred treatment approach in the present era; therefore, various techniques have been advocated to arrest caries lesions at an early stage on the grounds of better understanding of the dynamic nature of dental caries. Thus, study was conducted to compare and evaluate the penetration depth and enamel microhardness of Resin Infiltrant, CPP-ACPF and Novamin on artificial demineralized enamel surface after orthodontic banding.</p><p><strong>Material and methods: </strong>Eighty extracted sound premolars were banded. The bands were cemented with type 1 GIC and further divided into - Group I: Resin Infiltrant, Group II: CCP-ACPF, Group III: Novamin and Group IV: Control. The samples were incubated for 30 days and then thermocycled. A window of 4 mm × 4 mm was prepared on the buccal surface of samples and artificially demineralized for 4 weeks. A single application was made for Resin Infiltrant, while Novamin and CCP-ACPF were applied twice daily. These samples were otherwise immersed in artificial saliva, and this was protocol was observed for 14 days. For the evaluation of penetration depth, 10 samples from each group were bucco-lingually sectioned and immersed in methylene blue dye solution for 24 h and then evaluated under stereomicroscope. For the enamel surface microhardness, remaining 10 samples from each group were embedded in acrylic resin with outer buccal surface exposed and were tested by a using digital Micro-Vickers hardness tester.</p><p><strong>Results: </strong>All groups showed a significant difference in the depth of dye penetration and surface microhardness compared to the control group. As compared to the other tested groups, Resin Infiltrant exhibited the highest significant reduction in demineralization and increased microhardness. Novamin had a deeper penetration and increase in microhardness as compared to CCP-ACPF.</p><p><strong>Conclusion: </strong>Resin Infiltrant exhibited the highest potential to impede caries and constitutes a competent aerosol free micro-invasive strategy for combating non cavitated lesions approaching the outer layer dentine which are too advanced for remineralizing agents but do not necessarily require any drilling of tooth.</p>","PeriodicalId":72378,"journal":{"name":"Biomaterial investigations in dentistry","volume":" ","pages":"64-71"},"PeriodicalIF":0.0,"publicationDate":"2021-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/26415275.2021.1919119","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39114797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barrier membranes for tissue regeneration in dentistry.","authors":"Jun-Ichi Sasaki, Gabriela L Abe, Aonan Li, Pasiree Thongthai, Ririko Tsuboi, Tomoki Kohno, Satoshi Imazato","doi":"10.1080/26415275.2021.1925556","DOIUrl":"10.1080/26415275.2021.1925556","url":null,"abstract":"<p><p><b>Background:</b> In dentistry, barrier membranes are used for guided tissue regeneration (GTR) and guided bone regeneration (GBR). Various membranes are commercially available and extensive research and development of novel membranes have been conducted. In general, membranes are required to provide barrier function, biosafety, biocompatibility and appropriate mechanical properties. In addition, membranes are expected to be bioactive to promote tissue regeneration. <b>Objectives:</b> This review aims to organize the fundamental characteristics of the barrier membranes that are available and studied for dentistry, based on their components. <b>Results:</b> The principal components of barrier membranes are divided into nonbiodegradable and biodegradable materials. Nonbiodegradable membranes are manufactured from synthetic polymers, metals or composites of these materials. The first reported barrier membrane was made from expanded polytetrafluoroethylene (e-PTFE). Titanium has also been applied for dental regenerative therapy and shows favorable barrier function. Biodegradable membranes are mainly made from natural and synthetic polymers. Collagens are popular materials that are processed for clinical use by cross-linking. Aliphatic polyesters and their copolymers have been relatively recently introduced into GTR and GBR treatments. In addition, to improve the tissue regenerative function and mechanical strength of biodegradable membranes, inorganic materials such as calcium phosphate and bioactive glass have been incorporated at the research stage. <b>Conclusions:</b> Currently, there are still insufficient guidelines for barrier membrane choice in GTR and GBR, therefore dentists are required to understand the characteristics of barrier membranes.</p>","PeriodicalId":72378,"journal":{"name":"Biomaterial investigations in dentistry","volume":" ","pages":"54-63"},"PeriodicalIF":0.0,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158285/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39008148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of refractive index of fillers and polymer matrix on translucency and color matching of dental resin composite.","authors":"Maija Oivanen,&nbsp;Filip Keulemans,&nbsp;Sufyan Garoushi,&nbsp;Pekka K Vallittu,&nbsp;Lippo Lassila","doi":"10.1080/26415275.2021.1906879","DOIUrl":"https://doi.org/10.1080/26415275.2021.1906879","url":null,"abstract":"<p><strong>Objective: </strong>When restorative resin composites absorb light from the surrounding tooth structures, it creates a color-match, which is known as 'a chameleon effect'. In this study, series of co-monomer mixtures were prepared with an increasing refraction index (RI) and mixed with glass fillers. The aim of this study was to optimize the mismatch of RI of resin/fillers to create the chameleon effect.</p><p><strong>Materials and methods: </strong>BisGMA/TEGDMA resins were prepared with seven different mix fractions from 20 to 80%. Two different series (A&B) of submicron (Ø 0.7 μm) silanized fillers (70 wt%) (A: Schott RI = 1.53, B: Esschem RI = 1.54) were mixed with resins (30 wt%). Disc-shaped specimens (1 mm thickness, Ø10 mm) for each composite combination (<i>n</i> = 3) were prepared and light cured for 20 s. Commercial resin composite (OmniChroma, Tokuyama Dental) was used as control. The translucency parameter (TP) was measured using a spectrophotometer. The color matching abilities of the experimental composites were visually analyzed. Data were statistically analyzed using ANOVA.</p><p><strong>Results: </strong>The composition of resin and type of fillers had a statistically significant effect on TP values (<i>p</i> < .05). The highest TP values were achieved around 50%-50% fractions of Bis-GMA and TEGDMA for series A and around 60%-40% fraction of Bis-GMA and TEGDMA for series B. Data showed that a high or low fraction of BisGMA resulted in a low translucent composite. Experimental resin composite (80% Bis-GMA) from series A was behaving similarly to Omnichroma in reference to TP values and color matching.</p><p><strong>Conclusions: </strong>Including fillers with RI of 1.53 into BisGMA/TEGDMA resin with RI of 1.524 resulted in composite resin providing a good color match with surrounding structure 'chameleon effect'.</p>","PeriodicalId":72378,"journal":{"name":"Biomaterial investigations in dentistry","volume":" ","pages":"48-53"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/26415275.2021.1906879","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38875147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Studies of the early stages of the dynamic setting process of chemically activated restorative glass-ionomer cements.","authors":"Fernanda M Tsuzuki,&nbsp;Renata C Pascotto,&nbsp;Luis C Malacarne,&nbsp;Antonio C Bento,&nbsp;Antonio Medina Neto,&nbsp;Lidiane Vizioli de Castro-Hoshino,&nbsp;Monique Souza,&nbsp;John W Nicholson,&nbsp;Mauro L Baesso","doi":"10.1080/26415275.2021.1898964","DOIUrl":"https://doi.org/10.1080/26415275.2021.1898964","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the early stages of the setting process of chemically activated restorative glass-ionomer cements (GICs).</p><p><strong>Material and methods: </strong>Five GICs were evaluated (<i>n</i> = 5): Equia Forte (GC), Equia Forte HT (GC), Ketac Universal (3M ESPE), Maxxion R (FGM) and Riva Self Cure (SDI) by Thermography, Fourier Transform Infrared Attenuated Total Reflectance Spectroscopy (FTIR-ATR) and Gillmore needle indentation mechanical testing. The FTIR-ATR spectra showed the formation of metal carboxylates within the cements and enabled the stabilization time (ST) to be determined and the thermographic camera measured the temperature field images in the sample. Data were statistically analyzed by ANOVA and Tukey-Kramer (<i>α</i> = 5%).</p><p><strong>Results: </strong>The Gillmore needle test showed that the order of hardening was opposite to the order of ST values determined by FTIR. The results with the thermographic camera showed two stages of temperature variation, which coincided with the evolution of specific infrared bands. The exception was Maxxion R, which showed only a single step change in temperature.</p><p><strong>Conclusion: </strong>The early stages of the GIC setting reaction show temperature changes, both endothermic and exothermic, at specific times, confirming the occurrence of individual chemical reactions. The early setting involves reactions other than carboxylate formation.<b>Significance</b>: This study gives further detail of the early stages of the setting of GICs, and past research regarding the setting reaction of GIC.</p>","PeriodicalId":72378,"journal":{"name":"Biomaterial investigations in dentistry","volume":" ","pages":"39-47"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/26415275.2021.1898964","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38875146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of laboratory adhesion studies in eroded enamel and dentin: a scoping review.","authors":"Madalena Belmar da Costa, António H S Delgado, Teresa Pinheiro de Melo, Tomás Amorim, Ana Mano Azul","doi":"10.1080/26415275.2021.1884558","DOIUrl":"10.1080/26415275.2021.1884558","url":null,"abstract":"<p><strong>Aim: </strong>To summarize and report laboratory studies of adhesion in eroded substrates, which used bond strength as an outcome measure. To determine the strategies available to overcome bonding difficulties, the quality and consistency of the methodology and to find evidence gaps.</p><p><strong>Materials and methods: </strong>The present review followed PRISMA-ScR guidelines. A search was conducted on PubMed/Medline, Scopus and EMBASE (Ovid) databases to identify published peer-reviewed papers (2010-2020). For final qualitative synthesis, 29 articles were selected which respected the inclusion criteria. Data charting was carried out, independently, by two reviewers and quality assessment of the articles was performed.</p><p><strong>Results: </strong>The primary studies included fall into four major categories: comparison of restorative materials and application modes, enzymatic inhibitors, surface pretreatments or remineralization strategies. Most studies found evaluated dentin (76%), while 17% evaluated enamel, and 7% evaluated both substrates. The majority of the studies reported an effective intervention (83%). Bond strength to eroded dentin is significantly reduced, while in enamel erosion is beneficial. The bond strength to eroded dentin is material-dependent and favored in systems containing 10-MDP. Great disparities among the erosion models used were found, with citric acid in different concentrations being the preferred method, although standardization is lacking.</p><p><strong>Conclusions: </strong>Adhesives containing 10-MDP show beneficial results in eroded dentin, and surface preparation methods should be considered. Studies which evaluated adhesion to eroded enamel/dentin show high heterogeneity in what concerns aims and methodology. Strategies that focus on remineralizing dentin and strategies to protect bond longevity in this substrate require further research.</p>","PeriodicalId":72378,"journal":{"name":"Biomaterial investigations in dentistry","volume":" ","pages":"24-38"},"PeriodicalIF":0.0,"publicationDate":"2021-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25403292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of fluoride varnish on glass ionomer microhardness changes in endogenous acid erosion challenge.","authors":"Fatemeh Moharramkhani,&nbsp;Ladan Ranjbar Omrani,&nbsp;Mahdi Abbasi,&nbsp;Mohammad Javad Kharrazifard,&nbsp;Elham Ahmadi","doi":"10.1080/26415275.2021.1880907","DOIUrl":"https://doi.org/10.1080/26415275.2021.1880907","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to assess the effect of fluoride varnish on glass ionomer microhardness changes after endogenous acid erosion challenge.</p><p><strong>Methodology: </strong>In this study, 40 conventional glass ionomer (CGI; Fuji IX) and 40 resin-modified glass ionomer (RMGI; Fuji IILC) discs were fabricated and divided into 4 subgroups (<i>n</i> = 10) for immersion in synthetic gastric acid or saliva for 27 h with/without fluoride varnish application. The surface microhardness was measured at baseline and after immersion, and the change in microhardness was calculated. Data were analyzed using analysis of variance and T-test.</p><p><strong>Results: </strong>A reduction in microhardness was noted in all subgroups following immersion. The lowest change in microhardness of both CGI and RMGI occurred in artificial saliva. In CGI groups, the highest reduction in microhardness occurred in synthetic gastric acid with fluoride varnish application, and the reduction was significantly different from that of the CGI group with fluoride varnish application (<i>p</i> value = .01). In RMGI groups, the highest reduction in microhardness was noted in synthetic gastric acid without fluoride varnish application, and the reduction was significantly different from that of the other groups (<i>p</i> value < .05).</p><p><strong>Conclusions: </strong>Exposure to synthetic gastric acid caused a significant reduction in microhardness of RMGI. Varnish application significantly decreased the acid susceptibility of RMGI, but not that of CGI.</p>","PeriodicalId":72378,"journal":{"name":"Biomaterial investigations in dentistry","volume":"8 1","pages":"18-23"},"PeriodicalIF":0.0,"publicationDate":"2021-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/26415275.2021.1880907","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10292691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of resin cement on color stability of ceramic veneers: <i>in vitro</i> study.","authors":"Maryam Hoorizad,&nbsp;Sara Valizadeh,&nbsp;Haleh Heshmat,&nbsp;Seyedeh Farnaz Tabatabaei,&nbsp;Tahereh Shakeri","doi":"10.1080/26415275.2020.1855077","DOIUrl":"https://doi.org/10.1080/26415275.2020.1855077","url":null,"abstract":"<p><strong>Statement of the problem: </strong>Long-term success of ceramic veneers depends on the color stability of resin cement used for their cementation. Color change of cement may be seen through the ceramic and compromise esthetics.</p><p><strong>Purpose: </strong>This study aimed to compare the color change of two resin cements and their visibility through the ceramic veneers after accelerated artificial aging.</p><p><strong>Materials and methods: </strong>In this <i>in vitro</i> study, color change (ΔE) was measured in the following groups (<i>n</i> = 10) before and after accelerated artificial aging: group 1, IPS e.max press high translucent ceramic discs; groups 2, Variolink NLC resin cement discs; group 3, Choice 2 resin cement discs; groups 4, Variolink NLC discs bonded to e.max ceramic discs; group 5, Choice 2 disc bonded to e.max ceramic discs. Color change was measured using a spectrophotometer according to International Commission on Illumination Lab (CIELab). Data were analyzed using one-way ANOVA and Tukey's post-hoc test.</p><p><strong>Results: </strong>Group 2 showed the highest (Δ<i>E</i> = 10.4 ± 0.9) and group 1 the lowest (Δ<i>E</i> = 0.9 ± 0.4) color change. The color change of Variolink was significantly greater than Choice 2 either alone (<i>p</i> < .001) or through the ceramic discs (<i>p</i> < .004). The color change of both cements was lower through the ceramic veneer and this reduction was statistically significant (<i>p</i> < .001).</p><p><strong>Conclusion: </strong>Noticeable color change may be expected in areas of cement exposure for both cements studied. Also, in case of using Variolink cement, the color change may be seen through the ceramic veneers.</p>","PeriodicalId":72378,"journal":{"name":"Biomaterial investigations in dentistry","volume":" ","pages":"11-17"},"PeriodicalIF":0.0,"publicationDate":"2021-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/26415275.2020.1855077","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25342985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can maxilla and mandible bone quality explain differences in orthodontic mini-implant failures?","authors":"Omar Melendres Ugarte,&nbsp;Ivan Onone Gialain,&nbsp;Naor Maldonado de Carvalho,&nbsp;Gisele Lie Fukuoka,&nbsp;Rafael Yague Ballester,&nbsp;Paolo Maria Cattaneo,&nbsp;Marina Guimarães Roscoe,&nbsp;Josete Barbosa Cruz Meira","doi":"10.1080/26415275.2020.1863155","DOIUrl":"https://doi.org/10.1080/26415275.2020.1863155","url":null,"abstract":"<p><p><b>Purpose:</b> This study aimed to compare the risk of orthodontic mini-implant (OMI) failure between maxilla and mandible. A critical analysis of finite-element studies was used to explain the contradiction of the greatest clinical success for OMIs placed in the maxilla, despite the higher quality bone of mandible. <b>Materials and Methods:</b> Four tridimensional FE models were built, simulating an OMI inserted in a low-dense maxilla, control maxilla, control mandible, and high-dense mandible. A horizontal force was applied to simulate an anterior retraction of 2 N (clinical scenario) and 10 N (overloading condition). The intra-bone OMI displacement and the major principal bone strains were used to evaluate the risk of failure due to insufficient primary stability or peri-implant bone resorption. <b>Results:</b> The OMI displacement was far below the 50-100 µm threshold, suggesting that the primary stability would be sufficient in all models. However, the maxilla was more prone to lose its stability due to overload conditions, especially in the low-dense condition, in which major principal bone strains surpassed the pathologic bone resorption threshold of 3000 µstrain. <b>Conclusions:</b> The differences in orthodontic mini-implant failures cannot be explained by maxilla and mandible bone quality in finite-element analysis that does not incorporate the residual stress due to OMI insertion.</p>","PeriodicalId":72378,"journal":{"name":"Biomaterial investigations in dentistry","volume":" ","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2021-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/26415275.2020.1863155","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25316978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of mineral trioxide aggregate on osteo/odontogenic potential of mesenchymal stem cells: a comprehensive and systematic literature review.","authors":"Danial Babaki, Sanam Yaghoubi, Maryam M Matin","doi":"10.1080/26415275.2020.1848432","DOIUrl":"10.1080/26415275.2020.1848432","url":null,"abstract":"<p><p>The significance of dental materials in dentin-pulp complex tissue engineering is undeniable. The mechanical properties and bioactivity of mineral trioxide aggregate (MTA) make it a promising biomaterial for future stem cell-based endodontic therapies. There are numerous <i>in vitro</i> studies suggesting the low cytotoxicity of MTA towards various types of cells. Moreover, it has been shown that MTA can enhance mesenchymal stem cells' (MSCs) osteo/odontogenic ability. According to the preferred reporting items for systematic reviews and meta-analyses (PRISMA), a literature review was conducted in the Medline, PubMed, and Scopus databases. Among the identified records, the cytotoxicity and osteo/odontoblastic potential of MTA or its extract on stem cells were investigated. Previous studies have discovered the differentiation-inducing potential of MTA on MSCs, providing a background for dentin-pulp complex cell therapies using the MTA, however, animal trials are needed before moving into clinical trials. In conclusion, MTA can be a promising candidate dental biomaterial for futuristic stem cell-based endodontic therapies.</p>","PeriodicalId":72378,"journal":{"name":"Biomaterial investigations in dentistry","volume":"7 1","pages":"175-185"},"PeriodicalIF":0.0,"publicationDate":"2020-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7717865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38706114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}