Advances in geriatric medicine and research最新文献_第4页

The Association between Age-Related Changes in Oral Neuromechanics and Alzheimer's Disease. 老年口腔神经力学变化与阿尔茨海默病的关系

Advances in geriatric medicine and research Pub Date : 2021-01-01 Epub Date: 2021-04-27 DOI: 10.20900/agmr20210011

Fritzie I Arce-McShane

引用次数: 1

An Insight into Aging, Senescence, and Their Impacts on Wound Healing. 洞察老化、衰老及其对伤口愈合的影响。

Advances in geriatric medicine and research Pub Date : 2021-01-01 Epub Date: 2021-07-21 DOI: 10.20900/agmr20210017

Rex Jeya Rajkumar Samdavid Thanapaul, Maria Shvedova, Grace Haeun Shin, Daniel S Roh

引用次数: 0

Organelle-Specific Autophagy in Cellular Aging and Rejuvenation. 细胞衰老和返老还童中的细胞器特异性自噬。

Advances in geriatric medicine and research Pub Date : 2021-01-01 Epub Date: 2021-04-09 DOI: 10.20900/agmr20210010

Tyler J Butsch, Bhaswati Ghosh, K Adam Bohnert

引用次数: 7

Metabolism in Male Reproductive Aging. 男性生殖衰老过程中的新陈代谢。

Advances in geriatric medicine and research Pub Date : 2021-01-01 Epub Date: 2021-01-12 DOI: 10.20900/agmr20210005

Ralph G Meyer, Mirella L Meyer-Ficca

引用次数: 0

Pinpointing a Role for Vitamin D in Frailty: A Time for Animal Models? 确定维生素D在虚弱中的作用:是时候建立动物模型了?

Advances in geriatric medicine and research Pub Date : 2021-01-01 Epub Date: 2021-02-06 DOI: 10.20900/agmr20210007

Kenneth Ladd Seldeen, Bruce Robert Troen

{"title":"Pinpointing a Role for Vitamin D in Frailty: A Time for Animal Models?","authors":"Kenneth Ladd Seldeen, Bruce Robert Troen","doi":"10.20900/agmr20210007","DOIUrl":"https://doi.org/10.20900/agmr20210007","url":null,"abstract":"Frailty is a condition marked by greater susceptibility to adverse outcomes, including disability and mortality, which affects up to 50% of those 80 years of age and older. Concurrently, serum vitamin D insufficiency and deficiency, for which as many as 70% of older adults may be at risk, potentially play an important role in frailty onset and progression. Large population driven studies have uncovered associations between low serum vitamin D levels and higher incidence of frailty. However, attempts to apply vitamin D therapeutically to treat and/or prevent frailty have not yielded consistent support for benefits. Given the complexity and inconsistency arising from human studies involving vitamin D, our research group has recently published on animal models of vitamin D insufficiency. Combining our model with the emerging development of animal frailty assessment, we identified that higher than standard levels of vitamin D supplementation may delay frailty in mice. In this viewpoint article, we will discuss current knowledge regarding the importance of vitamin D in frailty progression, the emerging significance of animal models in addressing these relationships, and the future for pre-clinical and clinical research.","PeriodicalId":72094,"journal":{"name":"Advances in geriatric medicine and research","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f5/da/nihms-1672052.PMC7968870.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25493963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Understanding the Brain through Aging Eyes. 通过老化的眼睛了解大脑。

Advances in geriatric medicine and research Pub Date : 2021-01-01 Epub Date: 2021-03-01 DOI: 10.20900/agmr20210008

Marian Blazes, Cecilia S Lee

引用次数: 7

Naïve T Cell Quiescence in Immune Aging. Naïve免疫衰老中的T细胞静止。

Advances in geriatric medicine and research Pub Date : 2021-01-01 Epub Date: 2021-06-26 DOI: 10.20900/agmr20210015

Claire E Gustafson

引用次数: 3

Obesity, Vascular Disease and Frailty in Aging Women with HIV. 肥胖，血管疾病和衰弱的老年妇女艾滋病毒。

Advances in geriatric medicine and research Pub Date : 2021-01-01 Epub Date: 2021-06-22 DOI: 10.20900/agmr20210014

Deborah R Gustafson, Samy I McFarlane

{"title":"Obesity, Vascular Disease and Frailty in Aging Women with HIV.","authors":"Deborah R Gustafson, Samy I McFarlane","doi":"10.20900/agmr20210014","DOIUrl":"https://doi.org/10.20900/agmr20210014","url":null,"abstract":"Women with chronic HIV infection (WWH) living in the United States, experience a disproportionately high rate of obesity compared to uninfected populations. Both overweight and obesity, particularly central obesity, are major contributors to insulin resistance, hypertension, and dyslipidemia-the major components of metabolic syndromes, including type 2 diabetes, and leading to increased cardiovascular risk, including coronary heart disease, and cerebrovascular diseases. Notably, declining physical performance and frailty co-occur with vascular morbidities as well as changes in bone. These factors tend to exacerbate each other and accelerate the aging trajectory, leading to poorer quality of life, cognitive impairments, dementia, and eventually, death. In WWH, persistent HIV infection, sustained treatment for HIV infection, and concomitant obesity, may accelerate aging-related morbidities and poorer aging outcomes. Furthermore, health disparities factors common among some WWH, are independently associated with obesity and higher vascular risk. The purpose of this review is to describe the constellation of obesity, cardio- and cerebrovascular diseases, bone health and frailty among aging WWH, a 21st century emergence.","PeriodicalId":72094,"journal":{"name":"Advances in geriatric medicine and research","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8345026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39292076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Hospitalized Older Patients with Clostridioides difficile Infection Refractory to Conventional Antibiotic Therapy Benefit from Fecal Microbiota Transplant. 难辨梭状芽胞杆菌感染的住院老年患者对常规抗生素治疗难辨梭状芽胞杆菌感染获益于粪便菌群移植。

Advances in geriatric medicine and research Pub Date : 2021-01-01 Epub Date: 2021-04-30 DOI: 10.20900/agmr20210012

Jae Hyun Shin, Rachel Ann Hays, Cirle Alcantara Warren

{"title":"Hospitalized Older Patients with Clostridioides difficile Infection Refractory to Conventional Antibiotic Therapy Benefit from Fecal Microbiota Transplant.","authors":"Jae Hyun Shin, Rachel Ann Hays, Cirle Alcantara Warren","doi":"10.20900/agmr20210012","DOIUrl":"https://doi.org/10.20900/agmr20210012","url":null,"abstract":"Background: Options for Clostridioides difficile infection (CDI) refractory to conventional therapy are limited. Fecal microbiota transplant (FMT) is considered safe and effective treatment for recurrent CDI and could be a treatment option for refractory CDI. We investigated the efficacy and safety of FMT in hospitalized patients who were not responding to standard treatments for CDI.Methods: Electronic medical records of patients who received FMT inpatient for refractory CDI were reviewed as part of quality improvement efforts to evaluate safety and efficacy of FMT in inpatient setting.Results: Between July 2014 and December 2019, 9 patients (age 60-96) received FMT for CDI as inpatient for refractory or fulminant CDI. Most (7 of 9) of these patients had pseudomembranous colitis and underwent multiple FMTs (mean 2.15, range 1 to 3). Five patients had complete resolution and one patient had diarrhea that was C. difficile-negative. There was one recurrent CDI and two deaths, one of which may have been related to FMT or CDI. Compared to recurrent CDI at diagnosis, patients with refractory CDI had higher WBC and neutrophil counts, which decreased after FMT. The overall cure rate of FMT in refractory cases was 66.7%.Conclusions: This study shows moderate efficacy of FMT for treatment of refractory CDI although multiple FMT treatment may need to be administered in the presence of pseudomembranous colitis. Inpatient FMT may be an alternative strategy for managing refractory CDI in this population of patients who may not have any effective medical treatment available.","PeriodicalId":72094,"journal":{"name":"Advances in geriatric medicine and research","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39185140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurological Manifestations in COVID-19: An Unrecognized Crisis in Our Elderly? COVID-19的神经系统表现:老年人未被认识的危机?

Advances in geriatric medicine and research Pub Date : 2021-01-01 Epub Date: 2021-06-16 DOI: 10.20900/agmr20210013

Karl Krupp, Purnima Madhivanan, William D Scott Killgore, John M Ruiz, Scott Carvajal, Bruce M Coull, Michael A Grandner

{"title":"Neurological Manifestations in COVID-19: An Unrecognized Crisis in Our Elderly?","authors":"Karl Krupp, Purnima Madhivanan, William D Scott Killgore, John M Ruiz, Scott Carvajal, Bruce M Coull, Michael A Grandner","doi":"10.20900/agmr20210013","DOIUrl":"10.20900/agmr20210013","url":null,"abstract":"As of December 2020, there were more than 900,000 COVID-19 hospitalizations in the US with about 414,000 among individuals aged 65 years and older. Recent evidence suggests a growing number of older patients continue to suffer serious neurological comorbidities including polyneuropathy, cerebrovascular disease, central nervous system infection, cognitive deficits, and fatigue following discharge. Studies suggest that complaints manifest late in disease and persist beyond resolution of acute COVID-19 symptoms. Recent research reports that neurocognitive symptoms are correlated with severe disease, older age, male gender, and comorbidities including hypertension, renal failure, and neoplastic disease. The underlying causes are unclear, but current hypotheses include hypoxic-ischemic brain injury, immunopathological mechanisms, and neurotropism of SARS-CoV-2 infection. There is a pressing need for more research into the underlying mechanisms of post-COVID-19 neurological sequela, particularly in the elderly, a population already burdened with neurocognitive disorders.","PeriodicalId":72094,"journal":{"name":"Advances in geriatric medicine and research","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8279204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39190327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1