Annals of hematology & oncology最新文献_第8页

Large Granular Lymphocytes with Tortuous and Twisted Shapes of Aggressive Natural-Killer Cell Leukemia 侵袭性自然杀伤细胞白血病具有扭曲和扭曲形状的大颗粒淋巴细胞

Annals of hematology & oncology Pub Date : 2018-10-30 DOI: 10.26420/ANNHEMATOLONCOL.2018.1217

Chunrui Li

引用次数: 0

Skin Toxicity Ant Anti-EGFR-Therapy: A Mock Trouble for Elderly and Frail Patients with Mcrc 皮肤毒性蚂蚁抗EGFR治疗：老年人和体弱Mcrc患者的一个模拟问题

Annals of hematology & oncology Pub Date : 2018-10-01 DOI: 10.26420/annhematoloncol.2018.1213

R. Addeo

引用次数: 0

Pediatric Hodgkin Lymphoma; Experience with Euronet Pediatric Hodgkin Lymphoma Protocol in a Developing Country 儿童霍奇金淋巴瘤;发展中国家Euronet儿童霍奇金淋巴瘤方案的经验

Annals of hematology & oncology Pub Date : 2018-10-01 DOI: 10.26420/ANNHEMATOLONCOL.2018.1214

Tariq Ghafoor

{"title":"Pediatric Hodgkin Lymphoma; Experience with Euronet Pediatric Hodgkin Lymphoma Protocol in a Developing Country","authors":"Tariq Ghafoor","doi":"10.26420/ANNHEMATOLONCOL.2018.1214","DOIUrl":"https://doi.org/10.26420/ANNHEMATOLONCOL.2018.1214","url":null,"abstract":"Objective: To analyse outcome of Paediatric Hodgkin Lymphoma (HL) patients treated with Euronet Paediatric Hodgkin Lymphoma treatment protocol in a developing country. Patients and Methods: This is a prospective study conducted at Paediatric Oncology department at Combined Military Hospital (CMH) Rawalpindi, Pakistan. All newly diagnosed cases of HL, less than 18years registered from January 2012 onwards that completed their treatment until 30th June 2018 were included. Data regarding age, sex, staging, histopathology and outcome were analysed. Results: Total 102 patients including 80 (78.4%) males and 22 (21.6%) females were analysed. The mean age was 7.54±2.77 years. B symptoms were present in 58 (56.9%) patients. Ten (9.8%) patients had stage I disease, 33 (32.4%) stage II, 41 (40.2%) stage III and 18 (17.6%) stage IV disease. Mixed cellularity was the commonest histological subtype seen in 74 (72.5%) patients. Involved field radiotherapy was given to 17 (16.7%) patients having inadequate response after 2 cycles of OEPA chemotherapy. Eight (7.8%) patients died of treatment related complications and 10 (9.8%) patients relapsed. Nine of the relapsed (90%) cases responded to 2 nd line treatment including one requiring autologous stem cell transplant. One relapsed patient died of progressive disease. Overall Survival (OS) and Event Free Survival (EFS) was 91.2% and 82.4% respectively. Conclusion: In Pakistan, mixed cellularity is the commonest HL subtype seen in young males. Long duration of disease before presentation, malnutrition, presence of symptoms, disease is","PeriodicalId":72219,"journal":{"name":"Annals of hematology & oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48124444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Recent Advances of Non-Invasive MR pH Imaging Using Chemical Exchange Saturation Transfer 化学交换饱和转移无创磁共振pH成像的最新进展

Annals of hematology & oncology Pub Date : 2018-09-25 DOI: 10.26420/ANNHEMATOLONCOL.2018.1212

Wu Rh

引用次数: 0

An Unusual Presentation of a Low Grade Follicular Lymphoma Masquerading as a Meningioma 低级别滤泡性淋巴瘤伪装成脑膜瘤的罕见表现

Annals of hematology & oncology Pub Date : 2018-08-06 DOI: 10.26420/ANNHEMATOLONCOL.2018.1211

R. MacCann

引用次数: 3

Potential Hematology and Nutritional Complications of Bariatric Surgery 减肥手术的潜在血液学和营养并发症

Annals of hematology & oncology Pub Date : 2018-07-11 DOI: 10.26420/annhematoloncol.2018.1209

H. Al-Jafar

{"title":"Potential Hematology and Nutritional Complications of Bariatric Surgery","authors":"H. Al-Jafar","doi":"10.26420/annhematoloncol.2018.1209","DOIUrl":"https://doi.org/10.26420/annhematoloncol.2018.1209","url":null,"abstract":"Bariatrics is a specialized field of medicine that deals with the etiology, prevention and management of patients with morbid obesity. Surgical and nutritional complications are two adverse effects associated with bariatric surgery. For patients in recovery, post-bariatric surgical treatment and management often involves the care of a hematologist. Long term nutritional problems may develop following bariatic surgery and should be considered by physicians, although long-term nutritional complications are often rare or just temporary. Multivitamin and iron supplementation are required as part of a patient’s prophylactic post-bariatric surgical management protocol; therefore, the patient’s adherence to vitamin supplementation should be checked during follow up appointments. This review aims to emphasize the potential multi systemic hematological and nutritional complications of bariatric surgery. Vitamin deficiencies such as iron and vitamin B12 sometimes affect patients and therefore physicians should be aware of this in the treatment of patients with a history bariatric surgery. Inquiring about a patient’s history of bariatric surgery needs to be one of the first questions to ask a patient who is presenting with vitamin deficiencies as this can cause multi system abnormalities. Many patients are lost to follow up after bariatric surgery and come back with complications. Therefore, the importance of maintaining follow up appointments should be emphasized.","PeriodicalId":72219,"journal":{"name":"Annals of hematology & oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47008934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Successful Treatment of Macrophage Activation Syndrome and Symptom of Inappropriate Anti- Diuretic Hormone in Chronic Natural Killer Cell Lymphoproliferative Disorder with Cyclophosphamide 环磷酰胺成功治疗慢性自然杀伤细胞淋巴细胞增生性疾病巨噬细胞活化综合征及抗利尿激素不当症状

Annals of hematology & oncology Pub Date : 2018-06-12 DOI: 10.26420/annhematoloncol.2018.1205

Sarkissian S

引用次数: 1

A Novel Method to Assess Bone Marrow Purity is Useful in Determining Blast Percentage by Flow Cytometry in Acute Myeloid Leukemia and Myelodysplasia. 一种评估骨髓纯度的新方法可用于流式细胞术测定急性髓系白血病和骨髓异常增生的母细胞百分比。

Annals of hematology & oncology Pub Date : 2015-01-01

A M Aldawood, Z Kinkade, F G Rosado, O A Esan, L F Gibson, J A Vos

{"title":"A Novel Method to Assess Bone Marrow Purity is Useful in Determining Blast Percentage by Flow Cytometry in Acute Myeloid Leukemia and Myelodysplasia.","authors":"A M Aldawood, Z Kinkade, F G Rosado, O A Esan, L F Gibson, J A Vos","doi":"","DOIUrl":"","url":null,"abstract":"Blast quantification by Flow Cytometry (FCM) may become essential in situations where morphologic evaluation is difficult or unavailable. As hemodilution invariably occurs, a means of determining Bone Marrow Purity (BMP) and normalizing FCM blast counts is essential, especially when blast percentages are diagnostically critical as in Acute Myeloid Leukemia (AML) and Myelodysplasia (MDS). By evaluating different leukocyte populations in eight initial patients, a formula to predict BMP was developed and compared to the actual BMP determined by manual counts. Performance of the formula was then validated in 86 AML/MDS patients by comparing normalized FCM blast counts to those determined by the reference manual method. A BMP formula was empirically developed, primarily based on changes in lymphocytes which reliably correlated with the actual BMP (R2 = 0.8955). Components of the formula were derived entirely from automated lymphocyte and total leukocyte counts from the peripheral blood and FCM analyses. BMP formula was then validated in 86 AML/MDS patients. When used to normalize blast counts, the formula showed accurate correction when BMP fell between 40%-90%. In this group, correlation of normalized FCM and manual blast counts was acceptable (R2 = 0.8335), being greatest at lower blast percentages. Normalization of the FCM blast count appropriately reclassified disease in 26.8% of cases. We identified a practical means of estimating hemodilution and allowing FCM blast normalization in the evaluation of AML and MDS. BMP assessment by this simple method improves the quality of the FCM data and facilitates accurate diagnosis and patient management.","PeriodicalId":72219,"journal":{"name":"Annals of hematology & oncology","volume":"2 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507808/pdf/nihms-702002.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34031650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Colon Cancer Staging in Vulnerable Older Adults: Adherence to National Guidelines and Impact on Survival. 易受伤害的老年人结肠癌分期:遵守国家指南和对生存的影响。

Annals of hematology & oncology Pub Date : 2014-01-01

T B Leal, T Holden, L Cavalcante, G O Allen, J R Schumacher, M A Smith, J M Weiss, H B Neuman, N K LoConte

{"title":"Colon Cancer Staging in Vulnerable Older Adults: Adherence to National Guidelines and Impact on Survival.","authors":"T B Leal, T Holden, L Cavalcante, G O Allen, J R Schumacher, M A Smith, J M Weiss, H B Neuman, N K LoConte","doi":"","DOIUrl":"","url":null,"abstract":"Background: There is concern that elders are not adequately evaluated prior to colon cancer surgery. We sought to determine adherence with ACOVE-3 (Assessing Care of Vulnerable Elders) quality indicators for pre-operative staging prior to colectomy for colon cancer utilizing the Surveillance, Epidemiology and End Results (SEER)-Medicare linked database (1992-2005).Methods: We determined the proportion of patients aged 75 and older who had preoperative staging prior to colectomy for colon adenocarcinoma. Preoperative staging was defined as abdominopelvic computed tomography or magnetic resonance imaging scan (SCAN) and colonoscopy or flexible sigmoidoscopy (SCOPE). Multivariate logistic regression identified predictors of adherence. Odds ratios were adjusted for comorbidity, socioeconomic status, and disease severity. The association of adherence to ACOVE-3 and survival was quantified.Results: Of the 37,862 patients, the majority were 75-84 years, 28% of the patients were ≥85 years. Regarding preoperative staging in the 6-month interval prior to surgical resection, 8% had neither SCAN nor SCOPE, 6% had only SCAN, 43% had only SCOPE, and 43% had both SCAN and SCOPE. Compared to patients who were not staged, those evaluated with either SCOPE alone or SCAN plus SCOPE had lower odds of 3-year mortality. Patients who were staged with SCAN alone had an increased odds of death compared to those who had neither SCAN or SCOPE.Conclusions: These data demonstrate that the majority of vulnerable elders with colon cancer did not receive appropriate preoperative staging prior to resection. The findings also confirm that adherence to ACOVE-3 guidelines is associated with improved long-term survival.","PeriodicalId":72219,"journal":{"name":"Annals of hematology & oncology","volume":"1 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405259/pdf/nihms647192.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33252679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0