In Vitro and In Vivo Analysis of Extracellular Vesicle-Mediated Metastasis Using a Bright, Red-Shifted Bioluminescent Reporter Protein (Advanced Genetics 1/03)
Gloria I. Perez, David Broadbent, Ahmed A. Zarea, Benedikt Dolgikh, Matthew P. Bernard, Alicia Withrow, Amelia McGill, Victoria Toomajian, Lukose K. Thampy, Jack Harkema, Joel R. Walker, Thomas A. Kirkland, Michael H. Bachmann, Jens Schmidt, Masamitsu Kanada
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Abstract
Extracellular Vesicle Imaging
Cancer cell-derived extracellular vesicles (EVs) promote tumor growth and spread. Studying the distribution of EVs in the body is key to understanding cancer progression and developing therapies. In article number 2100055, Masamitsu Kanada and co-workers develop a highly sensitive EV reporter for tracking heterogeneous EV populations released from cancer cells in live mice.
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