Advanced genetics (Hoboken, N.J.)最新文献

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":72071,"journal":{"name":"Advanced genetics (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148105356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delving Into the Dialogue between Epigenetic Modifications and Immunometabolism in Cancer","authors":"Xiaowen Xie,&nbsp;Weici Liu,&nbsp;Pengpeng Zhang,&nbsp;Peng Luo,&nbsp;Bufu Tang,&nbsp;Wenjun Mao","doi":"10.1002/ggn2.202500034","DOIUrl":"https://doi.org/10.1002/ggn2.202500034","url":null,"abstract":"<p>Tumor immunometabolism and epigenetic modifications are intricately linked in reshaping the tumor microenvironment, with their crosstalk offering novel insights into cancer biology. Nutrient deprivation and metabolic byproducts drive metabolic reprogramming in immune cells, where metabolites act as epigenetic modulators to regulate immune-related gene expression and influence immune cell activation, differentiation, and functional states. The cellular complexity, dynamic interactions, and spatiotemporal heterogeneity of the tumor microenvironment pose significant challenges to current studies. Emerging technologies such as single-cell sequencing, spatial omics, and artificial intelligence provide powerful tools to address these complexities. This perspective discusses the crosstalk between tumor immunometabolism and epigenetic modifications, while also exploring how the emerging technologies may advance mechanistic insights and therapeutic innovation in this field.</p>","PeriodicalId":72071,"journal":{"name":"Advanced genetics (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/ggn2.202500034","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145196616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":72071,"journal":{"name":"Advanced genetics (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148131084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":72071,"journal":{"name":"Advanced genetics (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148130806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brachydactyly with Novel BMP8A and FGFR1 Variants: A Case Report with Review of Literature","authors":"Luke Hunter,&nbsp;Muhammad Ilyas","doi":"10.1002/ggn2.202500015","DOIUrl":"https://doi.org/10.1002/ggn2.202500015","url":null,"abstract":"<p>Bone morphogenetic proteins (BMPs) and the fibroblast growth factor receptor 1 (FGFR1) gene play essential roles in the development and maintenance of the skeletal system. Brachydactyly is a genetic condition characterized by shortened or missing bones in the hands and feet. Several types of brachydactyly have been identified, each associated with different genetic mutations. However, some cases do not fit into existing classifications, necessitating further genetic investigation. A 34-year-old female patient with an absent middle phalanx in the second digit of her left foot and her 13-year-old son, who presented with absent or malformed middle and distal phalanx in all ten toes, are evaluated. Whole Genome Sequencing (WGS) analysis identifies a missense variant (c.1073A &gt;T; p.K358M) in the BMP8A gene and a novel missense variant (c.1787C &gt;T, p.Ser596Phe) in the FGFR1 gene. Functional protein association network analysis demonstrates a strong association of BMP8A and FGFR1 with other brachydactyly disease-causing genes. Given that these mutations have not been previously linked to any recognized brachydactyly subtype, they likely define a distinct genetic condition. The findings suggest a novel form of brachydactyly, which naming is proposed as brachydactyly type AB.</p>","PeriodicalId":72071,"journal":{"name":"Advanced genetics (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/ggn2.202500015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145196521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two Decades of Optogenetic Tools: A Retrospective and a Look Ahead","authors":"Xiao Duan,&nbsp;Mo Zhu,&nbsp;Shiqiang Gao","doi":"10.1002/ggn2.202500021","DOIUrl":"https://doi.org/10.1002/ggn2.202500021","url":null,"abstract":"<p>Over the past two decades, optogenetics has evolved from a conceptual framework into a powerful and versatile technology for controlling cellular processes with light. Rooted in the discovery and characterization of natural photoreceptors, the field has advanced through the development of genetically encoded, light-sensitive proteins that enable precise spatiotemporal control of ion flux, intracellular signaling, gene expression, and protein interactions. This review traces key milestones in the emergence of optogenetics and highlights the development of major optogenetic tools. From the perspective of genetic tool innovation, the focus is on how these tools have been engineered and optimized for novel or enhanced functions, altered spectral properties, improved light sensitivity, subcellular targeting, and beyond. Their broadening applications are also explored across neuroscience, cardiovascular biology, hematology, plant sciences, and other emerging fields. In addition, current trends such as all-optical approaches, multiplexed control, and clinical translation, particularly in vision restoration are discussed. Finally, ongoing challenges are addressed and outline future directions in optogenetic tool development and in vivo applications, positioning optogenetics as a transformative platform for basic research and therapeutic advancement.</p>","PeriodicalId":72071,"journal":{"name":"Advanced genetics (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/ggn2.202500021","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145196451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":72071,"journal":{"name":"Advanced genetics (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148129443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced Dialogues: From Laboratory to Clinics: Plant Cell-Based Affordable Biologics","authors":"Henry Daniell","doi":"10.1002/ggn2.202500045","DOIUrl":"https://doi.org/10.1002/ggn2.202500045","url":null,"abstract":"&lt;p&gt;My research group at the University of Pennsylvania School of Dental Medicine focuses on noninvasive and affordable delivery of recombinant proteins. Although biologics have been used in the clinic for more than eight decades, they are mostly unaffordable, thereby limiting their access to a large global population. The high cost is largely due to their production in cell culture systems (bacteria, yeast, CHO cells) requiring prohibitively expensive fermentation systems, purification of host cell proteins (&gt;99%) to minimize allergic reactions, and instability of purified proteins requiring cold chain/transportation and invasive delivery through injections. Therefore, my lab pioneered the approach to develop recombinant proteins in edible plant cells that could be delivered orally via capsules or topically using chewing gums, eliminating the need for fermentation, purification, or cold chain. FDA approval of biologics bioencapsulated in plant cells has demonstrated a dramatic decrease in the cost of drugs (&lt;5%) and a fraction of the regulatory cost for launching new drugs. Some of the recent advances are discussed in this editorial.&lt;/p&gt;&lt;p&gt;Biologics are unavailable or unaffordable for a large majority of the global population because of the way they are produced and delivered. The estimated average cost to develop a new biological product is ≈$2.6 billion.&lt;sup&gt;[&lt;/sup&gt;&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt;&lt;sup&gt;]&lt;/sup&gt; Among FDA-approved biologics since 2015, &gt;90% are injectable drugs, which are produced in prohibitively expensive fermentation systems, requiring purification and a cold chain for storage and transportation.&lt;sup&gt;[&lt;/sup&gt;&lt;span&gt;&lt;sup&gt;2-4&lt;/sup&gt;&lt;/span&gt;&lt;sup&gt;]&lt;/sup&gt; These challenges became quite evident when only 2.2% of COVID-19 vaccines were available for low-income countries, and 19 million doses of mRNA vaccines were discarded in Africa due to a lack of cold chain.&lt;sup&gt;[&lt;/sup&gt;&lt;span&gt;&lt;sup&gt;5&lt;/sup&gt;&lt;/span&gt;&lt;sup&gt;]&lt;/sup&gt; While oral or topical drugs are highly preferred by patients because of their affordability and convenience, only two oral and four topical biologic drugs were approved by the FDA since 2015,&lt;sup&gt;[&lt;/sup&gt;&lt;span&gt;&lt;sup&gt;2, 3&lt;/sup&gt;&lt;/span&gt;&lt;sup&gt;]&lt;/sup&gt; probably because of regulatory guidelines developed over eight decades that are built on cell culture-based production of biologics and injectable delivery systems.&lt;/p&gt;&lt;p&gt;Strikingly, the per capita prescription of drug spending in the U.S. is the highest in the world. The interquartile range of biological product prices ranged from $18861 to $288759 between 2008 and 2021.&lt;sup&gt;[&lt;/sup&gt;&lt;span&gt;&lt;sup&gt;2-6&lt;/sup&gt;&lt;/span&gt;&lt;sup&gt;]&lt;/sup&gt; However, the cost of Palforzia 360 capsules with peanut cells (annual dose) is &lt;3% (≈$2500) of the median annual price of biologics ($84508).&lt;sup&gt;[&lt;/sup&gt;&lt;span&gt;&lt;sup&gt;2, 3&lt;/sup&gt;&lt;/span&gt;&lt;sup&gt;]&lt;/sup&gt; This median price excludes prohibitively expensive gene therapy drugs. Hemophilia A drug Roctavian costs $2.9 million per patient (WSJ June 29, 2023), and hemophilia B Hemgenix cost","PeriodicalId":72071,"journal":{"name":"Advanced genetics (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/ggn2.202500045","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145196679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":72071,"journal":{"name":"Advanced genetics (Hoboken, N.J.)","volume":"6 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148134987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Board: (Advanced Genetics 2/06)","authors":"","doi":"10.1002/ggn2.70004","DOIUrl":"10.1002/ggn2.70004","url":null,"abstract":"","PeriodicalId":72071,"journal":{"name":"Advanced genetics (Hoboken, N.J.)","volume":"6 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ggn2.70004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144598502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}