Aging and cancer最新文献

{"title":"Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis","authors":"Sherif Hamidu,&nbsp;Latif Adams,&nbsp;Eunice Ampem-Danso,&nbsp;Justice Kumi,&nbsp;Abigail Aning,&nbsp;Fatima Hamidu,&nbsp;Mustapha Abdul Mumin Mohammed,&nbsp;Ayuba Nii Darku Ankrah,&nbsp;Seth Kwabena Amponsah","doi":"10.1002/aac2.70017","DOIUrl":"https://doi.org/10.1002/aac2.70017","url":null,"abstract":"<p>Diabetic nephropathy (DN) is not merely a metabolic complication, it is an age-accelerated kidney disorder in which biological aging pathways amplify hyperglycemic injury. Mounting evidence implicates cellular senescence, mitochondrial dysfunction, chronic inflammation (“inflammaging”), and epigenetic drift as central drivers of DN progression. However, current therapies fail to address these aging mechanisms.</p><p>This review introduces a geroscience-based framework in which natural products are conceptualized as <i>geroprotective modulators</i> capable of reprogramming age-related molecular damage in the diabetic kidney. We integrate preclinical evidence showing that compounds such as resveratrol, quercetin, curcumin, ginsenosides, and berberine restore the AMPK–SIRT1–Nrf2 regulatory triad, thereby rejuvenating mitochondrial bioenergetics, suppressing inflammasome activation, and mitigating fibrosis.</p><p>A new mechanistic classification model is proposed, categorizing natural products by the specific hallmarks of aging they target; cellular senescence, mitochondrial decline, inflammaging, and epigenetic alterations rather than by chemical class. Finally, we advance a unifying hypothesis: simultaneous activation of the AMPK–SIRT1–Nrf2 axis represents the central mechanism through which diverse natural products confer renoprotection and longevity signaling in DN.</p><p>By linking geroscience to phytotherapy, this review provides a novel conceptual and mechanistic roadmap for developing multi-targeted interventions to slow kidney aging and improve outcomes in diabetic patients.</p>","PeriodicalId":72128,"journal":{"name":"Aging and cancer","volume":"7 2","pages":"52-66"},"PeriodicalIF":0.0,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aac2.70017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148292515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re-Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low- and Middle-Income Countries","authors":"Ibrahim Bidemi Abdullateef,&nbsp;Sunkanmi Folorunsho,&nbsp;Abdulazeez Opeyemi Abdulganiyu","doi":"10.1002/aac2.70019","DOIUrl":"https://doi.org/10.1002/aac2.70019","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <p>As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low- and middle-income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health policies, a trend contributing to what can be termed a “silent pandemic.” This perspective highlights the growing burden of cancer in aging populations in LMICs and critically examines the systemic gaps in prevention, diagnosis, treatment, survivorship care, and financial protection. Drawing on global and LMIC-specific evidence, the article explores key challenges such as underdiagnosis, limited access to age-sensitive screening, inadequate geriatric assessment, exclusion from clinical trials, and financial toxicity. It also provides evidence-informed recommendations to strengthen geriatric oncology care in resource-limited settings. These include integrating geriatric assessments into oncology practice, promoting age-inclusive research, expanding survivorship care and community support systems, and implementing financial protection policies. Addressing this neglected area is essential to achieving equitable cancer control and ensuring healthy aging in LMICs.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72128,"journal":{"name":"Aging and cancer","volume":"7 2","pages":"77-84"},"PeriodicalIF":0.0,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aac2.70019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148292452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment","authors":"Alexis E. Carey,&nbsp;Murilo Ramos Rocha,&nbsp;Cheyenne Palm,&nbsp;Vania Wang,&nbsp;Denys Balandin,&nbsp;Ethan Black,&nbsp;Kevin Y. Zhang,&nbsp;Fan Huang,&nbsp;Daniel J. Zabransky,&nbsp;Yash Chhabra,&nbsp;Mareike Peters,&nbsp;Gabriel Ghiaur,&nbsp;Ashani Weeraratna","doi":"10.1002/aac2.70015","DOIUrl":"https://doi.org/10.1002/aac2.70015","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Melanoma is the deadliest form of skin cancer, with increasing incidence rates among the older population. The immune system experiences age-related changes that can impact tumor progression and treatment efficacy. Additionally, aging leads to systemic non-immune changes, such as enhanced adiposity and iron accumulation in the bone marrow (BM).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This study aims to investigate how age-related alterations in the BM, alongside the presence of melanoma, influence the immune response and susceptibility to ferroptosis in aged mice.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods and Results</h3>\u0000 \u0000 <p>Utilizing an aged mouse model with melanoma, we observed significant changes in iron and lipid levels within the BM, as well as alterations in immune cell populations. Specifically, our findings indicate that tumor burden expands the myeloid compartment and contracts the lymphoid compartment in the BM niche. Aging increases neutral lipids within the BM, but tumor burden in aged mice appears to reverse this effect. We noted elevated intracellular neutral lipid levels in monocytes due to the tumor burden. Bone marrow–derived macrophages (BMDMs) from aged mice exhibited altered fatty acid synthase and fatty acid uptake protein expression. While aging leads to increased iron accumulation and lipid peroxidation in the BM, the presence of melanoma counteracts these changes. Disruptions in iron and lipid homeostasis heightened the risk of ferroptosis. Notably, imidazole ketone erastin and aging influenced intracellular ferrous iron levels and immune cell populations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Overall, melanoma induces an age-specific metabolic response in the BM, which may sensitize immune cells to ferroptosis inducers.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72128,"journal":{"name":"Aging and cancer","volume":"7 2","pages":"35-51"},"PeriodicalIF":0.0,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aac2.70015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148292506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia","authors":"Mobina Shrestha,&nbsp;Bishwas Mandal,&nbsp;Vishal Mandal,&nbsp;Asis Shrestha,&nbsp;Amir Babu Shrestha","doi":"10.1002/aac2.70018","DOIUrl":"https://doi.org/10.1002/aac2.70018","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The European LeukemiaNet (ELN) 2017 Genetic Risk Stratification System is widely used to categorize adult acute myeloid leukemia (AML) patients into prognostic groups. This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo-HSCT).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cohort of 186 adult AML patients was stratified into ELN2017 risk categories: favorable (19.6%), intermediate (54.6%), and adverse (25.76%). We analyzed overall survival (OS) and relapse-free survival (RFS), with subgroup analyses based on age, FLT3 and NPM1 mutation status, and allogeneic allo-HSCT.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Three-year OS was 68.09% (favorable), 45.36% (intermediate), and 22.87% (adverse). Five-year OS declined to 34.47%, 34.99%, and 13.72%, respectively. Corresponding 3-year RFS rates were 49.96%, 38%, and 12.98%, whereas 5-year RFS rates were 39.97%, 30.40%, and 6.49%. Patients aged ≥60 years showed poorer survival across all risk groups. Among FLT3-mutated cases, 5-year OS was 50% in the favorable group and 41.10% in the intermediate group. Allo-HSCT significantly improved 3-year OS in intermediate-risk patients from 33.80% to 63.00% and in adverse-risk patients from 10.10% to 46.15%.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>ELN2017 provides strong prognostic discrimination in adult AML despite the introduction of newer ELN guidelines. Patient age, FLT3/NPM1 mutations, and transplantation status further refine risk assessment and should guide individualized treatment strategies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72128,"journal":{"name":"Aging and cancer","volume":"7 2","pages":"67-76"},"PeriodicalIF":0.0,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aac2.70018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148292431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer","authors":"Nihanthy D. Sreenath,&nbsp;Mathigatta Shivarudraiah S,&nbsp;Rajath Govind,&nbsp;Kaushik M R","doi":"10.1002/aac2.70011","DOIUrl":"https://doi.org/10.1002/aac2.70011","url":null,"abstract":"<p>Cancer in older adults is a growing public health concern in India, with approximately 50% of all new cancer cases occurring in individuals aged 60 years and above, according to recent estimates from the Indian Council of Medical Research (ICMR). Older adults often present with a distinct set of medical, psychological, and social vulnerabilities that necessitate tailored approaches to cancer management. The increasing prevalence of solid malignancies among older adults presents substantial challenges for an already overburdened healthcare system.</p><p>However, oncology care in India lacks a geriatric-oriented approach, resulting in gaps in both accessibility and quality for older populations. This review provides a detailed exploration of the multidimensional issues of treating older adults with malignancies in India, examining current deficiencies in healthcare delivery, socio-economic constraints, and potential avenues for enhancing care quality through multidisciplinary collaboration, palliative care integration, and policy reform. The recommendations herein advocate for a model of care that emphasizes holistic support, ensuring dignity, accessibility, and quality outcomes for older adults with cancer in India.</p>","PeriodicalId":72128,"journal":{"name":"Aging and cancer","volume":"7 1","pages":"3-11"},"PeriodicalIF":0.0,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aac2.70011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147568507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential","authors":"Hanqing He,&nbsp;Jianwei Wang","doi":"10.1002/aac2.70016","DOIUrl":"https://doi.org/10.1002/aac2.70016","url":null,"abstract":"<p>Aging is a complex and systemic biological process. As a crucial conduit linking all organs and tissues, the blood system not only reflects systemic aging phenotypes but may also actively drive the progression of organismal aging. In recent years, a series of heterochronic parabiosis and plasma transfusion experiments have revealed that exposure to young blood can restore the function of multiple organs in aged individuals, spurring growing interest in the concept of “blood-based antiaging.” Studies have identified a range of rejuvenating factors in young plasma—such as GDF11, TIMP2, and PF4—while aged blood is enriched in pro-aging signals, including CCL11, C1q, β2-microglobulin, and components of the senescence-associated secretory phenotype (SASP). These findings suggest that blood serves not only as a vehicle for youth-promoting cues but also as a reservoir of aging-inducing signals. Further research has shown that hematopoietic stem cells (HSCs), the root of the hematopoietic system, undergo functional decline, myeloid-biased differentiation, and clonal hematopoiesis during aging—key features that are tightly linked to immunosenescence, inflammaging, and multi-organ dysfunction. Transplantation of young HSCs has been demonstrated to extend lifespan and improve neurological, cardiac, and immune functions, highlighting their promising role in antiaging interventions. This review aims to systematically outline the development of blood-based rejuvenation research, focusing on the regulatory roles of circulating aging-related factors and the mechanistic underpinnings of HSC aging, and to explore future strategies and translational prospects of targeting the hematopoietic system in aging intervention.</p>","PeriodicalId":72128,"journal":{"name":"Aging and cancer","volume":"7 1","pages":"21-31"},"PeriodicalIF":0.0,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aac2.70016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147569376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting and Comparing the Subjective Health Experience of Older Cancer Survivors and Non-Cancer Survivors: A Modeling Approach","authors":"Damien S. E. Broekharst,&nbsp;Sjaak Bloem,&nbsp;Eline J. Mertens,&nbsp;Nathascha Hanzen,&nbsp;Michel van Agthoven","doi":"10.1002/aac2.70012","DOIUrl":"https://doi.org/10.1002/aac2.70012","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Around 25% of the global population faces cancer in their lifetime, with many older cancer survivors enduring lasting treatment effects and risk of recurrence, which negatively impacts their subjective health experience. To ameliorate their subjective health experience, it is essential to comprehend its key predictors. Contemporary literature identifies frailty and vitality alongside acceptance and control as principal predictors. However, thus far they have not been integrated into a composite model. Therefore, this study substantiates a composite model integrating these predictors and compares its outcomes between older cancer survivors and non-cancer survivors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>An online questionnaire assessing sample characteristics, frailty, vitality, acceptance, control, and subjective health experience was administered to 753 older adults comprising 150 cancer survivors and 603 non-cancer survivors. Data were subjected to descriptive, reliability, validity, and model analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Frailty is more negatively linked to acceptance and control in older cancer survivors but has a weaker, non-significant connection to subjective health experience compared to non-cancer survivors. Vitality is positively associated with all variables. Control strongly impacted acceptance in both groups but has a non-significant positive link to subjective health in cancer survivors, unlike the significant negative link in non-cancer survivors. Acceptance positively influenced subjective health experiences equally in both groups. The moderate indirect negative effect of frailty on subjective health experience is more pronounced in older cancer survivors than non-cancer survivors. Vitality, acceptance, and their interaction with control constituted key mediators. The composite model explained more variance in the subjective health experience of older cancer survivors than non-cancer survivors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The analysis underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors, with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model, highlighting its potential utility in shaping future interventions for older cancer survivors.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72128,"journal":{"name":"Aging and cancer","volume":"7 1","pages":"12-20"},"PeriodicalIF":0.0,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aac2.70012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147562959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and Disparities in Lung Cancer and Respiratory Failure Mortality in the United States: A 24-Year Retrospective Study","authors":"Sardar M. I. Khan,&nbsp;Muneeb Khawar,&nbsp;Abdul Qadeer,&nbsp;Aqsa Komel,&nbsp;Azka Aisha,&nbsp;Arshia Batool,&nbsp;Ayesha Fatima,&nbsp;Javed Iqbal,&nbsp;Asraf Hussain,&nbsp;Anisha Manzoor,&nbsp;Muhammad Waqas","doi":"10.1002/aac2.70010","DOIUrl":"https://doi.org/10.1002/aac2.70010","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Lung cancer (LC) and respiratory failure (RF) are leading causes of adult mortality worldwide. Analyzing long-term mortality trends across demographic, racial, geographic, and socioeconomic groups is essential to address disparities and enhance outcomes. This study investigates US national mortality patterns for LC and RF from 1999 to 2023, focusing on changes in age-adjusted mortality rates (AAMRs) and key disparities.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Mortality data from the CDC WONDER database (1999–2023) for adults aged 25+ with LC (ICD-10: C34) or RF (ICD-10: J96) were analyzed. AAMRs per 100,000 were calculated, stratified by gender, race/ethnicity, region, state, and urban–rural status. Temporal trends were assessed using Joinpoint regression to estimate annual percent changes (APCs) with 95% confidence intervals (CIs), with significance at <i>p</i> &lt; 0.05.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Over 1999–2023, 456,325 deaths from LC and RF were recorded. AAMRs declined from 1999 to 2010 (APC = −1.2, 95% CI: −1.6 to −0.9) but rose from 2010 to 2023 (APC = 1.4, 95% CI: 1.1–1.7). Men's AAMRs steadily decreased, whereas women's dropped initially, then increased from 2011 to 2023 (APC = 2.0, 95% CI: 1.7 to 2.5). Non-Hispanic Whites saw a sharp AAMR rise from 2014 to 2017 (APC = 2.7, 95% CI: 0.9 to 3.3), with other racial/ethnic groups showing mixed trends. Regionally, the Northeast had the highest AAMRs (8.6, 95% CI: 8.5 to 8.7), and the Midwest the lowest (7.1, 95% CI: 7.0 to 7.1). Metropolitan areas saw increases post-2006, whereas nonmetropolitan areas rose after 2009 (APC = 2.3, 95% CI: 1.8–3.1). Mississippi had the highest state AAMR (14.0, 95% CI: 13.7–14.4), Wisconsin the lowest (3.7, 95% CI: 3.5–3.8).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>LC and RF mortality declined until 2010, then increased, revealing significant disparities. Targeted interventions are critical to address these trends and reduce inequities.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72128,"journal":{"name":"Aging and cancer","volume":"6 4","pages":"118-125"},"PeriodicalIF":0.0,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aac2.70010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145706293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breast Cancer and Aging: Understanding the Complex Relationship and Implications for Prevention and Screening","authors":"Mehran Radak,&nbsp;Armin Sharifi,&nbsp;Derek Richard,&nbsp;Hossein Fallahi","doi":"10.1002/aac2.70009","DOIUrl":"https://doi.org/10.1002/aac2.70009","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Breast cancer is a multifactorial disease that affects many women worldwide. Age is the most important risk factor for breast cancer, with an increased incidence markedly after the age of 50. The relationships of aging to breast cancer have been thoroughly examined, and notable connections regarding various age-related changes in breast tissue, as well as age-related hormonal changes, have been defined, increasing the risk of breast cancer. In order to create opportunities for early detection and prevention, it is vital that we understand the risk factors of breast cancer, including hypertension and physical activity, to name only a few factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This review examines breast cancer incidence and rate, associations of aging and breast cancer, and the significance of better understanding this connection. The review will consider how aging interacts with breast cancer risk and will review breast cancer biology, examination of breast tissue, hormone changes with age, and other age-related factors that may influence breast cancer risk and/or development. We will also explore breast cancer risk factors, including genetic constitution and lifestyle factors, and how these factors all interact with age characteristics. In addition, we will review strategies to reduce the risk of breast cancer and briefly review breast cancer screening guidelines, not limited to but including some of the difficulties of appropriate screening for an older woman.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In summary, this review serves to underscore the awareness and understanding of breast cancer in connection with aging, and by acknowledging risk factors, flattening the curve of acceptance, and encouraging early detection and intervention through appropriate screening, we may alleviate the burden of breast cancer in older women.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72128,"journal":{"name":"Aging and cancer","volume":"6 4","pages":"106-117"},"PeriodicalIF":0.0,"publicationDate":"2025-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aac2.70009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145706589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protein Tyrosine Phosphatase 4A1 (PTP4A1) Regulates Early Events in Colorectal Cancer Intraperitoneal Dissemination in the Aged Male Host","authors":"Zhikun Wang,&nbsp;Yueying Liu,&nbsp;Jing Yang,&nbsp;Tyvette S. Hilliard,&nbsp;Reihaneh Safavi-Sohi,&nbsp;Daniel D. Hu,&nbsp;Elizabeth I. Harper,&nbsp;Gena Dominique,&nbsp;Wanrui Wang,&nbsp;Jeffrey Johnson,&nbsp;Marwa Asem,&nbsp;William Milosevich,&nbsp;Julia Florek Carlson,&nbsp;Yunpeng Bai,&nbsp;Jinmin Miao,&nbsp;Zhong-Yin Zhang,&nbsp;Matthew M. Champion,&nbsp;M. Sharon Stack","doi":"10.1002/aac2.70008","DOIUrl":"https://doi.org/10.1002/aac2.70008","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Cancer predominantly affects older individuals, with age being a significant risk factor for cancer incidence and metastasis. Biological sex also plays a crucial role in influencing metastasis and survival outcomes. In colorectal cancer (CRC), both the incidence and mortality from metastatic disease are higher in males relative to females.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The aim of this study was to use a syngeneic murine intraperitoneal (i.p.) metastasis model of CRC (MC-38 cells) to compare disease burden between young and aged female and male mice.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>MC-38 cells tagged with red fluorescent protein were injected i.p. and tumor burden quantified longitudinally and at endpoint. As the peritoneal mesothelial cell is the initial site of tumor:host interaction in i.p. metastasis, primary murine peritoneal mesothelial cells were subjected to bottom up proteomic analysis to identify proteins differentially expressed among the cohorts.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Recapitulating human epidemiological data, aged male mice exhibited the highest i.p. metastatic burden. Proteomic results identified multiple differentially expressed proteins. Protein tyrosine phosphatase 4A1 (PTP4A1), highly overexpressed in the male aged cohort relative to male young, female aged or female young, was chosen for further study. Functional analyses indicated that PTP4A1 promotes cancer:mesothelial adhesion and a small molecule inhibitor of PTP4A1, designated CMPD-43, reduced RhoA activity and inhibited heterotypic cell adhesion.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These results provide a resource for comparative proteomics of the peritoneal mesothelial cell in sex- and age-based cohorts. Functional data support further consideration of PTP4A1 as a potential therapeutic target for impeding CRC metastasis particularly in an aged male cohort.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72128,"journal":{"name":"Aging and cancer","volume":"6 4","pages":"93-105"},"PeriodicalIF":0.0,"publicationDate":"2025-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aac2.70008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145706590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}