发布求助
文献互助 智能选刊 最新文献

Advances in geriatric medicine and research最新文献

筛选
英文 中文
The Clot Thickens: Recent Clues on Hematopoietic Stem Cell Contribution to Age-Related Platelet Biology Open New Questions. 血块变厚：造血干细胞对老年血小板生物学贡献的最新线索提出了新问题。
Advances in geriatric medicine and research Pub Date : 2021-01-01 Epub Date: 2021-10-28 DOI: 10.20900/agmr20210019
Donna M Poscablo, E Camilla Forsberg
{"title":"The Clot Thickens: Recent Clues on Hematopoietic Stem Cell Contribution to Age-Related Platelet Biology Open New Questions.","authors":"Donna M Poscablo, E Camilla Forsberg","doi":"10.20900/agmr20210019","DOIUrl":"10.20900/agmr20210019","url":null,"abstract":"<p><p>Platelets provide life-saving functions by halting external and internal bleeding. There is also a dark side to platelet biology, however. Recent reports provide evidence for increased platelet reactivity during aging of mice and humans, making platelets main suspects in the most prevalent aging-related human pathologies, including cardiovascular diseases, stroke, and cancer. What drives this platelet hyperreactivity during aging? Here, we discuss how hematopoietic stem cell differentiation pathways into the platelet lineage offer avenues to understand the fundamental differences between young and old platelets. Recent advances begin to unravel how the cellular and molecular regulation of the parent hematopoietic stem and progenitor cells likely imbue aging characteristics on the resulting Plt progeny. The resulting mechanistic insights into intrinsic platelet reactivity will provide strategies for selectively targeting age-related pathways. This brief viewpoint focuses on current concepts on aging hematopoiesis and the implications for platelet hyperactivity during aging.</p>","PeriodicalId":72094,"journal":{"name":"Advances in geriatric medicine and research","volume":"3 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8759758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39826179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Yoga for Healthy Aging: Science or Hype? 瑜伽有益于健康衰老:科学还是炒作?
Advances in geriatric medicine and research Pub Date : 2021-01-01 Epub Date: 2021-07-13 DOI: 10.20900/agmr20210016
Purnima Madhivanan, Karl Krupp, Randall Waechter, Rahu Shidhaye
{"title":"Yoga for Healthy Aging: Science or Hype?","authors":"Purnima Madhivanan,&nbsp;Karl Krupp,&nbsp;Randall Waechter,&nbsp;Rahu Shidhaye","doi":"10.20900/agmr20210016","DOIUrl":"https://doi.org/10.20900/agmr20210016","url":null,"abstract":"<p><p>Yoga, one of the world's oldest health systems is receiving new attention for claims that it can contribute to healthy aging. Until recently, scientific evidence for its efficacy has relied heavily on small and poorly-designed research, but this is changing. Multiple, well-designed studies provide data showing that yoga practice has positive effects on cellular aging, mobility, balance, mental health, and prevention of cognitive decline-all areas of concern for older adults. Since the cost of implementing yoga-based community and home-based interventions is low-policymakers are also eyeing yoga practice as a cost-effective way to reduce medical costs and improve outcomes among a growing aging population. This commentary reviews the evidence for both physical and mental health benefits from yoga, as well as concerns about injuries that have been associated with certain types of yoga practice. It reveals a surprising range of yoga programs and difficulty levels that provide opportunities for almost anyone to participate and gain health benefits with practice.</p>","PeriodicalId":72094,"journal":{"name":"Advances in geriatric medicine and research","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39292075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Association between Age-Related Changes in Oral Neuromechanics and Alzheimer's Disease. 老年口腔神经力学变化与阿尔茨海默病的关系
Advances in geriatric medicine and research Pub Date : 2021-01-01 Epub Date: 2021-04-27 DOI: 10.20900/agmr20210011
Fritzie I Arce-McShane
{"title":"The Association between Age-Related Changes in Oral Neuromechanics and Alzheimer's Disease.","authors":"Fritzie I Arce-McShane","doi":"10.20900/agmr20210011","DOIUrl":"https://doi.org/10.20900/agmr20210011","url":null,"abstract":"<p><p>The global population of 80 years and older is predicted to reach 437 million by 2050. As overall brain structure and function progressively degrades, older and younger adults show differences in sensorimotor performance and brain activity in the sensorimotor regions. Oral sensorimotor functions are an important area of focus in natural aging and Alzheimer's Disease (AD) because oral health issues are commonly found in both elderly and AD populations. While human behavioral studies on changes in oral sensorimotor functions abound, very little is known about their neuronal correlates in normal and pathological aging.</p>","PeriodicalId":72094,"journal":{"name":"Advances in geriatric medicine and research","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39027806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
An Insight into Aging, Senescence, and Their Impacts on Wound Healing. 洞察老化、衰老及其对伤口愈合的影响。
Advances in geriatric medicine and research Pub Date : 2021-01-01 Epub Date: 2021-07-21 DOI: 10.20900/agmr20210017
Rex Jeya Rajkumar Samdavid Thanapaul, Maria Shvedova, Grace Haeun Shin, Daniel S Roh
{"title":"An Insight into Aging, Senescence, and Their Impacts on Wound Healing.","authors":"Rex Jeya Rajkumar Samdavid Thanapaul, Maria Shvedova, Grace Haeun Shin, Daniel S Roh","doi":"10.20900/agmr20210017","DOIUrl":"10.20900/agmr20210017","url":null,"abstract":"<p><p>Cellular senescence has been found to have beneficial roles in development, tissue regeneration, and wound healing. However, in aging senescence increases, and the ability to properly repair and heal wounds significantly declines across multiple tissues. This age-related accumulation of senescent cells may cause loss of tissue homeostasis leading to dysregulation of normal and timely wound healing processes. The delays in wound healing of aging have widespread clinical and economic impacts, thus novel strategies to improve wound healing in aging are needed and targeting senescence may be a promising area.</p>","PeriodicalId":72094,"journal":{"name":"Advances in geriatric medicine and research","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39328412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Organelle-Specific Autophagy in Cellular Aging and Rejuvenation. 细胞衰老和返老还童中的细胞器特异性自噬。
Advances in geriatric medicine and research Pub Date : 2021-01-01 Epub Date: 2021-04-09 DOI: 10.20900/agmr20210010
Tyler J Butsch, Bhaswati Ghosh, K Adam Bohnert
{"title":"Organelle-Specific Autophagy in Cellular Aging and Rejuvenation.","authors":"Tyler J Butsch,&nbsp;Bhaswati Ghosh,&nbsp;K Adam Bohnert","doi":"10.20900/agmr20210010","DOIUrl":"https://doi.org/10.20900/agmr20210010","url":null,"abstract":"<p><p>The health of a cell requires proper functioning, regulation, and quality control of its organelles, the membrane-enclosed compartments inside the cell that carry out its essential biochemical tasks. Aging commonly perturbs organelle homeostasis, causing problems to cellular health that can spur the initiation and progression of degenerative diseases and related pathologies. Here, we discuss emerging evidence indicating that age-related defects in organelle homeostasis stem in part from dysfunction of the autophagy-lysosome system, a pivotal player in cellular quality control and damage clearance. We also highlight natural examples from biology where enhanced activity of the autophagy-lysosome system might be harnessed to erase age-related organelle damage, raising potential implications for cellular rejuvenation.</p>","PeriodicalId":72094,"journal":{"name":"Advances in geriatric medicine and research","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b8/96/nihms-1692523.PMC8096102.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38886726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Metabolism in Male Reproductive Aging. 男性生殖衰老过程中的新陈代谢。
Advances in geriatric medicine and research Pub Date : 2021-01-01 Epub Date: 2021-01-12 DOI: 10.20900/agmr20210005
Ralph G Meyer, Mirella L Meyer-Ficca
{"title":"Metabolism in Male Reproductive Aging.","authors":"Ralph G Meyer, Mirella L Meyer-Ficca","doi":"10.20900/agmr20210005","DOIUrl":"10.20900/agmr20210005","url":null,"abstract":"<p><p>Similar to female reproductive health, male reproductive health declines with increasing age, albeit in a more gradual way. In the US, the average age of first-time fathers has been steadily increasing since 1980. This is concerning because increasing paternal age is positively correlated with reduced sperm chromatin quality and higher numbers of DNA strand breaks (DNA sb), which negatively affects pregnancy outcome and child development. While underlying reasons are not well understood, one of the well-known hallmarks of aging is a significant decline of body nicotinamide adenine dinucleotide (NAD) levels. We propose that low body-wide NAD levels provide a plausible explanation for metabolic alterations that are associated with declining hormonal production and testicular volume, as well as reduced sperm quality in aging men.</p>","PeriodicalId":72094,"journal":{"name":"Advances in geriatric medicine and research","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7861562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25343844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pinpointing a Role for Vitamin D in Frailty: A Time for Animal Models? 确定维生素D在虚弱中的作用:是时候建立动物模型了?
Advances in geriatric medicine and research Pub Date : 2021-01-01 Epub Date: 2021-02-06 DOI: 10.20900/agmr20210007
Kenneth Ladd Seldeen, Bruce Robert Troen
{"title":"Pinpointing a Role for Vitamin D in Frailty: A Time for Animal Models?","authors":"Kenneth Ladd Seldeen,&nbsp;Bruce Robert Troen","doi":"10.20900/agmr20210007","DOIUrl":"https://doi.org/10.20900/agmr20210007","url":null,"abstract":"<p><p>Frailty is a condition marked by greater susceptibility to adverse outcomes, including disability and mortality, which affects up to 50% of those 80 years of age and older. Concurrently, serum vitamin D insufficiency and deficiency, for which as many as 70% of older adults may be at risk, potentially play an important role in frailty onset and progression. Large population driven studies have uncovered associations between low serum vitamin D levels and higher incidence of frailty. However, attempts to apply vitamin D therapeutically to treat and/or prevent frailty have not yielded consistent support for benefits. Given the complexity and inconsistency arising from human studies involving vitamin D, our research group has recently published on animal models of vitamin D insufficiency. Combining our model with the emerging development of animal frailty assessment, we identified that higher than standard levels of vitamin D supplementation may delay frailty in mice. In this viewpoint article, we will discuss current knowledge regarding the importance of vitamin D in frailty progression, the emerging significance of animal models in addressing these relationships, and the future for pre-clinical and clinical research.</p>","PeriodicalId":72094,"journal":{"name":"Advances in geriatric medicine and research","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f5/da/nihms-1672052.PMC7968870.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25493963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Understanding the Brain through Aging Eyes. 通过老化的眼睛了解大脑。
Advances in geriatric medicine and research Pub Date : 2021-01-01 Epub Date: 2021-03-01 DOI: 10.20900/agmr20210008
Marian Blazes, Cecilia S Lee
{"title":"Understanding the Brain through Aging Eyes.","authors":"Marian Blazes,&nbsp;Cecilia S Lee","doi":"10.20900/agmr20210008","DOIUrl":"https://doi.org/10.20900/agmr20210008","url":null,"abstract":"<p><p>The eye and brain share common mechanisms of aging and disease, thus the retina is an essential source of accessible information about neurodegenerative processes occurring in the brain. Advances in retinal imaging have led to the discovery of many potential biomarkers of Alzheimer's disease, although further research is needed to validate these associations. Understanding the mechanisms of retinal disease in the context of aging will extend our knowledge of AD and may enable advancements in diagnosis, monitoring, and treatment.</p>","PeriodicalId":72094,"journal":{"name":"Advances in geriatric medicine and research","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7971450/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25502513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Naïve T Cell Quiescence in Immune Aging. Naïve免疫衰老中的T细胞静止。
Advances in geriatric medicine and research Pub Date : 2021-01-01 Epub Date: 2021-06-26 DOI: 10.20900/agmr20210015
Claire E Gustafson
{"title":"Naïve T Cell Quiescence in Immune Aging.","authors":"Claire E Gustafson","doi":"10.20900/agmr20210015","DOIUrl":"https://doi.org/10.20900/agmr20210015","url":null,"abstract":"<p><p>Naïve T cells are critical for protection against emerging viral and bacterial infections. However, the ability of these cells to elicit effective long-term immune responses declines with age and contributes to increased disease susceptibility in older individuals. This decline has been linked with the breakdown of cellular quiescence that causes partial differentiation of naïve T cells with age, but the underlying mediators of this breakdown are unclear. Comparisons to stem cell quiescence in mice and man offer insight into naïve T cells and aging. However, the utilization of single cell technologies in combination with advances in the biology of human tissue aging is needed to provide further understanding of naïve T cell complexity and quiescence breakdown with age.</p>","PeriodicalId":72094,"journal":{"name":"Advances in geriatric medicine and research","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39221677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Obesity, Vascular Disease and Frailty in Aging Women with HIV. 肥胖，血管疾病和衰弱的老年妇女艾滋病毒。
Advances in geriatric medicine and research Pub Date : 2021-01-01 Epub Date: 2021-06-22 DOI: 10.20900/agmr20210014
Deborah R Gustafson, Samy I McFarlane
{"title":"Obesity, Vascular Disease and Frailty in Aging Women with HIV.","authors":"Deborah R Gustafson,&nbsp;Samy I McFarlane","doi":"10.20900/agmr20210014","DOIUrl":"https://doi.org/10.20900/agmr20210014","url":null,"abstract":"<p><p>Women with chronic HIV infection (WWH) living in the United States, experience a disproportionately high rate of obesity compared to uninfected populations. Both overweight and obesity, particularly central obesity, are major contributors to insulin resistance, hypertension, and dyslipidemia-the major components of metabolic syndromes, including type 2 diabetes, and leading to increased cardiovascular risk, including coronary heart disease, and cerebrovascular diseases. Notably, declining physical performance and frailty co-occur with vascular morbidities as well as changes in bone. These factors tend to exacerbate each other and accelerate the aging trajectory, leading to poorer quality of life, cognitive impairments, dementia, and eventually, death. In WWH, persistent HIV infection, sustained treatment for HIV infection, and concomitant obesity, may accelerate aging-related morbidities and poorer aging outcomes. Furthermore, health disparities factors common among some WWH, are independently associated with obesity and higher vascular risk. The purpose of this review is to describe the constellation of obesity, cardio- and cerebrovascular diseases, bone health and frailty among aging WWH, a 21st century emergence.</p>","PeriodicalId":72094,"journal":{"name":"Advances in geriatric medicine and research","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8345026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39292076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信