Bioelectronic medicine最新文献

{"title":"Efficacy and mechanisms of neuromodulation in the treatment of irritable bowel syndrome.","authors":"Kaijie Wang, Md Jahangir Alam, Xinya Lan, Fei Li, Jiande D Z Chen","doi":"10.1186/s42234-025-00186-5","DOIUrl":"10.1186/s42234-025-00186-5","url":null,"abstract":"<p><p>Disorders of gut-brain interaction (DGBI), including irritable bowel syndrome (IBS), have a significant impact on patients, reducing their quality of life and work efficiency. Pharmacological therapy is primarily used as a frontline treatment option for treating IBS. However, owing to the heterogeneous characteristics of IBS and its limited pathophysiological understanding, pharmacological therapy is rather disappointing. Therefore, patients with IBS often use alternative therapies, such as electrical neuromodulation, to treat IBS-related symptoms. Neuromodulation includes invasive and noninvasive methods via implanted electrodes and transcutaneous electrodes, respectively. In this manuscript, we reviewed the therapeutic effects of several electrical neuromodulation approaches, including sacral nerve stimulation, spinal cord stimulation, auricular vagal nerve stimulation, and transcutaneous electrical acustimulation, on the symptoms of IBS. Additionally, we discussed the potential mechanisms, adverse effects, advantages, and disadvantages of different neuromodulation treatment methods.</p>","PeriodicalId":72363,"journal":{"name":"Bioelectronic medicine","volume":"11 1","pages":"23"},"PeriodicalIF":0.0,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145194038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioelectronic medicine: wearable and implantable electronics.","authors":"Enming Song, Wouter A Serdijn","doi":"10.1186/s42234-025-00185-6","DOIUrl":"10.1186/s42234-025-00185-6","url":null,"abstract":"","PeriodicalId":72363,"journal":{"name":"Bioelectronic medicine","volume":"11 1","pages":"22"},"PeriodicalIF":0.0,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12447594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145088449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-system benefits of non-invasive spinal cord stimulation following cervical spinal cord injury: a case study.","authors":"Soshi Samejima, Claire Shackleton, Raza N Malik, Ali Hosseinzadeh, Lucas Rempel, Anh-Duong Phan, Alison Williams, Tom Nightingale, Amandeep Ghuman, Stacy Elliott, Matthias Walter, Klaus Krogh, Michael Berger, Tania Lam, Rahul Sachdeva, Andrei V Krassioukov","doi":"10.1186/s42234-025-00183-8","DOIUrl":"10.1186/s42234-025-00183-8","url":null,"abstract":"","PeriodicalId":72363,"journal":{"name":"Bioelectronic medicine","volume":"11 1","pages":"20"},"PeriodicalIF":0.0,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12412244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145002007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Clinical evaluation of a novel disposable neurostimulator used to accelerate regeneration of injured peripheral nerves in the hand.","authors":"Christopher J Coroneos, Carolyn Levis, Michael P Willand, Katelyn Jw So, James R Bain","doi":"10.1186/s42234-025-00184-7","DOIUrl":"10.1186/s42234-025-00184-7","url":null,"abstract":"","PeriodicalId":72363,"journal":{"name":"Bioelectronic medicine","volume":"11 1","pages":"21"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12400661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A scoping review of neuromodulation techniques for controlling blood pressure: what are the ups and downs to this approach?","authors":"Peter L Greechan, Ryan G L Koh, Paul B Yoo","doi":"10.1186/s42234-025-00181-w","DOIUrl":"10.1186/s42234-025-00181-w","url":null,"abstract":"<p><strong>Background and objectives: </strong>While there has been rapid progress in research aimed at developing device-based neuromodulation therapies for blood pressure (BP) disorders, there is a paucity of FDA-approved therapies. Currently, the only approved devices for treating resistant hypertension use renal denervation, however, this could soon change as clinical research progresses. With the evolution of interventional strategies for BP regulation, it is important to comprehend the developments to date in order to gauge directions for future research. The objective of this scoping review was to provide the current range of device-based BP neuromodulation approaches, overview salient characteristics of the included studies, address limitations, and detail avenues of further investigation.</p><p><strong>Methods: </strong>Our review was conducted using the Preferred Reporting Items for Reviews and and Meta-analysis framework. The literature search was performed across the Web of Science Core Collection, Scopus, and Pubmed databases. The search yielded 3503 studies, of which 100 studies remained following the screening process. In the last 10 years, there has been an increase in the number of experimental neurostimulation studies detailing increases and decreases in BP. Of all the included studies, most adopted a non-randomized experimental approach (89%), used animal participants (65%), used invasive neuromodulation methods (74%), and performed acute experiments (84%). More studies documented only depressor responses (49%) compared to pressor responses (35%), and 13% reported both pressor and depressor responses using multiple neural targets.</p><p><strong>Conclusions: </strong>This review addressed developments in device-based BP neuromodulation, highlighting a dominant focus on treating resistant hypertension compared to hypotensive disorders. While advancements in implantable electrodes have improved spatial selectivity of stimulation, non-invasive neurostimulation devices have become increasingly popular in recent years.</p>","PeriodicalId":72363,"journal":{"name":"Bioelectronic medicine","volume":"11 1","pages":"19"},"PeriodicalIF":0.0,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12355777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of electrical stimulation in bone regeneration: mechanistic insights and therapeutic advances.","authors":"Samira Farjaminejad, Aaron M Dingle","doi":"10.1186/s42234-025-00180-x","DOIUrl":"10.1186/s42234-025-00180-x","url":null,"abstract":"<p><p>Bone regeneration is a complex biological process that involves the coordinated action of osteoblasts, osteoclasts, and mesenchymal stem cells (MSCs). While bone possesses an intrinsic ability to heal, large defects, delayed unions, and non-unions require advanced therapeutic interventions. Electrical stimulation (ES) has emerged as a promising strategy to enhance bone healing by modulating cellular activity, promoting osteogenic differentiation, and accelerating vascularization. This review explores the mechanistic role of bioelectrical cues in bone regeneration, emphasizing the influence of voltage-gated ion channels, particularly voltage-gated calcium channels (VGCCs), in transducing electrical signals into biochemical responses. Various types of ES modalities, including direct current (DC), capacitive coupling (CC), Pulsed Electromagnetic Field (PEMF), and piezoelectric stimulation, are evaluated for their effectiveness in clinical and preclinical applications. Additionally, the synergistic potential of ES when combined with biomaterials, stem cells, and growth factors is discussed. Despite promising results, challenges remain in translating preclinical findings to clinical applications, with key hurdles including standardization of treatment protocols, variability in patient responses, and regulatory constraints. Large-animal models have provided insights into the efficacy of ES-based therapies, but limitations in field penetration and treatment reproducibility hinder widespread adoption. Future advancements in bioelectronic medicine, smart scaffolds, and artificial intelligence (AI)-driven personalized therapies hold potential to optimize ES-based bone regeneration. Addressing current limitations through interdisciplinary research will be critical in establishing ES as a mainstream therapeutic approach in orthopedic and maxillofacial regenerative medicine.</p>","PeriodicalId":72363,"journal":{"name":"Bioelectronic medicine","volume":"11 1","pages":"18"},"PeriodicalIF":0.0,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12333126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144801076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-time, neural signal processing for high-density brain-implantable devices.","authors":"Amir M Sodagar, Yousef Khazaei, Mahdi Nekoui, MohammadAli Shaeri","doi":"10.1186/s42234-025-00177-6","DOIUrl":"10.1186/s42234-025-00177-6","url":null,"abstract":"<p><p>Recent advances in the development of intra-cortical neural interfacing devices show the bright horizon of having access to brain-implantable microsystems with extremely high channel counts in the not-so-distant future. With the fabrication of high-density neural interfacing microelectrode arrays, the handling of the neural signals recorded from the brain is becoming the bottleneck in the realization of next generation wireless brain-implantable microsystems with thousands of parallel channels. Even though a spectrum of engineering efforts has been reported for this purpose at both system and circuit levels, it is now apparent that the most effective solution is to resolve this problem at the signal level. Employment of digital signal processing techniques for data reduction or compression has therefore become an inseparable part of the design of a high-density neural recording brain implant. This paper first addresses technical and technological challenges of transferring massive amount of recorded data off high-density neural recording brain implants. It then provides an overview of the 'on-implant signal processing' techniques that have been employed to successfully stream neuronal activities off the brain. What distinguishes this class of signal processing from signal processing in general is the critical importance of hardware efficiency in the implementation of such techniques in terms of power consumption, circuit size, and real-time operation. The focus of this review is on spike detection and extraction, temporal and spatial neural signal compression, and spike sorting.</p>","PeriodicalId":72363,"journal":{"name":"Bioelectronic medicine","volume":"11 1","pages":"17"},"PeriodicalIF":0.0,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12275325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliability and stability of Bioelectronic Medicine: a critical and pedagogical perspective.","authors":"Massimo Mariello","doi":"10.1186/s42234-025-00179-4","DOIUrl":"10.1186/s42234-025-00179-4","url":null,"abstract":"<p><p>Bioelectronic Medicine relies on wearable or implantable electronic devices interfacing with the nervous system and other active tissues, offering innovative therapeutic solutions. However, the long-term reliability and stability of these devices remain critical challenges that must be addressed for widespread clinical adoption. Advances in materials science, device engineering, power management, and biocompatibility are essential to ensure sustained functionality in dynamic biological environments. This perspective highlights key factors affecting the durability, reliability and stability of Bioelectronic Medicine technologies, explores current solutions and emerging approaches, and outlines the necessary steps to achieve robust, long-lasting bioelectronic therapeutics. The personal view expressed in this article is aimed to provide structured, accessible insights that support teaching and learning, and is envisioned to help motivate other investigators to develop further strategies for achieving clinically-relevant ultra-stable bioelectronics.</p>","PeriodicalId":72363,"journal":{"name":"Bioelectronic medicine","volume":"11 1","pages":"16"},"PeriodicalIF":0.0,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12255127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Neuroplasticity via vagus nerve stimulation to improve urinary dysfunction after spinal cord injury: a perspective.","authors":"Mia J Sargusingh, Juliet J A Addo, Margot S Damaser, Philippe Zimmern, Seth A Hays, Ana G Hernandez-Reynoso","doi":"10.1186/s42234-025-00178-5","DOIUrl":"10.1186/s42234-025-00178-5","url":null,"abstract":"<p><p>One problematic and undertreated consequence of spinal cord injury (SCI) is urinary dysfunction. Treatment is usually conservative, involving regulation of fluid intake and scheduled bladder emptying through intermittent catheterization. These interventions provide symptomatic relief but are associated with recurrent urinary tract infections and increased risk of kidney disease. Neuromodulation has been used to counteract aberrant signals, such as bladder overactivity, but has yet to address other symptoms, such as urethral sphincter tonic activity or poor bladder compliance. Combining rehabilitation with vagus nerve stimulation (VNS), which is known to engage neuromodulatory nuclei to promote synaptic neuroplasticity and recovery, has emerged as a potential therapy to restore function after neurological injury including SCI. Our perspective is that a congruent strategy of pairing VNS with bladder function after incomplete SCI can promote neuroplastic changes in spared neural pathways to strengthen neural control of bladder function.</p>","PeriodicalId":72363,"journal":{"name":"Bioelectronic medicine","volume":"11 1","pages":"15"},"PeriodicalIF":0.0,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12181832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144337295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of focused ultrasound neuromodulation of the superior mesenteric plexus on insulin sensitivity and post-operative hyperglycemia in a swine model of surgical stress.","authors":"Weiguo Song, Khaled Qanud, Dane A Thompson, Jared M Huston, Stavros Zanos","doi":"10.1186/s42234-025-00176-7","DOIUrl":"10.1186/s42234-025-00176-7","url":null,"abstract":"<p><p>Metabolic stress during major surgery increases insulin resistance and causes post-operative hyperglycemia (POHG), which may in turn contribute to post-operative morbidity and mortality. Intensive insulin therapy for POHG is often ineffective and may even worsen patient outcomes. Non-invasive focused ultrasound stimulation (FUS) of glucose-sensing abdominal neurons improves glucose metabolism in animal models of diabetes, but its potential role in treating POHG remains unknown. In this study, we explored whether FUS of the superior mesenteric plexus (SMP) alters insulin sensitivity and post-operative fasting blood glucose (FBG) in a swine model of surgical stress-induced POHG. In each of 3 anesthetized animals, FUS targeting the porta hepatis (PH) of the liver or the SMP was delivered and insulin sensitivity was assessed in each case. In another series of experiments, 4 animals received SMP-FUS and 3 sham stimulation, after which surgical stress was induced via small bowel resection. In the 7 surgically operated animals, insulin sensitivity was measured before and after SMP-FUS (or sham), and fasting blood glucose (FBG) was measured before and 16 h after surgery. In all animals, insulin sensitivity was assessed using the hyperinsulinemic-euglycemic clamp (HEC) method. Results: SMP-FUS elicits a greater increase in insulin sensitivity than PH-FUS. On the day of surgery, SMP-FUS increases insulin sensitivity, compared to sham treatment. The day after surgery, surgically operated animals develop mild hyperglycemia. SMP-FUS-treated animals have higher FBG than sham-FUS-treated animals. No clear relationship is observed between FUS-induced changes in insulin sensitivity and next-day FBG. Conclusion: While SMP-FUS improves insulin sensitivity during surgery, it may exacerbate POHG.</p>","PeriodicalId":72363,"journal":{"name":"Bioelectronic medicine","volume":"11 1","pages":"14"},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12175319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}