Aging and cancer最新文献

{"title":"Risk factors for suicide in patients with pancreatic ductal adenocarcinoma: A population-based study","authors":"Chao Wang,&nbsp;Haoda Chen,&nbsp;Yuanchi Weng,&nbsp;Xiaxing Deng,&nbsp;Weishen Wang,&nbsp;Baiyong Shen","doi":"10.1002/aac2.12069","DOIUrl":"10.1002/aac2.12069","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Patients diagnosed with pancreatic ductal adenocarcinoma (PDAC) face a notable risk of suicide. However, comprehensive population-based studies on suicide risk in PDAC patients have been lacking. This study seeks to explore the suicide risk in PDAC patients and identify the specific risk factors associated with suicide-related mortality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cohort of 101,382 PDAC patients was extracted from the Surveillance, Epidemiology, and End Results database, spanning from January 1, 2000, to December 31, 2017. The study employed the standardized mortality ratio (SMR) to assess the relative risk of suicide in PDAC patients compared to the general US population. The Nelson–Aalen estimator and the Fine and Grey method were utilized to pinpoint the risk factors linked to suicide-specific mortality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>PDAC patients exhibited a 3.51-fold higher risk of suicide compared to the general US population. This risk demonstrated an upward trend over the years. Notably, individuals aged 70–74 years faced a significantly elevated risk of suicide (SMR = 5.14, 95% CI: 3.10–8.03). Furthermore, there were distinct peaks in suicide risk at 1–4- and 25–28-month post-diagnoses (SMR = 15.04 and 2.72, respectively). Factors, such as gender, chemotherapy status, and marital status, emerged as significant independent predictors of suicide-specific mortality in PDAC patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study highlights a heightened suicide risk among PDAC patients in comparison to the general US population. It underscores the crucial need for continuous monitoring of the psychological well-being of all PDAC patients. Additionally, considering the elevated risk, the application of antidepressant therapy could be beneficial for those identified as having a higher risk of suicide.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72128,"journal":{"name":"Aging and cancer","volume":"5 1-2","pages":"35-47"},"PeriodicalIF":0.0,"publicationDate":"2024-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aac2.12069","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140210884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Promoting longevity with less cancer: The 2022 International Conference on Aging and Cancer","authors":"Yan Cui,&nbsp;Kai Wang,&nbsp;Danli Jiang,&nbsp;Yizhou Jiang,&nbsp;Dawei Shi,&nbsp;James DeGregori,&nbsp;Samuel Waxman,&nbsp;Ruibao Ren","doi":"10.1002/aac2.12068","DOIUrl":"10.1002/aac2.12068","url":null,"abstract":"<p>Aging and cancer are increasingly becoming big challenges for public health worldwide due to increased human life expectancy. Meanwhile, aging is one of the major risk factors for cancer. In December 2019, the first International Conference on Aging and Cancer was held in Haikou, Hainan province (island), China, preluding the establishment of the International Center for Aging and Cancer (ICAC) at Hainan, an institute dedicated to the research at the intersection of aging and cancer. Since then, the ICAC has hosted the annual conference each December in Hainan. The 2022 ICAC conference, with the theme of “promoting longevity with less cancer,” invited 17 internationally renowned scientists to share their new research and insights. Topics included DNA methylation in rejuvenation, development, and cellular senescence; lifespan regulation and longevity manipulation; metabolism and aging; cellular senescence and diseases; and novel therapeutics for cancer and antiaging/anticancer drug discovery. The forum highlighted the interconnectedness of aging and senescence with cancer evolution and risk. Although there is hope for preventing diseases like cancer by modulating systems that also control lifespan, attention has to be paid to the conflicting needs and competing demands in human biology.</p>","PeriodicalId":72128,"journal":{"name":"Aging and cancer","volume":"4 3-4","pages":"111-120"},"PeriodicalIF":0.0,"publicationDate":"2023-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aac2.12068","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136232958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detecting cellular senescence in vivo: Imagining imaging better","authors":"Zachary M. Rabinowitz,&nbsp;Lina Cui","doi":"10.1002/aac2.12067","DOIUrl":"10.1002/aac2.12067","url":null,"abstract":"<p>Methods to detect cellular senescence have become increasingly important, even more so in living animals and humans. This cellular state has been found to play fundamental roles in physiological processes as well as functioning detrimentally toward the advent or progression of pathological conditions. Importantly, the study of senescence involvement in these processes in vivo cannot be done without living-friendly technologies enabling senescence detection. Furthermore, senotherapies or therapies that selectively kill senescent cells have emerged as a new therapeutic strategy for aging and age-related diseases such as atherosclerosis, cancer, and neurodegenerative disorders and require tools to evaluate their use in vivo. As of now, our in vivo senescence detection toolkit includes genetically engineered reporter mouse models and small molecule imaging probes. Herein, we will focus on the detection of senescence in vivo, including a summary of its challenges, current detection methods and strategies, and a perspective on overcoming the current obstacles.</p>","PeriodicalId":72128,"journal":{"name":"Aging and cancer","volume":"4 3-4","pages":"97-110"},"PeriodicalIF":0.0,"publicationDate":"2023-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aac2.12067","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43749051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive factors and diagnostic significance of CT findings for anastomotic leak after gastric cancer surgery: A retrospective analysis","authors":"Birendra Kumar Sah,&nbsp;Yang Zhang,&nbsp;Jian Li,&nbsp;Chen Li,&nbsp;Huan Zhang,&nbsp;Min Yan,&nbsp;Zheng Gang Zhu","doi":"10.1002/aac2.12066","DOIUrl":"10.1002/aac2.12066","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Anastomotic leak following radical gastrectomy poses a significant risk to patients. Despite previous studies, effective methods for diagnosing anastomotic leaks after gastric cancer surgery remain elusive. In this study, we aimed to assess the overall burden of anastomotic leaks and investigate diagnostic factors, particularly radiological signs on postoperative computed tomography (CT), that may facilitate early detection.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We included a total of 70 gastric cancer patients who underwent curative gastrectomy and underwent CT examination post-surgery. Among them, 35 patients with anastomotic leak were matched with 35 patients without anastomotic leak. We compared the rates of various types of postoperative complications between the two groups and conducted univariate and multivariate analyses to identify predictive variables for postoperative diagnosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Patients with anastomotic leaks experienced significantly longer postoperative hospital stays and higher overall expenditures (<i>p</i> &lt; 0.001). Logistic regression analysis revealed that extraluminal gas at the anastomosis site, fever (<i>T</i> ≥ 38.5°C), and neutrophilia (NE ≥ 78%) on postoperative days 4–7 were independent diagnostic factors for anastomotic leaks (<i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The diagnostic factors identified in this study offer valuable insights into early detection of anastomotic leaks. We recommend early CT examination for patients exhibiting consistent fever and neutrophilia between postoperative days 4 and 7 following gastric cancer surgery.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72128,"journal":{"name":"Aging and cancer","volume":"4 2","pages":"85-93"},"PeriodicalIF":0.0,"publicationDate":"2023-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aac2.12066","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42218764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute myeloid leukemia in elderly patients: New targets, new therapies","authors":"Hae J. Park,&nbsp;Mark A. Gregory","doi":"10.1002/aac2.12065","DOIUrl":"10.1002/aac2.12065","url":null,"abstract":"<p>Prior to the past few years, the development of new therapies for acute myeloid leukemia (AML) has been disappointingly slow. For several decades, the standard therapy for AML has consisted of intensive induction chemotherapy, and potentially a subsequent hematopoietic stem cell transplant. Unfortunately, older patients are less responsive to, and are frequently unfit to tolerate, such intensive chemotherapy. Given that a majority of AML patients are elderly, this population has been most affected by the lack of newer less toxic therapies. However, in recent years, the treatment landscape for AML has dramatically shifted with the approval of many new drugs. As summarized in this review, several of these new drugs are targeted agents that are better tolerated than standard chemotherapy and could substantially benefit elderly patients. Although drug resistance remains a major concern, the treatment options for elderly AML patients are more numerous than ever before, bringing new promise for improved patient outcomes.</p>","PeriodicalId":72128,"journal":{"name":"Aging and cancer","volume":"4 2","pages":"51-73"},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aac2.12065","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45144618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allostatic load and risk of all-cause, cancer-specific, and cardiovascular mortality in older cancer survivors: An analysis of the National Health and Nutrition Examination Survey 1999–2010","authors":"Danting Yang,&nbsp;Meghann Wheeler,&nbsp;Shama D. Karanth,&nbsp;Livingstone Aduse-Poku,&nbsp;Christiaan Leeuwenburgh,&nbsp;Stephen Anton,&nbsp;Yi Guo,&nbsp;Jiang Bian,&nbsp;Muxuan Liang,&nbsp;Hyung-Suk Yoon,&nbsp;Tomi Akinyemiju,&nbsp;Dejana Braithwaite,&nbsp;Dongyu Zhang","doi":"10.1002/aac2.12064","DOIUrl":"10.1002/aac2.12064","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Allostatic load (AL) has been linked to an increased risk of death in various populations. However, to date, there is no research specifically investigating the effect of AL on mortality in older cancer survivors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To investigate the association between AL and mortality in older cancer survivors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>A total of 1291 adults aged 60 years or older who survived for ≥1 year since cancer diagnoses were identified from the 1999 to 2010 National Health and Nutrition Examination Survey. AL was the exposure of interest incorporating nine clinical measures/biomarkers; one point was added to AL if any of the measures/biomarkers exceeded the normal level. The sum of points was categorized as an ordinal variable to reflect low, moderate, and high ALs. Our outcomes of interest were all-cause, cancer-specific, and cardiovascular disease–specific mortality. Death was identified by linkage to the National Death Index. Multivariable Cox proportional hazards models were used to estimate adjusted hazard ratio (aHR) and 95% confidence intervals (CI) of mortality by AL category.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Overall, 53.6% of participants were male and 78.4% were white. The mean age of study participants at interview was 72.8 years (standard deviation = 7.1). A total of 546 participants died during the follow-up (median follow-up time: 8.0 years). Among them, 158 died of cancer, and 106 died of cardiovascular events. Results from multivariable Cox proportional hazards models showed that higher ALS was positively associated with higher all-cause mortality (ALS = 4–9 vs. ALS = 0–1: aHR = 1.52, 95% CI = 1.17–1.98, <i>p</i>-trend &lt; 0.01) and higher cancer-specific mortality (ALS = 4–9 vs. ALS = 0–1: aHR = 1.80, 95% CI = 1.12–2.90, <i>p</i>-trend = 0.01). The association between ALS and cardiovascular mortality was positive but nonsignificant (ALS = 4–9 vs. ALS = 0–1: aHR = 1.59, 95% CI = 0.86–2.94, <i>p</i>-trend = 0.11).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our study suggests that older cancer survivors can have a higher risk of death if they have a high burden of AL.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72128,"journal":{"name":"Aging and cancer","volume":"4 2","pages":"74-84"},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421616/pdf/nihms-1919026.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10005468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and treatment of colorectal cancer: Insights from multi-kingdom microbiota","authors":"Yue-Mei Hong,&nbsp;Dingka Song,&nbsp;Ning-Ning Liu,&nbsp;Hui Wang","doi":"10.1002/aac2.12063","DOIUrl":"10.1002/aac2.12063","url":null,"abstract":"<p>Colorectal cancer (CRC) is a multistage and highly heterogeneous malignant disease that mostly occurred in aged people accompanied by microbiota alteration. Emerging evidence has uncovered the role of bacterial microbiota in the initiation and development of CRC. However, the effects of nonbacterial members inhabiting the human body, such as fungi, archaea, and viruses, have been largely ignored. The multi-kingdom microbiota can be altered by dietary exposures and probiotic supplements. Furthermore, the efficacy of antitumor therapeutic strategies, such as radiotherapy, chemotherapy, and immunotherapy, are also closely associated with the alteration of multi-kingdom microbiota. In this review, we describe CRC-associated multi-kingdom microbiota dysbiosis and the role of daily diet on CRC progression through microbiota alteration. We then discuss the impact of microbiota in different CRC therapies and highlight the advances as well as challenges in understanding how multi-kingdom microbiome impacts the outcome of CRC.</p>","PeriodicalId":72128,"journal":{"name":"Aging and cancer","volume":"4 1","pages":"21-40"},"PeriodicalIF":0.0,"publicationDate":"2023-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aac2.12063","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42338571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and safety of Endostar combined with chemotherapy in treating advanced NSCLC patients with different ages","authors":"Wei Jiang,&nbsp;Jing Liang,&nbsp;Wei Sun,&nbsp;Wenhui Li,&nbsp;Jin Gao,&nbsp;Hui Wang,&nbsp;Wei Zhou,&nbsp;Lixiang Aa,&nbsp;Luhua Wang","doi":"10.1002/aac2.12062","DOIUrl":"10.1002/aac2.12062","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>This study aims to compare the real-world effectiveness and safety of Endostar in combination with chemotherapy in the treatment of advanced non-small cell lung cancer (NSCLC) in different age groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Electronic medical records of patients with NSCLC who received Endostar combined with chemotherapy from June 2012 to August 2019 in 7 cancer centers were retrospectively collected. Baseline characteristics before and after propensity score matching (PSM), effectiveness evaluation, and safety data of two age groups were analyzed. Tumor response was evaluated according to RECIST v1.1. Adverse events (AEs) were graded according to NCI-CTCAE 5.0.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In this study, 554 and 571 patients were assigned to ≤60 years non-aged group and &gt;60 years aged group, respectively. After propensity score matching (PSM) was introduced, 166 patients in each age group were analyzed. The median PFS for the two groups was 8.9 and 8.0 months, with the overall response rate was 24.7% and 26.5% (<i>p</i> = 0.7060), disease control rate was 64.5% versus 68.7% (<i>p</i> = 0.4600), respectively. Cox regression result showed that advanced age has no significant influence on PFS (hazard ratio = 1.02, 95% CI: 0.98−1.06, <i>p</i> = 0.3034) in contrast with younger patients. The most common AEs in both age groups were myelosuppression, gastrointestinal reactions, and hepatic impairment. The total incidence for the above AEs in the two groups was 18.67% versus 24.10%, 22.89% versus 21.69%, 12.05% versus 7.23%, with no statistically significant difference.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Compared with treating patients with NSCLC younger than 60 years old, the effectiveness of Endostar combined with chemotherapy in treating advanced patients showed no significant differences, with tolerable adverse events.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72128,"journal":{"name":"Aging and cancer","volume":"4 1","pages":"41-47"},"PeriodicalIF":0.0,"publicationDate":"2023-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aac2.12062","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41907510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The etiology of clonal mosaicism in human aging and disease","authors":"Sanne Massaar,&nbsp;Mathijs A. Sanders","doi":"10.1002/aac2.12061","DOIUrl":"10.1002/aac2.12061","url":null,"abstract":"<p>Our DNA is consistently assaulted by a variety of intrinsic and extrinsic mutational factors. Fortunately, DNA repair provides for protective barriers that limit the full manifestation of DNA damage. Yet, DNA repair represents no panacea as DNA damage continuously slips through these erected defenses and materializes as mutation, which can have undesirable consequences as seen for cancer. Acquisition of early driver mutations can engender mutated stem cells with increased cellular fitness resulting in clonal expansion (CE) and increased risk of malignant disease. Tissue clonal mosaicism as observed in the elderly is therefore the natural outcome of continuous driver mutation acquisition in stem cells and their subsequent clonal outgrowth. Hence, a major emerging theme is that CE is an idiosyncrasy of the aging human tissue. This phenomenon can have diverse health consequences that we here divide into three categories: cancer, non-cancer morbidity, and disease protection. This review outlines current day knowledge on clonal outgrowth, how it relates to health and aging, and how in the framework of DNA repair deficiencies these subjects are consolidated.</p>","PeriodicalId":72128,"journal":{"name":"Aging and cancer","volume":"4 1","pages":"3-20"},"PeriodicalIF":0.0,"publicationDate":"2023-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aac2.12061","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46722735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of surgery on the survival of elderly patients with early stage pancreatic cancer: A propensity-matched analysis","authors":"Jiali Wu,&nbsp;Zishan Xie,&nbsp;Chuqian Lei,&nbsp;Liwa Yu,&nbsp;Rui Huang,&nbsp;Ming Li,&nbsp;Lu Yuan,&nbsp;Weixing Zhang","doi":"10.1002/aac2.12057","DOIUrl":"10.1002/aac2.12057","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and objectives</h3>\u0000 \u0000 <p>Research about the effect of surgery in geriatric patients with early stage pancreatic ductal adenocarcinoma (PDAC) is limited, and it remains a subject of much debate. The purpose of this study was to evaluate the role of surgery on the survival of elderly patients with T1-3N0M0 PDAC and to further investigate the prognosis of these patients undergoing different surgical methods.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients aged ≥65 with T1-3N0M0 PDAC diagnosed in 2004–2016 were collected from the Surveillance, Epidemiology, and End Results database. The imbalance of baseline characteristics was reduced by propensity score matching. We used the log-rank tests to evaluate overall survival (OS) and cancer-specific survival (CSS) among different groups. Univariate and multivariate Cox regression analysis was utilized to explore prognostic factors in PDAC.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In total, 6363 patients were enrolled. After matching, 1110 patients were paired. We found that surgery could provide better survival (<i>p</i> &lt; 0.001). Moreover, compared with those who underwent partial resection or larger resection, patients who underwent local tumor destruction had poorer OS and CSS (<i>p</i> &lt; 0.001). However, no statistically significant survival differences were shown between the partial resection group and the larger resection group (<i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Surgical intervention could confer a survival benefit to elderly patients with early stage PDAC. Additionally, these patients could benefit from more radical operations, and radical operations with reasonable extents are advocated rather than too aggressive methods.</p>\u0000 </section>\u0000 </div>","PeriodicalId":72128,"journal":{"name":"Aging and cancer","volume":"3 3-4","pages":"169-178"},"PeriodicalIF":0.0,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aac2.12057","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49162261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}