Denis Gersdorf, Franziska Rambow, Reiner Weise, Ivayla Apostolova, Yuske Kobayashi, Jin Yamamura, Kristian Tecklenburg, Zsofia Zsebe, Susanne Klutmann, Kenichi Nakajima, Janos Mester
{"title":"Effects of Acquisition Matrix Size on the Accuracy and Repeatability of Parameters of Left Ventricular Function: A Phantom Study for ECG-gated Myocardial SPECT.","authors":"Denis Gersdorf, Franziska Rambow, Reiner Weise, Ivayla Apostolova, Yuske Kobayashi, Jin Yamamura, Kristian Tecklenburg, Zsofia Zsebe, Susanne Klutmann, Kenichi Nakajima, Janos Mester","doi":"10.17996/anc.21-00140","DOIUrl":"https://doi.org/10.17996/anc.21-00140","url":null,"abstract":"<p><p><i>Background</i>: The voxel size in ECG-gated myocardial SPECT (GSPECT) is a compromise between geometric resolution and count statistics with varying values and is rather inconsistent in different centers. We investigated the influence of typical acquisition matrix sizes for GSPECT on the reproducibility and accuracy of left ventricular function parameters using a dynamic heart phantom. <i>Methods</i>: Ten paired acquisitions, each pair with slightly different phantom positions, were obtained using identical imaging parameters except acquisition matrix: 128 × 128 matrix (3.3 mm voxel) and 64 × 64 matrix (6.6 mm voxel). In the next step, 128 × 128 data sets were compressed to an additional set of 64 × 64 matrix images. <i>Results</i>: Nominal value of left ventricular ejection fraction (LVEF) of the phantom was 67%. Both acquisition matrices led to significant overestimation of the LVEF. Overestimation was more pronounced in 64 × 64 than in 128 × 128 studies (79.8 ± 2.5% vs. 73.6 ± 1.4%, p<0.05). Calculated volumes were closer to the nominal values with 128 × 128 than with 64 × 64 studies. Variance showed a trend to be higher with 64 × 64 matrix, but the effect did not reach the level of statistical significance. <i>Conclusions</i>: LVEF overestimation and volume underestimation can be reduced by using finer matrix size without any negative effect on the reproducibility.</p>","PeriodicalId":72228,"journal":{"name":"Annals of nuclear cardiology","volume":"7 1","pages":"43-48"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040942/pdf/anc-7-43.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9226928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Selective Adenosine A2A Agonists May Change Myocardial Perfusion Imaging.","authors":"Kazuya Takehana","doi":"10.17996/anc.21-00147","DOIUrl":"https://doi.org/10.17996/anc.21-00147","url":null,"abstract":"<p><p>In recent years, the requirement for pharmacological stress myocardial perfusion imaging (SPECT) has increased, and adenosine stress testing is now the mainstream. Selective adenosine A2A receptor agonists will be applied clinically in the future. By selectively activating only A2A receptors, it can reduce complications such as bronchospasm, hypotension, and bradycardia, which have been problems with adenosine stress tests. In addition, since this drug can be administered in bolus injection, it has the advantage of being able to perform the test at one root.</p>","PeriodicalId":72228,"journal":{"name":"Annals of nuclear cardiology","volume":"7 1","pages":"63-66"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040943/pdf/anc-7-63.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9222340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nuclear Cardiology in the Post-COVID Era: What Will Be Its Legacy?","authors":"Takashi Kudo","doi":"10.17996/anc.21-00143","DOIUrl":"10.17996/anc.21-00143","url":null,"abstract":"<p><p>The pandemic of Coronavirus disease 2019 (COVID-19) caused a substantial negative impact on patients with cardiovascular disease. The negative impact of the pandemic on daily clinical practices for cardiovascular diseases (CVD) cannot be underestimated. The CVD patients (without COVID-19 infection), whose diagnosis and treatment have been delayed or postponed by the pandemic, are victims of COVID-19. In this context, COVID-19 is a \"syndemic\" disease. Several studies already revealed that negative changes already occurred in CVD patient management, such as increased in-hospital death, supply shortage of <sup>99m</sup>Tc/<sup>99</sup>Mo generator, etc. To clarify the impact of COVID-19 on the management of CVD, a global survey named \"INCAPS-COVID\" was conducted. This study revealed a substantial reduction (around 50%) of cardiovascular imaging practice in the early stage of the pandemic during March and April 2020. This pandemic has necessitated changes in cardiovascular management practices to adopt this condition. Some of those changes will become the legacy of the pandemic. Possible legacy will be; 1) Use of telemedicine; 2) Shift from exercise to pharmacological stress; 3) Shift from single photon emission computed tomography (SPECT) to positron emission tomography (PET). By adapting and changing to the challenges caused by the COVID-19 pandemic, nuclear cardiology will survive and will rise as an improved cardiovascular practice, even after the pandemic.</p>","PeriodicalId":72228,"journal":{"name":"Annals of nuclear cardiology","volume":"7 1","pages":"3-7"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040947/pdf/anc-7-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9219553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Efficacy of Add-on Therapy with Carvedilol and the Direct Renin Inhibitor Aliskiren for Improving Cardiac Sympathetic Nerve Activity, Cardiac Function, Symptoms, Exercise Capacity and Brain Natriuretic Peptide in Patients with Dilated Cardiomyopathy.","authors":"Takuji Toyama, Shu Kasama, Yusuke Miyaishi, Hakuken Kan, Eiji Yamashita, Ren Kawaguchi, Hitoshi Adachi, Hiroshi Hoshizaki, Shigeru Ohshima","doi":"10.17996/anc.21-00139","DOIUrl":"https://doi.org/10.17996/anc.21-00139","url":null,"abstract":"<p><p><i>Purpose/Method</i>: Aliskiren is a direct renin inhibitor that has been reported to be effective for CHF, but the usefulness of combined therapy with carvedilol and aliskiren has not been reported. Forty-four patients with dilated cardiomyopathy (DCM) were randomized into a group receiving add-on therapy with carvedilol plus aliskiren and another group receiving carvedilol alone for 6 months. Nuclear imagings with <sup>123</sup>I-Metaiodobenzylguanidine (MIBG) and <sup>99m</sup>Tc-Sestamibi were performed. Exercise capacity using a specific activity scale (SAS) and the New York Heart Association (NYHA) class were evaluated. Cardiac sympathetic nerve activity was evaluated by <sup>123</sup>I-MIBG imaging, with the delayed heart-to-mediastinum activity ratio (H/M), delayed total defect score (TDS), and washout rate (WR). <i>Results</i>: Combined add-on therapy with carvedilol and aliskiren improved several parameters much more than carvedilol alone (p<0.05) with respect to TDS, ejection fraction (EF), NYHA, SAS on 6 months and the changes in TDS, EF, end-diastolic volume and brain natriuretic peptide (BNP). <i>Conclusion</i>: Add-on therapy with carvedilol and aliskiren is more effective than carvedilol alone for improving cardiac sympathetic nerve activity, cardiac function, symptoms, exercise capacity, and brain natriuretic peptide in patients with DCM.</p>","PeriodicalId":72228,"journal":{"name":"Annals of nuclear cardiology","volume":"7 1","pages":"33-42"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040940/pdf/anc-7-33.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9222343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nuclear Cardiology: Basic and Advanced Concepts in Clinical Practice","authors":"","doi":"10.1007/978-3-030-62195-7","DOIUrl":"https://doi.org/10.1007/978-3-030-62195-7","url":null,"abstract":"","PeriodicalId":72228,"journal":{"name":"Annals of nuclear cardiology","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74003909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diagnosis of Pulmonary Embolism","authors":"B. Amorim, Marcel Yanagihara Rigolon, C. Ramos","doi":"10.1007/978-3-030-62195-7_31","DOIUrl":"https://doi.org/10.1007/978-3-030-62195-7_31","url":null,"abstract":"","PeriodicalId":72228,"journal":{"name":"Annals of nuclear cardiology","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88079528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Correlation Perspectives for the Diagnosis of Idiopathic Triglyceride Deposit Cardiomyovasculopathy.","authors":"Hideyuki Miyauchi, Takashi Iimori, Keisuke Hoshi, Masayuki Ohyama, Ken-Ichi Hirano, Yoshio Kobayashi","doi":"10.17996/anc.20-00128","DOIUrl":"https://doi.org/10.17996/anc.20-00128","url":null,"abstract":"<p><p><i>Background</i>: Triglyceride (TG) deposit cardiomyovasculopathy (TGCV) is a novel cardiovascular disorder and was recently encoded as an orphan disease in Europe (ORPHA code: 565612). Defective lipolysis results in TG accumulation in the myocardium and coronary arteries in TGCV. The myocardial washout rate (WR) of iodine-123-<i>β</i>-methyl iodophenyl-pentadecanoic acid (BMIPP) is an essential indicator to evaluate myocardial lipolysis in vivo. TGCV is classified into primary and idiopathic type with and without <i>PNPLA2</i> mutation, respectively. Here, we present the clinical correlation perspectives of TGCV patients in Chiba, Japan, to increase the awareness of this orphan disease and facilitate its diagnosis. <i>Methods</i>: We enrolled 234 patients who underwent BMIPP scintigraphy between September 2015 and July 2019. The diagnosis of TGCV was made based on the criteria we reported previously. Blood smear tests were performed for TGCV classification. The distributions of TGCV in each comorbidity were investigated. <i>Results</i>: In total, 104 patients were diagnosed with definitive idiopathic TGCV (I-TGCV). They had various comorbid conditions, including heart failure with reduced ejection fraction and multivessel coronary artery disease requiring revascularization. Moreover, the serum TG levels in I-TGCV patients were not high, and there was no correlation between serum TG level and BMIPP WR (n=205, p-value=0.31), supporting the pathophysiological hypothesis of TGCV. <i>Conclusion</i>: I-TGCV patients showed multiple coexistence of coronary artery disease, heart failure of unknown etiology, or diabetes mellitus. For patients with such clinical characteristics, BMIPP scintigraphy and calculation of WR should be considered proactively for the diagnosis of TGCV.</p>","PeriodicalId":72228,"journal":{"name":"Annals of nuclear cardiology","volume":"6 1","pages":"33-38"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10133925/pdf/anc-6-33.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9398079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cardiac Amyloidosis: Current Diagnostic Strategies Using Multimodality Imaging.","authors":"Kenji Fukushima, Shintaro Nakano, Ichiro Matsunari","doi":"10.17996/anc.20-00130","DOIUrl":"https://doi.org/10.17996/anc.20-00130","url":null,"abstract":"<p><p>Amyloidosis is a systemic disorder in which abnormal amyloid proteins deposit in body organs, leading to organ dysfunction and death. Cardiac amyloid deposition, causing a sort of restrictive cardiomyopathy and associated with increased risk of mortality. Most cases of cardiac amyloidosis are of either light chain or transthyretin type. Early and accurate diagnosis of cardiac amyloidosis may improve outcomes. However, diagnosis requires systematic approach including electrocardiography and biomarkers when encountered suspicious candidate. Diagnosis by multimodality noninvasive imaging have been substantially studied and established for differentiation from subtypes. Recent advance in the treatment of amyloidosis offers therapeutic monitoring and prognosis.</p>","PeriodicalId":72228,"journal":{"name":"Annals of nuclear cardiology","volume":"6 1","pages":"67-73"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10133936/pdf/anc-6-67.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9449495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"How to Write a Successful Article.","authors":"Ignasi Carrió","doi":"10.17996/anc.20-00127","DOIUrl":"https://doi.org/10.17996/anc.20-00127","url":null,"abstract":"<p><p>In this report, several issues relevant to scientific publishing in the field of medical imaging are described. How the quality of the research in medical imaging is evaluated is presented as well. The need for journals and the role of current metrics to judge the quality of articles and journals are discussed. Several recommendations are given to aspiring authors on how to write scientific articles in this field to help them optimize their chances of having their articles accepted. Recommendations on how to effectively deal with the review process and how to properly communicate with scientific journals are offered in order to facilitate authors' interaction with reviewers and editors of the journals in the field.</p>","PeriodicalId":72228,"journal":{"name":"Annals of nuclear cardiology","volume":"6 1","pages":"6-10"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10133931/pdf/anc-6-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9449494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Improving Quality of Clinical Diagnosis Report with Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging and Coronary Computed Tomography Angiography.","authors":"Rine Nakanishi, Hidenobu Hashimoto, Takanori Ikeda","doi":"10.17996/anc.20-00111","DOIUrl":"https://doi.org/10.17996/anc.20-00111","url":null,"abstract":"<p><p>Non-invasive cardiac imaging modalities including single-photon emission computed tomography myocardial perfusion image (SPECT-MPI) and coronary computed tomography angiography (CTA) have been widely used for diagnosis of coronary artery disease (CAD). The American Society of Nuclear Cardiology and Society of Cardiovascular Computed Tomography have recently published the guidelines for the instrumentation, acquisition, processing, interpretation, as well as reporting of SPECT and coronary CTA. These guidelines have highlighted and well documented how the imaging reporting influences medical practice for physician and treatment care for patients, suggesting that cardiac imaging reports for interpretation for patient management. This review article here summarizes improving quality of cardiac imaging reports by SPECT-MPI and coronary CTA.</p>","PeriodicalId":72228,"journal":{"name":"Annals of nuclear cardiology","volume":"6 1","pages":"86-90"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10133933/pdf/anc-6-86.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9393119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}