Atherosclerosis plus最新文献

{"title":"Clinical Service Quality and Unmet Needs in Homozygous Familial Hypercholesterolaemia Patients: Insights from UK Tertiary Centres","authors":"Heleen A. Hussein , Haya Haso , Bilal Bashir , Raabya Pasha , Anoushka Kamath , Maryam Ferdousi , Handrean Soran , Mariamma Baptist , Kirsty Nicholson","doi":"10.1016/j.athplu.2024.08.022","DOIUrl":"10.1016/j.athplu.2024.08.022","url":null,"abstract":"","PeriodicalId":72324,"journal":{"name":"Atherosclerosis plus","volume":"57 ","pages":"Page 5"},"PeriodicalIF":1.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142416448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Total Circulating PCSK9 Positively Correlates with Age and Free Circulating PCSK9 Positively Correlated with Body Mass Index in Healthy Volunteers","authors":"Anoushka Kamath , Maryam Ferdousi , Bilal Bashir , Raabya Pasha , Handrean Soran","doi":"10.1016/j.athplu.2024.08.006","DOIUrl":"10.1016/j.athplu.2024.08.006","url":null,"abstract":"","PeriodicalId":72324,"journal":{"name":"Atherosclerosis plus","volume":"57 ","pages":"Page 8"},"PeriodicalIF":1.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The pro-atherogenic enzyme PAPP-A is active in eluates from human carotid and femoral atherosclerotic plaques","authors":"Mette Faurholdt Gude ,&nbsp;Rikke Hjortebjerg ,&nbsp;Mette Bjerre ,&nbsp;Anne Kathrine Nissen Pedersen ,&nbsp;Claus Oxvig ,&nbsp;Lars Melholt Rasmussen ,&nbsp;Jan Frystyk ,&nbsp;Lasse Steffensen","doi":"10.1016/j.athplu.2024.09.001","DOIUrl":"10.1016/j.athplu.2024.09.001","url":null,"abstract":"<div><h3>Background</h3><p>Pregnancy-associated plasma protein-A (PAPP-A) regulates bioavailability of insulin-like growth factor 1 (IGF1) in various tissues by proteolytic cleavage of a subset of IGF-binding proteins (IGFBPs). Pre-clinical studies have established a role of PAPP-A in atherosclerosis and proposed that targeting the proteolytic activity of PAPP-A has therapeutic value.</p><p>This study aimed to investigate whether human atherosclerotic plaques contain proteolytically active PAPP-A, a prerequisite for further considering PAPP-A as a therapeutic target in patients.</p></div><div><h3>Methods</h3><p>We obtained carotid (<em>n</em> = 9) and femoral (<em>n</em> = 11) atherosclerotic plaques from patients undergoing vascular surgery and incubated freshly harvested plaque tissue in culture media for 24 h. Subsequently, conditioned media were assayed for PAPP-A, STC2, IGFBP4, and IGF1 using immunoassays. Enzymatic activity of PAPP-A was assessed by its ability to process recombinant IGFBP4-IGF1 complexes - a specific substrate of PAPP-A - by Western blotting.</p></div><div><h3>Results</h3><p>PAPP-A and STC2 were detectable in conditioned media from both carotid and femoral plaques, with higher STC2 concentrations in eluates from carotid plaque incubations (<em>p</em> = 0.02). IGFBP4 and IGF1 were undetectable. Conditioned media from all 20 plaques exhibited PAPP-A proteolytic activity. However, no correlation between PAPP-A concentration and its proteolytic activity was observed, whereas the PAPP-A: STC2 molar ratio correlated with PAPP-A activity (R² = 0.25, <em>p</em> = 0.03).</p></div><div><h3>Conclusion</h3><p>This study provides evidence for the presence of enzymatically active PAPP-A in atherosclerotic plaques and underscores the need for further investigating potential beneficial effects associated with targeting PAPP-A in atherosclerotic cardiovascular disease.</p></div>","PeriodicalId":72324,"journal":{"name":"Atherosclerosis plus","volume":"57 ","pages":"Pages 30-36"},"PeriodicalIF":1.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667089524000415/pdfft?md5=f8b0f80011afbf4438f5553d4df43beb&pid=1-s2.0-S2667089524000415-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142163577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ketogenic diet and extreme hypercholesterolaemia: A case of polygenic hypercholesteroalemia","authors":"T. Mazaheri ,&nbsp;A. David ,&nbsp;B. Jones ,&nbsp;J.Cegla","doi":"10.1016/j.athplu.2024.08.007","DOIUrl":"10.1016/j.athplu.2024.08.007","url":null,"abstract":"","PeriodicalId":72324,"journal":{"name":"Atherosclerosis plus","volume":"57 ","pages":"Pages 8-9"},"PeriodicalIF":1.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A New Diagnosis of Familial Chylomicronaemia Syndrome in a 15-Year-Old Male: From Lab to Clinic","authors":"S. Elgerray ∗ ,&nbsp;A. Bruce ,&nbsp;C. Saddington ,&nbsp;L. Kayali ,&nbsp;K. Smith ,&nbsp;H. Divyateja","doi":"10.1016/j.athplu.2024.08.004","DOIUrl":"10.1016/j.athplu.2024.08.004","url":null,"abstract":"","PeriodicalId":72324,"journal":{"name":"Atherosclerosis plus","volume":"57 ","pages":"Page 7"},"PeriodicalIF":1.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142416451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Target gene selection and design of precise base editing therapies for atherosclerotic cardiovascular disease","authors":"F.T. Fiedorek ∗ ,&nbsp;S. Vafai ,&nbsp;A.V. Khera ,&nbsp;T. Lister ,&nbsp;S. Kathiresan ,&nbsp;A.M. Bellinger","doi":"10.1016/j.athplu.2024.08.005","DOIUrl":"10.1016/j.athplu.2024.08.005","url":null,"abstract":"","PeriodicalId":72324,"journal":{"name":"Atherosclerosis plus","volume":"57 ","pages":"Page 8"},"PeriodicalIF":1.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142416452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of statins, ezetimibe and statins-ezetimibe therapies for children and adolescents with heterozygous familial hypercholesterolaemia: Systematic review, pairwise and network meta-analyses of randomised controlled trials","authors":"A. Llewellyn ,&nbsp;M. Simmonds ,&nbsp;D. Marshall ,&nbsp;M. Harden ,&nbsp;B. Woods ,&nbsp;S.E. Humphries ,&nbsp;U. Ramaswami ,&nbsp;L. Priestley-Barnham ,&nbsp;M. Fisher ,&nbsp;L. Tata ,&nbsp;N. Qureshi.","doi":"10.1016/j.athplu.2024.08.017","DOIUrl":"10.1016/j.athplu.2024.08.017","url":null,"abstract":"","PeriodicalId":72324,"journal":{"name":"Atherosclerosis plus","volume":"57 ","pages":"Pages 2-3"},"PeriodicalIF":1.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypertriglyceridaemia and Cardiovascular Autonomic Function in Patients Without Diabetes Mellitus","authors":"Bilal Bashir ,&nbsp;Maryam Ferdousi ,&nbsp;Raabya Pasha ,&nbsp;Anoushka Kamath ,&nbsp;Handrean Soran","doi":"10.1016/j.athplu.2024.08.021","DOIUrl":"10.1016/j.athplu.2024.08.021","url":null,"abstract":"","PeriodicalId":72324,"journal":{"name":"Atherosclerosis plus","volume":"57 ","pages":"Page 4"},"PeriodicalIF":1.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The long-term, real-world effectiveness and safety of lomitapide in homozygous familial hypercholesterolaemia (HoFH): Nine-year data from the Lomitapide Observational Worldwide Evaluation Registry (LOWER)","authors":"Dirk Blom ,&nbsp;Jaimini Cegla ∗ ,&nbsp;James Underberg ,&nbsp;Christopher P. Cannon ,&nbsp;Dominique Larrey ,&nbsp;Lukas Makris ,&nbsp;Sallyann O’Brien","doi":"10.1016/j.athplu.2024.08.014","DOIUrl":"10.1016/j.athplu.2024.08.014","url":null,"abstract":"","PeriodicalId":72324,"journal":{"name":"Atherosclerosis plus","volume":"57 ","pages":"Pages 1-2"},"PeriodicalIF":1.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statin Treatment in Type 1 Diabetes is Not Associated with Diabetic Peripheral Neuropathy","authors":"Raabya Pasha ,&nbsp;Zara Linn ,&nbsp;Alise Kalteniece ,&nbsp;Bilal Bashir ,&nbsp;Anoushka Kamath ,&nbsp;Eirene Kolakaluri ,&nbsp;Mariamma Baptist ,&nbsp;Shazli Azmi ,&nbsp;Maryam Ferdousi ,&nbsp;Rayaz Malik ,&nbsp;Handrean Soran","doi":"10.1016/j.athplu.2024.08.009","DOIUrl":"10.1016/j.athplu.2024.08.009","url":null,"abstract":"","PeriodicalId":72324,"journal":{"name":"Atherosclerosis plus","volume":"57 ","pages":"Page 9"},"PeriodicalIF":1.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}