Archives of rehabilitation research and clinical translation最新文献

{"title":"Biomechanical Properties Required for the Reduction of Knee Adduction Moment Using Gait Modification in Individuals With Obesity","authors":"Munkhdelger Dorjravdan BSc ,&nbsp;Kimihiko Mori PT, PhD ,&nbsp;Tomohiro Ushikubo PhD ,&nbsp;Takanari Kubo PT, PhD ,&nbsp;Yasuaki Arima PT, PhD ,&nbsp;Naoto Mano PT, PhD ,&nbsp;Masanori Wakida PT, PhD ,&nbsp;Yuta Chujo PT, PhD ,&nbsp;Meguru Taguchi MD ,&nbsp;Yutaka Kimura MD, PhD ,&nbsp;Kimitaka Hase MD, PhD","doi":"10.1016/j.arrct.2026.100591","DOIUrl":"10.1016/j.arrct.2026.100591","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the effects of gait modification on the knee lever arm (KLA) in individuals with obesity.</div></div><div><h3>Design</h3><div>This study was designed as a retrospective, cross-sectional, observational study to investigate the impact of gait modifications on knee joint loading in individuals with obesity. A convenience sample was used, and no formal sample size calculation was performed.</div></div><div><h3>Setting</h3><div>Single university hospital.</div></div><div><h3>Participants</h3><div>Fifty-three individuals (N=53) with obesity who had no history of lower-limb surgery, musculoskeletal disorders, or neuromuscular diseases affecting gait.</div></div><div><h3>Interventions</h3><div>Interventions: Not applicable.</div></div><div><h3>Main Outcome Measures</h3><div>Three-dimensional gait analyses were performed in individuals with obesity under 3 conditions: walking at a comfortable speed, with their toes outward (toe-out gait), and with a wider step width (wide-base gait). The peak knee adduction moment (KAM), area under the curve of KAM during stance (KAM impulse), and KLA were measured. Considering the relative position between foot placement and the center of gravity by gait modifications, the KLA was divided into the mediolateral shift of the center of pressure (center of pressure component of KLA [KLA-COP]) and the mediolateral tilt of the ground reaction force vector (tilt component of KLA [KLA-tilt]).</div></div><div><h3>Results</h3><div>Wide-base gait significantly reduced peak KAM, KAM impulse, KLA, and KLA-COP but increased the KLA-tilt, whereas the toe-out gait did not significantly reduce these parameters compared with other conditions. In the wide-base gait, the change in peak KAM was significantly correlated with changes in the hip abduction angle (<em>r</em>=−.66).</div></div><div><h3>Conclusions</h3><div>The results show that reducing the KLA-COP and increasing the KLA-tilt with a lateral shift in foot placement acted as abduction and adduction moments, respectively. In particular, changing the hip kinematics can enhance the effects of gait modification in individuals with obesity.</div></div>","PeriodicalId":72291,"journal":{"name":"Archives of rehabilitation research and clinical translation","volume":"8 2","pages":"Article 100591"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148246730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Effect of Schroth Method on Plantar Pressure and Related Muscle Imbalance in Children and Adolescent With Idiopathic Scoliosis","authors":"Yuanxi Shi MM ,&nbsp;Xiaoli Huang MB ,&nbsp;Zhendi Shu MM ,&nbsp;Qiongyi Pang PhD ,&nbsp;Fengxia Tu PhD","doi":"10.1016/j.arrct.2026.100594","DOIUrl":"10.1016/j.arrct.2026.100594","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the effects of Schroth method with a 6-month intervention on gait-specific dynamic plantar pressure distribution and functional muscular balance in children/adolescents with idiopathic scoliosis (IS).</div></div><div><h3>Design</h3><div>This is an observation before-after control study.</div></div><div><h3>Setting</h3><div>Conducted in the rehabilitation department of a tertiary hospital.</div></div><div><h3>Participants</h3><div>A total of 21 children/adolescents (N=21) with IS.</div></div><div><h3>Interventions</h3><div>All participants performed Schroth exercises ≥5 times/wk, each session ≥30 minutes. The training was completed independently at home under the supervision of guardians.</div></div><div><h3>Main Outcome Measures</h3><div>Plantar pressure parameters and surface electromyogram data of key postural muscles were collected before and after training. Outcome measures: (1) Cobb angle; (2) plantar pressure gait analysis: gait line length, single support line, left-right symmetry, heel-to-forefoot temporal difference, maximum force, maximum pressure, maximum temporal force in foot tripod regions; (3) surface electromyogram parameters: root mean square and mean power frequency, analyzed to assess activation and fatigue of the quadratus lumborum, erector spinae, gluteus medius, and semitendinosus.</div></div><div><h3>Results</h3><div>After 6-month Schroth intervention, patients with IS showed reduced Cobb angle (<em>P</em>&lt;.05) and decreased convex-concave gait line length difference (<em>P</em>&lt;.05), and improved left-right symmetry (<em>P</em>&lt;.05). Significant decreases were also observed in heel-to-forefoot temporal difference (absolute and relative to total gait time: <em>P</em>&lt;.05) and lumbar extensor/erector spinae root mean square values (<em>P</em>&lt;.05).</div></div><div><h3>Conclusions</h3><div>The Schroth method not only improves Cobb angle in patients with IS, but also reduces gait line length asymmetry and paraspinal muscles activation imbalance. In addition, it enhances gait left-right symmetry and optimizes dynamic foot pressure distribution.</div></div>","PeriodicalId":72291,"journal":{"name":"Archives of rehabilitation research and clinical translation","volume":"8 2","pages":"Article 100594"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148246732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical Strain During Walking in Adults With Cerebral Palsy: A Construct Validity Study","authors":"Sandra Linnea Klund-Hansen MSc ,&nbsp;Terje Gjøvaag PhD ,&nbsp;Eivind Lundgaard MSc ,&nbsp;Arve Opheim PhD ,&nbsp;Linda Rennie PhD","doi":"10.1016/j.arrct.2026.100617","DOIUrl":"10.1016/j.arrct.2026.100617","url":null,"abstract":"<div><h3>Objective</h3><div>To describe the physical strain of walking in adults with spastic cerebral palsy (CP) and investigate the construct (known-groups, convergent, and discriminant) validity of physical strain.</div></div><div><h3>Design</h3><div>Cross-sectional design.</div></div><div><h3>Setting</h3><div>Rehabilitation hospital.</div></div><div><h3>Participants</h3><div>A total of 94 ambulant adults (N=94) (41 men) with spastic CP.</div></div><div><h3>Interventions</h3><div>Not applicable.</div></div><div><h3>Main Outcome Measures</h3><div>Peak oxygen uptake (VO₂peak), physical strain (%VO₂peak), 6-minute walk test (6MWT), mobility (Timed Up and Go Test), and quality of life (QoL).</div></div><div><h3>Results</h3><div>The overall physical strain was median (interquartile range) 50% (18), mean (SD) VO₂peak of 36.2 (8.6), and median (interquartile range) 6MWT distance of 553 m (144). The physical strain test was significantly different between Gross Motor Function Classification System levels I and II (<em>P</em>=.002) and between Gross Motor Function Classification System levels I and III (<em>P</em>≤.001), and distinguished acceptably between unilateral and bilateral CP subgroups (area under the curve=0.739; <em>P</em>&lt;.001). The association between physical strain and 6MWT was high (<em>r</em>=−0.716; <em>P</em>&lt; .001), the association with timed Up and Go Test was weak-to-moderate (<em>r</em>=0.490; <em>P</em>&lt;.001), and the association with QoL was very weak and nonsignificant (<em>r</em>=0.157; <em>P</em>=.129).</div></div><div><h3>Conclusions</h3><div>Physical strain of walking in adults with spastic CP increased with decreasing gross motor function, and was significantly different between known-groups of adults with spastic CP. This study confirmed the hypotheses of a strong inverse association between physical strain and walking capacity. The weak-to-moderate association with functional mobility and the lack of association with QoL support divergent validity. Our results support the use of physical strain for adults with CP, inversely reflecting functional walking capacity, in clinical practice and research.</div></div>","PeriodicalId":72291,"journal":{"name":"Archives of rehabilitation research and clinical translation","volume":"8 2","pages":"Article 100617"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148247204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic Review and Meta-analysis of the Efficacy of Shorter Duration Modified Constraint-Induced Movement Therapy (mCIMT) Programs","authors":"Pavlina Psychouli PhD,&nbsp;Charalambos Anastasiou BSc,&nbsp;Ioannis Mamais PhD,&nbsp;Nefeli Efstathia Papasalourou MSc","doi":"10.1016/j.arrct.2026.100604","DOIUrl":"10.1016/j.arrct.2026.100604","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the efficacy of a specific group of modified constraint-induced movement therapy (mCIMT) protocols, including ≤39 hours of therapist-supervised training combined with ≥10 h/d of restraint, on upper limb motor function in adults with chronic stroke.</div></div><div><h3>Data Sources</h3><div>PubMed, Scopus, EBSCO, and the Cochrane Library were systematically searched up to March 20, 2025, using MeSH terms related to stroke, constraint-induced therapy, and upper limb function.</div></div><div><h3>Study Selection</h3><div>Randomized controlled trials (RCTs) involving adults with chronic stroke who received mCIMT compared with conventional rehabilitation were included. Exclusion criteria included multimodal interventions or insufficient outcome data. Of 6486 records, 5 RCTs (n=239) met the inclusion criteria.</div></div><div><h3>Data Extraction</h3><div>Two reviewers independently extracted study and participant characteristics, intervention details, and upper limb outcomes. Risk of bias was assessed with the Cochrane Risk of Bias Tool for Randomized Trials-2, and certainty of evidence was evaluated using Grading of Recommendations Assessment, Development and Evaluation (GRADE).</div></div><div><h3>Data Synthesis</h3><div>Meta-analysis revealed significant larger improvements for the intervention group compared with controls posttreatment: Wolf Motor Function Test Functional Ability (mean difference [MD]=0.59; 95% CI, 0.23-0.94), Motor Activity Log Quality of Movement (MD=1.08; 95% CI, 0.61-1.55), and Amount of Use (MD=1.01; 95% CI, 0.24-1.79). Wolf Motor Function Test Performance Time improved modestly (standardized mean difference=-0.36; 95% CI: -0.68 to -0.04). At follow-up, only Motor Activity Log scores demonstrated sustained gains. Heterogeneity was moderate to high for some outcomes, and overall evidence strength was rated very low because of small sample sizes and high risk of bias.</div></div><div><h3>Conclusions</h3><div>mCIMT protocols requiring fewer therapist hours but extended restraint time yield meaningful improvements in upper limb function among chronic stroke survivors, with real-world use gains persisting at follow-up. These findings suggest that optimizing, rather than maximizing, therapy intensity may improve feasibility and adherence, supporting broader clinical adoption. Further large-scale, high-quality RCTs with long-term follow-up are warranted to refine dosing guidelines and tailor interventions to patient subgroups.</div></div>","PeriodicalId":72291,"journal":{"name":"Archives of rehabilitation research and clinical translation","volume":"8 2","pages":"Article 100604"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148247518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and Tolerance of High-Intensity Interval Training in Adults With Cystic Fibrosis","authors":"Laurent Mely PhD ,&nbsp;Olivier Meurisse PT ,&nbsp;Laurene Norberciak PhD ,&nbsp;Morgane Auffret CRNs ,&nbsp;Nadège Goriot-Raynaud NPs ,&nbsp;Marion Buyse PhD ,&nbsp;Sophie Ramel MD","doi":"10.1016/j.arrct.2026.100599","DOIUrl":"10.1016/j.arrct.2026.100599","url":null,"abstract":"<div><h3>Objectives</h3><div>To assess the feasibility and the tolerance of a high-intensity interval training (HIIT) program compared with conventional rehabilitation during a 3-week hospital stay in adults with cystic fibrosis (CF) and to analyze the effectiveness and impact on health indicators of HIIT.</div></div><div><h3>Design</h3><div>A prospective, 2-center, open-label, randomized, controlled study.</div></div><div><h3>Setting</h3><div>Cystic Fibrosis Resource and Expert Centers, Roscoff and Giens (France).</div></div><div><h3>Participants</h3><div>A total of 62 adults (aged: 36.1±11y; M/F ratio: 1.3) with CF were included.</div></div><div><h3>Interventions</h3><div>Intervention group performed 3 HIIT sessions, alternating 30 seconds of work and 30 seconds of rest repeated 6 times ≥80% of maximum heart rate, and 2 low-intensity sessions per week. Control group (conventional rehabilitation) performed 5, 20-to-30-minute sessions per week at the first aerobic ventilatory threshold.</div></div><div><h3>Main Outcome Measures</h3><div>(1) Feasibility was evaluated by compliance; (2) tolerance by the degree of dyspnea and adverse effects; (3) effect on physical capacity using the 6-minute walk, body composition, the forced expiratory volume in 1 second (FEV1), and the multidimensional dyspnea profile; (4) impact on health indicators by the Fibrosis Quality of Life Questionnaire and the Hospital Anxiety and Depression; and (5) participant satisfaction by the STARFISH (perception of physical activity) and the Physical Activity Enjoyment Scale.</div></div><div><h3>Results</h3><div>Compliance with exercise sessions was marginally higher but statistically significant in the HIIT (93.3%) than the control (86.7%) group, <em>P</em>=.032. However, tolerance was lower in those with severe respiratory impairment and those without cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapy. Effectiveness on physical capacity (6-minute walk test, muscle strength, and FEV1) and quality of life was similar between the training methods.</div></div><div><h3>Conclusions</h3><div>HIIT is feasible, safe, and well tolerated and could be used as a timesaving alternative to conventional treatment, particularly in people under CFTR modulator therapy.</div></div>","PeriodicalId":72291,"journal":{"name":"Archives of rehabilitation research and clinical translation","volume":"8 2","pages":"Article 100599"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148246620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rehabilitation Underutilization: Using a Model of Rheumatoid Arthritis to Illustrate Unmet Needs","authors":"Chris Y. Lane PT, DPT, PhD ,&nbsp;Alexander J. Maturino BA ,&nbsp;Lauren Mihalek PT, DPT ,&nbsp;Kelli D. Allen PhD ,&nbsp;Beth L. Jonas MD ,&nbsp;Patricia Katz PhD ,&nbsp;Louise M. Thoma PT, DPT, PhD","doi":"10.1016/j.arrct.2025.100554","DOIUrl":"10.1016/j.arrct.2025.100554","url":null,"abstract":"<div><h3>Objective</h3><div>To quantify the proportion of individuals who have underutilized rehabilitation for rheumatoid arthritis (RA) and examine the associations of demographic and clinical characteristics with rehabilitation underutilization.</div></div><div><h3>Design</h3><div>Cross-sectional.</div></div><div><h3>Setting</h3><div>Online survey.</div></div><div><h3>Participants</h3><div>Adults with RA (N=309) who received care at an academic medical center rheumatology clinic from January 1, 2020 to December 31, 2021. Of 1506 patients identified from electronic medical records who met inclusion criteria, 659 were contacted, 354 enrolled in the study, and 309 completed the survey (age 56.5±14.1y, 82% women).</div></div><div><h3>Interventions</h3><div>Not applicable.</div></div><div><h3>Main Outcome Measures</h3><div>The primary outcome was rehabilitation underutilization, which was defined as reporting moderate-severe functional limitation (Patient-Reported Outcome Measure Information System Physical Function -10a score &lt;40) and never using rehabilitation services related to RA (self-reported use yes vs. no). The exposure variables were race and ethnicity, gender identity, health insurance, financial status, education status, work status, and body mass index.</div></div><div><h3>Results</h3><div>Of 309 adults with RA who participated, 47% reported moderate-severe functional limitation, 63% never used rehabilitation services related to RA, and 25% had underutilized rehabilitation. The following characteristics were strongly associated (adjusted OR range 2.8-15.8) with rehabilitation underutilization: Medicaid + Medicare, Medicaid, Medicare, no health insurance, lower financial status, lower education, disabled work status, obesity, and major comorbidity.</div></div><div><h3>Conclusions</h3><div>One in 4 adults with RA underutilized rehabilitation. There is a clear unmet need for rehabilitation, particularly in adults with lower socioeconomic status and groups with greater functional needs. Future work should develop strategies to facilitate rehabilitation use for adults with RA who need it.</div></div>","PeriodicalId":72291,"journal":{"name":"Archives of rehabilitation research and clinical translation","volume":"8 2","pages":"Article 100554"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148246633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementing Co-innovation to Develop an Accessible, Web-Based Exercise Program for People with Multiple Sclerosis","authors":"T. Bradley Willingham PhD,&nbsp;Julie F. Stowell PT, DPT,&nbsp;Marina Moldavskiy BS,&nbsp;Deborah Backus PT, PhD","doi":"10.1016/j.arrct.2025.100579","DOIUrl":"10.1016/j.arrct.2025.100579","url":null,"abstract":"<div><h3>Objective</h3><div>To apply a patient-centered co-innovation framework to develop and preliminarily evaluate a web-based exercise program for people with multiple sclerosis (MS).</div></div><div><h3>Design</h3><div>Exploratory sequential mixed methods study implimenting focus groups to identify needs and preferences, followed by a 6-week pilot intervention to generate further feedback while assessing safety and feasibility.</div></div><div><h3>Setting</h3><div>Ambulatory rehabilitation clinic with home-based, on-demand exercise delivery.</div></div><div><h3>Participants</h3><div>Adults with MS (N=31; focus groups: n=16; pilot testing: n=15).</div></div><div><h3>Interventions</h3><div>A 6-week tele-exercise program (3 sessions/wk; 20-45 min) delivered via instructional videos aligned with evidence-based guidelines, including aerobic and resistance options with modifications for varying mobility levels, plus weekly 20-minute one-on-one virtual coaching.</div></div><div><h3>Main Outcome Measures</h3><div>Focus group themes identified by Reflexive Thematic Analysis; postintervention user experience (1-5 Likert items and free response); feasibility (adherence); safety (adverse events); mobility outcomes (Six-Minute Walk Test [6MWT], Five Times Sit to Stand [5×STS], timed Up and Go [TUG], Timed 25-Foot Walk [T25FW]).</div></div><div><h3>Results</h3><div>Focus groups identified actionable needs spanning exercise type, instructional style, safety cues, modification options, scheduling/accountability, and delivery preferences, which directly informed program design (table 1). In pilot testing, no adverse events were reported. Adherence to assigned sessions averaged 75%±11% in Wave 1 and 56%±11% in Wave 2; among participants who completed ≥1 session, adherence was 93.8%±12.5% and 75.8%±30.4%, respectively. Mobility improved from baseline: 6MWT +20.4% (+188 ft), <em>P</em>=.001; 5×STS −16.6% (−3.54 s), <em>P</em>=.042; TUG −14.9% (−2.19 s), <em>P</em>=.048; Timed 25-Foot Walk −9.1% (−0.59 s), <em>P</em>=.365. User experience ratings indicated high usability and convenience.</div></div><div><h3>Conclusions</h3><div>Co-innovation strategies that systematically engage people with MS, clinicians, and researchers in an iterative design process can generate insights that inform the development of evidence-aligned, web-based exercise programs that address the complex and diverse needs of people with MS. Findings support further evaluation in larger, diverse cohorts and the exploration of social support features to enhance engagement.</div></div>","PeriodicalId":72291,"journal":{"name":"Archives of rehabilitation research and clinical translation","volume":"8 2","pages":"Article 100579"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148246727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Resistance Training on Breast Cancer-Related Lymphedema: A Meta-Analysis","authors":"Shuwei Wu MN ,&nbsp;Chen Zhong M.Med ,&nbsp;Zhaoxing Liu MD","doi":"10.1016/j.arrct.2026.100607","DOIUrl":"10.1016/j.arrct.2026.100607","url":null,"abstract":"<div><h3>Objectives</h3><div>To determine the effectiveness of resistance training (RT) on the incidence, severity, and objective physiological indicators of breast cancer-related lymphedema (BCRL), and to assess its impact on limb function.</div></div><div><h3>Data sources</h3><div>A systematic search was conducted in PubMed, Embase, Web of Science, Medline, Sinomed, China National Knowledge Infrastructure (CNKI), Wanfang, VIP Information Co., Ltd. (VIP), and the Chinese Medical Journal full-text database from inception to August 1, 2025.</div></div><div><h3>Study Selection</h3><div>Randomized controlled trials involving adults with breast cancer who were at risk of or had established BCRL, and comparing RT with nonresistance exercise, usual care, or alternative management approaches. A total of 38 Randomized controlled trials involving 4843 patients were included.</div></div><div><h3>Data Extraction</h3><div>Two reviewers independently screened the studies, extracted data using a standardized form, and assessed the risk of bias using the Cochrane Risk of Bias 2 tool.</div></div><div><h3>Data Synthesis</h3><div>Statistical analyses were performed using RevMan 5.4. RT significantly reduced the incidence of lymphedema (odds ratio [OR]=0.25, 95% CI, 0.19-0.32) and moderate-to-severe lymphedema (OR=0.21, 95% CI, 0.16-0.29). It also decreased upper limb volume (mean difference [MD]=−152.37, 95% CI, −153.81 to −150.94) and circumference differences (MD=−1.51, 95% CI, −1.62 to −1.41), while improving lymphatic drainage volume (MD=5.03, 95% CI, 4.67-5.39) and the rate of excellent or good limb function (OR=4.23, 95% CI, 2.72-6.57). Subgroup analyses revealed that a short-duration, high-frequency training paradigm and combined therapy regimens produced the most pronounced protective effects.</div></div><div><h3>Conclusions</h3><div>RT is a safe and effective intervention that significantly reduces the risk and severity of BCRL while improving limb volume, lymphatic function, and shoulder mobility. For optimal benefit in clinical practice, progressive RT should be delivered using a \"short-duration, high-frequency\" model integrated into combined therapy protocols.</div></div>","PeriodicalId":72291,"journal":{"name":"Archives of rehabilitation research and clinical translation","volume":"8 2","pages":"Article 100607"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148247522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precision Rehabilitation in Spinal Cord Injury: A Systematic Review of Omics Applications for Intervention Monitoring in Spinal Cord Injury","authors":"Alexander Stacul MSc ,&nbsp;Ezra Valido MD, PhD ,&nbsp;Nicole Nyfeler MSc ,&nbsp;Alessandro Bertolo PhD ,&nbsp;Ramona M. Zeh PhD ,&nbsp;Andrea O. Fontana MD, PhD ,&nbsp;Jürgen Pannek MD ,&nbsp;Jörg Krebs PhD ,&nbsp;Alexander Leichtle MD ,&nbsp;Marija Glisic PhD ,&nbsp;Jivko Stoyanov PhD","doi":"10.1016/j.arrct.2026.100598","DOIUrl":"10.1016/j.arrct.2026.100598","url":null,"abstract":"<div><h3>Objective</h3><div>To systematically evaluate the application and utility of omics technologies, high-throughput methods measuring the complete or targeted set of molecules inside a biological system at a certain timepoint, in monitoring and optimizing rehabilitation interventions in traumatic spinal cord injury.</div></div><div><h3>Data sources</h3><div>Embase, Medline/Ovid, and Web of Science were searched from inception to November 27, 2024.</div></div><div><h3>Study Selection</h3><div>Eligible studies included adults (≥18 years) with spinal cord injury undergoing rehabilitation interventions assessed using omics technologies (genomics, epigenomics, transcriptomics, proteomics, metabolomics, or metagenomics).</div></div><div><h3>Data Extraction</h3><div>Following PRISMA guidelines, independent screening, data extraction, and risk of bias (RoB) assessment (National Institutes of Health Quality Assessment Tools) were performed by 2 investigators. Based on RoB assessment, studies were classified from level 1 (most reliable) to level 4 (least reliable).</div></div><div><h3>Data synthesis</h3><div>Twenty-three trials were included: 8 randomized controlled trials, 5 non-randomized controlled trials, and 10 pre-post trials. Twenty-two studies (96%) exhibit a moderate RoB due to small sample size and heterogeneity. Omics technologies were primarily applied to exercise and electrical muscle stimulation interventions (65%), followed by hormonal and cellular therapies (22%), and diet (13%). Transcriptomic analyses revealed consistent molecular adaptations, including increased mitochondrial biogenesis (proliferator-activated receptor gamma coactivator 1-alpha) and reduced muscle atrophy gene expression (myostatin), correlating with enhanced insulin sensitivity and improved aerobic capacity. Metagenomics consistently identified microbiome shifts, such as decreased inflammatory taxa and increased beneficial taxa, associated with improved metabolic profiles and bowel function. Proteomics and metabolomics highlighted systemic changes related to neurorecovery, immune modulation, and sperm motility, linking molecular signatures directly to clinical outcomes.</div></div><div><h3>Conclusions</h3><div>Omics technologies enable early identification of molecular alterations. However, given small sample sizes and heterogeneity of the current studies, these findings should be interpreted with caution. Gradual integration of omics, particularly epigenomics which may capture long-term, injury-related changes holds promise for developing personalized rehabilitation protocols and monitoring clinical progression in spinal cord injury.</div></div>","PeriodicalId":72291,"journal":{"name":"Archives of rehabilitation research and clinical translation","volume":"8 2","pages":"Article 100598"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148247477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: “Efficacy of Acupuncture Combined With Robotic Therapy in the Treatment of Limb Dysfunction After Stroke: A Systematic Review and Meta-Analysis”","authors":"Xue Fu BSc,&nbsp;Juanjuan Li BSc","doi":"10.1016/j.arrct.2026.100605","DOIUrl":"10.1016/j.arrct.2026.100605","url":null,"abstract":"","PeriodicalId":72291,"journal":{"name":"Archives of rehabilitation research and clinical translation","volume":"8 2","pages":"Article 100605"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148247478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}