Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe最新文献

{"title":"Modification of the oxygen radical absorbance capacity assay and its application in evaluating the total antioxidative state in fish","authors":"Toshiki Nakano ,&nbsp;Satoshi Hayashi ,&nbsp;Yoshihiro Ochiai ,&nbsp;Hitoshi Shirakawa ,&nbsp;Haiyun Wu ,&nbsp;Hideaki Endo ,&nbsp;Hui Yu","doi":"10.1016/j.arres.2022.100049","DOIUrl":"10.1016/j.arres.2022.100049","url":null,"abstract":"<div><p>The oxygen radical absorbance capacity (ORAC) assay is widely accepted as a common method for evaluating the total antioxidative activity in animals and food. The ORAC assay can simultaneously detect both hydrophilic (H-) and lipophilic (L-) antioxidants in animal tissues. In the present study, we modified the ORAC assay and estimated the total antioxidative state in two important fish species. The liver was initially extracted using a hexane and dichloromethane (Hex/Dc) mixture to prepare L-antioxidants associated with an L-ORAC value followed by the use of an acetone, water, and acetic acid (A/W/AA) mixture to prepare H-antioxidants as associated with an H-ORAC value, according to the original ORAC procedure. We altered the extraction order and reagents used in the modified ORAC assay. The H-antioxidants were initially extracted using 75 mM phosphate buffer (pH 7.4) instead of A/W/AA followed by Hex/Dc. Surprisingly, the H-ORAC value of the liver in rainbow trout (<em>Oncorhynchus mykiss</em>) measured using our modified ORAC assay was five-fold higher than that measured using the original procedure. In contrast, there were no significant differences in the liver L-ORAC values between the modified and original procedures. In addition, the plasma total antioxidative activity measured using the modified ORAC procedure was ten-fold higher than that measured using the original procedure. Analysis of the modified ORAC assay method revealed that high doses of dietary oxytetracycline, a widely used antibiotic, can affect the total antioxidative state and induce oxidative stress in coho salmon (<em>Oncorhynchus kisutch</em>). The present study suggests that total antioxidative activity, particularly H-antioxidative activity, in animal tissues and food based on the original ORAC assay might be underestimated in the literature. The modified procedure of the ORAC assay was simply and effectively improved to evaluate the total antioxidative state in animal tissues.</p></div>","PeriodicalId":72106,"journal":{"name":"Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe","volume":"6 ","pages":"Article 100049"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667137922000212/pdfft?md5=d89a15322855b029e87f36f374afd5ae&pid=1-s2.0-S2667137922000212-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42650506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Memoriam: Emeritus Professor Robin L. Willson","authors":"Michael J. Davies,&nbsp;Kelvin J.A. Davies,&nbsp;Barry Halliwell,&nbsp;Malcolm J. Jackson,&nbsp;Giovanni E. Mann,&nbsp;Giuseppe Poli,&nbsp;Rafael Radi,&nbsp;Patrick A. Riley,&nbsp;Helmut Sies,&nbsp;John F. Ward,&nbsp;Peter Wardman,&nbsp;John Willson","doi":"10.1016/j.arres.2022.100046","DOIUrl":"https://doi.org/10.1016/j.arres.2022.100046","url":null,"abstract":"","PeriodicalId":72106,"journal":{"name":"Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe","volume":"6 ","pages":"Article 100046"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667137922000182/pdfft?md5=047bb44ec83763bdc41adf51b8759ee3&pid=1-s2.0-S2667137922000182-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137115641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obese female mice do not exhibit overt hyperuricemia despite hepatic steatosis and impaired glucose tolerance","authors":"Sara E. Lewis ,&nbsp;Lihua Li ,&nbsp;Marco Fazzari ,&nbsp;Sonia R. Salvatore ,&nbsp;Jiang Li ,&nbsp;Emily A. Hileman ,&nbsp;Brooke A. Maxwell ,&nbsp;Francisco J. Schopfer ,&nbsp;Gavin E. Arteel ,&nbsp;Nicholas K.H. Khoo ,&nbsp;Eric E. Kelley","doi":"10.1016/j.arres.2022.100051","DOIUrl":"10.1016/j.arres.2022.100051","url":null,"abstract":"<div><p>Recent reports have clearly demonstrated a tight correlation between obesity and elevated circulating uric acid levels (hyperuricemia). However, nearly all preclinical work in this area has been completed with male mice, leaving the field with a considerable gap in knowledge regarding female responses to obesity and hyperuricemia. This deficiency in sex as a biological variable extends beyond unknowns regarding uric acid (UA) to several important comorbidities associated with obesity including nonalcoholic fatty liver disease (NAFLD). To attempt to address this issue, herein we describe both phenotypic and metabolic responses to diet-induced obesity (DIO) in female mice. Six-week-old female C57BL/6J mice were fed a high-fat diet (60% calories derived from fat) for 32 weeks. The DIO female mice had significant weight gain over the course of the study, higher fasting blood glucose, impaired glucose tolerance, and elevated plasma insulin levels compared to age-matched on normal chow. While these classic indices of DIO and NAFLD were observed such as increased circulating levels of ALT and AST, there was no difference in circulating UA levels. Obese female mice also demonstrated increased hepatic triglyceride (TG), cholesterol, and cholesteryl ester. In addition, several markers of hepatic inflammation were significantly increased. Also, alterations in the expression of redox-related enzymes were observed in obese mice compared to lean controls including increases in extracellular superoxide dismutase (Sod3), heme oxygenase (Ho)-1, and xanthine dehydrogenase (Xdh). Interestingly, hepatic UA levels were significantly elevated (∼2-fold) in obese mice compared to their lean counterparts. These data demonstrate female mice assume a similar metabolic profile to that reported in several male models of obesity in the context of alterations in glucose tolerance, hepatic steatosis, and elevated transaminases (ALT and AST) in the absence of hyperuricemia affirming the need for further study.</p></div>","PeriodicalId":72106,"journal":{"name":"Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe","volume":"6 ","pages":"Article 100051"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/50/3d/nihms-1855876.PMC9770588.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9832993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"β-alanine scavenging of free radicals protects mitochondrial function and enhances both insulin secretion and glucose uptake in cells under metabolic stress","authors":"Merell P. Billacura ,&nbsp;Charlie Jr Lavilla ,&nbsp;Michael J. Cripps ,&nbsp;Katie Hanna ,&nbsp;Craig Sale ,&nbsp;Mark D. Turner","doi":"10.1016/j.arres.2022.100050","DOIUrl":"10.1016/j.arres.2022.100050","url":null,"abstract":"<div><p>Type 2 diabetes is a disease characterized by dysregulation of glucose homeostasis, with numerous diabetic complications attributable to the resulting chronic exposure of cells and tissues to elevated concentrations of glucose and fatty acids. This in part results from formation of advanced glycation end-products and advanced lipidation end-products that can form adducts with proteins, lipids, or DNA and disrupt their normal cellular function. There is, however, growing evidence that supplementation with the endogenous histidine-containing dipeptide, carnosine, or its rate-limiting precursor, β-alanine, can ameliorate aspects of metabolic dysregulation that occur in diabetes and related conditions. Here we investigated the scavenging potential of β-alanine in INS-1 pancreatic β-cells and C2C12 skeletal muscle myotubes, and show a significant reduction of &gt;60% in reactive species that were generated by glucolipotoxic metabolic stress in both cell types following incubation with β-alanine for 5 days. Furthermore, β-alanine supplementation resulted in a protective action that helped prevent the damaging action of metabolic stress that otherwise leads to inhibition of mitochondrial function in both cell types. This in turn resulted in &gt;60% preservation of insulin secretion and glucose uptake, in INS-1 cells and C2C12 cells respectively, which would otherwise be inhibited by metabolic stress. This suggests potential therapeutic benefit to taking β-alanine supplements as an alternative to carnosine.</p></div>","PeriodicalId":72106,"journal":{"name":"Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe","volume":"6 ","pages":"Article 100050"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667137922000224/pdfft?md5=97009e95e21fde58a3fda26d103dcd2e&pid=1-s2.0-S2667137922000224-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45212938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Redox imaging of dextran sodium sulfate-induced colitis mice treated with nitric oxide synthase inhibitors","authors":"Keiji Yasukawa ,&nbsp;Kazunori Yamada ,&nbsp;Hiroto Tokuda ,&nbsp;Susumu Koyama ,&nbsp;Hideo Utsumi","doi":"10.1016/j.arres.2022.100047","DOIUrl":"10.1016/j.arres.2022.100047","url":null,"abstract":"<div><p>Ulcerative colitis (UC) is an inflammatory bowel disease of unknown cause. Redox imbalance, as characterized by excessive production of reactive oxygen species (ROS) and nitric oxide (NO), and deficient levels of endogenous antioxidants, is associated with the pathogenesis of UC. Overhauser-enhanced magnetic resonance imaging (OMRI) combined with a spin-probe method produces high-resolution images of redox imbalance in disease states. We aimed to investigate the effect of NO synthase (NOS) inhibitors on colonic ROS generation in mice with colitis induced by dextran sodium sulfate (DSS) using the OMRI/spin-probe method. Symptoms of DSS-induced colitis were ameliorated by an inducible NOS (iNOS) inhibitor, aminoguanidine (AG), but not by a non-selective NOS inhibitor, <em>N</em>^G-Nitro-L-arginine methyl ester (L-NAME). Intracellular ROS generation, observed as the enhancement of OMRI contrast decay rates of a 3-methoxy-2,2,5,5-tetramethylpyrrolidine-1-oxyl probe in the colons of DSS-induced colitis mice, was suppressed by AG, in agreement with the results of an <em>in vivo</em> electron spin resonance study. AG had an inhibitory effect on ROS production at the upper colon and rectum during the initiation stage of colitis, and at the upper and lower colon during the advanced stage. Additionally, there were partial differences in the localization of iNOS protein and nitrite/nitrate levels. L-NAME treatment showed a tendency for increased ROS generation at the upper colon during the advanced stage. The OMRI/spin-probe method provides a novel tool for screening ROS inhibitory activity <em>in vivo</em> in DSS-induced colitis mice.</p></div>","PeriodicalId":72106,"journal":{"name":"Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe","volume":"6 ","pages":"Article 100047"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667137922000194/pdfft?md5=fe03a080b67b203de46b8882146b9503&pid=1-s2.0-S2667137922000194-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43242757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging roles of thiol oxidoreductase-dependent mechanisms on vasomotricity regulation","authors":"Carolina Morales Portas ,&nbsp;Geovana Stefani Garcia ,&nbsp;Renato Simões Gaspar ,&nbsp;Annelise da Silva Casagrande,&nbsp;Leonardo Yuji Tanaka","doi":"10.1016/j.arres.2022.100044","DOIUrl":"10.1016/j.arres.2022.100044","url":null,"abstract":"<div><p>Vasomotricity, defined by measurements of contraction or relaxation, is important to support correct blood supply and needs to be finely regulated during hemodynamic changes. Disruptions in either contraction or relaxation, mainly endothelium-mediated, are closely related to cardiovascular diseases and are found during early events of vascular structural alterations, including vessel remodeling. Both acute vasomotor changes and chronic vascular remodeling are regulated by redox processes, such as the production of nitric oxide (NO), which is the major vasoactive endothelium-derived paracrine molecule. However, it is still unclear if vasomotricity can be regulated by direct redox reactions or thiol posttranslational modifications induced by secondary mediators. Here, we have reviewed the literature concerning the control of vascular function based on redox processes and merged evidence with mechanisms supporting structural alterations. Such knowledge is important to summarize the resulting vascular effects that occur upon inhibition of specific redox regulators. This may provide a landscape to better understand the complex redox regulation of vasomotricity and determine a hierarchical map of events involving NO biology, calcium transient regulation, actin cytoskeleton and extracellular matrix organization. In addition, we have proposed that the thiol oxidoreductase protein disulfide isomerase A1 (PDI) has the potential to act as a central hub connecting these processes with local oxidant generation, which may globally impact vascular function in physiologic and pathologic processes. Altogether, the understanding of these redox processes may lead to potential therapeutic redox targets able to prevent or treat functional or structural vascular alterations.</p></div>","PeriodicalId":72106,"journal":{"name":"Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe","volume":"6 ","pages":"Article 100044"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667137922000169/pdfft?md5=9367dabf354f865509a1bd593e37c08a&pid=1-s2.0-S2667137922000169-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48684048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidative stress is inhibited by plant-based supplements: A quantitative lipidomic analysis of antioxidant activity and lipid compositional change","authors":"Julia Bahja,&nbsp;Nicolas A. Stewart,&nbsp;Marcus K. Dymond","doi":"10.1016/j.arres.2022.100054","DOIUrl":"https://doi.org/10.1016/j.arres.2022.100054","url":null,"abstract":"<div><p>Dietary supplements containing plant extracts are often marketed as having antioxidant properties. Using complex lipid mixtures derived from cellular tissue, we perform a targeted lipidomic assessment of the antioxidant activity of five plant extract supplements. Formulations derived from grape seed, milk thistle, pine bark, turmeric and hawthorn extract were evaluated. Overall, we find evidence to suggest that all supplements suppressed <em>in vitro</em> lipid oxidation to some degree. Suppression of oxidation was most effective in the dominant lipid classes, phosphatidylcholine (PC) and phosphatidylethanolamine (PE), which contain significant numbers of polyunsaturated lipids. Under the conditions of study, grape seed extract supplement was the most effective antioxidant showing statistically significant suppression of lipid oxidation in 11 of the 15 lipid classes quantified. Lipid compositional changes and metrics such as the PC: PE ratio and the double bond index were determined to provide an insight into the effect of oxidative stress and antioxidants on collective membrane properties. Finally, the likely stress that <em>in vivo</em> lipid oxidation could cause to cells, and the mitigating effects of supplements in this context, is also discussed.</p></div>","PeriodicalId":72106,"journal":{"name":"Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe","volume":"6 ","pages":"Article 100054"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667137922000261/pdfft?md5=d42f2f4da9e0a445fd162a5757f9ab3e&pid=1-s2.0-S2667137922000261-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137115640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structure and biological evaluation of Caenorhabditis elegans CISD-1/mitoNEET, a KLP-17 tail domain homologue, supports attenuation of paraquat-induced oxidative stress through a p38 MAPK-mediated antioxidant defense response","authors":"Jacob R. Boos ,&nbsp;Hanna N. Jandrain ,&nbsp;Emi Hagiuda ,&nbsp;Alexander T. Taguchi ,&nbsp;Kazuya Hasegawa ,&nbsp;Bailey L. Fedun ,&nbsp;Sarah J. Taylor ,&nbsp;Sofhia M. Elad ,&nbsp;Sarah E. Faber ,&nbsp;Takashi Kumasaka ,&nbsp;Toshio Iwasaki ,&nbsp;Werner J. Geldenhuys","doi":"10.1016/j.arres.2022.100048","DOIUrl":"10.1016/j.arres.2022.100048","url":null,"abstract":"<div><p>CISD-1/mitoNEET is an evolutionarily conserved outer mitochondrial membrane [2Fe-2S] protein that regulates mitochondrial function and morphology. The [2Fe-2S] clusters are redox reactive and shown to mediate oxidative stress <em>in vitro</em> and <em>in vivo</em>. However, there is limited research studying CISD-1/mitoNEET mediation of oxidative stress in response to environmental stressors. In this study, we have determined the X-ray crystal structure of <em>Caenorhabditis elegans</em> CISD-1/mitoNEET homologue and evaluated the mechanisms of oxidative stress resistance to the pro-oxidant paraquat in age-synchronized populations by generating <em>C. elegans</em> gain and loss of function CISD-1 models. The structure of the <em>C. elegans</em> CISD-1/mitoNEET soluble domain refined at 1.70-Å resolution uniquely shows a reversible disulfide linkage at the homo-dimeric interface and also represents the N-terminal tail domain for dimerization of the cognate kinesin motor protein KLP-17 involved in chromosome segregation dynamics and germline development of the nematode. Moreover, overexpression of CISD-1/mitoNEET in <em>C. elegans</em> has revealed beneficial effects on oxidative stress resistance against paraquat-induced reactive oxygen species generation, corroborated by increased activation of the p38 mitogen-activated protein kinase (MAPK) signaling cascade.</p></div>","PeriodicalId":72106,"journal":{"name":"Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe","volume":"6 ","pages":"Article 100048"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a8/b5/nihms-1855856.PMC9757825.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10401541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidative stress in patients with pulmonary hypertension","authors":"Tammy O. Wichman ,&nbsp;Galo Martin Sanchez Palacios ,&nbsp;Ross Davidson ,&nbsp;Christopher S. Wichman ,&nbsp;Matthew C. Zimmerman","doi":"10.1016/j.arres.2022.100053","DOIUrl":"10.1016/j.arres.2022.100053","url":null,"abstract":"<div><h3>Rationale</h3><p>Pulmonary arterial hypertension is a devastating cardiovascular disease that is progressive and fatal despite advances in therapy. Animal models have shown that oxidative stress may be pathogenic in pulmonary hypertension.</p></div><div><h3>Objectives</h3><p>We hypothesized that oxidative stress, as measured by increased levels of oxidants, including superoxide, may play a role in pulmonary arterial hypertension in humans. We also hypothesized that oxidants are elevated in patients with pulmonary arterial hypertension compared with normal controls and that they correlate with measures of pulmonary arterial hypertension severity.</p></div><div><h3>Methods and Measurements</h3><p>Using a novel application of electron paramagnetic resonance spectroscopy to measure free radical oxidants, we initially evaluated whether levels of oxidants from whole blood collected from the pulmonary artery obtained during right heart catheterization would correlate with oxidant levels in peripheral venous blood. We then measured oxidants in peripheral venous blood in patients with pulmonary arterial hypertension and normal controls.</p></div><div><h3>Main Results</h3><p>Results showed a significant correlation between oxidant levels in blood collected from the pulmonary artery and peripheral vein but no significant elevation of oxidants in pulmonary hypertension patients versus control subjects. Furthermore, there were no correlations between levels of oxidants and severity of pulmonary arterial hypertension, as assessed by symptoms, functional capacity, hemodynamics, and the REVEAL risk score.</p></div><div><h3>Conclusions</h3><p>Contrary to previous animal studies and indirect measures of oxidative stress, we were unable to confirm an oxidative environment in patients with pulmonary arterial hypertension, at least when assessed by levels of free radical oxidants, such as superoxide, in whole blood via electron paramagnetic resonance spectroscopy.</p></div>","PeriodicalId":72106,"journal":{"name":"Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe","volume":"6 ","pages":"Article 100053"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266713792200025X/pdfft?md5=8cc7af36fc2dc0a9035f848b938a6006&pid=1-s2.0-S266713792200025X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49035473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to ‘Vitamin B12 does not increase cell viability after hydrogen peroxide induced damage in mouse kidney proximal tubular cells and brain endothelial cells’","authors":"Azraa Ayesha ,&nbsp;Edward M Bahnson ,&nbsp;Yukako Kayashima ,&nbsp;Jennifer Wilder ,&nbsp;Phillip K Huynh ,&nbsp;Sylvia Hiller ,&nbsp;Nobuyo Maeda-Smithies ,&nbsp;Feng Li","doi":"10.1016/j.arres.2022.100052","DOIUrl":"10.1016/j.arres.2022.100052","url":null,"abstract":"","PeriodicalId":72106,"journal":{"name":"Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe","volume":"6 ","pages":"Article 100052"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667137922000248/pdfft?md5=0eae6c9e5c057a43f27f91be25fbbc27&pid=1-s2.0-S2667137922000248-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43343939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}