Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe最新文献

{"title":"Endogenous ozone as a regular reactive oxygen species in (patho) physiology","authors":"Arnold N. Onyango","doi":"10.1016/j.arres.2023.100075","DOIUrl":"https://doi.org/10.1016/j.arres.2023.100075","url":null,"abstract":"","PeriodicalId":72106,"journal":{"name":"Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe","volume":"9 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49776018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alterations in thiol redox state and lipid peroxidation in the brain areas of male mice during aging","authors":"Konstantinos Grintzalis ,&nbsp;Nikolaos Patsoukis ,&nbsp;Ioannis Papapostolou ,&nbsp;George Zervoudakis ,&nbsp;Electra Kalaitzopoulou ,&nbsp;Christos D. Georgiou ,&nbsp;Nikolaos A. Matsokis ,&nbsp;Nikolaos T. Panagopoulos","doi":"10.1016/j.arres.2022.100043","DOIUrl":"10.1016/j.arres.2022.100043","url":null,"abstract":"<div><p>Aging is a natural process in organisms with its underlying mechanisms remaining unknown. Brain aging is accompanied by cognitive deficits and movement disorders, which signify the importance of elaborating its main mechanisms. In this study, oxidative stress biomarkers for lipid peroxidation and thiol redox state were assessed in different brain areas in male mice, categorised in respect to aging as young (three months), middle (eleven months) and elder aged (twenty-three months). Senescence was associated with an increase of lipid peroxidation and a decrease of reduced and oxidized glutathione. In some brain areas, reduced cysteine and oxidized protein thiols were increased with aging. Results support the theory that aging is associated with oxidative stress in the brain of mice and provide an insight in the biochemical aspect of aging in reference to thiol redox status as a potential marker for aging.</p></div>","PeriodicalId":72106,"journal":{"name":"Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe","volume":"6 ","pages":"Article 100043"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667137922000157/pdfft?md5=5a6e5c0a963ad4754a239e0cf344c58e&pid=1-s2.0-S2667137922000157-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54184921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term selection for faster development and early reproduction leads to up-regulation of genes involved in redox homeostasis","authors":"Nidhi Krishna Shrivastava,&nbsp;Abhishek Kumar Farand,&nbsp;Mallikarjun N. Shakarad","doi":"10.1016/j.arres.2022.100045","DOIUrl":"10.1016/j.arres.2022.100045","url":null,"abstract":"<div><p>ROS produced by Duox is necessary for normal host survival in response to commensal and or infectious microbes. However, failure in the homeostatic balance between synthesis and elimination of ROS leads to damage of major macromolecules and eventual death of the organism. The \"evolutionary option\" to use ROS to perform biological functions, in particular, is a double-edged sword. Rapid development is suggested to result in increased production of ROS due to increased metabolic demands as a consequence of sustained proliferation. We assessed redox homeostasis by measuring the transcript levels of genes involved in ROS production (<em>Duox</em> and <em>Nox</em>) and scavenging (<em>Irc, Sod1</em> and <em>Cat</em>) in three population types of <em>Drosophila melanogaster.</em> We discuss the role and interplay between ROS generating and ROS scavenging genes in maintaining developmental integrity and physiological homeostasis under rapid development.</p></div>","PeriodicalId":72106,"journal":{"name":"Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe","volume":"6 ","pages":"Article 100045"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667137922000170/pdfft?md5=a7ccdd70351a20ab8d7e1d81a3f0a201&pid=1-s2.0-S2667137922000170-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46504966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modification of the oxygen radical absorbance capacity assay and its application in evaluating the total antioxidative state in fish","authors":"Toshiki Nakano ,&nbsp;Satoshi Hayashi ,&nbsp;Yoshihiro Ochiai ,&nbsp;Hitoshi Shirakawa ,&nbsp;Haiyun Wu ,&nbsp;Hideaki Endo ,&nbsp;Hui Yu","doi":"10.1016/j.arres.2022.100049","DOIUrl":"10.1016/j.arres.2022.100049","url":null,"abstract":"<div><p>The oxygen radical absorbance capacity (ORAC) assay is widely accepted as a common method for evaluating the total antioxidative activity in animals and food. The ORAC assay can simultaneously detect both hydrophilic (H-) and lipophilic (L-) antioxidants in animal tissues. In the present study, we modified the ORAC assay and estimated the total antioxidative state in two important fish species. The liver was initially extracted using a hexane and dichloromethane (Hex/Dc) mixture to prepare L-antioxidants associated with an L-ORAC value followed by the use of an acetone, water, and acetic acid (A/W/AA) mixture to prepare H-antioxidants as associated with an H-ORAC value, according to the original ORAC procedure. We altered the extraction order and reagents used in the modified ORAC assay. The H-antioxidants were initially extracted using 75 mM phosphate buffer (pH 7.4) instead of A/W/AA followed by Hex/Dc. Surprisingly, the H-ORAC value of the liver in rainbow trout (<em>Oncorhynchus mykiss</em>) measured using our modified ORAC assay was five-fold higher than that measured using the original procedure. In contrast, there were no significant differences in the liver L-ORAC values between the modified and original procedures. In addition, the plasma total antioxidative activity measured using the modified ORAC procedure was ten-fold higher than that measured using the original procedure. Analysis of the modified ORAC assay method revealed that high doses of dietary oxytetracycline, a widely used antibiotic, can affect the total antioxidative state and induce oxidative stress in coho salmon (<em>Oncorhynchus kisutch</em>). The present study suggests that total antioxidative activity, particularly H-antioxidative activity, in animal tissues and food based on the original ORAC assay might be underestimated in the literature. The modified procedure of the ORAC assay was simply and effectively improved to evaluate the total antioxidative state in animal tissues.</p></div>","PeriodicalId":72106,"journal":{"name":"Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe","volume":"6 ","pages":"Article 100049"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667137922000212/pdfft?md5=d89a15322855b029e87f36f374afd5ae&pid=1-s2.0-S2667137922000212-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42650506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diisononyl phthalate inhibits cardiac glycolysis and oxidative phosphorylation by down-regulating cytosolic and mitochondrial energy metabolizing enzymes in murine model","authors":"S. A Kehinde ,&nbsp;A. Ore ,&nbsp;A. T Olajide ,&nbsp;I. E Ajagunna ,&nbsp;F. A Oloyede ,&nbsp;T. O Faniyi ,&nbsp;J. O Fatoki","doi":"10.1016/j.arres.2022.100041","DOIUrl":"10.1016/j.arres.2022.100041","url":null,"abstract":"<div><p>The recent increase of diisononyl phthalate (DiNP) applications in a wide range of plastic consumer products, as well as its relative environmental exposure and interactions, has compelled an investigation of its toxicity. Phthalate exposure has been associated with heart dysfunction in animals in a few studies, the bulk of which are linked to the high molecular weight phthalates. The effect of DiNP on cardiac energy transduction was assessed utilizing cellular respiration enzymes as indices. Eighteen wistar rats were divided into 3 groups of six rats each: Group A received Tween-80 (control), DiNP (20 mg/kg/BW) was given to Group B, and 200mg/kg DiNP was given to Group C orally (gavage) for 14 days. The activity of cardiac glycolytic, oxidative phosphorylation enzymes and histopathological changes were assessed. The glycolytic and tricarboxylic acid cycle enzymes studied were predominantly down-regulated in a dose-dependent manner, with the exception of cardiac citrate synthase, which showed no significant variation in activity when compared to the control. Furthermore, all respiratory chain complexes (Complex I-IV) decreased significantly relative to control, with the exception of complex IV activity at 20mg/kg/BW which showed no significant difference <em>(P&lt;0.05)</em>. Cardiac histopathological alterations confirmed the aforementioned metabolic disturbances. Finally, DiNP exposure impairs cardiac energy transduction enzymes, implying cardiac cells produced insufficient energy (ATP) to carry out its morphological and physiological functions efficiently as the heart requires a constant supply of energy in the form of ATP to support contraction, relaxation, and prevent cardiomyopathies.</p></div>","PeriodicalId":72106,"journal":{"name":"Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe","volume":"6 ","pages":"Article 100041"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667137922000133/pdfft?md5=83080e2b30576955f45c4486d88b5dc8&pid=1-s2.0-S2667137922000133-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45413984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Memoriam: Emeritus Professor Robin L. Willson","authors":"Michael J. Davies,&nbsp;Kelvin J.A. Davies,&nbsp;Barry Halliwell,&nbsp;Malcolm J. Jackson,&nbsp;Giovanni E. Mann,&nbsp;Giuseppe Poli,&nbsp;Rafael Radi,&nbsp;Patrick A. Riley,&nbsp;Helmut Sies,&nbsp;John F. Ward,&nbsp;Peter Wardman,&nbsp;John Willson","doi":"10.1016/j.arres.2022.100046","DOIUrl":"https://doi.org/10.1016/j.arres.2022.100046","url":null,"abstract":"","PeriodicalId":72106,"journal":{"name":"Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe","volume":"6 ","pages":"Article 100046"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667137922000182/pdfft?md5=047bb44ec83763bdc41adf51b8759ee3&pid=1-s2.0-S2667137922000182-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137115641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obese female mice do not exhibit overt hyperuricemia despite hepatic steatosis and impaired glucose tolerance","authors":"Sara E. Lewis ,&nbsp;Lihua Li ,&nbsp;Marco Fazzari ,&nbsp;Sonia R. Salvatore ,&nbsp;Jiang Li ,&nbsp;Emily A. Hileman ,&nbsp;Brooke A. Maxwell ,&nbsp;Francisco J. Schopfer ,&nbsp;Gavin E. Arteel ,&nbsp;Nicholas K.H. Khoo ,&nbsp;Eric E. Kelley","doi":"10.1016/j.arres.2022.100051","DOIUrl":"10.1016/j.arres.2022.100051","url":null,"abstract":"<div><p>Recent reports have clearly demonstrated a tight correlation between obesity and elevated circulating uric acid levels (hyperuricemia). However, nearly all preclinical work in this area has been completed with male mice, leaving the field with a considerable gap in knowledge regarding female responses to obesity and hyperuricemia. This deficiency in sex as a biological variable extends beyond unknowns regarding uric acid (UA) to several important comorbidities associated with obesity including nonalcoholic fatty liver disease (NAFLD). To attempt to address this issue, herein we describe both phenotypic and metabolic responses to diet-induced obesity (DIO) in female mice. Six-week-old female C57BL/6J mice were fed a high-fat diet (60% calories derived from fat) for 32 weeks. The DIO female mice had significant weight gain over the course of the study, higher fasting blood glucose, impaired glucose tolerance, and elevated plasma insulin levels compared to age-matched on normal chow. While these classic indices of DIO and NAFLD were observed such as increased circulating levels of ALT and AST, there was no difference in circulating UA levels. Obese female mice also demonstrated increased hepatic triglyceride (TG), cholesterol, and cholesteryl ester. In addition, several markers of hepatic inflammation were significantly increased. Also, alterations in the expression of redox-related enzymes were observed in obese mice compared to lean controls including increases in extracellular superoxide dismutase (Sod3), heme oxygenase (Ho)-1, and xanthine dehydrogenase (Xdh). Interestingly, hepatic UA levels were significantly elevated (∼2-fold) in obese mice compared to their lean counterparts. These data demonstrate female mice assume a similar metabolic profile to that reported in several male models of obesity in the context of alterations in glucose tolerance, hepatic steatosis, and elevated transaminases (ALT and AST) in the absence of hyperuricemia affirming the need for further study.</p></div>","PeriodicalId":72106,"journal":{"name":"Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe","volume":"6 ","pages":"Article 100051"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/50/3d/nihms-1855876.PMC9770588.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9832993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"β-alanine scavenging of free radicals protects mitochondrial function and enhances both insulin secretion and glucose uptake in cells under metabolic stress","authors":"Merell P. Billacura ,&nbsp;Charlie Jr Lavilla ,&nbsp;Michael J. Cripps ,&nbsp;Katie Hanna ,&nbsp;Craig Sale ,&nbsp;Mark D. Turner","doi":"10.1016/j.arres.2022.100050","DOIUrl":"10.1016/j.arres.2022.100050","url":null,"abstract":"<div><p>Type 2 diabetes is a disease characterized by dysregulation of glucose homeostasis, with numerous diabetic complications attributable to the resulting chronic exposure of cells and tissues to elevated concentrations of glucose and fatty acids. This in part results from formation of advanced glycation end-products and advanced lipidation end-products that can form adducts with proteins, lipids, or DNA and disrupt their normal cellular function. There is, however, growing evidence that supplementation with the endogenous histidine-containing dipeptide, carnosine, or its rate-limiting precursor, β-alanine, can ameliorate aspects of metabolic dysregulation that occur in diabetes and related conditions. Here we investigated the scavenging potential of β-alanine in INS-1 pancreatic β-cells and C2C12 skeletal muscle myotubes, and show a significant reduction of &gt;60% in reactive species that were generated by glucolipotoxic metabolic stress in both cell types following incubation with β-alanine for 5 days. Furthermore, β-alanine supplementation resulted in a protective action that helped prevent the damaging action of metabolic stress that otherwise leads to inhibition of mitochondrial function in both cell types. This in turn resulted in &gt;60% preservation of insulin secretion and glucose uptake, in INS-1 cells and C2C12 cells respectively, which would otherwise be inhibited by metabolic stress. This suggests potential therapeutic benefit to taking β-alanine supplements as an alternative to carnosine.</p></div>","PeriodicalId":72106,"journal":{"name":"Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe","volume":"6 ","pages":"Article 100050"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667137922000224/pdfft?md5=97009e95e21fde58a3fda26d103dcd2e&pid=1-s2.0-S2667137922000224-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45212938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Redox imaging of dextran sodium sulfate-induced colitis mice treated with nitric oxide synthase inhibitors","authors":"Keiji Yasukawa ,&nbsp;Kazunori Yamada ,&nbsp;Hiroto Tokuda ,&nbsp;Susumu Koyama ,&nbsp;Hideo Utsumi","doi":"10.1016/j.arres.2022.100047","DOIUrl":"10.1016/j.arres.2022.100047","url":null,"abstract":"<div><p>Ulcerative colitis (UC) is an inflammatory bowel disease of unknown cause. Redox imbalance, as characterized by excessive production of reactive oxygen species (ROS) and nitric oxide (NO), and deficient levels of endogenous antioxidants, is associated with the pathogenesis of UC. Overhauser-enhanced magnetic resonance imaging (OMRI) combined with a spin-probe method produces high-resolution images of redox imbalance in disease states. We aimed to investigate the effect of NO synthase (NOS) inhibitors on colonic ROS generation in mice with colitis induced by dextran sodium sulfate (DSS) using the OMRI/spin-probe method. Symptoms of DSS-induced colitis were ameliorated by an inducible NOS (iNOS) inhibitor, aminoguanidine (AG), but not by a non-selective NOS inhibitor, <em>N</em>^G-Nitro-L-arginine methyl ester (L-NAME). Intracellular ROS generation, observed as the enhancement of OMRI contrast decay rates of a 3-methoxy-2,2,5,5-tetramethylpyrrolidine-1-oxyl probe in the colons of DSS-induced colitis mice, was suppressed by AG, in agreement with the results of an <em>in vivo</em> electron spin resonance study. AG had an inhibitory effect on ROS production at the upper colon and rectum during the initiation stage of colitis, and at the upper and lower colon during the advanced stage. Additionally, there were partial differences in the localization of iNOS protein and nitrite/nitrate levels. L-NAME treatment showed a tendency for increased ROS generation at the upper colon during the advanced stage. The OMRI/spin-probe method provides a novel tool for screening ROS inhibitory activity <em>in vivo</em> in DSS-induced colitis mice.</p></div>","PeriodicalId":72106,"journal":{"name":"Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe","volume":"6 ","pages":"Article 100047"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667137922000194/pdfft?md5=fe03a080b67b203de46b8882146b9503&pid=1-s2.0-S2667137922000194-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43242757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging roles of thiol oxidoreductase-dependent mechanisms on vasomotricity regulation","authors":"Carolina Morales Portas ,&nbsp;Geovana Stefani Garcia ,&nbsp;Renato Simões Gaspar ,&nbsp;Annelise da Silva Casagrande,&nbsp;Leonardo Yuji Tanaka","doi":"10.1016/j.arres.2022.100044","DOIUrl":"10.1016/j.arres.2022.100044","url":null,"abstract":"<div><p>Vasomotricity, defined by measurements of contraction or relaxation, is important to support correct blood supply and needs to be finely regulated during hemodynamic changes. Disruptions in either contraction or relaxation, mainly endothelium-mediated, are closely related to cardiovascular diseases and are found during early events of vascular structural alterations, including vessel remodeling. Both acute vasomotor changes and chronic vascular remodeling are regulated by redox processes, such as the production of nitric oxide (NO), which is the major vasoactive endothelium-derived paracrine molecule. However, it is still unclear if vasomotricity can be regulated by direct redox reactions or thiol posttranslational modifications induced by secondary mediators. Here, we have reviewed the literature concerning the control of vascular function based on redox processes and merged evidence with mechanisms supporting structural alterations. Such knowledge is important to summarize the resulting vascular effects that occur upon inhibition of specific redox regulators. This may provide a landscape to better understand the complex redox regulation of vasomotricity and determine a hierarchical map of events involving NO biology, calcium transient regulation, actin cytoskeleton and extracellular matrix organization. In addition, we have proposed that the thiol oxidoreductase protein disulfide isomerase A1 (PDI) has the potential to act as a central hub connecting these processes with local oxidant generation, which may globally impact vascular function in physiologic and pathologic processes. Altogether, the understanding of these redox processes may lead to potential therapeutic redox targets able to prevent or treat functional or structural vascular alterations.</p></div>","PeriodicalId":72106,"journal":{"name":"Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe","volume":"6 ","pages":"Article 100044"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667137922000169/pdfft?md5=9367dabf354f865509a1bd593e37c08a&pid=1-s2.0-S2667137922000169-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48684048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}