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Advances in kidney disease and health最新文献

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Genetics in Kidney Diseases 肾脏疾病的遗传学
Advances in kidney disease and health Pub Date : 2025-01-01 Epub Date: 2025-03-31 DOI: 10.1053/j.akdh.2024.10.003
Samuel Mon-Wei Yu, Kirk Campbell
{"title":"Genetics in Kidney Diseases","authors":"Samuel Mon-Wei Yu,&nbsp;Kirk Campbell","doi":"10.1053/j.akdh.2024.10.003","DOIUrl":"10.1053/j.akdh.2024.10.003","url":null,"abstract":"<div><div>With the increasing availability of genetic testing, nephrologists can now incorporate genetic testing results into traditional biochemical profiles and kidney biopsy data to provide more accurate diagnoses. Moreover, if available, therapeutic approaches can be further tailored to individual genetic testing results to avoid unnecessary exposure to prolonged immunosuppressive medications with often undesirable side effects. Identifying new genetic mutations in kidney diseases also opens new avenues to novel drug targets. Here, we present five clinical questions summarizing some genetic kidney diseases and updates.</div></div>","PeriodicalId":72096,"journal":{"name":"Advances in kidney disease and health","volume":"32 1","pages":"Pages 33-40"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute Kidney Injury and Critical Care Nephrology 急性肾损伤和重症肾病学
Advances in kidney disease and health Pub Date : 2025-01-01 Epub Date: 2025-03-31 DOI: 10.1053/j.akdh.2024.12.002
Marco Bonilla , Jay L. Koyner , Javier A. Neyra
{"title":"Acute Kidney Injury and Critical Care Nephrology","authors":"Marco Bonilla ,&nbsp;Jay L. Koyner ,&nbsp;Javier A. Neyra","doi":"10.1053/j.akdh.2024.12.002","DOIUrl":"10.1053/j.akdh.2024.12.002","url":null,"abstract":"<div><div>Critical care nephrology is an increasingly vital subspecialty within internal medicine that focuses on the comprehensive management of a spectrum of kidney-related complications that arise in critically ill patients. This field plays a crucial role in heterogeneous intensive care unit settings, where the dynamic and complex nature of critical illnesses and acute kidney injury phenotypes often necessitates specialized renal care, including renal replacement therapy. In this manuscript, we present board-style review questions that illustrate distinct clinical scenarios and interventions in critical care nephrology, with an emphasis on key teaching points.</div></div>","PeriodicalId":72096,"journal":{"name":"Advances in kidney disease and health","volume":"32 1","pages":"Pages 12-23"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Conservative Management for Kidney Failure 肾衰竭的保守治疗
Advances in kidney disease and health Pub Date : 2025-01-01 Epub Date: 2025-03-31 DOI: 10.1053/j.akdh.2024.11.003
Samantha Gelfand
{"title":"Conservative Management for Kidney Failure","authors":"Samantha Gelfand","doi":"10.1053/j.akdh.2024.11.003","DOIUrl":"10.1053/j.akdh.2024.11.003","url":null,"abstract":"<div><div>Conservative kidney management (CKM) is active medical management of kidney failure without dialysis. The main focus of care is optimizing quality of life by preserving kidney function for as long as possible and medically managing symptoms of kidney failure.</div></div>","PeriodicalId":72096,"journal":{"name":"Advances in kidney disease and health","volume":"32 1","pages":"Pages 24-32"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Onconephrology Onconephrology
Advances in kidney disease and health Pub Date : 2025-01-01 Epub Date: 2025-03-31 DOI: 10.1053/j.akdh.2024.10.005
Sheron Latcha , Victoria Gutgarts , Belen Nunez Cespedes , Sandra M. Herrmann
{"title":"Onconephrology","authors":"Sheron Latcha ,&nbsp;Victoria Gutgarts ,&nbsp;Belen Nunez Cespedes ,&nbsp;Sandra M. Herrmann","doi":"10.1053/j.akdh.2024.10.005","DOIUrl":"10.1053/j.akdh.2024.10.005","url":null,"abstract":"<div><div>Subspecialized training in the field of onconephrology offers a uniquely informed approach to the care of the patient with both cancer and kidney disease. There is a significant knowledge gap that has been created by the fact that patients with an estimated glomerular filtration rate &lt;30 mL/min are generally excluded from clinical cancer trials. Thus, oncologists rely on the clinical experience and expertise of onconephrologists to dose cytotoxic chemotherapies, to recognize and manage complications of newer targeted drugs and immunotherapies, to become partners in establishing guidelines relating to the management of these complications, and to collaborate on the design of future clinical trials in this cohort. In this section, we provide a glimpse into some common clinical scenarios encountered by the onconephrologist and demonstrate how clinical data and observations inform decision-making in these situations.</div></div>","PeriodicalId":72096,"journal":{"name":"Advances in kidney disease and health","volume":"32 1","pages":"Pages 69-78"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transplant Nephrology 移植肾脏病学。
Advances in kidney disease and health Pub Date : 2024-11-01 Epub Date: 2024-11-20 DOI: 10.1053/j.akdh.2024.08.004
Donal J. Sexton , Serena Bagnasco , Sam Kant
{"title":"Transplant Nephrology","authors":"Donal J. Sexton ,&nbsp;Serena Bagnasco ,&nbsp;Sam Kant","doi":"10.1053/j.akdh.2024.08.004","DOIUrl":"10.1053/j.akdh.2024.08.004","url":null,"abstract":"<div><div>The progressive rise in the number of kidney transplant recipients in the last 2 decades is reflective of the technological advances in the field. Nephrologists are responsible for providing long-term longitudinal care to these patients. It is pertinent that nephrologists understand the various nuances of aspects such as immunosuppression, opportunistic infections, and identification of causes associated with graft dysfunction.</div></div>","PeriodicalId":72096,"journal":{"name":"Advances in kidney disease and health","volume":"31 6","pages":"Pages 566-573"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronic Dialysis Therapies 慢性透析疗法。
Advances in kidney disease and health Pub Date : 2024-11-01 Epub Date: 2024-11-20 DOI: 10.1053/j.akdh.2024.06.003
Alexander Morales, Jeffrey H. William
{"title":"Chronic Dialysis Therapies","authors":"Alexander Morales,&nbsp;Jeffrey H. William","doi":"10.1053/j.akdh.2024.06.003","DOIUrl":"10.1053/j.akdh.2024.06.003","url":null,"abstract":"<div><div>While both in-center and home dialysis modalities have improved life expectancy for people with end-stage kidney disease and have served as a bridge to eventual kidney transplantation, kidney health care providers must be keenly aware of the potential complications associated with these therapies. The following questions aim to shed light on some of the more important potential physiological consequences and medical dilemmas associated with the three primary dialysis modalities including in-center hemodialysis, home hemodialysis, and peritoneal dialysis. Moreover, we hope to highlight that caring for those requiring dialytic therapy necessitates a significant breadth of understanding in other core internal medicine disciplines beyond nephrology itself, including cardiovascular, infectious, and musculoskeletal disease entities.</div></div>","PeriodicalId":72096,"journal":{"name":"Advances in kidney disease and health","volume":"31 6","pages":"Pages 553-565"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronic Kidney Disease—Part 1: Evaluation & Risk Assessment in CKD, Methods to Delay CKD Progression 慢性肾脏病-第 1 部分：慢性肾脏病的评估和风险评估，延缓慢性肾脏病进展的方法。
Advances in kidney disease and health Pub Date : 2024-11-01 Epub Date: 2024-11-20 DOI: 10.1053/j.akdh.2024.07.004
Dana Larsen , Laalasa Varanasi , Michelle M. Estrella
{"title":"Chronic Kidney Disease—Part 1: Evaluation & Risk Assessment in CKD, Methods to Delay CKD Progression","authors":"Dana Larsen ,&nbsp;Laalasa Varanasi ,&nbsp;Michelle M. Estrella","doi":"10.1053/j.akdh.2024.07.004","DOIUrl":"10.1053/j.akdh.2024.07.004","url":null,"abstract":"<div><div>Chronic kidney disease (CKD) is common and leads to significant morbidity and mortality. Early detection and deployment of effective therapies could prevent CKD progression and related cardiovascular diseases. This review provides a case-based overview of key issues surrounding the diagnosis, staging, and management of CKD.</div></div>","PeriodicalId":72096,"journal":{"name":"Advances in kidney disease and health","volume":"31 6","pages":"Pages 538-545"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hypertension 高血压。
Advances in kidney disease and health Pub Date : 2024-11-01 Epub Date: 2024-11-20 DOI: 10.1053/j.akdh.2024.08.005
Jordana B. Cohen , Debbie L. Cohen
{"title":"Hypertension","authors":"Jordana B. Cohen ,&nbsp;Debbie L. Cohen","doi":"10.1053/j.akdh.2024.08.005","DOIUrl":"10.1053/j.akdh.2024.08.005","url":null,"abstract":"<div><div>Resistant and uncontrolled hypertension are common presentations to the nephrology clinic. Many of these patients benefit from evaluation for secondary hypertension in order to optimize antihypertensive therapy and reduce the risks of target organ damage from uncontrolled hypertension. The purpose of this review is to present several cases of difficult-to-control and/or secondary hypertension and to identify optimal approaches to evaluating and managing hypertension in these high-risk patients.</div></div>","PeriodicalId":72096,"journal":{"name":"Advances in kidney disease and health","volume":"31 6","pages":"Pages 546-552"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Potassium Homeostasis 钾平衡
Advances in kidney disease and health Pub Date : 2024-11-01 Epub Date: 2024-11-20 DOI: 10.1053/j.akdh.2024.08.001
Niraj B. Desai , Melanie P. Hoenig
{"title":"Potassium Homeostasis","authors":"Niraj B. Desai ,&nbsp;Melanie P. Hoenig","doi":"10.1053/j.akdh.2024.08.001","DOIUrl":"10.1053/j.akdh.2024.08.001","url":null,"abstract":"<div><div>Potassium homeostasis is essential for maintaining the normal resting membrane potential of excitable cells. Yet daily dietary potassium typically far exceeds total extracellular potassium, thus the body has elegant strategies to shift potassium into cells promptly after a meal and then the kidneys efficiently excrete potassium. Potassium excretion depends on adequate kidney perfusion and filtration, sodium delivery to the distal nephron and aldosterone action on the distal nephron. Both hypokalemia and hyperkalemia have been associated with an increase in mortality. In this piece, we share 5 challenging cases to explore normal potassium homeostasis and disorders that can lead to derangements in potassium balance or excretion.</div></div>","PeriodicalId":72096,"journal":{"name":"Advances in kidney disease and health","volume":"31 6","pages":"Pages 504-513"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rapidly Progressive Glomerulonephritis 快速进展性肾小球肾炎。
Advances in kidney disease and health Pub Date : 2024-11-01 Epub Date: 2024-11-20 DOI: 10.1053/j.akdh.2024.08.006
Abbal Koirala , Purva D. Sharma , Kenar D. Jhaveri , Koyal Jain , Duvuru Geetha
{"title":"Rapidly Progressive Glomerulonephritis","authors":"Abbal Koirala ,&nbsp;Purva D. Sharma ,&nbsp;Kenar D. Jhaveri ,&nbsp;Koyal Jain ,&nbsp;Duvuru Geetha","doi":"10.1053/j.akdh.2024.08.006","DOIUrl":"10.1053/j.akdh.2024.08.006","url":null,"abstract":"<div><div>Rapidly progressive glomerulonephritis (RPGN) is a syndrome characterized by a swift decline in kidney function, often over a few months, accompanied by features of nephritic syndrome. It can result in decreased urine output and commonly involves the presence of extensive crescents in kidney biopsies. RPGN is classified into 3 main types based on immune deposit distribution and visualization through immunofluorescence and electron microscopy: antiglomerular basement membrane disease, immune complex glomerulonephritis, and pauci-immune glomerulonephritis. Early diagnosis and prompt treatment are critical to prevent progression to ESRD. Standard treatment options for RPGN include glucocorticoids, cyclophosphamide, or rituximab, with plasma exchange especially important for antiglomerular basement membrane disease and select cases of ANCA-associated vasculitis. Clinical trials for glomerular diseases have primarily excluded patients with RPGN or dialysis dependence. Establishment of clinical registries is required for the optimization of therapeutic protocols for the treatment of RPGN.</div></div>","PeriodicalId":72096,"journal":{"name":"Advances in kidney disease and health","volume":"31 6","pages":"Pages 485-495"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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