Andreas Konstantinou, Sivasanker Masillamany, Ajit Thomas Abraham, Deepak Hariharan, Vincent Sui Kwong Yip, Hemant Mahendrakumar Kocher
{"title":"A positive resection margin does not determine long-term survival following colorectal liver metastasis resection.","authors":"Andreas Konstantinou, Sivasanker Masillamany, Ajit Thomas Abraham, Deepak Hariharan, Vincent Sui Kwong Yip, Hemant Mahendrakumar Kocher","doi":"10.14701/ahbps.24-233","DOIUrl":"https://doi.org/10.14701/ahbps.24-233","url":null,"abstract":"<p><strong>Backgrounds/aims: </strong>This study evaluates whether positive resection margins after colorectal liver metastasis (CRLM) surgery are linked to tumor recurrence and impact long-term survival.</p><p><strong>Methods: </strong>The oncological outcomes of patients undergoing curative resection for CRLM at a single institution were analyzed concerning clinicopathological factors using both univariate and multivariate statistical methods.</p><p><strong>Results: </strong>Among 138 patients who underwent liver resection for CRLM, hepatic tumor recurrence was noted in 70 patients (50.7%), with no significant difference between those with R0 and R1 resections (<i>p</i> = 0.33). Positive resection margins were associated with tumor proximity to major liver vascular structures, while negative margins corresponded more frequently with T4 stage colorectal cancer. Multivariate analysis indicated that R1 margins in CRLM resections do not affect overall or disease-free survival. Nonetheless, the proximity of tumors to major liver vascular structures and R1 margins from initial colorectal cancer resections were significant independent predictors of poorer survival outcomes.</p><p><strong>Conclusions: </strong>With the advent of modern perioperative systemic therapies, both hepatic recurrence and survival outcomes following hepatectomy for colorectal liver metastases seem unaffected by the presence of R1 resection margins.</p>","PeriodicalId":72220,"journal":{"name":"Annals of hepato-biliary-pancreatic surgery","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Safety and efficacy of minimally invasive splenectomy with endotherapy for non-cirrhotic portal fibrosis: a retrospective cohort study.","authors":"Lokesh Agarwal, Sanjamjot Singh, Vaibhav Kumar Varshney, Subhash Chandra Soni, B Selvakumar, Peeyush Varshney, Shaikh Muna Afroz, Tashmeen Kaur Sethi, Binit Sureka","doi":"10.14701/ahbps.25-033","DOIUrl":"https://doi.org/10.14701/ahbps.25-033","url":null,"abstract":"<p><p>Non-cirrhotic portal fibrosis (NCPF), a leading cause of non-cirrhotic portal hypertension (NCPH), commonly presents with splenomegaly, esophageal varices, and preserved liver function. While minimally invasive splenectomy (MIS) offers advantages over open splenectomy, concerns persist due to the risks associated with portal hypertension. This study evaluates the feasibility, safety, and long-term outcomes of MIS in non-bleeder NCPF patients, highlighting perioperative challenges and techniques. Thirteen consecutive non-bleeder NCPF patients undergoing MIS between November 2017 and December 2023 were analyzed. Procedures included eight laparoscopic and four robotic splenectomies, with one conversion to open surgery. Additionally, two patients underwent laparoscopic and one robotic gastric devascularization. Perioperative parameters such as operative time, blood loss, hospital stay, and complications were recorded. The median operative time was 240 minutes, and median blood loss was 150 mL. One patient required transfusion, and one developed splanchnic venous thrombosis, managed conservatively. Median hospital stay was three days, with no 90-day mortality. Follow-up assessments included clinical evaluation, blood tests, Doppler ultrasound of the splenoportal axis, and upper gastrointestinal endoscopy. At a median follow-up of 16 months (interquartile range 12-43), significant improvements were observed in hemoglobin, leukocyte, and platelet counts (<i>p</i> < 0.01). Esophageal variceal grades decreased from 2 to 1, while portal vein peak systolic velocity improved from 18 to 27.7 cm/sec (<i>p</i> < 0.01), indicating reduced portal hypertension. No postoperative infections or variceal bleeding recurrences were noted. MIS is a safe and effective treatment option for non-bleeder NCPF with favorable long-term outcomes when performed by skilled surgeons.</p>","PeriodicalId":72220,"journal":{"name":"Annals of hepato-biliary-pancreatic surgery","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Factors affecting recurrence of pain after surgery for chronic pancreatitis: A retrospective and prospective study.","authors":"Sunil Kumar Godara, Shaganti Rakesh, Rahul, Sujeet Kumar Singh Gautam, Rajneesh Kumar Singh","doi":"10.14701/ahbps.25-001","DOIUrl":"https://doi.org/10.14701/ahbps.25-001","url":null,"abstract":"<p><strong>Backgrounds/aims: </strong>Postoperative pain recurrence is a challenging issue in chronic pancreatitis (CP). This study explores the incidence and factors contributing to recurrent pain after surgery.</p><p><strong>Methods: </strong>An ambispective observational study evaluated patients with painful CP undergoing surgery from 2011 to 2022. The intensity frequency consequence (IFC) pain score and the painDETECT questionnaire were utilized to assess pain before and after surgery. Patients were categorized into 2 groups based on their IFC pain scores: a pain group and a pain-free group. Clinical, radiological, surgical, and post-surgical parameters were compared between these groups using the student t-test and logistic regression for continuous and categorical variables, respectively. A <i>p</i>-value of < 0.05 was deemed significant. Multivariate analysis was conducted.</p><p><strong>Results: </strong>A total of 125 patients were enrolled (pain group, 71 [56.8%]; pain-free group, 54 [43.2%]). In the pain group, 65 experienced mild and 6 experienced moderate pain. The average post-surgery pain score was significantly lower than the pre-surgery score (13.7 vs 2.5, <i>p</i> < 0.001). Multivariate analyses revealed that intravenous (IV) analgesics and preoperative endoscopic interventions were independent predictors of recurrent pain.</p><p><strong>Conclusions: </strong>The incidence of recurrent pain in CP patients post-surgery was 56.8%, with a significant reduction in pain intensity postoperatively. Patients who required preoperative IV analgesics and underwent endoscopic interventions demonstrated a higher risk of recurrent pain. Neuropathic pain was not identified as a cause of pain recurrence in this study.</p>","PeriodicalId":72220,"journal":{"name":"Annals of hepato-biliary-pancreatic surgery","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lam Sihardo, Arnetta Naomi Louise Lalisang, Ridho Ardhi Syaiful, Afid Brilliana Putra, Yarman Mazni, Agi Satria Putranto, Toar Jean Maurice Lalisang
{"title":"Seizing tumor factors for mortality and survival outcomes following liver resection in Indonesia's hepatocellular carcinoma patients.","authors":"Lam Sihardo, Arnetta Naomi Louise Lalisang, Ridho Ardhi Syaiful, Afid Brilliana Putra, Yarman Mazni, Agi Satria Putranto, Toar Jean Maurice Lalisang","doi":"10.14701/ahbps.24-179","DOIUrl":"10.14701/ahbps.24-179","url":null,"abstract":"<p><strong>Backgrounds/aims: </strong>The 3-year mortality rate for hepatocellular carcinoma (HCC) in Indonesia was 94.4%. This underscores a significant health issue in Southeast Asia, particularly in Indonesia due to its large population. This study aimed to characterize the outcomes of liver resection for HCC at a National Referral Center in Indonesia.</p><p><strong>Methods: </strong>Between 2010 and 2020, all patients with HCC undergoing liver resection were included as subjects. Variables collected included sex, age, hepatitis status, and tumor's characteristics. Mortality and survival were the primary outcomes of the study.</p><p><strong>Results: </strong>Among seventy patients, the mortality rate was 71.4%, with a median overall survival of 19.0 months (95% confidence interval [95%CI]: 6.831.2). Thirty-one patients (44.3%) had extra-large HCC tumors (> 10 cm). Those with extra-large tumors had a lower median survival of 8.0 months. Child-Pugh B and Edmonson-Steiner grade 4 were associated with an increased mortality risk, with unadjusted hazard ratios (HRs) of 2.2 (95%CI: 1.14.3, <i>p</i> = 0.026) and 3.2 (95%CI: 1.37.7, <i>p</i> = 0.011), respectively. Multivariate analysis indicated that Child-Pugh class B significantly increased the risk of mortality, with an adjusted HR of 2.3 (95%CI: 1.05.2, <i>p</i> = 0.046).</p><p><strong>Conclusions: </strong>While surgical resection is feasible for tumors of any size, most clinical features are not statistically significantly associated with survival outcomes. The prevalence of extra-large tumors among Indonesian HCC patients highlights the importance of early diagnosis and intervention. Surgical intervention at an earlier stage and with better grade tumors could potentially enhance survival outcomes.</p>","PeriodicalId":72220,"journal":{"name":"Annals of hepato-biliary-pancreatic surgery","volume":" ","pages":"11-20"},"PeriodicalIF":1.1,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zofia Czarnecka, Kevin Verhoeff, David Bigam, Khaled Dajani, James Shapiro, Blaire Anderson
{"title":"Impact of soft pancreas on pancreaticoduodenectomy outcomes and the development of the preoperative soft pancreas risk score.","authors":"Zofia Czarnecka, Kevin Verhoeff, David Bigam, Khaled Dajani, James Shapiro, Blaire Anderson","doi":"10.14701/ahbps.24-172","DOIUrl":"10.14701/ahbps.24-172","url":null,"abstract":"<p><strong>Backgrounds/aims: </strong>Pancreatic texture is difficult to predict without palpation. Soft pancreatic texture is associated with increased post-operative complications, including postoperative pancreatic fistula (POPF), cardiac, and respiratory complications. We aimed to develop a calculator predicting pancreatic texture using patient factors and to illustrate complications from soft pancreatic texture following pancreaticoduodenectomy.</p><p><strong>Methods: </strong>Data was collected from the 2016 to 2021 American College of Surgeons National Surgical Quality Improvement database including 17,706 pancreaticoduodenectomy cases. Patients were categorized into two cohorts based on pancreatic texture (9,686 hard, 8,020 soft). Multivariable modeling assessed the impact of patient factors on complications, mortality, and pancreatic texture. These preoperative factors were integrated into a risk calculator (preoperative soft pancreas risk score [PSPRS]) that predicts pancreatic texture.</p><p><strong>Results: </strong>Patients with a soft pancreas had higher rates of postoperative complications compared to those with a hard pancreas (56.5% vs 42.2%; <i>p</i> < 0.001), particularly a threefold increase in POPF rate, and at least a twofold increase in rates of acute kidney injury, deep organ space infection, septic shock, and prolonged length of stay. Female sex (odds ratio [OR]: 1.14, confidence interval [CI]: 1.06-1.22, <i>p</i> < 0.001) and higher body mass index (OR: 1.12, CI: 1.09-1.16, <i>p</i> < 0.001) were independently associated with a soft pancreas. PSPRS ≥6 correctly identified >40% of patients preoperatively as having a hard pancreas (68.9% specificity).</p><p><strong>Conclusions: </strong>A soft pancreas was independently associated with serious postoperative complications. Our results were integrated into a risk calculator predicting pancreatic texture from preoperative patient factors, potentially enhancing preoperative counseling and surgical decision-making.</p>","PeriodicalId":72220,"journal":{"name":"Annals of hepato-biliary-pancreatic surgery","volume":" ","pages":"62-71"},"PeriodicalIF":1.1,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Giovanni D Tebala, Paolo Pietro Bianchi, Giles Bond-Smith, Andrea Coratti, Fabrizio Panaro, Graziano Pernazza, Davide Cavaliere
{"title":"Robotic versus laparoscopic cholecystectomy: Can they be compared? A narrative review and personal considerations disproving low-level evidence.","authors":"Giovanni D Tebala, Paolo Pietro Bianchi, Giles Bond-Smith, Andrea Coratti, Fabrizio Panaro, Graziano Pernazza, Davide Cavaliere","doi":"10.14701/ahbps.24-192","DOIUrl":"10.14701/ahbps.24-192","url":null,"abstract":"<p><p>Laparoscopic cholecystectomy (LC) is the gold standard for the treatment of symptomatic gallstones, acute cholecystitis, and acute gallstone pancreatitis. In recent years, the development and diffusion of robotic surgery have provided surgeons with the opportunity to apply this innovative approach to cholecystectomy, yielding interesting results. However, as with any new surgical technique, robotic cholecystectomy (RC) has met with skepticism within the surgical community. Beyond the understandable concerns regarding increased costs, some authors have claimed that RC is associated with a higher complication rate compared to LC. We reviewed the existing literature on this subject, discussing the limitations and strengths of the most significant publications and critically analyzing them. The analysis of the literature indicates that RC is safe and effective, with no definitive evidence of its inferiority compared to LC. Some of the published papers are of low quality and biased, even with significant sample sizes. Furthermore, we believe that comparing an established technique like LC with a new and not yet standardized one such as RC is somewhat illogical. RC represents a significant advance in minimally invasive surgery and should be viewed as an opportunity to familiarize oneself with the robotic device and to enhance the surgeon's skills in preparation for more complex robotic operations. The robotic approach can be beneficial in selected cases of cholecystectomy where fine dissection is required. With further reductions in costs, RC could become the future gold standard for benign gallbladder disorders.</p>","PeriodicalId":72220,"journal":{"name":"Annals of hepato-biliary-pancreatic surgery","volume":" ","pages":"5-10"},"PeriodicalIF":1.1,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thanh Khiem Nguyen, Ham Hoi Nguyen, Tuan Hiep Luong, Thanh Tung Lai, Van Duy Le, Pisey Chantha
{"title":"Laparoscopic total pancreatectomy with total mesopancreas dissection using counterclockwise technique and tail-first approach.","authors":"Thanh Khiem Nguyen, Ham Hoi Nguyen, Tuan Hiep Luong, Thanh Tung Lai, Van Duy Le, Pisey Chantha","doi":"10.14701/ahbps.24-176","DOIUrl":"10.14701/ahbps.24-176","url":null,"abstract":"<p><p>Laparoscopic total pancreatectomy (LTP) is technically challenging and infrequently documented in the literature. In this paper, we present a new approach for performing fully LTP, a pancreatic tail-first approach with a counterclockwise technique, to accomplish total mesopancreas dissection and standard lymphadenectomy en bloc. Firstly, the tail and body of the pancreas without the spleen were dissected retrogradely, starting from the lower border of the body of pancreas and then from left to right. After that, a counterclockwise dissection of the tail and body of the pancreas was performed. The splenic artery and vein were divided at the terminal end of the pancreatic tail. The spleen was preserved. The entire body and tail of the pancreas were then pulled to the right side. This maneuver facilitated the isolation and dissection of arteries in the retropancreatic region more easily via laparoscopy, including the splenic artery, gastroduodenal artery, and supporting superior mesenteric artery first-approach. It also enabled total mesopancreas dissection. The inferior pancreaticoduodenal artery was resected last during this phase. The remainder of the dissection was like that of a laparoscopic pancreaticoduodenectomy with total mesopancreas dissection, involving two laparoscopic manual anastomoses. The operative time was 490 minutes and the total blood loss was 100 mL. Pathology revealed a low-grade intraductal papillary mucinous neoplasm extending from the head to the tail of the pancreas.</p>","PeriodicalId":72220,"journal":{"name":"Annals of hepato-biliary-pancreatic surgery","volume":" ","pages":"79-82"},"PeriodicalIF":1.1,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830897/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ana Duarte, Vasyl Katerenchuk, Rita Poeira, Paula Rocha, Filipe Pissarra, Margarida Canas, Sandra Dias, Diogo Andrade, Hugo Pinto Marques, Susana Cadilha, José Silva Pinto
{"title":"Anesthesia management for total robotic liver transplantation: Inaugural case series in Europe.","authors":"Ana Duarte, Vasyl Katerenchuk, Rita Poeira, Paula Rocha, Filipe Pissarra, Margarida Canas, Sandra Dias, Diogo Andrade, Hugo Pinto Marques, Susana Cadilha, José Silva Pinto","doi":"10.14701/ahbps.24-170","DOIUrl":"10.14701/ahbps.24-170","url":null,"abstract":"<p><p>Robotic liver transplantation represents a cutting-edge technique that may surpass traditional open surgery. Nonetheless, it introduces unique anesthetic challenges, including extended pneumoperitoneum, restricted patient access, and a risk of undetected blood loss. This article describes an anesthetic approach and patient outcomes for the first four total robotic liver transplants performed at a tertiary university hospital in Portugal, along with inaugural procedures of their kind in Europe. We retrospectively analyzed surgical and anesthetic data from four patients who underwent total robotic liver transplantation from February to April 2024. Data encompassed clinical profile, preoperative assessment, surgical and anesthesia details, postoperative course, and outcomes. Patients' age ranged from 51 to 69 years. Their cirrhosis was primarily due to alcohol use, hepatitis C virus infection, hepatocellular carcinoma, or nonalcoholic steatohepatitis. General anesthesia was administered. Hemodynamic monitoring and goal-directed fluid therapy were conducted using a PiCCO system. Blood loss varied from 1,000 to 5,000 mL. Blood products were transfused as needed. All donor livers underwent hypothermic oxygenated machine perfusion before transplantation. After surgery, two patients were immediately extubated, while two required extended ventilation. Hospital stays ranged from 10 to 40 days. The 30-day survival rate was 100%. This initial case series affirmed the feasibility and safety of total robotic liver transplantation for carefully selected patients, yielding favorable short-term results. Anesthetic management can rely on proactive strategies, acute situational awareness, and effective multidisciplinary collaboration.</p>","PeriodicalId":72220,"journal":{"name":"Annals of hepato-biliary-pancreatic surgery","volume":" ","pages":"88-94"},"PeriodicalIF":1.1,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alvaro Ducas, Alberto Mangano, Leonardo Borgioli, Jessica Cassiani, Paula Lopez, Pier Cristoforo Giulianotti
{"title":"The role of artificial intelligence in pancreatic surgery: Current and future perspectives.","authors":"Alvaro Ducas, Alberto Mangano, Leonardo Borgioli, Jessica Cassiani, Paula Lopez, Pier Cristoforo Giulianotti","doi":"10.14701/ahbps.24-130","DOIUrl":"10.14701/ahbps.24-130","url":null,"abstract":"","PeriodicalId":72220,"journal":{"name":"Annals of hepato-biliary-pancreatic surgery","volume":" ","pages":"1-4"},"PeriodicalIF":1.1,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142128162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Agastya Patel, Francesco Lancellotti, Ajith Kumar Siriwardena, Vinotha Nadarajah, Nicola de Liguori Carino
{"title":"Irreversible electroporation as an intraoperative adjunctive treatment for locally advanced pancreatic cancer after neoadjuvant therapy: An initial clinical experience.","authors":"Agastya Patel, Francesco Lancellotti, Ajith Kumar Siriwardena, Vinotha Nadarajah, Nicola de Liguori Carino","doi":"10.14701/ahbps.24-193","DOIUrl":"10.14701/ahbps.24-193","url":null,"abstract":"<p><strong>Backgrounds/aims: </strong>Irreversible electroporation (IRE) may have a potential application as either a \"back-up therapy\" or for margin accentuation during trial dissection of locally advanced pancreatic cancer (LAPC). The aim of this report was to describe our experience with IRE in terms of its potential applications mentioned above.</p><p><strong>Methods: </strong>A clinical policy to use IRE in LAPC patients undergoing exploratory surgery after neoadjuvant therapy (NAT) was initiated in 2017. If resection was feasible, IRE was used for margin accentuation. If not, then IRE was undertaken as a \"back-up therapy\" of non-resectable tumor. Data on baseline characteristics, perioperative 90-day morbidity, recurrence-free survival (RFS) and overall survival (OS) were collected.</p><p><strong>Results: </strong>IRE was successfully performed in 18 (95%) patients. IRE was abandoned in one case for technical reasons. Nine patients who were found to have an unresectable disease underwent IRE as a \"back-up therapy\" while the remaining patients received IRE for margin accentuation. Complications were recorded in 33% patients. There was no procedure-related mortality. In the group receiving IRE for margin accentuation, the median RFS was 10.0 months (range, 4.5-15.0 months). The median OS of our cohort was 22 months (range, 14.75-27.50 months).</p><p><strong>Conclusions: </strong>This report shows that in patients with LAPC undergoing exploratory surgery following NAT, IRE seems technically feasible for margin accentuation or as a \"back-up therapy\". More data are needed to determine procedure-related morbidity, mortality, and any effects of IRE on cancer-related survival.</p>","PeriodicalId":72220,"journal":{"name":"Annals of hepato-biliary-pancreatic surgery","volume":" ","pages":"72-78"},"PeriodicalIF":1.1,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}