Aging Biology最新文献

GCN2 Mediates Access to Stored Amino Acids for Somatic Maintenance during Drosophila Aging GCN2 在果蝇衰老过程中为体细胞维持提供储存的氨基酸

Aging Biology Pub Date : 2024-02-20 DOI: 10.59368/agingbio.20240026

Matthew D W Piper, Joshua N. Johnstone, C. Mirth, Travis K. Johnson, Ralf B. Schittenhelm

引用次数: 0

Genetic and Pharmacological Inhibition of PAPP-A Reduces Bleomycin-Induced Pulmonary Fibrosis in Aged Mice via Reduced IGF Signaling 遗传和药物抑制 PAPP-A 可通过减少 IGF 信号传导减轻博莱霉素诱导的老年小鼠肺纤维化

Aging Biology Pub Date : 2024-02-13 DOI: 10.59368/agingbio.20240023

Cheryl A. Conover, L. Bale, Sally A. West, Claus Oxvig, Kristian S. Andersen, A. Roden, Andrew J. Haak

引用次数: 0

An Enterobacteriaceae bloom in aging animals is restrained by the gut microbiome. 肠道微生物群抑制了衰老动物体内肠杆菌的大量繁殖。

Aging Biology Pub Date : 2024-01-01 Epub Date: 2024-03-15 DOI: 10.59368/agingbio.20240024

Rebecca Choi, Rahul Bodkhe, Barbara Pees, Dan Kim, Maureen Berg, David Monnin, Juhyun Cho, Vivek Narayan, Ethan Deller, Cathy Savage-Dunn, Michael Shapira

{"title":"An Enterobacteriaceae bloom in aging animals is restrained by the gut microbiome.","authors":"Rebecca Choi, Rahul Bodkhe, Barbara Pees, Dan Kim, Maureen Berg, David Monnin, Juhyun Cho, Vivek Narayan, Ethan Deller, Cathy Savage-Dunn, Michael Shapira","doi":"10.59368/agingbio.20240024","DOIUrl":"10.59368/agingbio.20240024","url":null,"abstract":"The gut microbiome plays important roles in host function and health. Core microbiomes have been described for different species, and imbalances in their composition, known as dysbiosis, are associated with pathology. Changes in the gut microbiome and dysbiosis are common in aging, possibly due to multi-tissue deterioration, which includes metabolic shifts, dysregulated immunity, and disrupted epithelial barriers. However, the characteristics of these changes, as reported in different studies, are varied and sometimes conflicting. Using clonal populations of Caenorhabditis elegans to highlight trends shared among individuals, we employed 16s rRNA gene sequencing, CFU counts and fluorescent imaging, identifying an Enterobacteriaceae bloom as a common denominator in aging animals. Experiments using Enterobacter hormaechei, a representative commensal, suggested that the Enterobacteriaceae bloom was facilitated by a decline in Sma/BMP immune signaling in aging animals and demonstrated its potential for exacerbating infection susceptibility. However, such detrimental effects were context-dependent, mitigated by competition with commensal communities, highlighting the latter as determinants of healthy versus unhealthy aging, depending on their ability to restrain opportunistic pathobionts.","PeriodicalId":72130,"journal":{"name":"Aging Biology","volume":"2 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11085993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140913576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early-Onset Hearing Loss in Mouse Models of Alzheimer's Disease and Increased DNA Damage in the Cochlea. 阿尔茨海默病小鼠模型中的早发性听力损失与耳蜗中 DNA 损伤的增加

Aging Biology Pub Date : 2024-01-01 Epub Date: 2024-02-20 DOI: 10.59368/agingbio.20240025

Jae-Hyeon Park, Burcin Duan Sahbaz, Komal Pekhale, Xixia Chu, Mustafa N Okur, Mhamed Grati, Kevin Isgrig, Wade Chien, Elena Chrysostomou, Lauren Sullivan, Deborah L Croteau, Uri Manor, Vilhelm A Bohr

{"title":"Early-Onset Hearing Loss in Mouse Models of Alzheimer's Disease and Increased DNA Damage in the Cochlea.","authors":"Jae-Hyeon Park, Burcin Duan Sahbaz, Komal Pekhale, Xixia Chu, Mustafa N Okur, Mhamed Grati, Kevin Isgrig, Wade Chien, Elena Chrysostomou, Lauren Sullivan, Deborah L Croteau, Uri Manor, Vilhelm A Bohr","doi":"10.59368/agingbio.20240025","DOIUrl":"10.59368/agingbio.20240025","url":null,"abstract":"There is considerable interest in whether sensory deficiency is associated with the development of Alzheimer's disease (AD). Notably, the relationship between hearing impairment and AD is of high relevance but still poorly understood. In this study, we found early-onset hearing loss in two AD mouse models, 3xTgAD and 3xTgAD/Polβ+/-. The 3xTgAD/Polβ+/- mouse is DNA repair deficient and has more humanized AD features than the 3xTgAD. Both AD mouse models showed increased auditory brainstem response (ABR) thresholds between 16 and 32 kHz at 4 weeks of age, much earlier than any AD cognitive and behavioral changes. The ABR thresholds were significantly higher in 3xTgAD/Polβ+/- mice than in 3xTgAD mice at 16 kHz, and distortion product otoacoustic emission signals were reduced, indicating that DNA damage may be a factor underlying early hearing impairment in AD. Poly ADP-ribosylation and protein expression levels of DNA damage markers increased significantly in the cochlea of the AD mice but not in the adjacent auditory cortex. Phosphoglycerate mutase 2 levels and the number of synaptic ribbons in the presynaptic zones of inner hair cells were decreased in the cochlea of the AD mice. Furthermore, the activity of sirtuin 3 was downregulated in the cochlea of these mice, indicative of impaired mitochondrial function. Taken together, these findings provide new insights into potential mechanisms for hearing dysfunction in AD and suggest that DNA damage in the cochlea might contribute to the development of early hearing loss in AD.","PeriodicalId":72130,"journal":{"name":"Aging Biology","volume":"1 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10948084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140159623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Embryogenesis of Longer-Lived Mammalian Species Occurs in a More Severe Hypoxic-Hypercapnic Environment 长寿哺乳动物物种的胚胎发育发生在更严重的低氧-高碳酸环境中

Aging Biology Pub Date : 2023-12-15 DOI: 10.59368/agingbio.20230018

Khachik K. Muradian, V. Fraifeld

引用次数: 0

Erratum to “Aging Rate Indicators: Speedometers for Aging Research in Mice” 老化率指标：小鼠老化研究的速度计 "勘误表用于小鼠衰老研究的速度计"

Aging Biology Pub Date : 2023-11-20 DOI: 10.59368/agingbio.20230016

Richard A Miller, Xinna Li, Gonzalo Garcia

引用次数: 0

Stochasticity Explains Nongenetic Inheritance of Lifespan and Apparent Trade-Offs between Reproduction and Aging. 随机性解释了寿命的非基因遗传和生殖与衰老之间的明显权衡。

Aging Biology Pub Date : 2023-08-04 DOI: 10.59368/agingbio.20230012

Elizabeth D Drake, Mirre J P Simons

{"title":"Stochasticity Explains Nongenetic Inheritance of Lifespan and Apparent Trade-Offs between Reproduction and Aging.","authors":"Elizabeth D Drake, Mirre J P Simons","doi":"10.59368/agingbio.20230012","DOIUrl":"10.59368/agingbio.20230012","url":null,"abstract":"Stochastic effects are central to the biology and demography of aging. Genetically identical individuals do not all die at the exact same time but show a distribution of lifespan. Although such effects are appreciated, any cascading effects from the stochastic effects of aging are underappreciated. We show here that genetically identical female flies (Drosophila melanogaster) that live long produce longer-lived daughters. In line with previous work, we also find that daughters born to older mothers are shorter-lived, also termed the Lansing effect. We further show that longer-lived flies produce less offspring, suggesting an apparent trade-off due to stochastic effects alone. We explain these effects using an extension of the reliability theory of aging by dichotomizing aging physiology in reproduction and lifespan-supporting units. These simple models reproduce the nongenetic inheritance of lifespan, the Lansing effect, and trade-offs between reproduction and lifespan. Our work implies that if nongenetic inheritance of lifespan is widespread, it explains the generally low heritability of this trait. Furthermore, trade-offs between performance, for example, reproduction, and lifespan may be less widespread than predicted by the evolutionary biology of aging, stemming from stochasticity rather than differential investment. Antiaging treatments could therefore come without any unintended costs to other physiology, a perceived risk that limits the translation of these treatments to humans.","PeriodicalId":72130,"journal":{"name":"Aging Biology","volume":"25 1","pages":"20230012"},"PeriodicalIF":0.0,"publicationDate":"2023-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7617532/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88754960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

When a Calorie Is Not a Calorie: Metabolic and Molecular Effects of Intermittent Fasting in Humans; Exploratory Outcomes of a Randomized Clinical Trial 当卡路里不再是卡路里:人类间歇性禁食的代谢和分子效应一项随机临床试验的探索性结果

Aging Biology Pub Date : 2023-08-04 DOI: 10.59368/agingbio.20230013

L. Fontana, V. Tosti, R. Barve, Beatrice Bertozzi, N. Veronese, F. Spelta, E. Cava, M. Mattson, L. Piccio, D. Early, R. Head

引用次数: 0

Restricting the Possibilities for Mechanisms of Calorie Restriction 限制热量限制机制的可能性

Aging Biology Pub Date : 2023-06-29 DOI: 10.59368/agingbio.20230006

Peter D. Adams

引用次数: 0

How Much Should We Fast? A New Study by the Fontana Group Suggests That Intermittent Fasting May Be Too Mild for Humans. 我们应该禁食多少？Fontana小组的一项新研究表明，间歇性禁食对人类来说可能太温和了。

Aging Biology Pub Date : 2023-01-01 Epub Date: 2023-06-27 DOI: 10.59368/agingbio.20230004

Vera Gorbunova

引用次数: 0