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Improving Health Behaviors and Weight Parameters With Motivational Interviewing and the TEEEN Program in an Ethnically and Socioeconomically Diverse Pediatric Population. 在种族和社会经济多样化的儿科人群中,通过动机访谈和TEEEN®计划改善健康行为和体重参数
American journal of medicine open Pub Date : 2023-04-24 eCollection Date: 2023-12-01 DOI: 10.1016/j.ajmo.2023.100042
Jessica Castrillon Lal, Luba Margai, Helen Sarah Zitkovsky, Lori Lyn Price, Shirley González
{"title":"Improving Health Behaviors and Weight Parameters With Motivational Interviewing and the TEEEN Program in an Ethnically and Socioeconomically Diverse Pediatric Population.","authors":"Jessica Castrillon Lal, Luba Margai, Helen Sarah Zitkovsky, Lori Lyn Price, Shirley González","doi":"10.1016/j.ajmo.2023.100042","DOIUrl":"10.1016/j.ajmo.2023.100042","url":null,"abstract":"<p><strong>Objective: </strong>Obesity affects 14.7 million children and adolescents in the United States. Children's health behaviors are affected by parental health practices. Therefore, pediatric obesity interventions should include parents. The objective of this study was to assess the changes in self-reported health behaviors in a diverse population attending the TEEEN program, with motivational interviewing of child-parent dyads as a key component, for 1 year.</p><p><strong>Methods: </strong>Here we assessed the changes in Family and Nutrition and Physical Activity (FNPA) screening tool scores, a tool that assesses obesogenic behaviors, in the context of MI of child-parent dyads in a racially, ethnically, and socioeconomically diverse population who attended the TEEEN (Teens, Empowerment, Education, Exercise, Nutrition) program, a nonclinic and family-based behavior program in Massachusetts, for 1 year.</p><p><strong>Results: </strong>Participation in the TEEEN program, which includes MI of child-parent dyads, was associated with a significant increase in the overall FNPA score (median change= 4 points, <i>P</i> = .007). We observed that 76.5% of children experienced a decrease in BMI% and BMI z-score. The change in BMI% (median= -0.9, <i>P</i> = .006) and change in BMI z-score (median= -0.2, <i>P</i> = .008) were statistically significant.</p><p><strong>Conclusion: </strong>Participation in the TEEEN program seemed to be beneficial based on aspects of the FNPA screening tool and changes in weight parameters. The FNPA screening tool enhanced-motivational interviewing of child-parent dyads shows promise as an approach to address obesogenic behaviors. This study provides a detailed framework for medical providers to address pediatric obesity in a nonclinic setting with less time constraints.</p>","PeriodicalId":72168,"journal":{"name":"American journal of medicine open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11256232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42373709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improving Health Behaviors and Weight Parameters With Motivational Interviewing and the TEEEN Program in an Ethnically and Socioeconomically Diverse Pediatric Population 在种族和社会经济不同的儿科人群中,通过动机性访谈和青少年计划改善健康行为和体重参数
American journal of medicine open Pub Date : 2023-04-24 DOI: 10.1016/j.ajmo.2023.100042
Jessica Castrillon Lal , Luba Margai , Helen Sarah Zitkovsky , Lori Lyn Price , Shirley González , American Board of Obesity Medicine Diplomate
{"title":"Improving Health Behaviors and Weight Parameters With Motivational Interviewing and the TEEEN Program in an Ethnically and Socioeconomically Diverse Pediatric Population","authors":"Jessica Castrillon Lal ,&nbsp;Luba Margai ,&nbsp;Helen Sarah Zitkovsky ,&nbsp;Lori Lyn Price ,&nbsp;Shirley González ,&nbsp;American Board of Obesity Medicine Diplomate","doi":"10.1016/j.ajmo.2023.100042","DOIUrl":"https://doi.org/10.1016/j.ajmo.2023.100042","url":null,"abstract":"<div><h3>Objective</h3><p>Obesity affects 14.7 million children and adolescents in the United States. Children's health behaviors are affected by parental health practices. Therefore, pediatric obesity interventions should include parents. The objective of this study was to assess the changes in self-reported health behaviors in a diverse population attending the TEEEN program, with motivational interviewing of child-parent dyads as a key component, for 1 year.</p></div><div><h3>Methods</h3><p>Here we assessed the changes in Family and Nutrition and Physical Activity (FNPA) screening tool scores, a tool that assesses obesogenic behaviors, in the context of MI of child-parent dyads in a racially, ethnically, and socioeconomically diverse population who attended the TEEEN (Teens, Empowerment, Education, Exercise, Nutrition) program, a nonclinic and family-based behavior program in Massachusetts, for 1 year.</p></div><div><h3>Results</h3><p>Participation in the TEEEN program, which includes MI of child-parent dyads, was associated with a significant increase in the overall FNPA score (median change= 4 points, <em>P</em> = .007). We observed that 76.5% of children experienced a decrease in BMI% and BMI z-score. The change in BMI% (median= −0.9, <em>P</em> = .006) and change in BMI z-score (median= −0.2, <em>P</em> = .008) were statistically significant.</p></div><div><h3>Conclusion</h3><p>Participation in the TEEEN program seemed to be beneficial based on aspects of the FNPA screening tool and changes in weight parameters. The FNPA screening tool enhanced-motivational interviewing of child-parent dyads shows promise as an approach to address obesogenic behaviors. This study provides a detailed framework for medical providers to address pediatric obesity in a nonclinic setting with less time constraints.</p></div>","PeriodicalId":72168,"journal":{"name":"American journal of medicine open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49734707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence and Clinical Burden of Idiopathic Dilated Cardiomyopathy in the United States 美国特发性扩张型心肌病的患病率和临床负担
American journal of medicine open Pub Date : 2023-02-25 DOI: 10.1016/j.ajmo.2023.100038
Yaa Ababio , Scott P. Kelly , Franca S Angeli , Joanne Berghout , Kui Huang , Kathy Liu , Sara Burns , Cynthia Senerchia , Rob Moccia , Gabriel C. Brooks
{"title":"Prevalence and Clinical Burden of Idiopathic Dilated Cardiomyopathy in the United States","authors":"Yaa Ababio ,&nbsp;Scott P. Kelly ,&nbsp;Franca S Angeli ,&nbsp;Joanne Berghout ,&nbsp;Kui Huang ,&nbsp;Kathy Liu ,&nbsp;Sara Burns ,&nbsp;Cynthia Senerchia ,&nbsp;Rob Moccia ,&nbsp;Gabriel C. Brooks","doi":"10.1016/j.ajmo.2023.100038","DOIUrl":"https://doi.org/10.1016/j.ajmo.2023.100038","url":null,"abstract":"<div><h3>Background</h3><p>Dilated cardiomyopathy (DCM) contributes significantly to heart failure prevalence, yet supporting epidemiologic data is sparse. This study sought to estimate the period prevalence of DCM and the proportion of idiopathic DCM in the United States using a large, diverse electronic health records (EHR) database.</p></div><div><h3>Methods</h3><p>This retrospective, observational study included 56,812,806 deidentified patients in Optum EHR with visits between 2017 and 2019. Suspected DCM cases were identified using ICD-10 coding. Deidentified clinical notes from 1000 randomly selected cases were manually reviewed to determine the diagnosis of DCM and estimate the proportion of idiopathic DCM. The period prevalence and clinical burden of DCM and idiopathic DCM were estimated.</p></div><div><h3>Results</h3><p>Manual clinical review demonstrated that our definition had a positive predictive value of 92.5% for DCM, with 46.3% estimated as the idiopathic DCM proportion. The estimated period prevalence of DCM between 2017 and 2019 was 118.33 per 100,000. Prevalence increased for adults ≥65 years of age, males, and African Americans. Extrapolation to the 2019 US population led to an overall estimated burden of roughly 388,350 patients. Adjusting for the proportion of cases with idiopathic DCM yielded an idiopathic DCM prevalence of 59.23 per 100,000 and a burden of 194,385 patients. Evidence of clinical genetic testing in this population was scarce, with less than 0.43% of DCM cases reporting a testing code.</p></div><div><h3>Conclusions</h3><p>This study establishes a conservative period prevalence for DCM and idiopathic DCM and demonstrates very low molecular genetic testing for DCM. These findings suggest that the clinical burden of genetic DCM may be underestimated.</p></div>","PeriodicalId":72168,"journal":{"name":"American journal of medicine open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49734708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PCSK9 Inhibitor Use and Outcomes Using Concomitant Lipid-Lowering Therapies in the Veterans Health Administration. 退伍军人健康管理局PCSK9抑制剂的使用和伴随降脂治疗的结果
American journal of medicine open Pub Date : 2023-02-18 eCollection Date: 2023-06-01 DOI: 10.1016/j.ajmo.2023.100035
Jessica Eloso, Asma Awad, Xinhua Zhao, Francesca E Cunningham, Rongping Zhang, Diane Dong, Cathy Kelley, Peter A Glassman, Sherrie L Aspinall
{"title":"PCSK9 Inhibitor Use and Outcomes Using Concomitant Lipid-Lowering Therapies in the Veterans Health Administration.","authors":"Jessica Eloso, Asma Awad, Xinhua Zhao, Francesca E Cunningham, Rongping Zhang, Diane Dong, Cathy Kelley, Peter A Glassman, Sherrie L Aspinall","doi":"10.1016/j.ajmo.2023.100035","DOIUrl":"10.1016/j.ajmo.2023.100035","url":null,"abstract":"<p><strong>Background: </strong>Real-world data on use of PCSK9 inhibitors (PCSK9-Is), with or without statins and/or ezetimibe, and associated outcomes, can inform more effective prescribing. The objective was to evaluate clinical effectiveness and safety of PCSK9-Is within the Veterans Health Administration (VHA).</p><p><strong>Methods: </strong>In this retrospective cohort study, we included Veterans who had at least one outpatient prescription for alirocumab and/or evolocumab filled within VHA between August 21, 2015, and September 30, 2020. Analyses included 4 mutually exclusive subgroups: PCSK9-I alone, PCSK9-I+statin, PCSK9-I+ezetimibe, and PCSK9-I+statin+ezetimibe subgroups. Primary outcomes included medication possession ratio, persistence, and low-density lipoprotein (LDL).</p><p><strong>Results: </strong>Among Veterans in the analytical cohort (<i>n</i> = 2428), 36.2% were on PCSK9-I monotherapy; 24.0% received a PCSK9-I+statin; 27.4% were on a PCSK9-I+ezetimibe; and 12.4% received triple therapy, that is, PCSK9-I+statin+ezetimibe. The mean medication possession ratio (standard deviation [SD]) for PCSK9-I monotherapy was 83.8% (13.3) compared to 84.3% (11.2) with PCSK9-I+statin therapy, 87.1% (10.1) with PCSK9-I+ezetimibe therapy, and 85.8% (11.7) with triple therapy. The percentage of patients who discontinued PCSK9-I in the monotherapy subgroup was 12.3% vs 9.5%, 6.6%, and 7.4% in the concomitant statin, ezetimibe, and triple-therapy subgroups, respectively (<i>p</i> = .002 among the groups). Mean LDL level was greater in the PCSK9-I monotherapy subgroup (85.6 mg/dL) compared with the concomitant statin (66.5 mg/dL), ezetimibe (65.7 mg/dL), and triple-therapy subgroups (68.1 mg/dL).</p><p><strong>Conclusions: </strong>Veterans showed good adherence and/or persistence with PCSK9-I regimens. On average, those receiving concomitant therapy with a statin and/or ezetimibe achieved significantly lower LDL levels.</p>","PeriodicalId":72168,"journal":{"name":"American journal of medicine open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11256282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49482490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author's response 作者的回应
American journal of medicine open Pub Date : 2022-12-01 DOI: 10.1016/j.ajmo.2022.100018
Dayawa D. Agoons , Batakeh B. Agoons , Kelechi E. Emmanuel , Firdausi A. Matawalle , Jessica M. Cunningham
{"title":"Author's response","authors":"Dayawa D. Agoons ,&nbsp;Batakeh B. Agoons ,&nbsp;Kelechi E. Emmanuel ,&nbsp;Firdausi A. Matawalle ,&nbsp;Jessica M. Cunningham","doi":"10.1016/j.ajmo.2022.100018","DOIUrl":"https://doi.org/10.1016/j.ajmo.2022.100018","url":null,"abstract":"","PeriodicalId":72168,"journal":{"name":"American journal of medicine open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667036422000127/pdfft?md5=b99c07c227a3565a3e8b2131e88fcf3f&pid=1-s2.0-S2667036422000127-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136884685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gender inequality for tenure as Full Professor of medicine in France 法国医学正教授终身职位的性别不平等
American journal of medicine open Pub Date : 2022-12-01 DOI: 10.1016/j.ajmo.2022.100024
Sophie Ziai , Florian Naudet , Bruno Laviolle , Jean-Sébastien Allain
{"title":"Gender inequality for tenure as Full Professor of medicine in France","authors":"Sophie Ziai ,&nbsp;Florian Naudet ,&nbsp;Bruno Laviolle ,&nbsp;Jean-Sébastien Allain","doi":"10.1016/j.ajmo.2022.100024","DOIUrl":"10.1016/j.ajmo.2022.100024","url":null,"abstract":"<div><h3>Introduction</h3><p>Under-representation of women in high academic and medical positions is reported in many countries. This study aims to compare degrees and careers between men and women tenured as Full Professors of Medicine in recent years in France.</p></div><div><h3>Methods</h3><p>We identified all new tenured French Full Professors between 2017 and 2021 and collected the publicly available data (gender, year of birth, curriculum) from the Bibliographic Agency for Higher Education, a public institution under the aegis of the Ministry for Higher Education Research and Innovation. The primary outcome was the gender difference in age appointment of Full Professors. Secondary outcomes were gender differences in career development.</p></div><div><h3>Results</h3><p>Among 820 Full Professors, only 266 (32.4%) were women. They were tenured at a later age than men (43.7 vs 42.4 years, p&lt;0.001), while they graduated for the MD (29.5 vs 29.9 years, p&lt;0.005) or PhD (35.3 vs 36.0 years, p&lt;0.05) several months earlier. Women were also more often Associate Professors than men before becoming Full Professors (67.3% vs 59.2%, p&lt;0.05).  Before achieving Full professor tenure, the average delay is longer for women from MD graduation (14.6 vs 12.5 years), PhD graduation (8.7 vs 6.4 years), or Associate Professor nomination (7.5 vs 5.5 years), with a difference of 2.2, 2.4 and 2.0 years respectively (p&lt;0.001 for all comparisons).</p></div><div><h3>Conclusion</h3><p>Gender inequalities remain in regards to access to Full Professor status, the highest position in the medical fields.</p></div>","PeriodicalId":72168,"journal":{"name":"American journal of medicine open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266703642200019X/pdfft?md5=d8e476e2f836219434afcda66baf572c&pid=1-s2.0-S266703642200019X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45007099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A realist process evaluation of the INtegrating DEPrEssioN and Diabetes treatmENT (INDEPENDENT) randomized controlled trial in India 印度抑郁症和糖尿病联合治疗(独立)随机对照试验的现实过程评价
American journal of medicine open Pub Date : 2022-12-01 DOI: 10.1016/j.ajmo.2022.100015
Leslie C.M. Johnson , Nancy J. Thompson , Mohammed K. Ali , Kirk Elifson , Lydia Chwastiak , Viswanathan Mohan , Ranjit Mohan Anjana , Subramani Poongothai , Nikhil Tandon
{"title":"A realist process evaluation of the INtegrating DEPrEssioN and Diabetes treatmENT (INDEPENDENT) randomized controlled trial in India","authors":"Leslie C.M. Johnson ,&nbsp;Nancy J. Thompson ,&nbsp;Mohammed K. Ali ,&nbsp;Kirk Elifson ,&nbsp;Lydia Chwastiak ,&nbsp;Viswanathan Mohan ,&nbsp;Ranjit Mohan Anjana ,&nbsp;Subramani Poongothai ,&nbsp;Nikhil Tandon","doi":"10.1016/j.ajmo.2022.100015","DOIUrl":"10.1016/j.ajmo.2022.100015","url":null,"abstract":"<div><h3>Aims</h3><p>We aimed to determine what key resources, mechanisms, and contextual factors are necessary to integrate depression and diabetes treatment into low-resource settings.</p></div><div><h3>Methods</h3><p>A realist evaluation framework was employed to conduct a comparative case study. Data were collected through document review, key informant interviews (<em>n</em>=4), activity logs, and interviews with implementing health care providers (n=11) to test and refine program theories for collaborative care.</p></div><div><h3>Results</h3><p>Efforts to enhance patient care coordination (i.e., adapting clinics’ patient flow and resources, on-going trainings, and on-site support for care coordinators) improved implementation of depression treatment by usual care diabetes physicians. Clinician's avoidance of the term depression was identified as a barrier to mental health counseling and treatment.</p></div><div><h3>Conclusions</h3><p>The variations in organizational features and processes linked to implementation activities across two clinics provided an opportunity to examine how and why different contextual factors help or hinder the implementation process. Findings from this study demonstrate that successful implementation of an integrated depression and diabetes care model is feasible in a low-resource setting, while the revised program theories provide an explanatory framework of coordinated care implementation processes that can inform future efforts to disseminate and scale this care model.</p></div>","PeriodicalId":72168,"journal":{"name":"American journal of medicine open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ea/f0/nihms-1858340.PMC9788650.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10506006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corticosteroid administration and glycemic outcomes during treatment of acute exacerbation of chronic obstructive pulmonary disease 慢性阻塞性肺疾病急性加重期治疗期间皮质类固醇给药与血糖结局
American journal of medicine open Pub Date : 2022-12-01 DOI: 10.1016/j.ajmo.2022.100027
Herman Joseph Johannesmeyer , Kayvan Moussavi , Kerry Anne Rambaran , Kristica Kolyouthapong
{"title":"Corticosteroid administration and glycemic outcomes during treatment of acute exacerbation of chronic obstructive pulmonary disease","authors":"Herman Joseph Johannesmeyer ,&nbsp;Kayvan Moussavi ,&nbsp;Kerry Anne Rambaran ,&nbsp;Kristica Kolyouthapong","doi":"10.1016/j.ajmo.2022.100027","DOIUrl":"10.1016/j.ajmo.2022.100027","url":null,"abstract":"<div><h3>Background</h3><p>While international guidelines recommend low doses of systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease (AECOPD) clinical practice patterns show significant heterogeneity. Increasing doses of corticosteroids have inconsistently been associated with a greater risk of hyperglycemia.</p></div><div><h3>Methods</h3><p>Patients admitted to inpatient services for AECOPD were retrospectively enrolled. Hospitalization corticosteroid doses, daily blood glucose levels, and other markers of corticosteroid excess were collected. Correlative and regression analyses were conducted to assess the relationship between corticosteroid dose and average hospitalization blood glucose.</p></div><div><h3>Results</h3><p>Daily corticosteroid dose significantly predicted a higher blood glucose (rs=0.179, p=0.0095; p&lt;0.0028 respectively) and cumulative corticosteroid dose predicted a longer hospital length of stay in bivariate and multivariate analyses (rs=0.679, p&lt;0.0001; p&lt;0.0001 respectively). Patients that experienced hypernatremia, hypokalemia, acute hyperglycemia, and acute hypertension received larger corticosteroid doses than patients that did not experience these complicating events.</p></div><div><h3>Conclusions</h3><p>We identified that increasing amounts of corticosteroids administered to inpatients experiencing AECOPD experienced higher average hospitalization blood glucose values, protracted hospitalizations, and other untoward effects.</p></div>","PeriodicalId":72168,"journal":{"name":"American journal of medicine open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266703642200022X/pdfft?md5=641ab8f5fbbe02e6d7309c7b3fa65326&pid=1-s2.0-S266703642200022X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46002353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trauma-related acute kidney injury during inpatient care of femoral fractures increases the risk of mortality: A claims data analysis 股骨骨折住院治疗期间创伤性急性肾损伤增加死亡风险:索赔数据分析
American journal of medicine open Pub Date : 2022-12-01 DOI: 10.1016/j.ajmo.2022.100009
Gisela Büchele , Martin Rehm , Rebecca Halbgebauer , Dietrich Rothenbacher , Markus Huber-Lang
{"title":"Trauma-related acute kidney injury during inpatient care of femoral fractures increases the risk of mortality: A claims data analysis","authors":"Gisela Büchele ,&nbsp;Martin Rehm ,&nbsp;Rebecca Halbgebauer ,&nbsp;Dietrich Rothenbacher ,&nbsp;Markus Huber-Lang","doi":"10.1016/j.ajmo.2022.100009","DOIUrl":"10.1016/j.ajmo.2022.100009","url":null,"abstract":"<div><p><em>Objectives:</em> Although femoral fractures can hit anyone, they carry an especially high burden in the elderly and are multifaceted in their injury pattern, related complications, and subsequent therapeutic strategies. An often underestimated posttraumatic risk is the development of trauma-related acute kidney injury (TRAKI). However, for TRAKI, no outcome study with a large data approach exists addressing fractures. Therefore, we analyzed the development of TRAKI in regard to different covariates and quantified the association of TRAKI with overall mortality.</p><p><em>Design:</em> Retrospective cohort study with claims data.</p><p><em>Setting and participants:</em> 119,000 patients from Germany with femur fracture.</p><p><em>Methods:</em> We calculated cumulative mortality, mortality rates per 100 person-years (both occurring within 180 days after fracture), and adjusted hazard ratios with 95%-confidence intervals (CI).</p><p><em>Results:</em> Patients with femur shaft fractures showed an incidence of 6.1% for TRAKI, followed by patients with femur neck fractures with an incidence of 5.7%, and by patients with distal fractures with an incidence of 4.5%, respectively. Overall, in patients with any femur fracture, we found a 3.17-times higher mortality rate (95%-CI: 3.02-3.26) during 180 days of observation in patients who developed TRAKI in comparison to patients without. The risk for development of TRAKI was significantly increased with increasing TRAKI stage, age, and time until surgical intervention.</p><p><em>Conclusions and implications:</em> In conclusion, patients suffering from proximal-, shaft-, and distal femoral fracture face an over 3-times higher 180 day-mortality rate in case of posttraumatic TRAKI, which should be considered in peri-traumatic care to improve the long-term outcome of these patients.</p></div>","PeriodicalId":72168,"journal":{"name":"American journal of medicine open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667036422000048/pdfft?md5=d0da7aa8145eec79a6caf108bfbdc864&pid=1-s2.0-S2667036422000048-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45733828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Medicaid insured persons with diabetes have increased proportion of missed appointments and high HbA1c 医疗补助参保的糖尿病患者错过预约和高糖化血红蛋白的比例增加
American journal of medicine open Pub Date : 2022-12-01 DOI: 10.1016/j.ajmo.2022.100022
Ramya Radhakrishnan, William Cade, Ernesto Bernal-Mizrachi, Rajesh Garg
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