Archives of microbiology & immunology最新文献

Role of Gut Microbiota in Long COVID: Impact on Immune Function and Organ System Health. 肠道菌群在长期COVID中的作用：对免疫功能和器官系统健康的影响。

Archives of microbiology & immunology Pub Date : 2025-01-01 Epub Date: 2025-02-04

Angelie Pathak, Devendra K Agrawal

{"title":"Role of Gut Microbiota in Long COVID: Impact on Immune Function and Organ System Health.","authors":"Angelie Pathak, Devendra K Agrawal","doi":"","DOIUrl":"","url":null,"abstract":"SARS-CoV-2 infection has led to a range of long-lasting symptoms, collectively referred to as long COVID. Current research highlights the critical role of angiotensin-converting enzyme 2 (ACE2) in regulating gut microbiota diversity, vascular function, and homeostasis within the renin-angiotensin system (RAS). ACE2 is utilized by the SARS-CoV-2 virus to enter host cells, but its downregulation following infection contributes to gut microbiota dysbiosis and RAS disruption. These imbalances have been linked to a range of long COVID symptoms, including joint pain, chest pain, chronic cough, fatigue, brain fog, anxiety, depression, myalgia, peripheral neuropathy, memory difficulties, and impaired attention. This review investigates the dysregulation caused by SARS-CoV-2 infection and the long-term effects it has on various organ systems, including the musculoskeletal, neurological, renal, respiratory, and cardiovascular systems. We explored the bidirectional interactions between the gut microbiota, immune function, and these organ systems, focusing on how microbiota dysregulation contributes to the chronic inflammation and dysfunction observed in long COVID symptoms. Understanding these interactions is key for identifying effective therapeutic strategies and interventional targets aimed at mitigating the impact of long COVID on organ health and improving patient outcomes.","PeriodicalId":72285,"journal":{"name":"Archives of microbiology & immunology","volume":"9 1","pages":"38-53"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11883900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An In-Depth Insight into Clinical, Cellular and Molecular Factors in COVID19-Associated Cardiovascular Ailments for Identifying Novel Disease Biomarkers, Drug Targets and Clinical Management Strategies. 深入了解covid - 19相关心血管疾病的临床、细胞和分子因素，以确定新的疾病生物标志物、药物靶点和临床管理策略。

Archives of microbiology & immunology Pub Date : 2024-01-01 Epub Date: 2024-07-19 DOI: 10.26502/ami.936500177

Muneera AlTaweel, Abdulmohsen Almusaad, Gousay Alkhazmari, Hussain Alrowaily, Maram Alsubaiee, Mareyah Alshaikh Husain, Nouf Alomayrin, Rafyel Almuaiweed, Norah Aleid, Abdulrahman A Alarfaj, Zainab Albahrani, Yaqob Taleb, Aftab A Jalbani, Sarah Almukhaylid, Ayman Soliman, Zafar Iqbal

{"title":"An In-Depth Insight into Clinical, Cellular and Molecular Factors in COVID19-Associated Cardiovascular Ailments for Identifying Novel Disease Biomarkers, Drug Targets and Clinical Management Strategies.","authors":"Muneera AlTaweel, Abdulmohsen Almusaad, Gousay Alkhazmari, Hussain Alrowaily, Maram Alsubaiee, Mareyah Alshaikh Husain, Nouf Alomayrin, Rafyel Almuaiweed, Norah Aleid, Abdulrahman A Alarfaj, Zainab Albahrani, Yaqob Taleb, Aftab A Jalbani, Sarah Almukhaylid, Ayman Soliman, Zafar Iqbal","doi":"10.26502/ami.936500177","DOIUrl":"10.26502/ami.936500177","url":null,"abstract":"COVID-19 was initially identified as a respiratory system disorder, but it has been reported to interact with and influence the cardiovascular system, in addition to many other body systems. Although COVID-19-associated cardiovascular (CV) complications are common, resulting in high acute phase mortality and a large number of morbidities in the chronic phase, thus severely impacting patients' quality of life and health outcomes, yet clinical, cellular, and molecular biological factors underlying the pathophysiology of cardiovascular complications associated with COVID-19 are poorly understood. This review investigates putative underlying clinical factors as well as cellular and molecular biological mechanisms by which COVID-19 leads to acute CV complications, including state-of-the-art genomic sequencing-based findings, and assessing the long-term CV consequences of COVID-19, aiming to shed light on developing strategies for differential diagnosis, risk prognostic stratification, prevention, and clinical management of CV sequels in COVID-19 patients. We found that the relationship between COVID-19 and CV risk is complex and multifaceted. Intriguingly, in addition to acute COVID-19 detertriuos effects, COVID-19 survivors may experience long-term CV effects as well that may have long-lasting clinical consequences. Here in this article, we provide a detailed account of a large number of genomic alterations, microRNAs, and novel viral as well as host proteins in CVDs associated with COVID-19, which has helped identify some novel drug targets to treat COVID-19-related cardiovascular complications.","PeriodicalId":72285,"journal":{"name":"Archives of microbiology & immunology","volume":"8 3","pages":"290-308"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11658003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long COVID: Complications, Underlying Mechanisms, and Treatment Strategies. 长冠肺炎:并发症、潜在机制和治疗策略。

Archives of microbiology & immunology Pub Date : 2023-01-01

Farigol Hakem Zadeh, Daniel R Wilson, Devendra K Agrawal

{"title":"Long COVID: Complications, Underlying Mechanisms, and Treatment Strategies.","authors":"Farigol Hakem Zadeh, Daniel R Wilson, Devendra K Agrawal","doi":"","DOIUrl":"","url":null,"abstract":"Long Covid is one of the most prevalent and puzzling conditions that arose with the Covid pandemic. Covid-19 infection generally resolves within several weeks but some experience new or lingering symptoms. Though there is no formal definition for such lingering symptoms the CDC boadly describes long Covid as persons having a wide range of new, recurring or sustained health issues four or more weeks after first being infected with SARS-CoV2. The WHO defines long Covid as the manifestation of symptoms from a \"probable or confirmed\" Covid-19 infection that start approximately 3 months after the onset of the acute infection and last for more than 2 months. Numerous studies have looked at the implications of long Covid on various organs. Many specific mechanisms have been proposed for such changes. In this article, we provide an overview of some of the main mechanisms by which long Covid induces end-organ damage proposed in recent research studies. We also review various treatment options, current clinical trials, and other potential therapeutic avenues to control long Covid followed by the information about the effect of vaccination on long Covid. Lastly, we discuss some of the questions and knowledge gaps in the present understanding of long Covid. We believe more studies of the effects long Covid has on quality of life, future health and life expectancy are required to better understand and eventually prevent or treat the disease. We acknowledge the effects of long Covid are not limited to those in this article but as it may affect the health of future offspring and therefore, we deem it important to identify more prognostic and therapeutic targets to control this condition.","PeriodicalId":72285,"journal":{"name":"Archives of microbiology & immunology","volume":"7 2","pages":"36-61"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10310313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9741855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-Matrix Real Time PCR in 108 Patients with Polymorphic Signs Suggestive of Fibromyalgia or Related to A Tick Bite 108例提示纤维肌痛或与蜱虫叮咬相关的多态体征的多矩阵实时PCR分析

Archives of microbiology & immunology Pub Date : 2023-01-01 DOI: 10.26502/ami.936500124

Marie Mas, Alexis Lacout, Véronique Perronne, Yannick Lequette, Yves Gadiolet, Béatrice Rambeaud, Paul Trouillas, Michel Franck, Christian Perronne

引用次数: 0

Distinguishing Swine Flu (H1N1) from COVID-19: Clinical, Virological, and Immunological Perspectives 区分猪流感(H1N1)与COVID-19:临床、病毒学和免疫学观点

Archives of microbiology & immunology Pub Date : 2023-01-01 DOI: 10.26502/ami.936500125

Irene Batta, Tejinder Kaur, Devendra K. Agrawal

{"title":"Distinguishing Swine Flu (H1N1) from COVID-19: Clinical, Virological, and Immunological Perspectives","authors":"Irene Batta, Tejinder Kaur, Devendra K. Agrawal","doi":"10.26502/ami.936500125","DOIUrl":"https://doi.org/10.26502/ami.936500125","url":null,"abstract":"This article provides an in-depth examination on the differences between the influenza A strain, H1N1 (also called Swine Flu) and Covid-19 focusing on the immune response and clinical symptoms. Flu symptoms due to influenza A strain, H1N1, were initially discovered in 2009. This variant of influenza A is believed to have emerged through reassortment, a process where the resulting virus inherits gene segments from each of its parental viruses. This reassortment event has resulted in a variant with altered characteristics, potentially affecting the level of immunity in humans. The symptoms of this strain typically manifest 1-4 days after exposure and include fever, cough, sore throat, runny/stuffy nose, body aches, fatigue, and gastrointestinal symptoms such as diarrhea. The transmission dynamics of this new variant, including human-to-human transmission, are still under investigation by health authorities. Individuals with weakened immune systems are generally more susceptible to severe illness. Risk factors associated with swine flu can include older adults, young children, pregnant women, and individuals with obesity. Historical variants of swine flu, such as the 2015 variant in India, have been associated with significant case numbers and deaths, often due to respiratory failure. Since the epidemic of Covid-19 due to SARS-CoV2 in early 2020, several symptoms of COVID-19 and swine flu overlap. In this article, we critically reviewed the differences and similarities in the immune response and clinical symptoms due to H1N1 virus and SARS-CoV2 in human.","PeriodicalId":72285,"journal":{"name":"Archives of microbiology & immunology","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135506640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neutrophils and Pregnancy-Associated Malaria 中性粒细胞与妊娠相关疟疾

Archives of microbiology & immunology Pub Date : 2023-01-01 DOI: 10.26502/ami.936500119

Moussa Djimde, Kassoum Kayentao, Charles Arama, Alassane Dicko, Petra F. Mens, Henk H.D.F. Schallig

引用次数: 0

Analysis of Antibody Responses of Vaccinated Persons with Coronavac 冠状病毒疫苗接种者抗体反应分析

Archives of microbiology & immunology Pub Date : 2023-01-01 DOI: 10.26502/ami.936500122

Aydin BALCI, Muhammed Emin DÜZ, Sibel Günay

引用次数: 0

Tafazzin Knockdown in Murine Mesenchymal Stem Cells Enhances the Tafazzin Knockdown Mediated Elevation in Interleukin-10 Secretion from Murine B Lymphocytes Tafazzin敲低小鼠间充质干细胞增强Tafazzin敲低介导的小鼠B淋巴细胞白细胞介素-10分泌升高

Archives of microbiology & immunology Pub Date : 2023-01-01 DOI: 10.26502/ami.936500111

Hana M. Zegallai, Ejlal Abu-El-Rub, Grant M. Hatch

{"title":"Tafazzin Knockdown in Murine Mesenchymal Stem Cells Enhances the Tafazzin Knockdown Mediated Elevation in Interleukin-10 Secretion from Murine B Lymphocytes","authors":"Hana M. Zegallai, Ejlal Abu-El-Rub, Grant M. Hatch","doi":"10.26502/ami.936500111","DOIUrl":"https://doi.org/10.26502/ami.936500111","url":null,"abstract":"Barth Syndrome is a rare X-linked genetic disorder caused by mutations in the TAFAZZIN gene. We recently demonstrated that tafazzin (Taz) protein deficiency in murine mesenchymal stems (MSCs) reduces immune function of activated wild type (WT) B lymphocytes. Interleukin-10 (IL-10) is a key anti-inflammatory cytokine capable of exerting immunosuppressive effects on myeloid cells. Here we examined if Taz deficiency in murine MSCs altered proliferation and IL-10 production in Taz deficient lipopolysaccharide (LPS)-activated murine B lymphocytes. Bone marrow MSCs and splenic B lymphocytes were isolated from WT or Taz knockdown (TazKD) mice. WT or Taz deficient MSCs were co-cultured with either LPS-activated WT or LPS-activated Taz deficient B lymphocytes for 24 h and B cell proliferation and IL-10 production determined. Taz deficient MSCs exhibited increased phosphatidylinositol-3-kinase (PI3K) mRNA expression compared to WT MSCs indicative of enhanced immunosuppression. Co-culture of Taz deficient MSCs with Taz deficient LPS-activated B cells resulted in a greater reduction in proliferation of B cells compared to Taz deficient MSCs co-cultured with LPS-activated WT B cells. In addition, co-culture of Taz deficient MSCs with Taz deficient LPS-activated B cells resulted in an enhanced production of IL-10 compared to Taz deficient MSCs co-cultured with LPS-activated WT B cells. Thus, Taz deficiency in murine MSCs potentiates the Taz knockdown-mediated elevation in IL-10 secretion from LPS-activated Taz knockdown B lymphocytes. These data suggest that Taz deficient MSCs may modulate the activity of other Taz deficient immune cells potentially promoting an enhanced immunosuppressive state.","PeriodicalId":72285,"journal":{"name":"Archives of microbiology & immunology","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136028698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Novel Peptide that Disrupts the Lck-IP₃R Protein-Protein Interaction Induces Widespread Cell Death in Leukemia and Lymphoma. 一种破坏Lck-IP3R蛋白-蛋白相互作用的新型肽诱导白血病和淋巴瘤的广泛细胞死亡。

Archives of microbiology & immunology Pub Date : 2023-01-01 Epub Date: 2023-08-30 DOI: 10.26502/ami.936500114

Michael W Harr, Andrew Lavik, Karen McColl, Fei Zhong, Ben Haberer, Khadijah Aldabbagh, Vivien Yee, Clark W Distelhorst

{"title":"A Novel Peptide that Disrupts the Lck-IP3R Protein-Protein Interaction Induces Widespread Cell Death in Leukemia and Lymphoma.","authors":"Michael W Harr, Andrew Lavik, Karen McColl, Fei Zhong, Ben Haberer, Khadijah Aldabbagh, Vivien Yee, Clark W Distelhorst","doi":"10.26502/ami.936500114","DOIUrl":"10.26502/ami.936500114","url":null,"abstract":"There is increasing evidence that the T-cell protein, Lck, is involved in the pathogenesis of chronic lymphocytic leukemia (CLL) as well as other leukemias and lymphomas. We previously discovered that Lck binds to domain 5 of inositol 1,4,5-trisphosphate receptors (IP3R) to regulate Ca2+ homeostasis. Using bioinformatics, we targeted a region within domain 5 of IP3R-1 predicted to facilitate protein-protein interactions (PPIs). We generated a synthetic 21 amino acid peptide, KKRMDLVLELKNNASKLLLAI, which constitutes a domain 5 sub-domain (D5SD) of IP3R-1 that specifically binds Lck via its SH2 domain. With the addition of an HIV-TAT sequence to enable cell permeability of D5SD peptide, we observed wide-spread, Ca2+-dependent, cell killing of hematological cancer cells when the Lck-IP3R PPI was disrupted by TAT-D5SD. All cell lines and primary cells were sensitive to D5SD peptide, but malignant T-cells were less sensitive compared with B-cell or myeloid malignancies. Mining of RNA-seq data showed that LCK was expressed in primary diffuse large B-cell lymphoma (DLBCL) as well as acute myeloid leukemia (AML). In fact, LCK shows a similar pattern of expression as many well-characterized AML oncogenes and is part of a protein interactome that includes FLT3-ITD, Notch-1, and Kit. Consistent with these findings, our data suggest that the Lck-IP3R PPI may protect malignant hematopoietic cells from death. Importantly, TAT-D5SD showed no cytotoxicity in three different non-hematopoietic cell lines; thus its ability to induce cell death appears specific to hematopoietic cells. Together, these data show that a peptide designed to disrupt the Lck-IP3R PPI has a wide range of pre-clinical activity in leukemia and lymphoma.","PeriodicalId":72285,"journal":{"name":"Archives of microbiology & immunology","volume":"7 3","pages":"165-177"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10569261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41221615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

After Years of Medical Wandering, A Diagnosis of Chronic Babesiosis Saves A Patient 经过多年的医疗流浪，慢性巴贝斯虫病的诊断挽救了病人

Archives of microbiology & immunology Pub Date : 2023-01-01 DOI: 10.26502/ami.936500123

Alexis LACOUT, Ahed ZEDAN, Christian PERRONNE

引用次数: 0