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Intermittent Transfusions for Treatment of Thalassemia in the State of Georgia, 2007-2016 2007-2016年格鲁吉亚州治疗地中海贫血的间歇性输血
Annals of hematology & oncology Pub Date : 2021-04-10 DOI: 10.26420/ANNHEMATOLONCOL.2021.1340
Rollins Mr, J. Boudreaux, J. Eckman, J. Branscomb, M. Zhou, A. Snyder
{"title":"Intermittent Transfusions for Treatment of Thalassemia in the State of Georgia, 2007-2016","authors":"Rollins Mr, J. Boudreaux, J. Eckman, J. Branscomb, M. Zhou, A. Snyder","doi":"10.26420/ANNHEMATOLONCOL.2021.1340","DOIUrl":"https://doi.org/10.26420/ANNHEMATOLONCOL.2021.1340","url":null,"abstract":"Background: Individuals with Non-Transfusion Dependent Thalassemia (NTDT) may require infrequent transfusions. Knowing transfusion history, while important, can be challenging in this subgroup. Study Design: Hospital discharge data in Georgia (2007-2016) was reviewed. Thalassemia patients were defined as ≥3 encounters with a thalassemia diagnosis code. Transfusion was defined by the presence of a diagnosis, CPT, revenue, or HCPCS code for red cell transfusion. Results: There were 428 patients identified; 57 received multi-site transfusions. Conclusion: Georgia hospitals provide intermittent transfusions to low volumes of probable NTDT patients. Patient and provider education may help assure adherence to best practices, avoiding serious transfusion complications.","PeriodicalId":72219,"journal":{"name":"Annals of hematology & oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43275613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TdT Negativity and ETP Phenotype in Young Patients with Acute T- Lymphoid Leukemia: A Case Report 青年急性T淋巴细胞白血病患者的TdT阴性和ETP表型：一例报告
Annals of hematology & oncology Pub Date : 2021-04-05 DOI: 10.26420/ANNHEMATOLONCOL.2021.1339
Cetin D, Midik Mm, Karadag Fk, Ozsan N, Pariltay E, Akin H, Saydam G
{"title":"TdT Negativity and ETP Phenotype in Young Patients with Acute T- Lymphoid Leukemia: A Case Report","authors":"Cetin D, Midik Mm, Karadag Fk, Ozsan N, Pariltay E, Akin H, Saydam G","doi":"10.26420/ANNHEMATOLONCOL.2021.1339","DOIUrl":"https://doi.org/10.26420/ANNHEMATOLONCOL.2021.1339","url":null,"abstract":"TdT is generally positive in patients with T-Acute Lymphoblastic Leukemia/ Lymphoma (T-ALL/LBL) and can often become negative after chemotherapy. TdT negativity at the time of diagnosis is not a common condition and is evaluated in favor of a poor prognosis. Due to its infrequent occurrence, there are not enough clinical studies, and there are often publications on the basis of case and case series. While its incidence increases in young people and children, the possibility of accompanying Early T Precursor (ETP) phenotype also increases. The presence of the ETP phenotype has negative repercussions on prognosis. Here, we will describe the diagnosis and treatment process of a young adult patient with TdT negative T-ALL accompanied by the ETP phenotype.","PeriodicalId":72219,"journal":{"name":"Annals of hematology & oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43013821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hemophagocytic Lymphohistiocytosis after Initiation of Combined Immunotherapy for Metastatic Melanoma 开始联合免疫治疗转移性黑色素瘤后的噬血细胞淋巴组织细胞增多症
Annals of hematology & oncology Pub Date : 2021-03-29 DOI: 10.26420/ANNHEMATOLONCOL.2021.1337
T. Gambichler, Rached Na, N. Nowack, B. Behle, L. Susok
{"title":"Hemophagocytic Lymphohistiocytosis after Initiation of Combined Immunotherapy for Metastatic Melanoma","authors":"T. Gambichler, Rached Na, N. Nowack, B. Behle, L. Susok","doi":"10.26420/ANNHEMATOLONCOL.2021.1337","DOIUrl":"https://doi.org/10.26420/ANNHEMATOLONCOL.2021.1337","url":null,"abstract":"Hemophagocytic Lymphohistiocytosis (HLH), which is a severe, potentially fatal condition characterized by T lymphocyte overactivation, is predominantly caused by infections, hematological malignancies, and autoimmune conditions. HLH due to therapy with Immune Checkpoint Inhibitors (ICI) has rarely been reported. We describe a 60-year-old male with metastatic melanoma who developed HLH after the initiation of nivolumab plus ipilimumab treatment. Prompt diagnosis and high-dose mono-prednisolone therapy resulted in rapid resolution of his subjective symptoms and laboratory findings. Apart from this case presentation we provide a brief overview on clinical characteristics of previously observed ICI-induced HLH cases. Given the increasing use of ICI in a variety of cancers, the frequency of HLH will very likely raise. HLH morbidity and mortality are often the result of delayed diagnosis and inappropriate treatment. Hence, HLH must be considered in ICI-treated cancer patients who present with symptoms such as fever, cytopenias and hyperferritinemia.","PeriodicalId":72219,"journal":{"name":"Annals of hematology & oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43288150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Massive Bone Marrow Carcinomatosis Presenting with Leukoerythroblastic Blood Reaction 以白细胞-红细胞血液反应为表现的大规模骨髓癌
Annals of hematology & oncology Pub Date : 2021-03-25 DOI: 10.26420/ANNHEMATOLONCOL.2021.1336
Ana Garzó, J. VerduBelmar, E. Campos, De Paz Fj, F. Tarín
{"title":"Massive Bone Marrow Carcinomatosis Presenting with Leukoerythroblastic Blood Reaction","authors":"Ana Garzó, J. VerduBelmar, E. Campos, De Paz Fj, F. Tarín","doi":"10.26420/ANNHEMATOLONCOL.2021.1336","DOIUrl":"https://doi.org/10.26420/ANNHEMATOLONCOL.2021.1336","url":null,"abstract":"We present a case of an extensive bone marrow infiltrate of poorly differentiated carcinoma, in a 19-year-old male with suspected progression of sinusal undifferentiated carcinoma, after several lines of treatment.","PeriodicalId":72219,"journal":{"name":"Annals of hematology & oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49050203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EBV-Associated Post-Transplant Lymphoproliferative Disease (PTLD) in Allogeneic Transplantation 同种异体移植中ebv相关的移植后淋巴增生性疾病(PTLD)
Annals of hematology & oncology Pub Date : 2021-03-16 DOI: 10.26420/ANNHEMATOLONCOL.2021.1335
Cutini I, Peruzzi B, Caporale R, Nozzoli C, Gozzini A, Innocenti C, Boncompagni R, Fani A, Saccardi R
{"title":"EBV-Associated Post-Transplant Lymphoproliferative Disease (PTLD) in Allogeneic Transplantation","authors":"Cutini I, Peruzzi B, Caporale R, Nozzoli C, Gozzini A, Innocenti C, Boncompagni R, Fani A, Saccardi R","doi":"10.26420/ANNHEMATOLONCOL.2021.1335","DOIUrl":"https://doi.org/10.26420/ANNHEMATOLONCOL.2021.1335","url":null,"abstract":"Post-Transplant Lymphoproliferative Disease (PTLD) following both Solid Organ Transplantation (SOT) and Hematopoietic Stem Cell Transplantation (HSCT) is a rare life-threatening complication. The majority of PLTDs are associated to Epstein Bar Virus (EBV) [1] reactivation, usually in the early phase [2] after transplant, when the patient is severely immunocompromised and is unable to control virus replication [3]. Despite the mortality of EBV-associated PTLD has been reduced over the years, the different histological patterns of its presentation, ranging from indolent to high grade B cell lymphoma, still play a role in the outcome. Herein, we report the case of a 60-years-old man diagnosed with acute myeloid leukemia who underwent allogeneic transplantation and developed a fatal Hemophagocytic Histiocytosis (HLH) secondary to an aggressive EBV-associated PTLD, not responding to a rituximab-based treatment.","PeriodicalId":72219,"journal":{"name":"Annals of hematology & oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47708110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IgG4-Related Disease and Successful Treatment with Rituximab in a Three-Year-Old Boy IgG4相关疾病与利妥昔单抗在一名三岁男孩中的成功治疗
Annals of hematology & oncology Pub Date : 2021-03-16 DOI: 10.26420/ANNHEMATOLONCOL.2021.1334
J. Marissen, Julia Pagel, A. Steinmetz, C. Härtel, M. Lauten
{"title":"IgG4-Related Disease and Successful Treatment with Rituximab in a Three-Year-Old Boy","authors":"J. Marissen, Julia Pagel, A. Steinmetz, C. Härtel, M. Lauten","doi":"10.26420/ANNHEMATOLONCOL.2021.1334","DOIUrl":"https://doi.org/10.26420/ANNHEMATOLONCOL.2021.1334","url":null,"abstract":"IgG4-Related Disease (IgG4-RD) is a rare inflammatory disease, which may affect all organs and lead to severe fibrosis and organ damage. Mainly described in Japanese or Asian adults, case reports on children-variously affected by the disease-are increasing worldwide. While glucocorticoids are broadly used as first line treatment, several cases require second line options due to relapse or resistance to first line treatment. We report a boy who was diagnosed with IgG4-related disease at the age of three years. He presented an IgG4-associated tumorous lesion in the upper lobe of the left lung, pleural and pericardial effusion and enlarged abdominal lymph nodes. Therapy with surgery and glucocorticoids followed by rituximab treatment led to continuous complete remission 27 months after diagnosis of IgG4-RD.","PeriodicalId":72219,"journal":{"name":"Annals of hematology & oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44304103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unusual Manifestations of Paraprotein-Associated Hematological Diseases: Report of 2 Cases and Literature Review 副蛋白相关血液病的异常表现2例报告并文献复习
Annals of hematology & oncology Pub Date : 2021-03-11 DOI: 10.26420/ANNHEMATOLONCOL.2021.1333
Karakatsanis S, Papadatos Ss, Polyzos D, Gravani A, Syrigos N, Tsakania A, Kanellis G, M. L, Papanikolaou A
{"title":"Unusual Manifestations of Paraprotein-Associated Hematological Diseases: Report of 2 Cases and Literature Review","authors":"Karakatsanis S, Papadatos Ss, Polyzos D, Gravani A, Syrigos N, Tsakania A, Kanellis G, M. L, Papanikolaou A","doi":"10.26420/ANNHEMATOLONCOL.2021.1333","DOIUrl":"https://doi.org/10.26420/ANNHEMATOLONCOL.2021.1333","url":null,"abstract":"With this review we firstly describe uncommon manifestations of paraprotein-associated hematological diseases in 2 patients presenting with hemoptysis. The differential diagnosis in both cases included qualitative and quantitative platelet abnormalities, infectious diseases, malignancies, vasculitis, collagen diseases and blood disorders. Among other interventions undertaken, bone marrow biopsy provided evidence of a primary hematological disease while serum protein electrophoresis and immunofixation indicated the presence of a paraprotein. As a “take-away” lesson from the literature review performed on the basis of these cases the bleeding diathesis that is occasionally associated with paraproteinemia should be pointed out, irrespectively of the primary hematological condition. Thus, while investigating a patient with bleeding diathesis, at least a serum protein electrophoresis should be among the requested laboratory tests. Moreover, clinical vigilance is required in order to recognize other unusual manifestations of not so unusual hematological abnormalities.","PeriodicalId":72219,"journal":{"name":"Annals of hematology & oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42241922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular Screening of Hemoglobin D Variant in Anemia Patients of Eastern UP Population, India 印度东部UP人群贫血患者血红蛋白D变体的分子筛查
Annals of hematology & oncology Pub Date : 2021-03-05 DOI: 10.26420/ANNHEMATOLONCOL.2021.1330
Rai, U. Yadav, P. Kumar, Mishra Op
{"title":"Molecular Screening of Hemoglobin D Variant in Anemia Patients of Eastern UP Population, India","authors":"Rai, U. Yadav, P. Kumar, Mishra Op","doi":"10.26420/ANNHEMATOLONCOL.2021.1330","DOIUrl":"https://doi.org/10.26420/ANNHEMATOLONCOL.2021.1330","url":null,"abstract":"Hemoglobinopathy is the commonest inherited monogenic disorders, which are highly prevalent in India. The three most predominant hemoglobinopathies are HbS, HbE, the aim of the present study is to determine the frequency of HbD in Eastern UP population. After taking written consent, blood samples was collected from 350 individuals and genomic DNA was extracted from a the collected blood samples. PCR-RFP method was used to analyze the mutation. Out of 350 samples analyzed, one individual was heterozygous (HbD/N) and two individuals were homozygous (HbD/D) for Hb D mutation. In conclusion, the overall βD allele frequency in Eastern Uttar Pradesh was observed as 0.71%.","PeriodicalId":72219,"journal":{"name":"Annals of hematology & oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48378825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synchronous Occurrence of Hodgkin’s Lymphoma and Lung Cancer 霍奇金淋巴瘤与肺癌同时发生
Annals of hematology & oncology Pub Date : 2021-03-05 DOI: 10.26420/ANNHEMATOLONCOL.2021.1332
R. Erdem, F. Aykaş, M. Göçer, O. In, Aslan, Mustafa Celik, G. Cetin, E. Kurtoğlu
{"title":"Synchronous Occurrence of Hodgkin’s Lymphoma and Lung Cancer","authors":"R. Erdem, F. Aykaş, M. Göçer, O. In, Aslan, Mustafa Celik, G. Cetin, E. Kurtoğlu","doi":"10.26420/ANNHEMATOLONCOL.2021.1332","DOIUrl":"https://doi.org/10.26420/ANNHEMATOLONCOL.2021.1332","url":null,"abstract":"Hodgkin lymphoma is an uncommon neoplasm that characterized young age of onset, Hodgkin and Reed-Sternberg (HRS) cells derived from B-lymphocytes and a high cure rate, even when the patient presents with advanced metastatic spread. Lung cancer is the most common cancer worldwide and is still responsible for the most cancer deaths. We present an extremely rare case of coexisting Hodgkin lymphoma and lung cancer in a 67-year-old male patient. He initially presented with chest pain. Pet/ct revealed mass in the right lung and lymph nodes in the neck. Biopsy from the premaxillary lymph node was compatible with classical Hodgkin lymphoma. In terms of second primary malignancy, a biopsy was also performed from the mass in the right lung. Pathology showed a pulmonary adenocarcinoma and a right upper lobectomy was then performed. This patient was treated with gemcitabine plus docetaxel for lung cancer. At the end of treatment pet/ct was complete response including lymph nodes in the neck. Therefore, we did not give any treatment for Hodgkin lymphoma. The patient is still being followed up in remission.","PeriodicalId":72219,"journal":{"name":"Annals of hematology & oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47008653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
School Personnel’s Self-Esteem, Sense of Self-Efficacy and Interventions on Weight-Related Bullying According to Their Weight Perception and Dieting Behaviors 学校人员的自尊、自我效能感及体重感知和节食行为对体重相关欺凌的干预
Annals of hematology & oncology Pub Date : 2021-02-18 DOI: 10.26420/annhematoloncol.2021.1328
A. A., G. C, Maiano C, Robert Mazaye C, LeBlanc L
{"title":"School Personnel’s Self-Esteem, Sense of Self-Efficacy and Interventions on Weight-Related Bullying According to Their Weight Perception and Dieting Behaviors","authors":"A. A., G. C, Maiano C, Robert Mazaye C, LeBlanc L","doi":"10.26420/annhematoloncol.2021.1328","DOIUrl":"https://doi.org/10.26420/annhematoloncol.2021.1328","url":null,"abstract":"To increase academic performance in children, elementary school personnel are encouraged to focus on socio-emotional learning. Better classroom management and safer environments, exempt of bullying and particularly of weight-related bullying, appear like ways of fostering socio-emotional learning in children. However, some school personnel’s characteristics could impact their ability to act on these dimensions. This research is interested in how weightrelated intervention behaviors, self-esteem and sense of self-efficacy vary according to school personnel’s dieting behaviors and weight perception are related to their self-esteem, sense of self-efficacy, and intervention behaviors on weight-related bullying. A total of 164 Canadian participants filled in questionnaires focusing on bullying, self-esteem, and sense of self-efficacy. Results show that most school personnel felt competent to manage their group of students and to intervene on weight-related bullying. Those who were on a diet and who perceived their weight as higher seem significantly more involved in promoting motivation for school and learning engagement in their students as well as more likely to intervene with the bully when encountering weight-related bullying situations. For their part, participants of normal weight who were on a diet had a significantly lower self-esteem than those dieting and having a perception of overweight. These results are encouraging because they suggest that elementary school personnel feel competent with regards to the socioemotional learning of their students and is actively involved in providing them a safe learning environment.","PeriodicalId":72219,"journal":{"name":"Annals of hematology & oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47060495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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