Aging and cancer最新文献

{"title":"Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer","authors":"Nihanthy D. Sreenath,&nbsp;Mathigatta Shivarudraiah S,&nbsp;Rajath Govind,&nbsp;Kaushik M R","doi":"10.1002/aac2.70011","DOIUrl":"https://doi.org/10.1002/aac2.70011","url":null,"abstract":"<p>Cancer in older adults is a growing public health concern in India, with approximately 50% of all new cancer cases occurring in individuals aged 60 years and above, according to recent estimates from the Indian Council of Medical Research (ICMR). Older adults often present with a distinct set of medical, psychological, and social vulnerabilities that necessitate tailored approaches to cancer management. The increasing prevalence of solid malignancies among older adults presents substantial challenges for an already overburdened healthcare system.</p><p>However, oncology care in India lacks a geriatric-oriented approach, resulting in gaps in both accessibility and quality for older populations. This review provides a detailed exploration of the multidimensional issues of treating older adults with malignancies in India, examining current deficiencies in healthcare delivery, socio-economic constraints, and potential avenues for enhancing care quality through multidisciplinary collaboration, palliative care integration, and policy reform. The recommendations herein advocate for a model of care that emphasizes holistic support, ensuring dignity, accessibility, and quality outcomes for older adults with cancer in India.</p>","PeriodicalId":72128,"journal":{"name":"Aging and cancer","volume":"7 1","pages":"3-11"},"PeriodicalIF":0.0,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aac2.70011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147568507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential","authors":"Hanqing He,&nbsp;Jianwei Wang","doi":"10.1002/aac2.70016","DOIUrl":"https://doi.org/10.1002/aac2.70016","url":null,"abstract":"<p>Aging is a complex and systemic biological process. As a crucial conduit linking all organs and tissues, the blood system not only reflects systemic aging phenotypes but may also actively drive the progression of organismal aging. In recent years, a series of heterochronic parabiosis and plasma transfusion experiments have revealed that exposure to young blood can restore the function of multiple organs in aged individuals, spurring growing interest in the concept of “blood-based antiaging.” Studies have identified a range of rejuvenating factors in young plasma—such as GDF11, TIMP2, and PF4—while aged blood is enriched in pro-aging signals, including CCL11, C1q, β2-microglobulin, and components of the senescence-associated secretory phenotype (SASP). These findings suggest that blood serves not only as a vehicle for youth-promoting cues but also as a reservoir of aging-inducing signals. Further research has shown that hematopoietic stem cells (HSCs), the root of the hematopoietic system, undergo functional decline, myeloid-biased differentiation, and clonal hematopoiesis during aging—key features that are tightly linked to immunosenescence, inflammaging, and multi-organ dysfunction. Transplantation of young HSCs has been demonstrated to extend lifespan and improve neurological, cardiac, and immune functions, highlighting their promising role in antiaging interventions. This review aims to systematically outline the development of blood-based rejuvenation research, focusing on the regulatory roles of circulating aging-related factors and the mechanistic underpinnings of HSC aging, and to explore future strategies and translational prospects of targeting the hematopoietic system in aging intervention.</p>","PeriodicalId":72128,"journal":{"name":"Aging and cancer","volume":"7 1","pages":"21-31"},"PeriodicalIF":0.0,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aac2.70016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147569376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting and Comparing the Subjective Health Experience of Older Cancer Survivors and Non-Cancer Survivors: A Modeling Approach","authors":"Damien S. E. Broekharst,&nbsp;Sjaak Bloem,&nbsp;Eline J. Mertens,&nbsp;Nathascha Hanzen,&nbsp;Michel van Agthoven","doi":"10.1002/aac2.70012","DOIUrl":"https://doi.org/10.1002/aac2.70012","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Around 25% of the global population faces cancer in their lifetime, with many older cancer survivors enduring lasting treatment effects and risk of recurrence, which negatively impacts their subjective health experience. To ameliorate their subjective health experience, it is essential to comprehend its key predictors. Contemporary literature identifies frailty and vitality alongside acceptance and control as principal predictors. However, thus far they have not been integrated into a composite model. Therefore, this study substantiates a composite model integrating these predictors and compares its outcomes between older cancer survivors and non-cancer survivors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>An online questionnaire assessing sample characteristics, frailty, vitality, acceptance, control, and subjective health experience was administered to 753 older adults comprising 150 cancer survivors and 603 non-cancer survivors. Data were subjected to descriptive, reliability, validity, and model analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Frailty is more negatively linked to acceptance and control in older cancer survivors but has a weaker, non-significant connection to subjective health experience compared to non-cancer survivors. Vitality is positively associated with all variables. Control strongly impacted acceptance in both groups but has a non-significant positive link to subjective health in cancer survivors, unlike the significant negative link in non-cancer survivors. Acceptance positively influenced subjective health experiences equally in both groups. The moderate indirect negative effect of frailty on subjective health experience is more pronounced in older cancer survivors than non-cancer survivors. Vitality, acceptance, and their interaction with control constituted key mediators. The composite model explained more variance in the subjective health experience of older cancer survivors than non-cancer survivors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The analysis underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors, with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model, highlighting its potential utility in shaping future interventions for older cancer survivors.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72128,"journal":{"name":"Aging and cancer","volume":"7 1","pages":"12-20"},"PeriodicalIF":0.0,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aac2.70012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147562959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and Disparities in Lung Cancer and Respiratory Failure Mortality in the United States: A 24-Year Retrospective Study","authors":"Sardar M. I. Khan,&nbsp;Muneeb Khawar,&nbsp;Abdul Qadeer,&nbsp;Aqsa Komel,&nbsp;Azka Aisha,&nbsp;Arshia Batool,&nbsp;Ayesha Fatima,&nbsp;Javed Iqbal,&nbsp;Asraf Hussain,&nbsp;Anisha Manzoor,&nbsp;Muhammad Waqas","doi":"10.1002/aac2.70010","DOIUrl":"https://doi.org/10.1002/aac2.70010","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Lung cancer (LC) and respiratory failure (RF) are leading causes of adult mortality worldwide. Analyzing long-term mortality trends across demographic, racial, geographic, and socioeconomic groups is essential to address disparities and enhance outcomes. This study investigates US national mortality patterns for LC and RF from 1999 to 2023, focusing on changes in age-adjusted mortality rates (AAMRs) and key disparities.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Mortality data from the CDC WONDER database (1999–2023) for adults aged 25+ with LC (ICD-10: C34) or RF (ICD-10: J96) were analyzed. AAMRs per 100,000 were calculated, stratified by gender, race/ethnicity, region, state, and urban–rural status. Temporal trends were assessed using Joinpoint regression to estimate annual percent changes (APCs) with 95% confidence intervals (CIs), with significance at <i>p</i> &lt; 0.05.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Over 1999–2023, 456,325 deaths from LC and RF were recorded. AAMRs declined from 1999 to 2010 (APC = −1.2, 95% CI: −1.6 to −0.9) but rose from 2010 to 2023 (APC = 1.4, 95% CI: 1.1–1.7). Men's AAMRs steadily decreased, whereas women's dropped initially, then increased from 2011 to 2023 (APC = 2.0, 95% CI: 1.7 to 2.5). Non-Hispanic Whites saw a sharp AAMR rise from 2014 to 2017 (APC = 2.7, 95% CI: 0.9 to 3.3), with other racial/ethnic groups showing mixed trends. Regionally, the Northeast had the highest AAMRs (8.6, 95% CI: 8.5 to 8.7), and the Midwest the lowest (7.1, 95% CI: 7.0 to 7.1). Metropolitan areas saw increases post-2006, whereas nonmetropolitan areas rose after 2009 (APC = 2.3, 95% CI: 1.8–3.1). Mississippi had the highest state AAMR (14.0, 95% CI: 13.7–14.4), Wisconsin the lowest (3.7, 95% CI: 3.5–3.8).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>LC and RF mortality declined until 2010, then increased, revealing significant disparities. Targeted interventions are critical to address these trends and reduce inequities.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72128,"journal":{"name":"Aging and cancer","volume":"6 4","pages":"118-125"},"PeriodicalIF":0.0,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aac2.70010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145706293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breast Cancer and Aging: Understanding the Complex Relationship and Implications for Prevention and Screening","authors":"Mehran Radak,&nbsp;Armin Sharifi,&nbsp;Derek Richard,&nbsp;Hossein Fallahi","doi":"10.1002/aac2.70009","DOIUrl":"https://doi.org/10.1002/aac2.70009","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Breast cancer is a multifactorial disease that affects many women worldwide. Age is the most important risk factor for breast cancer, with an increased incidence markedly after the age of 50. The relationships of aging to breast cancer have been thoroughly examined, and notable connections regarding various age-related changes in breast tissue, as well as age-related hormonal changes, have been defined, increasing the risk of breast cancer. In order to create opportunities for early detection and prevention, it is vital that we understand the risk factors of breast cancer, including hypertension and physical activity, to name only a few factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This review examines breast cancer incidence and rate, associations of aging and breast cancer, and the significance of better understanding this connection. The review will consider how aging interacts with breast cancer risk and will review breast cancer biology, examination of breast tissue, hormone changes with age, and other age-related factors that may influence breast cancer risk and/or development. We will also explore breast cancer risk factors, including genetic constitution and lifestyle factors, and how these factors all interact with age characteristics. In addition, we will review strategies to reduce the risk of breast cancer and briefly review breast cancer screening guidelines, not limited to but including some of the difficulties of appropriate screening for an older woman.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In summary, this review serves to underscore the awareness and understanding of breast cancer in connection with aging, and by acknowledging risk factors, flattening the curve of acceptance, and encouraging early detection and intervention through appropriate screening, we may alleviate the burden of breast cancer in older women.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72128,"journal":{"name":"Aging and cancer","volume":"6 4","pages":"106-117"},"PeriodicalIF":0.0,"publicationDate":"2025-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aac2.70009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145706589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protein Tyrosine Phosphatase 4A1 (PTP4A1) Regulates Early Events in Colorectal Cancer Intraperitoneal Dissemination in the Aged Male Host","authors":"Zhikun Wang,&nbsp;Yueying Liu,&nbsp;Jing Yang,&nbsp;Tyvette S. Hilliard,&nbsp;Reihaneh Safavi-Sohi,&nbsp;Daniel D. Hu,&nbsp;Elizabeth I. Harper,&nbsp;Gena Dominique,&nbsp;Wanrui Wang,&nbsp;Jeffrey Johnson,&nbsp;Marwa Asem,&nbsp;William Milosevich,&nbsp;Julia Florek Carlson,&nbsp;Yunpeng Bai,&nbsp;Jinmin Miao,&nbsp;Zhong-Yin Zhang,&nbsp;Matthew M. Champion,&nbsp;M. Sharon Stack","doi":"10.1002/aac2.70008","DOIUrl":"https://doi.org/10.1002/aac2.70008","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Cancer predominantly affects older individuals, with age being a significant risk factor for cancer incidence and metastasis. Biological sex also plays a crucial role in influencing metastasis and survival outcomes. In colorectal cancer (CRC), both the incidence and mortality from metastatic disease are higher in males relative to females.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The aim of this study was to use a syngeneic murine intraperitoneal (i.p.) metastasis model of CRC (MC-38 cells) to compare disease burden between young and aged female and male mice.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>MC-38 cells tagged with red fluorescent protein were injected i.p. and tumor burden quantified longitudinally and at endpoint. As the peritoneal mesothelial cell is the initial site of tumor:host interaction in i.p. metastasis, primary murine peritoneal mesothelial cells were subjected to bottom up proteomic analysis to identify proteins differentially expressed among the cohorts.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Recapitulating human epidemiological data, aged male mice exhibited the highest i.p. metastatic burden. Proteomic results identified multiple differentially expressed proteins. Protein tyrosine phosphatase 4A1 (PTP4A1), highly overexpressed in the male aged cohort relative to male young, female aged or female young, was chosen for further study. Functional analyses indicated that PTP4A1 promotes cancer:mesothelial adhesion and a small molecule inhibitor of PTP4A1, designated CMPD-43, reduced RhoA activity and inhibited heterotypic cell adhesion.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These results provide a resource for comparative proteomics of the peritoneal mesothelial cell in sex- and age-based cohorts. Functional data support further consideration of PTP4A1 as a potential therapeutic target for impeding CRC metastasis particularly in an aged male cohort.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72128,"journal":{"name":"Aging and cancer","volume":"6 4","pages":"93-105"},"PeriodicalIF":0.0,"publicationDate":"2025-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aac2.70008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145706590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-Related Changes in Myeloid Cells and Their Impact on Subcutaneous Melanoma Growth in Mice","authors":"Kaitlyn M. Landreth,&nbsp;Dylan D. Thomas,&nbsp;Remi Nohoesu,&nbsp;Angisha Basnet,&nbsp;F. Heath Damron,&nbsp;Mary Garland-Kledzik,&nbsp;Emel Sen Kilic,&nbsp;Tracy W. Liu","doi":"10.1002/aac2.70006","DOIUrl":"https://doi.org/10.1002/aac2.70006","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Advancing age increases cancer risk due to DNA damage accumulation and a decline in immune function. While aging is known to reduce adaptive immunity, it also leads to an increase in immunosuppressive myeloid cells, which promote tumor progression and are linked to poorer outcomes in melanoma.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Aims&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study aims to characterize how aging alters Gr-1&lt;sup&gt;+&lt;/sup&gt; myeloid cell function and their impact on melanoma growth and immunotherapy response.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Subcutaneous tumor growth using several YUMM melanoma cell lines was evaluated in 2-, 6-, and 12-month-old wild-type mice. Immune profiling of tumor-bearing and age-matched healthy mice was performed via flow cytometry and single-cell RNA sequencing. Gr-1&lt;sup&gt;+&lt;/sup&gt; myeloid cells were isolated to evaluate CD8&lt;sup&gt;+&lt;/sup&gt; T cell suppression, reactive oxygen species production, and extracellular trap formation. Altered tumor growth, Gr-1&lt;sup&gt;+&lt;/sup&gt; myeloid cell function, and immune checkpoint therapy response were evaluated comparing 2-month- and 6-month-old wild-type and syngeneic myeloperoxidase-deficient mice.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Aging only accelerated YUMM1.7 tumor growth and was associated with increased myeloid-derived suppressor cells, regulatory T cells, and exhausted T cells. Gr-1⁺ myeloid cells from aged, tumor-bearing mice showed enhanced CD8⁺ T cell suppression, reactive oxygen species production, and extracellular trap formation. Myeloperoxidase deficiency abrogated age-dependent tumor growth and improved immunotherapy response in YUMM1.7 tumor-bearing mice.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Our findings highlight a context-dependent immune response to melanoma with aging, indicating that age-related variations in melanoma growth and immunotherapy response are not ubiquitous. Age-accelerated tumor growth is associated with increased immunosuppressive cell populations alongside enhanced Gr-1&lt;sup&gt;+&lt;/sup&gt; myeloid cell-mediated immunosuppression driven in part by myeloperoxidase. Myeloperoxidase deficiency effectively reduced Gr-1&lt;sup&gt;+&lt;/sup&gt; myeloid cell immunosuppression, decreased reactive oxygen species, and diminished extracellular trap formation, thereby eliminating age-dependent differences in tumor growth and immunotherapy response. This work underscores the impact of aging on Gr-1&lt;sup&gt;+&lt;/sup&gt; myeloid cells on cancer progressi","PeriodicalId":72128,"journal":{"name":"Aging and cancer","volume":"6 3","pages":"71-87"},"PeriodicalIF":0.0,"publicationDate":"2025-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aac2.70006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145585332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cystic Ovarian Teratoma: Clinical and Radiographic Insights Into Chronic Pelvic Pain","authors":"Hashim U. Ali,&nbsp;Fahad H. Malik,&nbsp;Mohammad M. Zia,&nbsp;Ashar Ahmed,&nbsp;Mahfujul Z. Haque,&nbsp;Masood Siddiqui","doi":"10.1002/aac2.70007","DOIUrl":"https://doi.org/10.1002/aac2.70007","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <p>In this case report, we present the clinical course of an 88-year-old woman with chronic pelvic pain attributed to an incidental benign mature cystic ovarian teratoma on imaging and discuss common imaging modalities and discussions with patients, along with the diagnostic workup.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72128,"journal":{"name":"Aging and cancer","volume":"6 3","pages":"88-90"},"PeriodicalIF":0.0,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aac2.70007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145585216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Long Term Effects of a 12-Session Community Exercise Program on Health Measures in Cancer Patients","authors":"Isaac Oppong,&nbsp;Roozbeh Naemi","doi":"10.1002/aac2.70003","DOIUrl":"https://doi.org/10.1002/aac2.70003","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>To assess the long-term effects of a community cancer exercise program on quality of life, fatigue, weight, waist circumference, physical activity levels, lower extremity strength, body mass index (BMI), heart rate, and blood pressure, across non-metastatic and metastatic patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 918 participants (F/M: 1.77; mean age = 61 years, SD = 13.233) diagnosed with cancer within the last five years completed a 12-session guided physical activity program. Sessions included functional, aerobic, and resistance training aligned with ACSM guidelines for cancer patients. Blood pressure, quality of life, fatigue, BMI, lower extremity strength, body weight, and physical activity levels were measured at baseline, 12 sessions, and at 6 months, and 12 months during follow-up. The Wilcoxon signed-rank test was used to assess changes over time.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Significant improvements were observed in physical activity levels, health-related quality of life, and overall quality of life, sustained at 6- and 12-month follow-ups. Waist circumference, fatigue, and blood pressure significantly decreased across all time points. Lower extremity strength improved up to 6 months but was not significant at 12 months. No significant changes were observed in body weight or BMI. Non-metastatic patients experienced significant improvements in blood pressure, waist circumference, fatigue, and functional ability, while metastatic patients maintained their baseline health measures, suggesting a stabilizing effect.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study demonstrates that a community-based exercise program benefits non-metastatic cancer patients by improving quality of life, physical activity levels, and functional health, while helping metastatic patients maintain health outcomes. These findings highlight the importance of structured exercise programs in cancer care and support their implementation in real-world settings.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72128,"journal":{"name":"Aging and cancer","volume":"6 2","pages":"54-68"},"PeriodicalIF":0.0,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aac2.70003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aging-Driven Blood–Brain Barrier Dysfunction and Its Impact on CNS Cancer Susceptibility: A Comprehensive Narrative Review","authors":"Quang La,&nbsp;Aiman Baloch,&nbsp;David F. Lo","doi":"10.1002/aac2.70002","DOIUrl":"https://doi.org/10.1002/aac2.70002","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Aging significantly affects the structural and functional integrity of the blood–brain barrier (BBB), increasing the susceptibility of the central nervous system (CNS) to both primary and metastatic cancers. As the BBB deteriorates, it promotes tumor cell infiltration, alters drug permeability, and contributes to a proinflammatory microenvironment that supports tumor progression. These age-related changes present major obstacles in the effective treatment of CNS malignancies in elderly patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This review synthesizes current literature on the mechanisms of BBB aging and its impact on CNS cancer development and treatment. It examines key structural alterations, such as tight junction protein loss, endothelial dysfunction, and pericyte reduction, as well as functional changes including impaired immune regulation and transporter dysfunction. The review also evaluates therapeutic challenges and emerging strategies to overcome the BBB barrier in the aging brain.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Aging induces BBB dysfunction by weakening cellular junctions, disrupting the neurovascular unit, and promoting chronic neuroinflammation. These alterations facilitate tumor cell entry and survival in the brain and reduce the effectiveness of cancer therapies due to impaired drug delivery. Promising interventions, including nanoparticle-based therapies, focused ultrasound techniques, and targeted chemoimmunotherapy, are under development to enhance therapeutic outcomes in elderly patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The age-related breakdown of the BBB contributes significantly to increased cancer risk and therapeutic resistance in the CNS. Addressing BBB dysfunction through age-specific interventions and advanced drug delivery strategies is critical to improving outcomes for older adults with CNS malignancies. Further research into the molecular pathways of BBB aging will support the development of personalized and effective treatments.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72128,"journal":{"name":"Aging and cancer","volume":"6 2","pages":"46-53"},"PeriodicalIF":0.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aac2.70002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}