发布求助
文献互助 智能选刊 最新文献

Advances in carbohydrate chemistry and biochemistry最新文献

筛选
英文 中文
Pseudo-glycoconjugates with a C-glycoside linkage. 与c -糖苷键结合的伪糖。
2区 化学
Advances in carbohydrate chemistry and biochemistry Pub Date : 2022-01-01 DOI: 10.1016/bs.accb.2022.10.002
Go Hirai
{"title":"Pseudo-glycoconjugates with a C-glycoside linkage.","authors":"Go Hirai","doi":"10.1016/bs.accb.2022.10.002","DOIUrl":"https://doi.org/10.1016/bs.accb.2022.10.002","url":null,"abstract":"<p><p>Work by the author and colleagues has been focused on the development of pseudo-glycans (pseudo-glycoconjugates), in which the O-glycosidic linkage of the natural-type glycan structure is replaced by a C-glycosidic linkage. These analogs are not degraded by cellular glycoside hydrolases and are thus expected to be useful molecular tools that may maintain the original biological activity for a long period in the cell. However, their biological potential is not yet well understood because only a few pseudo glycans have so far been synthesized. This article aims to provide a bird's-eye view of our recent studies on the creation of C-glycoside analogs of ganglioside GM3 based on the CHF-sialoside linkage, and summarizes the chemical insights acquired during our stereoselective synthesis of the C-sialoside bond, ultimately leading to pseudo-GM3. Conformational analysis of the synthesized CHF-sialoside disaccharides confirmed that the anticipated conformational control by F-atom introduction was successful, and furthermore, enhanced the biological activity. In order to improve access to C-glycoside analogs based on pseudo-GM3, it is still important to streamline the synthesis process. With this in mind, we designed and developed a direct C-glycosylation method using atom-transfer radical coupling, and employed it in syntheses of pseudo-isomaltose and pseudo-KRN7000.</p>","PeriodicalId":7215,"journal":{"name":"Advances in carbohydrate chemistry and biochemistry","volume":"82 ","pages":"35-77"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9123349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Preface. 前言。
2区 化学
Advances in carbohydrate chemistry and biochemistry Pub Date : 2022-01-01 DOI: 10.1016/S0065-2318(22)00019-1
David C Baker
{"title":"Preface.","authors":"David C Baker","doi":"10.1016/S0065-2318(22)00019-1","DOIUrl":"10.1016/S0065-2318(22)00019-1","url":null,"abstract":"","PeriodicalId":7215,"journal":{"name":"Advances in carbohydrate chemistry and biochemistry","volume":" ","pages":"ix-x"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40496357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combining computational and experimental studies for a better understanding of cellulose and its analogs. 结合计算和实验研究，以更好地了解纤维素及其类似物。
2区 化学
Advances in carbohydrate chemistry and biochemistry Pub Date : 2021-01-01 Epub Date: 2021-11-24 DOI: 10.1016/bs.accb.2021.10.002
Yoshiharu Nishiyama
{"title":"Combining computational and experimental studies for a better understanding of cellulose and its analogs.","authors":"Yoshiharu Nishiyama","doi":"10.1016/bs.accb.2021.10.002","DOIUrl":"https://doi.org/10.1016/bs.accb.2021.10.002","url":null,"abstract":"<p><p>Over the last decade, the structural refinement of cellulose allomorphs and their analogs has been advanced using high-resolution fiber diffraction. This also includes structures of crystals complexed with small molecules, which can inherently involve disorders. Computational methods, including density functional theory, in combination with molecular modeling are leading to improved structural analyses. Spectroscopic techniques such as vibrational spectroscopy give quantitative and robust data directly related to structural insights on cellulose. These data will benefit from improved molecular modeling's capacity for interpretation and will also serve as a gauge to measure the capacity of molecular modeling as an aid in structural determinations. Improvement in the capacity to directly simulate experimental data such as that from scattering, diffraction, and spectra will be the key for further integration of modeling and experimental approaches.</p>","PeriodicalId":7215,"journal":{"name":"Advances in carbohydrate chemistry and biochemistry","volume":"80 ","pages":"1-14"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39697559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent advances on glycosyltransferases involved in the biosynthesis of the proteoglycan linkage region. 参与蛋白聚糖连接区生物合成的糖基转移酶的研究进展。
2区 化学
Advances in carbohydrate chemistry and biochemistry Pub Date : 2021-01-01 Epub Date: 2021-11-24 DOI: 10.1016/bs.accb.2021.10.003
Jia Gao, Xuefei Huang
{"title":"Recent advances on glycosyltransferases involved in the biosynthesis of the proteoglycan linkage region.","authors":"Jia Gao,&nbsp;Xuefei Huang","doi":"10.1016/bs.accb.2021.10.003","DOIUrl":"https://doi.org/10.1016/bs.accb.2021.10.003","url":null,"abstract":"<p><p>Proteoglycans (PGs) are an essential family of glycoproteins, which can play roles in many important biological events including cell proliferation, cancer development, and pathogen infections. Proteoglycans consist of a core protein with one or multiple glycosaminoglycan (GAG) chains, which are covalently attached to serine residues of serine-glycine dipeptide within the core protein through a common tetrasaccharide linkage. In the past three decades, four key glycosyl transferases involved in the biosynthesis of PG linkage have been discovered and investigated. This review aims to provide an overview on progress made on these four enzymes, with foci on enzyme expression/purification, substrate specificity, activity determination, product characterization, and structure-activity relationship analysis.</p>","PeriodicalId":7215,"journal":{"name":"Advances in carbohydrate chemistry and biochemistry","volume":"80 ","pages":"95-119"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9112072/pdf/nihms-1806823.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39697562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preface. 前言。
2区 化学
Advances in carbohydrate chemistry and biochemistry Pub Date : 2021-01-01 DOI: 10.1016/S0065-2318(21)00015-9
David C Baker
{"title":"Preface.","authors":"David C Baker","doi":"10.1016/S0065-2318(21)00015-9","DOIUrl":"https://doi.org/10.1016/S0065-2318(21)00015-9","url":null,"abstract":"","PeriodicalId":7215,"journal":{"name":"Advances in carbohydrate chemistry and biochemistry","volume":"80 ","pages":"ix-x"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39697563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical Synthesis of Saponins. 皂苷的化学合成。
2区 化学
Advances in carbohydrate chemistry and biochemistry Pub Date : 2021-01-01 DOI: 10.1016/bs.accb.2021.10.001
You Yang, Stephane Laval, Biao Yu
{"title":"Chemical Synthesis of Saponins.","authors":"You Yang,&nbsp;Stephane Laval,&nbsp;Biao Yu","doi":"10.1016/bs.accb.2021.10.001","DOIUrl":"https://doi.org/10.1016/bs.accb.2021.10.001","url":null,"abstract":"<p><p>Saponins are a large family of amphiphilic glycosides of steroids and triterpenes found in plants and some marine organisms. By expressing a large diversity of structures on both sugar chains and aglycones, saponins exhibit a wide range of biological and pharmacological properties and serve as major active principles in folk medicines, especially in traditional Chinese medicines. Isolation of saponins from natural sources is usually a formidable task due to the microheterogeneity of saponins in Nature. Chemical synthesis can provide access to large amounts of natural saponins as well as congeners for understanding their structure-activity relationships and mechanisms of action. This article presents a comprehensive account on chemical synthesis of saponins. First highlighted are general considerations on saponin synthesis, including preparation of aglycones and carbohydrate building blocks, assembly strategies, and protecting-group strategies. Next described is the state of the art in the synthesis of each type of saponins, with an emphasis on those representative saponins having sophisticated structures and potent biological activities.</p>","PeriodicalId":7215,"journal":{"name":"Advances in carbohydrate chemistry and biochemistry","volume":"79 ","pages":"63-150"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39692407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Strategies in Synthesis of Heparin/Heparan Sulfate Oligosaccharides: 2000-Present. 肝素/硫酸肝素寡糖的合成策略:2000-至今。
2区 化学
Advances in carbohydrate chemistry and biochemistry Pub Date : 2021-01-01 DOI: 10.1016/bs.accb.2021.11.003
Steven B Dulaney, Xuefei Huang
{"title":"Strategies in Synthesis of Heparin/Heparan Sulfate Oligosaccharides: 2000-Present.","authors":"Steven B Dulaney,&nbsp;Xuefei Huang","doi":"10.1016/bs.accb.2021.11.003","DOIUrl":"https://doi.org/10.1016/bs.accb.2021.11.003","url":null,"abstract":"<p><p>Heparin and heparan sulfate are members of the glycosaminoglycan family that are involved in a multitude of biological processes. The great interests in the anticoagulant properties of heparin have stimulated major advances in synthetic strategies toward clinically effective analogues, as demonstrated importantly by the approval of the fully synthetic pentasaccharide fragment, termed fondaparinux (Arixtra®), of the heparin macromolecule for treatment of deep-vein thrombosis. Given the highly complex nature of heparin and heparan sulfate, the chemical synthesis of their components is a challenging endeavor. In the past decade, multiple approaches have been developed to improve the overall synthetic efficiency. New strategies have emerged that can generate libraries of oligosaccharide components of heparin and heparan sulfate. This article discusses recent developments in the assembly of heparin and heparan sulfate oligosaccharides and the associated challenges in their synthesis.</p>","PeriodicalId":7215,"journal":{"name":"Advances in carbohydrate chemistry and biochemistry","volume":"80 ","pages":"121-164"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39697560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Copyright 版权
2区 化学
Advances in carbohydrate chemistry and biochemistry Pub Date : 2021-01-01 DOI: 10.1016/s0065-2318(21)00012-3
{"title":"Copyright","authors":"","doi":"10.1016/s0065-2318(21)00012-3","DOIUrl":"https://doi.org/10.1016/s0065-2318(21)00012-3","url":null,"abstract":"","PeriodicalId":7215,"journal":{"name":"Advances in carbohydrate chemistry and biochemistry","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55858340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Series Page 系列页面
2区 化学
Advances in carbohydrate chemistry and biochemistry Pub Date : 2021-01-01 DOI: 10.1016/s0065-2318(21)00025-1
{"title":"Series Page","authors":"","doi":"10.1016/s0065-2318(21)00025-1","DOIUrl":"https://doi.org/10.1016/s0065-2318(21)00025-1","url":null,"abstract":"","PeriodicalId":7215,"journal":{"name":"Advances in carbohydrate chemistry and biochemistry","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55858352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combining Computational Chemistry and Crystallography for a Better Understanding of the Structure of Cellulose. 结合计算化学和晶体学来更好地理解纤维素的结构。
2区 化学
Advances in carbohydrate chemistry and biochemistry Pub Date : 2021-01-01 DOI: 10.1016/bs.accb.2021.11.002
Alfred D French
{"title":"Combining Computational Chemistry and Crystallography for a Better Understanding of the Structure of Cellulose.","authors":"Alfred D French","doi":"10.1016/bs.accb.2021.11.002","DOIUrl":"https://doi.org/10.1016/bs.accb.2021.11.002","url":null,"abstract":"<p><p>The approaches in this article seek to enhance understanding of cellulose at the molecular level, independent of the source and the particular crystalline form of cellulose. Four main areas of structure research are reviewed. Initially, the molecular shape is inferred from the crystal structures of many small molecules that have β-(1→4) linkages. Then, conformational analyses with potential energy calculations of cellobiose are covered, followed by the use of Atoms-In-Molecules theory to learn about interactions in experimental and theoretical structures. The last section covers models of cellulose nanoparticles. Controversies addressed include the stability of twofold screw-axis conformations, the influence of different computational methods, the predictability of crystalline conformations by studies of isolated molecules, and the twisting of model cellulose crystals.</p>","PeriodicalId":7215,"journal":{"name":"Advances in carbohydrate chemistry and biochemistry","volume":"80 ","pages":"15-93"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39697561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信