Advances in cancer biology - metastasis最新文献

{"title":"Decoding the role of S100 proteins in mammary gland regulation and their role in breast cancer metastasis","authors":"Parul Singh, Syed Azmal Ali","doi":"10.1016/j.adcanc.2023.100106","DOIUrl":"https://doi.org/10.1016/j.adcanc.2023.100106","url":null,"abstract":"","PeriodicalId":72083,"journal":{"name":"Advances in cancer biology - metastasis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46439132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pancreatic adenocarcinoma in the elderly – recurrence and survival: A physician's challenge","authors":"Mashood Iqbal ,&nbsp;Uzzam Ahmed Khawaja ,&nbsp;Umar Soomro ,&nbsp;Syed A.A. Rizvi ,&nbsp;Zoya H. Rizvi","doi":"10.1016/j.adcanc.2023.100092","DOIUrl":"10.1016/j.adcanc.2023.100092","url":null,"abstract":"<div><p>Pancreatic Ductal Adenocarcinomas (PDAC) is one of the most lethal cancer, shifting it from the fourth highest to the third-highest cause of cancer-related deaths in the United States recently. The majority of the cases are diagnosed when the disease has metastasized and is associated with poor 5-year survival. A long-term survival data of PDAC has not been well reported in the literature. Pancreatic Cancer requires the imminent need of a multidisciplinary approach. The key to an improved long-term outcome involves early diagnosis and curative resection along with chemotherapeutic agents. Gemcitabine has played a positive role as an adjuvant after surgical resection. Regular follow-ups post-resection are mandatory for the detection of neoplastic recurrence. To add to what is already a challenging task, isolated recurrence of PDAC poses greater challenges for the physicians treating the patients because there is no general consensus on how to manage these specific groups of patients. To effectively handle this challenging task, a definite strategy must be adopted. Long-term survival if accomplished must therefore be accompanied by regular follow-up visits including Spiral CT scans and keeping an eye on the serum tumor marker CA19-9, a prognostic survival predictor.</p></div>","PeriodicalId":72083,"journal":{"name":"Advances in cancer biology - metastasis","volume":"7 ","pages":"Article 100092"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46634574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro Characterization of a novel murine model of cancerous progression","authors":"Steven D. Scahill ,&nbsp;Kelly Jean Sherman ,&nbsp;Jessie J. Guidry ,&nbsp;Whitney Walkowski ,&nbsp;Theresa Nguyen ,&nbsp;Durwood B. Ray ,&nbsp;David H. Jones ,&nbsp;Harry J. Gould III ,&nbsp;Dennis Paul","doi":"10.1016/j.adcanc.2023.100101","DOIUrl":"https://doi.org/10.1016/j.adcanc.2023.100101","url":null,"abstract":"<div><p>To evaluate a potentially valuable tool to study cancer progression and metastasis, we characterized a novel murine model composed of a parental oncogene-transformed embryonic fibroblast line and five cell lines isolated from progressively advanced tumors. Lines derived from distant metastases displayed significantly greater rates of motility, invasiveness, and extracellular acidification than lines derived from a primary tumor or local metastases. A comprehensive proteomic analysis of these cells showed numerous oncogenes to be upregulated and tumor suppressors to be downregulated in the advanced lines, and provided novel targets for future examination. The first cell line capable of extravasation displayed particularly high proteomic variation, which could provide insight into its epithelial to mesenchymal transition. The proteomic variation was less than that of an established human breast cancer model, indicating that the observed differences are more likely contributive to tumorigenesis. In total, we validated a novel cell model for the study of tumorigenesis, while providing a robust proteomic data set to guide future research.</p></div>","PeriodicalId":72083,"journal":{"name":"Advances in cancer biology - metastasis","volume":"7 ","pages":"Article 100101"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49816076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An investigation on the role of differentially expressed genes in thyroid cancer under the influence of hypoxia","authors":"Divya Ramesh Menon,&nbsp;Bindiya Ellathuparambil Saidumohamed,&nbsp;Sinoy Johnson,&nbsp;Sayuj Koyyappurath,&nbsp;Ajith Vengellur","doi":"10.1016/j.adcanc.2022.100084","DOIUrl":"https://doi.org/10.1016/j.adcanc.2022.100084","url":null,"abstract":"<div><p>Thyroid cancer is a common endocrine malignancy with a significant increase in its incidence in the past three decades. Even though research has significantly aided the management of the disease, the progression towards advanced forms of cancers remains indeterminate. In order to investigate the current challenges in thyroid cancer studies, the present work employed systematic and interactive transcriptomic data to construct plausible protein-protein interaction networks to reveal the putative transcriptional control mechanisms in cancer. The data from 4 different datasets consisting of normal samples vs thyroid cancer samples were chosen. Hypoxia being a significant hallmark of cancer was predicted to have a functional role in the progression of cancer. Consequently, prognostic pathways involved in cancer in response to hypoxia were predicted in the present study. The genes from the datasets were intersected with the hypoxia hallmark gene set to detect the significantly differentially expressed genes which were deregulated under the influence of hypoxia. These genes were analyzed by bioinformatic tools and a high correlation was found between 12 significant genes (PLAUR, BGN, SDC2, DUSP1, FOS, EGFR, CP, PPARGC1A, CITED2, RORA, HSPA5 and ACKR3) indicating a significant association between them. Of all the genes PLAUR was found to be novel and it was significantly upregulated under the influence of hypoxia. The hub genes and their role as predicted biomarkers were also determined by ROC curve analysis. This may assist in further research towards understanding role of hypoxia in Thyroid cancer.</p></div>","PeriodicalId":72083,"journal":{"name":"Advances in cancer biology - metastasis","volume":"7 ","pages":"Article 100084"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49864007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposure to Moringa oleifera microRNAs induces proteomic changes linked to tumorigenesis and epithelial-mesenchymal transition in HeLa cells","authors":"Marina Potestà ,&nbsp;Angelo Gismondi ,&nbsp;Chiara D'Ambrosio ,&nbsp;Valentina Roglia ,&nbsp;Lorenzo Camoni ,&nbsp;Mauro Marra ,&nbsp;Antonella Canini ,&nbsp;Simona Arena ,&nbsp;Andrea Scaloni ,&nbsp;Carla Montesano ,&nbsp;Antonella Minutolo","doi":"10.1016/j.adcanc.2023.100097","DOIUrl":"10.1016/j.adcanc.2023.100097","url":null,"abstract":"<div><p>Cervical cancer (CC) is one of the most frequent cancers in women worldwide. The epithelial-mesenchymal transition (EMT) and the extracellular release of TGF-β are phenomena typically associated with different tumorigenic processes, including tumour cell proliferation and metastatization. Specific human microRNAs (miRNAs; miRs) involved in these tumorigenic processes have been identified, becoming important diagnostic and prognostic markers, and even potential therapeutic targets. In parallel, different studies have also shown that plant miRNAs can mediate a cross-kingdom regulation (CKR) of mammalian genes and modulate host's gene expression under pathological conditions, restoring the regulatory activity of endogenous miRNAs lost in cancer. In our previous studies, the miRNome from Moringa oleifera Lam. (henceforth moringa or mol) has been sequenced, showing the presence of several conserved miRNAs in the plant kingdom, whose ability to differentially regulate proliferation and apoptosis in healthy and cancer cells has been demonstrated. Furthermore, the effects of mol-miR treatment on tumorigenesis and EMT have been proved in liver tumour cells. According to these premises, we here investigated the proteomic profile of CC-derived HeLa cells exposed to a mol-miRNA pool, demonstrating the down-representation of specific factors involved in tumorigenesis. The treatment with plant miRs was able to modulate proteins involved in several biological processes linked to EMT. Furthermore, it reduced the expression of TGF-β and significantly inhibited cell motility, as observed following Scratch test and cell viability measurements, with a significant increase of apoptotic events. In conclusion, our results suggest and pave the way for the development of new potential therapeutic approaches based on CKR mediated by plant miRNAs for contrasting human cervical cancer, even in the form of adjuvants to classic treatments for limiting their side effects.</p></div>","PeriodicalId":72083,"journal":{"name":"Advances in cancer biology - metastasis","volume":"7 ","pages":"Article 100097"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44219437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and clinical implications of circulating cancer associated fibroblasts in lung cancer patients","authors":"Sheefa Mirza ,&nbsp;Clement Penny ,&nbsp;Nayan Jain ,&nbsp;Rakesh Rawal","doi":"10.1016/j.adcanc.2023.100095","DOIUrl":"10.1016/j.adcanc.2023.100095","url":null,"abstract":"<div><h3>Objectives</h3><p>In tumor microenvironment (TME), cancer-associated fibroblasts (CAFs) are known to expedite cancer progression (metastasis). CAF-secreted cytokines confer a survival advantage to circulating tumor stem cells (CTSCs) (indicators of residual-disease) facilitating immune system evasion. Collectively, CAFs serve as “bio-incubator\" by providing favourable \"soil\" for their subsequent growth in the circulation during EMT and are thus considered as an important target in diagnostic and therapeutic applications. Thus, the aim of this study was to check the presence of circulating CAF (cCAFs) in blood of lung cancer patients as a liquid biopsy approach.</p></div><div><h3>Materials and methods</h3><p>Mononuclear cells isolated from the peripheral blood of non-metastatic lung cancer patients were cultured to confirm the presence of cCAF. CAF-specific marker α-SMA and FAP was used to characterise them using Western blot and real time PCR. Furthermore, correlation between expression of cCAFs and various clinico-pathological parameters were examined.</p></div><div><h3>Results</h3><p>Cultured MNCs showed the presence of cCAFs which was further confirmed by western blotting. All patients were found positive for the presence of cCAFs (α-SMA expression), while healthy individuals lacked this, being α-SMA negative. Moreover, significant trend was observed between different stages of lung cancer patients (<em>p</em> &lt; 0.014), suggesting its probable role in lung cancer progression.</p></div><div><h3>Conclusion</h3><p>Thus, cCAFs could be companion biomarker for the early detection of tumors as well as it could be efficient biomarker for the prediction of metastasis. However, validation of cCAFs as robust marker is still required to be tested in a more number of patients. This should be done using more than one marker associated with CAFs for their clinical application, as it has a potential implication to monitor the effectiveness of a specific cancer therapy and disease progression.</p></div>","PeriodicalId":72083,"journal":{"name":"Advances in cancer biology - metastasis","volume":"7 ","pages":"Article 100095"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43242467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive analysis of notch signalling genes in breast cancer: Expression pattern and prognostic significance","authors":"Shazia Sofi, Hina Qayoom, Nusrat Jan, Nighat Khaliq, Mohd Zahoor ul Haq Shah, Abdullah Almilaibary, M. A. Mir","doi":"10.1016/j.adcanc.2023.100104","DOIUrl":"https://doi.org/10.1016/j.adcanc.2023.100104","url":null,"abstract":"","PeriodicalId":72083,"journal":{"name":"Advances in cancer biology - metastasis","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41971333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"miR-96 and its versatile role in cancer","authors":"Mohammedazim Bagban ,&nbsp;Khanishka Sharma ,&nbsp;Sana Saifi ,&nbsp;Ilamathi Ilangovan ,&nbsp;Saleema Sultana ,&nbsp;Ekin Nur Numanoğlu ,&nbsp;Anshu","doi":"10.1016/j.adcanc.2022.100082","DOIUrl":"https://doi.org/10.1016/j.adcanc.2022.100082","url":null,"abstract":"","PeriodicalId":72083,"journal":{"name":"Advances in cancer biology - metastasis","volume":"7 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49816081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CX3CL1 as potential immunotherapeutic tool for bone metastases in lung cancer: A preclinical study","authors":"Charlotte Cohen ,&nbsp;Emilie Goguet ,&nbsp;Julie Antomarchi ,&nbsp;Rasha Al-Sahlanee ,&nbsp;Julien Cherfils-Vicini ,&nbsp;Nicolas Glaichenhaus ,&nbsp;Thierry Balaguer ,&nbsp;Damien Ambrosetti ,&nbsp;Marie-Ange Millet ,&nbsp;Babou Karimdjee Soilihi ,&nbsp;Nicolas Amoretti ,&nbsp;Heidy Schmid-Antomarchi ,&nbsp;Annie Schmid-Alliana","doi":"10.1016/j.adcanc.2022.100069","DOIUrl":"10.1016/j.adcanc.2022.100069","url":null,"abstract":"<div><p>The chemokine CX3CL1 emerges as a double-edged sword in the pathophysiology of cancer. We investigated whether CX3CL1 would act as an impediment or as a support to the development of non-small cell lung cancer skeletal metastases.</p><p>We set up an <em>in vivo</em> experimental skeletal metastasis model using the LL2 lung cancer cell line expressing low or high levels of CX3CL1. The resulting bone tumors were analyzed using histological, flow cytometry and transcriptomic techniques.</p><p>The increased CX3CL1 expression was associated with a strong anti-tumor effect. We observed a significant reduced tumor burden in the high-CX3CL1 group compared to the low-CX3CL1 group with significant differences in the composition of the tumor-infiltrating leukocytes and immunity- and osteogenesis-related gene expression.</p><p>Our results highlight the CX3CL1 ability to reduce cancer cell tumorigenicity by potentially disrupting both the vicious cycle linking bone resorption and the tumor cell proliferation as well as by generating an immune permissive tumor microenvironment rich in cancer-fighting immune cells, especially M1 monocytes, B cells and NK cells. In that regard, CX3CL1 could be an interesting tool to increase and/or predict the success of immune-based therapies requiring immune cell trafficking.</p></div>","PeriodicalId":72083,"journal":{"name":"Advances in cancer biology - metastasis","volume":"6 ","pages":"Article 100069"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667394022000430/pdfft?md5=477ae67125f0d4374994092f054eb399&pid=1-s2.0-S2667394022000430-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47541608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic aftermaths of tobacco addiction on the physiological composite of human secretome and the prognostic potential of U2AF26 in oral cancers","authors":"Sapna Khowal ,&nbsp;Seema Monga ,&nbsp;Samar Husain Naqvi ,&nbsp;Saima Wajid","doi":"10.1016/j.adcanc.2022.100075","DOIUrl":"10.1016/j.adcanc.2022.100075","url":null,"abstract":"<div><h3>Objectives</h3><p>Tobacco chewing and smoking practices have been a common trend among human populations. Tobacco addiction is a commonly known etiology for oral cancers. The study showcases a clinical case (I_5; a 36y male) with a chronic inflamed persistent oral lesion and positive addiction history of tobacco chewing &amp; smoking to screen out a prognostic target for oral malignancy.</p></div><div><h3>Method</h3><p>Two-dimensional gel electrophoreses (2DE), using the depleted serum proteome of I_5 and healthy control, were performed for resolving the complex protein repertoire of the secretome. MALDI-TOF-MS and <em>in-silico</em> peptide analyses were used for characterizing the 2DE protein spot of interest. The relative real-time PCR, used for validation of the modulations in the expression of the gene of interest, involved oral cancer (n = 14) and pre-cancer lesions (n = 9). The adjacent normal tissues (encircling oral diseased lesions) and healthy oral epithelia were used as the controls.</p></div><div><h3>Results</h3><p>The comparative analysis of 2DE profiles uncovered substantial disparities between the depleted secretome of the case (I_5) and the control. The qualitative differential spot ‘a’ (absent in I_5 but present in healthy control) corresponding to HNCUP U2AF26-III was found to down-regulate in the serum proteome of OSCC cases (both tobacco addicts &amp; non-addicts) compared to healthy non-addicts. Also, the expression of the <em>nccpU2AF26</em> showed significant down-regulation in oral-precancerous and cancerous samples in comparison with the healthy oral epithelia while the expression levels were found to be significantly up-regulated when lesions were compared with their adjacent normal tissues.</p></div><div><h3>Conclusions</h3><p>The serum proteome of a chronic tobacco addict deficits in multiple proteins constituting the physiological human secretome. The U2AF26-III may function as a prognostic biomarker and therapeutic target for oral malignancies. Also, a non-canonical transcript (<em>nccpU2AF26</em>) lacking exon 3 and 4 was identified to be present in normal oral epithelia and POLs, highlighting the need for rigorous analyses of the role(s) played by U2AF26 non-canonical isoform(s) in the genesis of oral precancer and cancer lesions.</p></div>","PeriodicalId":72083,"journal":{"name":"Advances in cancer biology - metastasis","volume":"6 ","pages":"Article 100075"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667394022000491/pdfft?md5=d7e58a783323422e36a0067b1ed40296&pid=1-s2.0-S2667394022000491-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44447726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}