Advances in carbohydrate chemistry and biochemistry最新文献_第6页

Modulating LPS signal transduction at the LPS receptor complex with synthetic Lipid A analogues. 合成脂质A类似物调节脂多糖受体复合物的脂多糖信号转导。

2区化学

Advances in carbohydrate chemistry and biochemistry Pub Date : 2014-01-01 DOI: 10.1016/B978-0-12-800128-8.00005-4

Aileen F B White, Alexei V Demchenko

{"title":"Modulating LPS signal transduction at the LPS receptor complex with synthetic Lipid A analogues.","authors":"Aileen F B White, Alexei V Demchenko","doi":"10.1016/B978-0-12-800128-8.00005-4","DOIUrl":"https://doi.org/10.1016/B978-0-12-800128-8.00005-4","url":null,"abstract":"Sepsis, defined as a clinical syndrome brought about by an amplified and dysregulated inflammatory response to infections, is one of the leading causes of death worldwide. Despite persistent attempts to develop treatment strategies to manage sepsis in the clinical setting, the basic elements of treatment have not changed since the 1960s. As such, the development of effective therapies for reducing inflammatory reactions and end-organ dysfunction in critically ill patients with sepsis remains a global priority. Advances in understanding of the immune response to sepsis provide the opportunity to develop more effective pharmaceuticals. This article details current information on the modulation of the lipopolysaccharide (LPS) receptor complex with synthetic Lipid A mimetics. As the initial and most critical event in sepsis pathophysiology, the LPS receptor provides an attractive target for antisepsis agents. One of the well-studied approaches to sepsis therapy involves the use of derivatives of Lipid A, the membrane-anchor portion of an LPS, which is largely responsible for its endotoxic activity. This article describes the structural and conformational requirements influencing the ability of Lipid A analogues to compete with LPS for binding to the LPS receptor complex and to inhibit the induction of the signal transduction pathway by impairing LPS-initiated receptor dimerization. ","PeriodicalId":7215,"journal":{"name":"Advances in carbohydrate chemistry and biochemistry","volume":"71 ","pages":"339-89"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/B978-0-12-800128-8.00005-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32884450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Struther Arnott: 1934–2013 斯特拉瑟·阿诺特:1934-2013

2区化学

Advances in carbohydrate chemistry and biochemistry Pub Date : 2013-12-31 DOI: 10.1016/B978-0-12-408092-8.10000-X

Rengaswami Chandrasekaran

引用次数: 1

Obituaries 3 – Saul Roseman 讣告3-索尔·罗斯曼

2区化学

Advances in carbohydrate chemistry and biochemistry Pub Date : 2013-12-31 DOI: 10.1016/B978-0-12-408093-5.09996-2

C. Subhash

引用次数: 0

Bacterial cell-envelope glycoconjugates. 细菌细胞包膜糖结合。

2区化学

Advances in carbohydrate chemistry and biochemistry Pub Date : 2013-01-01 DOI: 10.1016/B978-0-12-408093-5.00006-X

Paul Messner, Christina Schäffer, Paul Kosma

{"title":"Bacterial cell-envelope glycoconjugates.","authors":"Paul Messner, Christina Schäffer, Paul Kosma","doi":"10.1016/B978-0-12-408093-5.00006-X","DOIUrl":"https://doi.org/10.1016/B978-0-12-408093-5.00006-X","url":null,"abstract":"Prokaryotic glycosylation fulfills an important role in maintaining and protecting the structural integrity and function of the bacterial cell wall, as well as serving as a flexible adaption mechanism to evade environmental and host-induced pressure. The scope of bacterial and archaeal protein glycosylation has considerably expanded over the past decade(s), with numerous examples covering the glycosylation of flagella, pili, glycosylated enzymes, as well as surface-layer proteins. This article addresses structure, analysis, function, genetic basis, biosynthesis, and biomedical and biotechnological applications of cell-envelope glycoconjugates, S-layer glycoprotein glycans, and \"nonclassical\" secondary-cell wall polysaccharides. The latter group of polymers mediates the important attachment and regular orientation of the S-layer to the cell wall. The structures of these glycopolymers reveal an enormous diversity, resembling the structural variability of bacterial lipopolysaccharides and capsular polysaccharides. While most examples are presented for Gram-positive bacteria, the S-layer glycan of the Gram-negative pathogen Tannerella forsythia is also discussed. In addition, archaeal S-layer glycoproteins are briefly summarized. ","PeriodicalId":7215,"journal":{"name":"Advances in carbohydrate chemistry and biochemistry","volume":"69 ","pages":"209-72"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/B978-0-12-408093-5.00006-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31900983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 36

Obituaries 2 - John Grant Buchanan 讣告-约翰·格兰特·布坎南

2区化学

Advances in carbohydrate chemistry and biochemistry Pub Date : 2013-01-01 DOI: 10.1016/B978-0-12-408093-5.09997-4

W. Richard

引用次数: 1

Seven decades of "advances". 70年的“进步”。

2区化学

Advances in carbohydrate chemistry and biochemistry Pub Date : 2013-01-01 DOI: 10.1016/B978-0-12-408092-8.00003-3

Derek Horton

引用次数: 3

De novo asymmetric synthesis of the pyranoses: from monosaccharides to oligosaccharides. 从头不对称合成吡喃糖:从单糖到低聚糖。

2区化学

Advances in carbohydrate chemistry and biochemistry Pub Date : 2013-01-01 DOI: 10.1016/B978-0-12-408093-5.00004-6

Alhanouf Z Aljahdali, Pei Shi, Yashan Zhong, George A O'Doherty

引用次数: 30

Different aspects of new developments in the carbohydrate field. Preface. 碳水化合物领域新发展的不同方面。前言。

2区化学

Advances in carbohydrate chemistry and biochemistry Pub Date : 2013-01-01 DOI: 10.1016/B978-0-12-408093-5.09995-0

Derek Horton

引用次数: 0

Recent advances toward the development of inhibitors to attenuate tumor metastasis via the interruption of lectin-ligand interactions. 通过阻断凝集素-配体相互作用来减弱肿瘤转移的抑制剂的研究进展。

2区化学

Advances in carbohydrate chemistry and biochemistry Pub Date : 2013-01-01 DOI: 10.1016/B978-0-12-408093-5.00005-8

Hevey Rachel, Ling Chang-Chun

{"title":"Recent advances toward the development of inhibitors to attenuate tumor metastasis via the interruption of lectin-ligand interactions.","authors":"Hevey Rachel, Ling Chang-Chun","doi":"10.1016/B978-0-12-408093-5.00005-8","DOIUrl":"https://doi.org/10.1016/B978-0-12-408093-5.00005-8","url":null,"abstract":"Aberrant glycosylation is a well-recognized phenomenon that occurs on the surface of tumor cells, and the overexpression of a number of ligands (such as TF, sialyl Tn, and sialyl Lewis X) has been correlated to a worse prognosis for the patient. These unique carbohydrate structures play an integral role in cell-cell communication and have also been associated with more metastatic cancer phenotypes, which can result from binding to lectins present on cell surfaces. The most well studied metastasis-associated lectins are the galectins and selectins, which have been correlated to adhesion, neoangiogenesis, and immune-cell evasion processes. In order to slow the rate of metastatic lesion formation, a number of approaches have been successfully developed which involve interfering with the tumor lectin-substrate binding event. Through the generation of inhibitors, or by attenuating lectin and/or carbohydrate expression, promising results have been observed both in vitro and in vivo. This article briefly summarizes the involvement of lectins in the metastatic process and also describes different approaches used to prevent these undesirable carbohydrate-lectin binding events, which should ultimately lead to improvement in current cancer therapies. ","PeriodicalId":7215,"journal":{"name":"Advances in carbohydrate chemistry and biochemistry","volume":"69 ","pages":"125-207"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/B978-0-12-408093-5.00005-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31900981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Preface. 前言。

2区化学

Advances in carbohydrate chemistry and biochemistry Pub Date : 2013-01-01 DOI: 10.1016/B978-0-12-408092-8.09999-7

Derek Horton

引用次数: 0