Archives of medical case reports and case study最新文献_第7页

Overall Review On Permeation Enhancers in Drug Delivery Systems 药物传递系统中渗透促进剂的研究综述

Archives of medical case reports and case study Pub Date : 2021-07-21 DOI: 10.31579/2692-9392/051

A. Krishna sailaja, Ganparaju Vaishnavi

{"title":"Overall Review On Permeation Enhancers in Drug Delivery Systems","authors":"A. Krishna sailaja, Ganparaju Vaishnavi","doi":"10.31579/2692-9392/051","DOIUrl":"https://doi.org/10.31579/2692-9392/051","url":null,"abstract":"60%-70% Several drugs can be administered orally as liquids, capsules, tablets, or chewable tablets because the oral route is the most convenient, safest and less expensive. The important challenge in the oral drug delivery is the growth of novel approaches to approve absorption of poorly permeable drugs across the intestinal permeability. The Biopharmaceutics Classification System (BCS) categorized based on their solubility and permeability. The BCS Class III, Class IV with low permeability across the biological membranes with low bioavailability. While these drugs are pharmacologically effective, poor absorption due to low permeability becomes the rate-limiting step to improve oral bioavailability. Various approaches for improving the permeability include physical, chemical, colloidal carriers and other methods such as prodrugs, permeation enhancers, ion-pairing, nanoencapsulation and combination/hybridization of one or more traditional approaches to improve drug permeability for better absorption. Among many advantages over other routes of administration 3 crucial ones are avoiding metabolism in liver, minimal negative effects and increased bioavailability.This article discusses the commonly various strategiesand various approaches for improving the permeability of BCS Class III and Class IVdrugs to enhance bioavailability.","PeriodicalId":72284,"journal":{"name":"Archives of medical case reports and case study","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45036445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Calculations of the Spread of the COVID 19 epidemic in New York City based on the Analytical Model 基于分析模型的新冠肺炎疫情在纽约市传播的计算

Archives of medical case reports and case study Pub Date : 2021-07-21 DOI: 10.31579/2692-9392/064

F. Mairanowski, D. Below

引用次数: 1

Pesky Hiccups; May be Risky! 打嗝；可能很危险！

Archives of medical case reports and case study Pub Date : 2021-07-21 DOI: 10.31579/2692-9392/065

Abeer M. SHAWKY

{"title":"Pesky Hiccups; May be Risky!","authors":"Abeer M. SHAWKY","doi":"10.31579/2692-9392/065","DOIUrl":"https://doi.org/10.31579/2692-9392/065","url":null,"abstract":"Background: Hiccups are benign and self-limited condition, but attention should be paid to the underlying conditions when persist. There are various causes of persistent hiccups, including metabolic abnormalities, psychogenic disorders, malignancy, nervous system pathology, medications, pulmonary disorders, or gastrointestinal etiologies. It is rarely attributed to cardiac disease. Case Summary: We report a case of intractable hiccups in a 67 y/o male as the initial symptom of coronary heart disease. He presented with a few-week history of hiccups and no other complaints. Echocardiography demonstrated wall motion abnormalities in the left ventricle with severe impairment of systolic function. He was He was admnistered chlorpromazine and anti-ischemic treatment, and a thallium viability study was advised before cardiac catheterization to confirm viable or nonviable myocardium. He refused further evaluation and was discharged with appropriate care. The gentleman was readmitted for heart failure two weeks after discharge due to poor medication adherence. The delay in treatment had affected his chances of survival, and his hiccuping symptoms had recurred and persisted. Finally, he died after two months from the time of diagnosis. Discussion: This case makes highlights the importance of having a high index of suspicion, especially in elderly diabetic patients where benign self-limiting conditions like hiccups can only present symptoms of severe cardiac disease. Cardiac disease should be considered even when the symptoms are only gastrointestinal; simple investigations in the form of changes in electrocardiogram with cardiac enzyme elevation may disclose the cardiac findings, as they did in our case!","PeriodicalId":72284,"journal":{"name":"Archives of medical case reports and case study","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47384240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bronchiolitis Obliterans Organizing Pneumonia after Breast Cancer Radiotherapy and letrozole: A Case Report and Literature Review 乳腺癌放疗和来曲唑后闭塞性细支气管炎组织肺炎1例并文献复习

Archives of medical case reports and case study Pub Date : 2021-07-21 DOI: 10.31579/2692-9392/049

Alati Aurélia, C. Pierre, Leobon Sophie

{"title":"Bronchiolitis Obliterans Organizing Pneumonia after Breast Cancer Radiotherapy and letrozole: A Case Report and Literature Review","authors":"Alati Aurélia, C. Pierre, Leobon Sophie","doi":"10.31579/2692-9392/049","DOIUrl":"https://doi.org/10.31579/2692-9392/049","url":null,"abstract":"Objectives: Bronchiolitis obliterans organizing pneumonia occurs with prevalence rate 1–3% after breast conservative treatment in series. In response to radiation of a lung or surrounding tissues, an inflammatory reaction can affect both lungs and is located within the radiation field. Characteristic imaging features include multiple alveolar opacities and diffuse ground-glass shadows. Letrozole may induce iatrogenic organizing pneumonia. Materials and methods: we report the case of a 76-year-old female who underwent conservative treatment for an invasive ductal carcinoma of the left breast. Hypofractionated radiotherapy was delivered with a total dose of 42.5 Gy in 16 sessions of 2.65 Gy using a three-dimensional technique. After the radiotherapy ended letrozole was indicated. Results: Several weeks after the radiotherapy ended and letrozole was introduced, she described a flu-like syndrome. Samples were negative, and there was no improvement after four courses of antibiotics. Imaging suggested bronchiolitis obliterans organizing pneumonia. Her symptomatology lessened after the letrozole was discontinued, and 11 months after radiotherapy finished, her imaging results were clear. Conclusion: Physicians must consider bronchiolitis obliterans organizing pneumonia. Cases may increase with hypofractionated radiation treatment and new drugs. Letrozole may potentiate the risk. Dosimetry may be adapted to the lung and subpleural areas for patients with risk factors and taking adjuvant or concurrent drugs with potential pneumotoxicity.","PeriodicalId":72284,"journal":{"name":"Archives of medical case reports and case study","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42275111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microbiome in immuno-rheumatology 免疫风湿病学中的微生物组

Archives of medical case reports and case study Pub Date : 2021-05-12 DOI: 10.31579/2694-0248/038

L. Gonzalez

引用次数: 0

Ménétrier Disease; 2-Year-Old Boy Presenting With Prolonged Emesis, Generalized Edema and Chance Histopathological Finding of Cytomegalovirus Gastritis: A Case Report Ménétrier病；2岁男孩出现长时间呕吐、全身水肿和巨细胞病毒性胃炎的偶然组织病理学发现：一例报告

Archives of medical case reports and case study Pub Date : 2021-05-12 DOI: 10.31579/2694-0248/029

Shipra Garg

{"title":"Ménétrier Disease; 2-Year-Old Boy Presenting With Prolonged Emesis, Generalized Edema and Chance Histopathological Finding of Cytomegalovirus Gastritis: A Case Report","authors":"Shipra Garg","doi":"10.31579/2694-0248/029","DOIUrl":"https://doi.org/10.31579/2694-0248/029","url":null,"abstract":"Ménétrier disease (MD) is characterized by enlarged gastric folds with associated protein losing gastropathy. In children it is a rare and self-limited cause of protein losing gastropathy. We report a case of a 2-year-old male who presented with prolonged, refractory emesis and peripheral edema. Workup revealed severe hypoalbuminemia, hypoproteinemia, iron deficiency anemia, and high stool alpha-1 antitrypsin. Hepatic protein synthesis was normal with no urinary protein loss. Endoscopy showed antrum sparing, severe erosive gastritis in body and fundus, characteristic of MD. Histologic examination displayed inflammation with eosinophilia, foveolar hyperplasia, atrophic oxyntic epithelium, and rare CMV inclusions. Patient received antiviral therapy, intravenous albumin, diuretic and was discharged on high protein diet. Follow-up revealed clinical recovery, with endoscopy and histology showing normal gastric mucosa throughout the stomach. It is important to remain vigilant of this condition in pediatric population and to include it in the differential diagnosis in cases of protein losing gastroenteropathy.","PeriodicalId":72284,"journal":{"name":"Archives of medical case reports and case study","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49394742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hepatic Lesions of Total Parenteral Nutrition (Tpn) Secondary to Umbilical Venous Catheter (Uvc) Malposition in A Very Low-Birth Weight Infant in China 我国极低出生体重儿脐静脉导管（Uvc）错位引起的全肠外营养（Tpn）肝损害

Archives of medical case reports and case study Pub Date : 2021-05-12 DOI: 10.31579/2694-0248/036

Xiao Luo

引用次数: 0

Microbiome in immuno-rheumatology 免疫风湿病学中的微生物组

Archives of medical case reports and case study Pub Date : 2021-05-12 DOI: 10.31579/2692-9392/038

L. A. Gutiérrez-González

引用次数: 0

Poisoning with Soranjan (Colchicum): a case report 秋水仙碱中毒1例

Archives of medical case reports and case study Pub Date : 2021-05-12 DOI: 10.31579/2694-0248/039

Amir Noyani

引用次数: 0

Methods to Improve the Efficacy of Autoinflation Procedures and to Classify Eustachian Tube Patency 方法提高自动充气手术的疗效，对咽鼓管通畅程度进行分类

Archives of medical case reports and case study Pub Date : 2021-04-09 DOI: 10.31579/2692-9392/025

S. Stangerup

引用次数: 1