Advances in carbohydrate chemistry and biochemistry最新文献_第7页

Molecular architecture and therapeutic potential of lectin mimics. 凝集素模拟物的分子结构和治疗潜力。

2区化学

Advances in carbohydrate chemistry and biochemistry Pub Date : 2012-01-01 DOI: 10.1016/B978-0-12-396523-3.00002-6

Yu Nakagawa, Ito Yukishige

{"title":"Molecular architecture and therapeutic potential of lectin mimics.","authors":"Yu Nakagawa, Ito Yukishige","doi":"10.1016/B978-0-12-396523-3.00002-6","DOIUrl":"https://doi.org/10.1016/B978-0-12-396523-3.00002-6","url":null,"abstract":"Lectins are proteins of non-immune origin that bind specific carbohydrates without chemical modification. Coupled with the emerging biological and pathological significance of carbohydrates, lectins have become extensively used as research tools in glycobiology. However, lectin-based drug development has been impeded by high manufacturing costs, low chemical stability, and the potential risk of initiating an unfavorable immune response. As alternatives to lectins, non-protein small molecules having carbohydrate-binding properties (lectin mimics) are currently attracting a great deal of attention because of their ease of preparation and chemical modification. Lectin mimics of synthetic origin are divided roughly into two groups, boronic acid-dependent and boronic acid-independent lectin mimics. This article outlines their representative architectures and carbohydrate-binding properties, and discusses their therapeutic potential by reviewing recent attempts to develop antiviral and antimicrobial agents using their architectures. We also focus on the naturally occurring lectin mimics, pradimicins and benanomicins. They are the only class of non-protein natural products having a C-type lectin-like ability to recognize d-mannopyranosides in the presence of Ca(2+) ions. Their molecular basis of carbohydrate recognition and therapeutic potential are also discussed.","PeriodicalId":7215,"journal":{"name":"Advances in carbohydrate chemistry and biochemistry","volume":"68 ","pages":"1-58"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/B978-0-12-396523-3.00002-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31105071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Strategies in synthesis of heparin/heparan sulfate oligosaccharides: 2000-present. 肝素/硫酸肝素寡糖的合成策略：2000 年至今。

2区化学

Advances in carbohydrate chemistry and biochemistry Pub Date : 2012-01-01 DOI: 10.1016/B978-0-12-396527-1.00003-6

Steven B Dulaney, Xuefei Huang

引用次数: 0

Carbohydrates. Preface. 碳水化合物。前言。

2区化学

Advances in carbohydrate chemistry and biochemistry Pub Date : 2012-01-01 DOI: 10.1016/B978-0-12-396527-1.00006-1

Derek Horton

引用次数: 0

Carbohydrate science. Preface. 碳水化合物的科学。前言。

2区化学

Advances in carbohydrate chemistry and biochemistry Pub Date : 2012-01-01 DOI: 10.1016/B978-0-12-396523-3.09988-7

Derek Horton

引用次数: 0

Effect of protein dynamics and solvent in ligand recognition by promiscuous aminoglycoside-modifying enzymes. 混杂氨基糖苷修饰酶对配体识别的蛋白质动力学和溶剂的影响。

2区化学

Advances in carbohydrate chemistry and biochemistry Pub Date : 2012-01-01 DOI: 10.1016/B978-0-12-396527-1.00005-X

Engin H Serpersu, Adrianne L Norris

引用次数: 12

Combining computational chemistry and crystallography for a better understanding of the structure of cellulose. 结合计算化学和晶体学，以更好地了解纤维素的结构。

2区化学

Advances in carbohydrate chemistry and biochemistry Pub Date : 2012-01-01 DOI: 10.1016/B978-0-12-396527-1.00002-4

Alfred D French

引用次数: 28

Enzymatic conversions of starch. 淀粉的酶转化。

2区化学

Advances in carbohydrate chemistry and biochemistry Pub Date : 2012-01-01 DOI: 10.1016/B978-0-12-396523-3.00001-4

Piotr Tomasik, Derek Horton

引用次数: 90

Chemical synthesis of glycosylphosphatidylinositol anchors. 糖基磷脂酰肌醇锚的化学合成。

2区化学

Advances in carbohydrate chemistry and biochemistry Pub Date : 2012-01-01 DOI: 10.1016/B978-0-12-396527-1.00004-8

Benjamin M Swarts, Zhongwu Guo

引用次数: 15

Nathan Sharon: 1925-2011. Nathan Sharon: 1925-2011。

2区化学

Advances in carbohydrate chemistry and biochemistry Pub Date : 2012-01-01 DOI: 10.1016/b978-0-12-396527-1.00001-2

David Mirelman, Edward A Bayer, Yair Reisner

引用次数: 0

Toward automated glycan analysis. 走向自动聚糖分析。

2区化学

Advances in carbohydrate chemistry and biochemistry Pub Date : 2011-01-01 DOI: 10.1016/B978-0-12-385520-6.00005-4

Shin-Ichiro Nishimura

{"title":"Toward automated glycan analysis.","authors":"Shin-Ichiro Nishimura","doi":"10.1016/B978-0-12-385520-6.00005-4","DOIUrl":"https://doi.org/10.1016/B978-0-12-385520-6.00005-4","url":null,"abstract":"As drastic structural changes in cell-surface glycans of glycoproteins and glycosphingolipids, as well as serum glycoproteins, are often observed during cell differentiation and cancer progression, it is considered that glycans can be potential candidates for novel diagnostic and therapeutic biomarkers. Although there have been substantial advances in our understanding of the effects of glycosylation on some biological systems, we still do not fully understand the significance and mechanism of glycoform alteration that is widely observed in many human diseases. This is due to the highly complicated structures of the glycans and the extremely tedious and time-consuming processes required for their separation from complex mixtures and their subsequent analysis. As a result, with a few notable exceptions, the therapeutic potential of complex glycans has not been well exploited. This article is focused on the state of the art and current advances in glycomics, and efforts for the development of automated glycan analysis, which should greatly accelerate functional glycobiology and its medical/pharmaceutical applications. The \"glycoblotting method\" is the only method currently available that allows rapid and large-scale clinical glycomics of human whole-serum glycoproteins, because it requires very little material and, when combined with an automated system \"SweetBlot,\" takes only ∼14h to complete whole glycan profiling by mass spectrometry. The upcoming goal is to combine glycoblotting methods and various MS-based platforms for the development of a fully automated glycan analytical system and accelerating research to discover highly sensitive and clinically important biomarker molecules.","PeriodicalId":7215,"journal":{"name":"Advances in carbohydrate chemistry and biochemistry","volume":"65 ","pages":"219-71"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/B978-0-12-385520-6.00005-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30010328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 60