Bioelectronic medicine最新文献_第10页

The Fourth Bioelectronic Medicine Summit "Technology Targeting Molecular Mechanisms": current progress, challenges, and charting the future. 第四届生物电子医学峰会 "针对分子机制的技术"：当前进展、挑战和未来展望。

Bioelectronic medicine Pub Date : 2021-05-24 DOI: 10.1186/s42234-021-00068-6

Timir Datta-Chaudhuri, Theodoros Zanos, Eric H Chang, Peder S Olofsson, Stephan Bickel, Chad Bouton, Daniel Grande, Loren Rieth, Cynthia Aranow, Ona Bloom, Ashesh D Mehta, Gene Civillico, Molly M Stevens, Eric Głowacki, Christopher Bettinger, Martin Schüettler, Chris Puleo, Robert Rennaker, Saroj Mohanta, Daniela Carnevale, Silvia V Conde, Bruno Bonaz, David Chernoff, Suraj Kapa, Magnus Berggren, Kip Ludwig, Stavros Zanos, Larry Miller, Doug Weber, Daniel Yoshor, Lawrence Steinman, Sangeeta S Chavan, Valentin A Pavlov, Yousef Al-Abed, Kevin J Tracey

{"title":"The Fourth Bioelectronic Medicine Summit \"Technology Targeting Molecular Mechanisms\": current progress, challenges, and charting the future.","authors":"Timir Datta-Chaudhuri, Theodoros Zanos, Eric H Chang, Peder S Olofsson, Stephan Bickel, Chad Bouton, Daniel Grande, Loren Rieth, Cynthia Aranow, Ona Bloom, Ashesh D Mehta, Gene Civillico, Molly M Stevens, Eric Głowacki, Christopher Bettinger, Martin Schüettler, Chris Puleo, Robert Rennaker, Saroj Mohanta, Daniela Carnevale, Silvia V Conde, Bruno Bonaz, David Chernoff, Suraj Kapa, Magnus Berggren, Kip Ludwig, Stavros Zanos, Larry Miller, Doug Weber, Daniel Yoshor, Lawrence Steinman, Sangeeta S Chavan, Valentin A Pavlov, Yousef Al-Abed, Kevin J Tracey","doi":"10.1186/s42234-021-00068-6","DOIUrl":"10.1186/s42234-021-00068-6","url":null,"abstract":"There is a broad and growing interest in Bioelectronic Medicine, a dynamic field that continues to generate new approaches in disease treatment. The fourth bioelectronic medicine summit \"Technology targeting molecular mechanisms\" took place on September 23 and 24, 2020. This virtual meeting was hosted by the Feinstein Institutes for Medical Research, Northwell Health. The summit called international attention to Bioelectronic Medicine as a platform for new developments in science, technology, and healthcare. The meeting was an arena for exchanging new ideas and seeding potential collaborations involving teams in academia and industry. The summit provided a forum for leaders in the field to discuss current progress, challenges, and future developments in Bioelectronic Medicine. The main topics discussed at the summit are outlined here.","PeriodicalId":72363,"journal":{"name":"Bioelectronic medicine","volume":" ","pages":"7"},"PeriodicalIF":0.0,"publicationDate":"2021-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8142479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38927738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Progress and challenges of implantable neural interfaces based on nature-derived materials. 基于自然衍生材料的植入式神经接口的进展和挑战。

Bioelectronic medicine Pub Date : 2021-04-27 DOI: 10.1186/s42234-021-00067-7

Eugenio Redolfi Riva, Silvestro Micera

{"title":"Progress and challenges of implantable neural interfaces based on nature-derived materials.","authors":"Eugenio Redolfi Riva, Silvestro Micera","doi":"10.1186/s42234-021-00067-7","DOIUrl":"10.1186/s42234-021-00067-7","url":null,"abstract":"Neural interfaces are bioelectronic devices capable of stimulating a population of neurons or nerve fascicles and recording electrical signals in a specific area. Despite their success in restoring sensory-motor functions in people with disabilities, their long-term exploitation is still limited by poor biocompatibility, mechanical mismatch between the device and neural tissue and the risk of a chronic inflammatory response upon implantation.In this context, the use of nature-derived materials can help address these issues. Examples of these materials, such as extracellular matrix proteins, peptides, lipids and polysaccharides, have been employed for decades in biomedical science. Their excellent biocompatibility, biodegradability in the absence of toxic compound release, physiochemical properties that are similar to those of human tissues and reduced immunogenicity make them outstanding candidates to improve neural interface biocompatibility and long-term implantation safety. The objective of this review is to highlight progress and challenges concerning the impact of nature-derived materials on neural interface design. The use of these materials as biocompatible coatings and as building blocks of insulation materials for use in implantable neural interfaces is discussed. Moreover, future perspectives are presented to show the increasingly important uses of these materials for neural interface fabrication and their possible use for other applications in the framework of neural engineering.","PeriodicalId":72363,"journal":{"name":"Bioelectronic medicine","volume":" ","pages":"6"},"PeriodicalIF":0.0,"publicationDate":"2021-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s42234-021-00067-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38831656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

How artificial intelligence can help us 'Choose Wisely'. 人工智能如何帮助我们“明智地选择”。

Bioelectronic medicine Pub Date : 2021-04-21 DOI: 10.1186/s42234-021-00066-8

Nishila Mehta, Karen Born, Benjamin Fine

引用次数: 2

Neuroimaging evaluation of deep brain stimulation in the treatment of representative neurodegenerative and neuropsychiatric disorders. 脑深部刺激治疗代表性神经退行性和神经精神疾病的神经影像学评价。

Bioelectronic medicine Pub Date : 2021-03-30 DOI: 10.1186/s42234-021-00065-9

Shichun Peng, Vijay Dhawan, David Eidelberg, Yilong Ma

{"title":"Neuroimaging evaluation of deep brain stimulation in the treatment of representative neurodegenerative and neuropsychiatric disorders.","authors":"Shichun Peng, Vijay Dhawan, David Eidelberg, Yilong Ma","doi":"10.1186/s42234-021-00065-9","DOIUrl":"https://doi.org/10.1186/s42234-021-00065-9","url":null,"abstract":"Brain stimulation technology has become a viable modality of reversible interventions in the effective treatment of many neurological and psychiatric disorders. It is aimed to restore brain dysfunction by the targeted delivery of specific electronic signal within or outside the brain to modulate neural activity on local and circuit levels. Development of therapeutic approaches with brain stimulation goes in tandem with the use of neuroimaging methodology in every step of the way. Indeed, multimodality neuroimaging tools have played important roles in target identification, neurosurgical planning, placement of stimulators and post-operative confirmation. They have also been indispensable in pre-treatment screen to identify potential responders and in post-treatment to assess the modulation of brain circuitry in relation to clinical outcome measures. Studies in patients to date have elucidated novel neurobiological mechanisms underlying the neuropathogenesis, action of stimulations, brain responses and therapeutic efficacy. In this article, we review some applications of deep brain stimulation for the treatment of several diseases in the field of neurology and psychiatry. We highlight how the synergistic combination of brain stimulation and neuroimaging technology is posed to accelerate the development of symptomatic therapies and bring revolutionary advances in the domain of bioelectronic medicine.","PeriodicalId":72363,"journal":{"name":"Bioelectronic medicine","volume":" ","pages":"4"},"PeriodicalIF":0.0,"publicationDate":"2021-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s42234-021-00065-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25530504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Effect of defibrillation on the performance of an implantable vagus nerve stimulation system. 除颤对植入式迷走神经刺激系统性能的影响。

Bioelectronic medicine Pub Date : 2021-03-16 DOI: 10.1186/s42234-021-00064-w

Imad Libbus, Scott R Stubbs, Scott T Mazar, Scott Mindrebo, Bruce H KenKnight, Lorenzo A DiCarlo

{"title":"Effect of defibrillation on the performance of an implantable vagus nerve stimulation system.","authors":"Imad Libbus, Scott R Stubbs, Scott T Mazar, Scott Mindrebo, Bruce H KenKnight, Lorenzo A DiCarlo","doi":"10.1186/s42234-021-00064-w","DOIUrl":"10.1186/s42234-021-00064-w","url":null,"abstract":"Background: Vagus Nerve Stimulation (VNS) delivers Autonomic Regulation Therapy (ART) for heart failure (HF), and has been associated with improvement in cardiac function and heart failure symptoms. VNS is delivered using an implantable pulse generator (IPG) and lead with electrodes placed around the cervical vagus nerve. Because HF patients may receive concomitant cardiac defibrillation therapy, testing was conducted to determine the effect of defibrillation (DF) on the VNS system.Methods: DF testing was conducted on three ART IPGs (LivaNova USA, Inc.) according to international standard ISO14708-1, which evaluated whether DF had any permanent effects on the system. Each IPG was connected to a defibrillation pulse generator and subjected to a series of high-energy pulses.Results: The specified series of pulses were successfully delivered to each of the three devices. All three IPGs passed factory electrical tests, and interrogation confirmed that software and data were unchanged from the pre-programmed values. No shifts in parameters or failures were observed.Conclusions: Implantable VNS systems were tested for immunity to defibrillation, and were found to be unaffected by a series of high-energy defibrillation pulses. These results suggest that this VNS system can be used safely and continue to function after patients have been defibrillated.","PeriodicalId":72363,"journal":{"name":"Bioelectronic medicine","volume":" ","pages":"3"},"PeriodicalIF":0.0,"publicationDate":"2021-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7962382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25480669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changing the tune using bioelectronics. 利用生物电子学改变曲调。

Bioelectronic medicine Pub Date : 2021-02-23 DOI: 10.1186/s42234-021-00063-x

Eric H Chang

引用次数: 5

Cut wires: The Electrophysiology of Regenerated Tissue. 断线:再生组织的电生理学。

Bioelectronic medicine Pub Date : 2021-02-23 DOI: 10.1186/s42234-021-00062-y

Alexis L Lowe, Nitish V Thakor

{"title":"Cut wires: The Electrophysiology of Regenerated Tissue.","authors":"Alexis L Lowe, Nitish V Thakor","doi":"10.1186/s42234-021-00062-y","DOIUrl":"https://doi.org/10.1186/s42234-021-00062-y","url":null,"abstract":"When nerves are damaged by trauma or disease, they are still capable of firing off electrical command signals that originate from the brain. Furthermore, those damaged nerves have an innate ability to partially regenerate, so they can heal from trauma and even reinnervate new muscle targets. For an amputee who has his/her damaged nerves surgically reconstructed, the electrical signals that are generated by the reinnervated muscle tissue can be sensed and interpreted with bioelectronics to control assistive devices or robotic prostheses. No two amputees will have identical physiologies because there are many surgical options for reconstructing residual limbs, which may in turn impact how well someone can interface with a robotic prosthesis later on. In this review, we aim to investigate what the literature has to say about different pathways for peripheral nerve regeneration and how each pathway can impact the neuromuscular tissue's final electrophysiology. This information is important because it can guide us in planning the development of future bioelectronic devices, such as prosthetic limbs or neurostimulators. Future devices will primarily have to interface with tissue that has undergone some natural regeneration process, and so we have explored and reported here what is known about the bioelectrical features of neuromuscular tissue regeneration.","PeriodicalId":72363,"journal":{"name":"Bioelectronic medicine","volume":" ","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2021-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s42234-021-00062-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25400492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abstracts from the Fourth Bioelectronic Medicine Summit: Technology Targeting Molecular Mechanisms : BEM, Virtual, 23-24 September 2020. 第四届生物电子医学峰会:靶向分子机制的技术:BEM，虚拟，2020年9月23日至24日。

Bioelectronic medicine Pub Date : 2020-12-23 DOI: 10.1186/s42234-020-00060-6

引用次数: 2

Immunity and the carotid body: implications for metabolic diseases. 免疫与颈动脉体：对代谢性疾病的影响。

Bioelectronic medicine Pub Date : 2020-12-23 DOI: 10.1186/s42234-020-00061-5

Silvia V Conde, Joana F Sacramento, Fatima O Martins

{"title":"Immunity and the carotid body: implications for metabolic diseases.","authors":"Silvia V Conde, Joana F Sacramento, Fatima O Martins","doi":"10.1186/s42234-020-00061-5","DOIUrl":"10.1186/s42234-020-00061-5","url":null,"abstract":"Neuro-immune communication has gained enormous interest in recent years due to increasing knowledge of the way in which the brain coordinates functional alterations in inflammatory and autoimmune responses, and the mechanisms of neuron-immune cell interactions in the context of metabolic diseases such as obesity and type 2 diabetes. In this review, we will explain how this relationship between the nervous and immune system impacts the pro- and anti-inflammatory pathways with specific reference to the hypothalamus-pituitary-adrenal gland axis and the vagal reflex and will explore the possible involvement of the carotid body (CB) in the neural control of inflammation. We will also highlight the mechanisms of vagal anti-inflammatory reflex control of immunity and metabolism, and the consequences of functional disarrangement of this reflex in settlement and development of metabolic diseases, with special attention to obesity and type 2 diabetes. Additionally, the role of CB in the interplay between metabolism and immune responses will be discussed, with specific reference to the different stimuli that promote CB activation and the balance between sympathetic and parasympathetic in this context. In doing so, we clarify the multivarious neuronal reflexes that coordinate tissue-specific responses (gut, pancreas, adipose tissue and liver) critical to metabolic control, and metabolic disease settlement and development. In the final section, we will summarize how electrical modulation of the carotid sinus nerve may be utilized to adjust these reflex responses and thus control inflammation and metabolic diseases, envisioning new therapeutics horizons.","PeriodicalId":72363,"journal":{"name":"Bioelectronic medicine","volume":"6 1","pages":"24"},"PeriodicalIF":0.0,"publicationDate":"2020-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39079093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Recent progress on peripheral neural interface technology towards bioelectronic medicine. 外周神经接口技术在生物电子医学中的研究进展。

Bioelectronic medicine Pub Date : 2020-11-30 DOI: 10.1186/s42234-020-00059-z

Youngjun Cho, Jaeu Park, Chengkuo Lee, Sanghoon Lee

{"title":"Recent progress on peripheral neural interface technology towards bioelectronic medicine.","authors":"Youngjun Cho, Jaeu Park, Chengkuo Lee, Sanghoon Lee","doi":"10.1186/s42234-020-00059-z","DOIUrl":"https://doi.org/10.1186/s42234-020-00059-z","url":null,"abstract":"Modulation of the peripheral nervous system (PNS) has a great potential for therapeutic intervention as well as restore bodily functions. Recent interest has focused on autonomic nerves, as they regulate extensive functions implicated in organ physiology, chronic disease state and appear tractable to targeted modulation of discrete nerve units. Therapeutic interventions based on specific bioelectronic neuromodulation depend on reliable neural interface to stimulate and record autonomic nerves. Furthermore, the function of stimulation and recording requires energy which should be delivered to the interface. Due to the physiological and anatomical challenges of autonomic nerves, various forms of this active neural interface need to be developed to achieve next generation of neural interface for bioelectronic medicine. In this article, we present an overview of the state-of-the-art for peripheral neural interface technology in relation to autonomic nerves. Also, we reveal the current status of wireless neural interface for peripheral nerve applications. Recent studies of a novel concept of self-sustainable neural interface without battery and electronic components are presented. Finally, the recent results of non-invasive stimulation such as ultrasound and magnetic stimulation are covered and the perspective of the future research direction is provided.","PeriodicalId":72363,"journal":{"name":"Bioelectronic medicine","volume":"6 1","pages":"23"},"PeriodicalIF":0.0,"publicationDate":"2020-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s42234-020-00059-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38687541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 28