AsiaIntervention最新文献

{"title":"Temporal profile of right and left ventricular wall deformation analysis using 2D speckle tracking echocardiography following atrial septal defect closure.","authors":"Shahnawaz Ali Ansari, Aditya Kapoor, Arpita Katheria, Harshit Khare, Arshad Nazir, Ankit Sahu, Roopali Khanna, Sudeep Kumar, Surendra Kumar Agarwal, Shantanu Pande, Prabhat Tewari, Bipin Chandra, Naveen Garg, Satyendra Tewari","doi":"10.4244/AIJ-D-25-00027","DOIUrl":"10.4244/AIJ-D-25-00027","url":null,"abstract":"<p><strong>Background: </strong>Analysing temporal strain changes in right ventricular (RV) and left ventricular (LV) walls post-atrial septal defect (ASD) closure is of clinical importance.</p><p><strong>Aims: </strong>We aimed to evaluate acute/short-term changes in RV/LV wall deformation after ASD closure using two-dimensional speckle tracking echocardiography (2D-STE).</p><p><strong>Methods: </strong>A total of 43 patients with ASD and 20 controls had echocardiograms before and after ASD closure.</p><p><strong>Results: </strong>Of the 43 patients with secundum ASD (mean age 27.37 years), 48.8% were closed surgically, while 51.2% underwent device closure. At baseline, LV global longitudinal strain (GLS; 2-chamber view GLS: 16.95% vs 20.73%; p=0.0001, apical long-axis view GLS 16.48% vs 20.90%; p=0.0001, 4-chamber view GLS 16.93% vs 21.56%; p=0.0001, average GLS 16.75% vs 21.31%; p=0.0001) and RV GLS (19.22% vs 24.27%; p=0.0001) were significantly lower in the patients with ASD compared to controls. After closure, the average LV GLS rapidly improved at 24 hours from baseline (16.75% to 17.28%; p=0.004), with sustained increases at 1 and 3 months (18.16% and 19.40%; p=0.001). The mean RV GLS also improved at all serial timepoints (baseline, 24 hrs, 1 month, and 3 months) with values of 19.22%, 19.85%, 20.70%, and 22.23%, respectively (p=0.0001). As compared to surgery, LV GLS and RV GLS were much better in the device group (average LV GLS at 24 hrs, 1 month, and 3 months: 16.54% vs 17.98%, 17.34% vs 18.92%, and 18.80% vs 19.96%, respectively; mean RV GLS at 24 hrs, 1, and 3 months: 17.83% vs 21.78%, 18.73% vs 22.58%, and 20.70% vs 23.70%, respectively).</p><p><strong>Conclusions: </strong>This GLS study demonstrates significant reverse remodelling of both the RV and LV after ASD closure. Device closure was associated with superior strain rate recovery compared to surgery at the 3-month midterm follow-up.</p>","PeriodicalId":72310,"journal":{"name":"AsiaIntervention","volume":"11 3","pages":"190-198"},"PeriodicalIF":0.0,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12494086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical evaluation of the Hydra self-expanding THV: 30-day results from the GENESIS-II study.","authors":"Nagendra Boopathy Senguttuvan, John Jose, Anmol Sonawane, Sandeep Bansal, Rahul Gupta, Praveen Chandra","doi":"10.4244/AIJ-D-24-00075","DOIUrl":"10.4244/AIJ-D-24-00075","url":null,"abstract":"<p><strong>Background: </strong>The Hydra transcatheter heart valve (THV) utilised in the GENESIS-II study is equipped with an active release mechanism for tentacle deployment, distinguishing it from the Hydra THV used in earlier studies.</p><p><strong>Aims: </strong>The primary objective of the GENESIS-II study is to assess the ongoing safety and performance of the Hydra THV in treating severe aortic stenosis in patients deemed at high surgical risk.</p><p><strong>Methods: </strong>This is a prospective, multicentre, non-randomised, investigational study conducted between November 2021 and November 2023. The study enrolled a total of 40 patients exhibiting high surgical risk and symptomatic severe aortic stenosis from 19 sites across India. The primary safety endpoint of the study was cardiovascular mortality at 30 days, while the primary performance endpoint was device success as defined by Valve Academic Research Consortium-2. The 6-month follow-up of the GENESIS-II study is ongoing.</p><p><strong>Results: </strong>Among the 40 patients, the average age was 74.4±6.7 years, and 65% were male. The rate of device success was 95%. At 30 days, 2.5% of patients experienced cardiovascular mortality, and the incidence of new permanent pacemaker implantation was 7.9%. There was a progressive enhancement in the effective orifice area, transitioning from 0.6±0.2 cm² at baseline to 1.9±0.6 cm² at 30 days (p<0.001). Similarly, the mean aortic valve gradient demonstrated significant improvement from 53.1±12.5 mmHg at baseline to 8.4±4.0 mmHg at 30 days (p<0.001) post-intervention.</p><p><strong>Conclusions: </strong>The Hydra THV is the first device with an active release mechanism for deploying the supra-annular valve. The observed high rates of device success and procedural safety in the GENESIS-II study may support the continued safety and performance of the device.</p>","PeriodicalId":72310,"journal":{"name":"AsiaIntervention","volume":"11 3","pages":"155-163"},"PeriodicalIF":0.0,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12494087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficiency of orbital atherectomy for nodular calcium in bending vessels: in vitro vessel models.","authors":"Yutaka Tanaka, Haruki Mitsui, Keisuke Murakami, Shigeru Saito, Kiyotaka Iwasaki","doi":"10.4244/AIJ-D-25-00012","DOIUrl":"10.4244/AIJ-D-25-00012","url":null,"abstract":"<p><strong>Background: </strong>Orbital atherectomy (OA) operates via high-speed elliptical crown rotation, enabling focal plaque modification through controlled forward and backward movement.</p><p><strong>Aims: </strong>This study aimed to identify the anatomical conditions that optimise OA effectiveness on nodular calcium within curved lesions, using <i>in vitro</i> models to allow quantitative assessment of the debulked volume.</p><p><strong>Methods: </strong>Forty stenotic vessel models containing nodular calcium were created with varying anatomical parameters: two calcium positions (inner vs outer curve), two curvature radii (CR: 10 mm or 20 mm), and two bending angles (BA: 100° or 60°). Each model underwent OA with the Diamondback 360 Coronary OA System, using two 30-second low-speed passes and one 30-second high-speed pass. Microcomputed tomography was performed pre- and post-ablation to measure the calcium volume reduction, maximum depth, and width.</p><p><strong>Results: </strong>Ablation was significantly greater for nodular calcium on the inner curve compared to that on the outer curve (6.6±0.4 mm³ vs 2.7±0.4 mm³; p<0.0001). Among models with calcium on the inner curve, CR20/BA60 showed the highest volume reduction (8.3±1.4 mm³). For models with calcium on the outer curve, CR20/BA100 resulted in the greatest ablation (5.2±0.9 mm³). Ablation depth, more than width, correlated with the total ablated volume.</p><p><strong>Conclusions: </strong>Nodular calcium located on the inner curve is more effectively treated with OA. The combination of curvature radius and the bending angle significantly influences procedural efficiency, underscoring the importance of lesion anatomy in OA planning.</p>","PeriodicalId":72310,"journal":{"name":"AsiaIntervention","volume":"11 3","pages":"164-169"},"PeriodicalIF":0.0,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12494085/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe lipid-rich plaque with post-stenting longitudinal plaque migration on optical coherence tomography and refractory no-reflow.","authors":"Esmond Yan Hang Fong, Leon Chung Yin Leung, Angus Shing Fung Chui, Alan Ka Chun Chan, Michael Kang Yin Lee","doi":"10.4244/AIJ-D-24-00068","DOIUrl":"10.4244/AIJ-D-24-00068","url":null,"abstract":"","PeriodicalId":72310,"journal":{"name":"AsiaIntervention","volume":"11 3","pages":"217-218"},"PeriodicalIF":0.0,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12494077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-dimensional reverse CART by rotation-overlap method: CLARP manoeuvre.","authors":"Calvin Leung, Cheuk Bong Ho, Michael Chi Shing, Michael Kang-Yin Lee, Alan Ka Chun Chan","doi":"10.4244/AIJ-D-25-00014","DOIUrl":"10.4244/AIJ-D-25-00014","url":null,"abstract":"","PeriodicalId":72310,"journal":{"name":"AsiaIntervention","volume":"11 3","pages":"208-209"},"PeriodicalIF":0.0,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12494074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coil embolisation of a large distal left anterior descending artery aneurysm.","authors":"Yerramareddy Vijayachandra, Prakash Chandra Jain, Antony Wilson, Jayalakshmi Sreeram, Aishwarya Mahesh Kumar","doi":"10.4244/AIJ-D-25-00011","DOIUrl":"10.4244/AIJ-D-25-00011","url":null,"abstract":"","PeriodicalId":72310,"journal":{"name":"AsiaIntervention","volume":"11 3","pages":"215-216"},"PeriodicalIF":0.0,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12494076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of multimodality imaging in a female with syncope and right ventricular dysfunction.","authors":"Rajesh Vijayvergiya, Akash Batta, Ganesh Kasinadhuni, Manphool Singhal","doi":"10.4244/AIJ-D-25-00003","DOIUrl":"10.4244/AIJ-D-25-00003","url":null,"abstract":"","PeriodicalId":72310,"journal":{"name":"AsiaIntervention","volume":"11 3","pages":"221-222"},"PeriodicalIF":0.0,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12494075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of drug-coated balloons in East Asian and Caucasian patients: a post hoc analysis of the EASTBOURNE Registry.","authors":"Antoine El Khoury, Sara Malakouti, Alfonso Ielasi, Jegan Sivalingam, Antonio Greco, Bharat Vashdev Khialani, Dario Gattuso, Bernardo Cortese","doi":"10.4244/AIJ-D-24-00044","DOIUrl":"10.4244/AIJ-D-24-00044","url":null,"abstract":"<p><strong>Background: </strong>The treatment of coronary artery disease (CAD) has evolved significantly over the years with the emergence of drug-coated balloons (DCBs). Research has shown that ethnicity can influence procedural approaches and clinical outcomes. Despite this, there are still limited data on DCB performance in different ethnic groups - particularly Caucasian and East Asian patients.</p><p><strong>Aims: </strong>In this <i>post hoc</i> analysis of the EASTBOURNE Registry, we aimed to assess differences in clinical outcomes between Caucasian and East Asian patients.</p><p><strong>Methods: </strong>EASTBOURNE was a prospective, investigator-driven, multicentre, international study investigating the safety and efficacy of a sirolimus-coated balloon (SCB). A propensity-matching analysis was performed to mitigate differences in variables. The primary endpoint was target lesion revascularisation (TLR) at 12 months.</p><p><strong>Results: </strong>From September 2016 to December 2020, EASTBOURNE enrolled 2,123 patients from 38 centres. This analysis includes 2,084 patients: 1,657 in the Caucasian group and 427 in the East Asian group. After propensity matching, we analysed 602 patients with no significant differences in clinical characteristics. In procedural terms, the Caucasian population had higher baseline percentage diameter stenosis and contrast media usage, but they had lower predilatation rates and used shorter SCBs at higher pressures; the rate of bailout stenting was also higher. Twelve-month follow-up showed higher rates of TLR (6.0% vs 1.5%; p<0.001), whereas major adverse cardiovascular events, all-cause death, and spontaneous myocardial infarction did not differ significantly. Bleeding Academic Research Consortium Type 2-5 bleedings were lower (0.0 vs 5.0%; p<0.001).</p><p><strong>Conclusions: </strong>In this subgroup analysis of the EASTBOURNE Registry comparing patients of Caucasian versus East Asian origin treated with SCBs, there were higher incidences of TLR but less bleeding in the Caucasian population compared to East Asian patients.</p>","PeriodicalId":72310,"journal":{"name":"AsiaIntervention","volume":"11 2","pages":"e129-e138"},"PeriodicalIF":0.0,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12308709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical safety and performance of a biodegradable polymer-coated sirolimus-eluting stent in an all-comers population: results from the S-FLEX Russia registry.","authors":"Alexey Protopopov, Nikita Litvinyuk, Dmitriy Stolyarov, Danil Rashytov, Oleg Krestyaninov, Aram Badoyan, Victor Maiskov, Denis Samochatov, Denis Shestov, Dmitriy Skrypnik, Andrey Kostin","doi":"10.4244/AIJ-D-24-00045","DOIUrl":"10.4244/AIJ-D-24-00045","url":null,"abstract":"<p><strong>Background: </strong>The safety and clinical performance of the Supraflex Cruz sirolimus-eluting stent (SES) have not been explored within a Russian population until now.</p><p><strong>Aims: </strong>The S-FLEX Russia registry was designed to evaluate the clinical safety and performance of the Supraflex Cruz SES in a real-world, all-comers Russian population undergoing percutaneous coronary intervention (PCI).</p><p><strong>Methods: </strong>This was a prospective, multicentre, single-arm, observational registry that included 522 patients who underwent PCI with the Supraflex Cruz SES between August 2021 and February 2022, at five hospitals in Russia. Subgroups prespecified for data analysis included patients with diabetes mellitus, bifurcation lesions, type B2/C lesions and at least one long lesion (>20 mm). The primary endpoint was target lesion failure (TLF), a composite of cardiac death, target vessel myocardial infarction (TVMI) and clinically driven target lesion revascularisation (CD-TLR) at 12-month follow-up.</p><p><strong>Results: </strong>The mean age of the patient population was 64.26±9.46 years. Device and procedural success were 99.4% and 98.9%, respectively. At 12 months, TLF was observed in 16 (3.1%) patients, comprising 8 (1.5%) cardiac deaths, 6 (1.1%) TVMI, and 2 (0.4%) CD-TLR. Only 1 (0.2%) instance of definite stent thrombosis was observed at 12-month follow-up. In the high-risk subgroups, TLF at 12 months was 5.6% in patients with diabetes, 8.5% in bifurcation lesions, 2.8% in complex B2/C lesions, and 1.9% in long lesions (>20 mm).</p><p><strong>Conclusions: </strong>Low rates of TLF and stent thrombosis at 12-month follow-up demonstrate the excellent safety and clinical performance of the Supraflex Cruz SES in a real-world, all-comers Russian population, including prespecified high-risk subgroups.</p>","PeriodicalId":72310,"journal":{"name":"AsiaIntervention","volume":"11 2","pages":"e101-e109"},"PeriodicalIF":0.0,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12285379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144710018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrathin-strut stents - towards zero stent-related events?","authors":"Sripal Bangalore","doi":"10.4244/AIJ-E-25-00004","DOIUrl":"10.4244/AIJ-E-25-00004","url":null,"abstract":"","PeriodicalId":72310,"journal":{"name":"AsiaIntervention","volume":"11 2","pages":"e97-e98"},"PeriodicalIF":0.0,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12285411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144710022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}