Acta materia medica最新文献_第2页

Phenylethanoid glycoside verbascoside ameliorates podocyte injury of diabetic kidney disease by regulating NR4A1-LKB1-AMPK signaling 苯乙糖苷马鞭草糖苷通过调节NR4A1-LKB1-AMPK信号改善糖尿病肾病足细胞损伤

Acta materia medica Pub Date : 2023-02-28 DOI: 10.15212/amm-2022-0044

XIN-YAN Chen, Min Shi, Le-tian Yang, F. Guo, Yan Liang, Liang Ma, P. Fu

引用次数: 2

Organoid models for Chinese herbal medicine studies 中草药研究的类器官模型

Acta materia medica Pub Date : 2023-02-24 DOI: 10.15212/amm-2022-0047

Xuanting Mou, Aolin Zhang, Tao He, Renjie Chen, Fanfan Zhou, Tsz Ching Yeung, C. Wang, Chao Tang, Xiaoyan Lu, Lu Li, Xiaohui Fan

引用次数: 1

Smart stimuli-responsive carrier-free nanoassembly of SN38 prodrug as efficient chemotherapeutic nanomedicine SN38前药作为高效化疗纳米药物的智能刺激响应无载体纳米组装

Acta materia medica Pub Date : 2023-02-24 DOI: 10.15212/amm-2023-0003

Guanting Li, Qianhui Jin, Fengli Xia, Shuwen Fu, Xuanbo Zhang, Hongying Xiao, Chutong Tian, Qingzhi Lv, J. Sun, Zhonggui He, Bingjun Sun

{"title":"Smart stimuli-responsive carrier-free nanoassembly of SN38 prodrug as efficient chemotherapeutic nanomedicine","authors":"Guanting Li, Qianhui Jin, Fengli Xia, Shuwen Fu, Xuanbo Zhang, Hongying Xiao, Chutong Tian, Qingzhi Lv, J. Sun, Zhonggui He, Bingjun Sun","doi":"10.15212/amm-2023-0003","DOIUrl":"https://doi.org/10.15212/amm-2023-0003","url":null,"abstract":"The compound 7-ethyl-10-hydroxy-camptothecin (SN38) is a broad-spectrum antitumor agent whose applications are greatly limited by its poor solubility. Therefore, irinotecan, the hydrophilic derived prodrug of SN38, has been developed as the commercial formulation Campto® for colorectal cancer. However, only 1% to 0.1% of irinotecan is converted to active SN38 in vivo, thus leading to unsatisfactory antitumor activity in clinical settings. Herein, we report a smart stimuli-responsive SN38 prodrug nanoassembly for efficient cancer therapy. First, SN38 was conjugated with an endogenous lipid, cholesterol (CST), via a redox dual-responsive disulfide bond (namely SN38-SS-CST). The prodrug self-assembled into uniform prodrug nanoassemblies with good colloidal stability and ultrahigh drug loading. SN38-SS-CST NPs released sufficient SN38 in the redox environments of tumor cells but remained intact in normal tissues. Finally, SN38-SS-CST NPs potently inhibited the growth of colon cancer without causing systemic toxicity, thus indicating their promise as a translational chemotherapeutic nanomedicine.","PeriodicalId":72055,"journal":{"name":"Acta materia medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48099874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Computational strategies for PROTAC drug discovery PROTAC药物发现的计算策略

Acta materia medica Pub Date : 2023-02-03 DOI: 10.15212/amm-2022-0041

J. Wu, Wanhe Wang, Chung-Hang Leung

引用次数: 1

Recent advances in nano-targeting drug delivery systems for rheumatoid arthritis treatment 类风湿性关节炎纳米靶向药物递送系统的研究进展

Acta materia medica Pub Date : 2023-01-18 DOI: 10.15212/amm-2022-0039

Hanmei Li, Rui Gou, Jiaying Liao, Yao Wang, Rui Qu, Qi Tang, Jingyao Gan, Liang Zou, Sanjun Shi

引用次数: 5

Efficacy of corticosteroids as an adjunctive therapy in the treatment of community-acquired pneumonia: a systematic review and meta-analysis 皮质类固醇作为辅助疗法治疗社区获得性肺炎的疗效:一项系统综述和荟萃分析

Acta materia medica Pub Date : 2023-01-10 DOI: 10.15212/amm-2022-0037

Lydia Mukanhaire, Huijie Li, Zhengyue Fan, Liping Yang, Y. Zheng, Zhuoling Ran, Xiaoyu Zong, Lingjian Zhang, Y. Gong, Changqing Yang, Jian Gong

{"title":"Efficacy of corticosteroids as an adjunctive therapy in the treatment of community-acquired pneumonia: a systematic review and meta-analysis","authors":"Lydia Mukanhaire, Huijie Li, Zhengyue Fan, Liping Yang, Y. Zheng, Zhuoling Ran, Xiaoyu Zong, Lingjian Zhang, Y. Gong, Changqing Yang, Jian Gong","doi":"10.15212/amm-2022-0037","DOIUrl":"https://doi.org/10.15212/amm-2022-0037","url":null,"abstract":"The objective of this study was to systematically evaluate the clinical efficacy of the complementary use of corticosteroids in the treatment of community-acquired pneumonia (CAP). We searched all relevant documents in five scientific databases from inception to June 2022 to collect clinical trials (randomized controlled trials and controlled trials) reporting on the adjunctive use of corticosteroids in CAP treatment. The primary outcome was mortality, and secondary outcomes included the time to clinical stability, therapeutic efficacy, duration of antibiotic treatment and length of hospital/ICU stay. Therapeutic efficacy was defined as the rate of achieving clinical recovery with no fever, improvement or disappearance of cough. Clinical stability was defined by improvements in laboratory values. Two researchers independently screened the literature according to the inclusion and exclusion criteria, extracted data and evaluated the quality of literature. Statistical analysis and meta-analysis of intervention measures and indicators were performed with IBM SPSS and RevMan 5.4 software. Nine randomized controlled trials comprising 2673 participants with CAP (1335 in the corticosteroid group and 1338 in the control group) were identified and included in this study. The mean cumulative corticosteroid dose and treatment duration were 298.00±287.140 mg and 5.22±1.787 days, respectively. Corticosteroid treatment was not associated with a significant decrease in mortality (RR; 95% CI, 0.96 [0.67–1.38], P=0.83). Because of the low number of included patients in our study, more studies with larger sample sizes and high-quality randomized, double-blind controlled trials are needed to confirm the results.","PeriodicalId":72055,"journal":{"name":"Acta materia medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44842843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in microneedle patches for long-acting contraception 长效避孕微针贴的研究进展

Acta materia medica Pub Date : 2023-01-05 DOI: 10.15212/amm-2022-0042

Xue Jiang, Yong-ming Zeng, Wen Zhang, Chenyuan Wang, Wei Li

引用次数: 1

STING agonist delivery by lipid calcium phosphate nanoparticles enhances immune activation for neuroblastoma 脂质磷酸钙纳米颗粒递送STING激动剂增强神经母细胞瘤的免疫激活

Acta materia medica Pub Date : 2023-01-01 DOI: 10.15212/amm-2023-0011

Bo Feng, Xiao Lu, Guangqin Zhang, Libo Zhao, Dong Mei

{"title":"STING agonist delivery by lipid calcium phosphate nanoparticles enhances immune activation for neuroblastoma","authors":"Bo Feng, Xiao Lu, Guangqin Zhang, Libo Zhao, Dong Mei","doi":"10.15212/amm-2023-0011","DOIUrl":"https://doi.org/10.15212/amm-2023-0011","url":null,"abstract":"Neuroblastoma (NB) is a common solid tumor in children and infants, the formation and regression of which is closely linked to the tumor-host immune relationship. Stimulator of interferon genes (STING) agonists, particularly cyclic dinucleotide (CDN), have promising potential in NB therapy by generating innate and adaptive immune stimulation, thus leading to tumor control. CDN delivery in vivo is challenging due to the negative charge, hydrophilicity, and susceptibility to degradation by phosphodiesterase, which hinders the effectiveness of CDN. Thus, our study proposed four methods to load CDN into liposomes, using 2′,3′-cGAMP as the model drug. Lipid nanoparticles were prepared, followed by physicochemical characterization. Subsequently, cellular inhibition and immune stimulation were investigated. As a result, lipid calcium phosphate nanoparticles (LCP-NPs) possessed the highest encapsulation efficiency among the four preparation methods, with a diameter of 82.57±3.72 nm. LCP-NPs maintained size stability under refrigeration conditions at 4°C within 48 h. The surface of the liposome was positively charged. Compared to free cGAMP, LCP-NPs resulted in a slower release, enhanced cytotoxicity against tumor cells, greater activation of the cGAS-STING pathway, and increased expression of the immune factors. Taken together, these findings clearly demonstrated the effectiveness of the liposomal delivery system for cGAMP and provided a promising strategy for the treatment of NB.","PeriodicalId":72055,"journal":{"name":"Acta materia medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67303295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Recent advances in the molecular design and applications of proteolysis targeting chimera-based multi-specific antiviral modality 蛋白水解靶向嵌合体多特异性抗病毒模式的分子设计与应用进展

Acta materia medica Pub Date : 2023-01-01 DOI: 10.15212/amm-2023-0019

Yang Zhou, Shujing Xu, Nerea López-Carrobles, Dang Ding, Xinyong Liu, L. Menéndez-Arias, P. Zhan

引用次数: 1

Animal models of Alzheimer’s disease: preclinical insights and challenges 阿尔茨海默病的动物模型:临床前的见解和挑战

Acta materia medica Pub Date : 2023-01-01 DOI: 10.15212/amm-2023-0001

Qing-Qing Xu, Wen Yang, Mei Zhong, Zhi-xiu Lin, Nora E. Gray, Yan-Fang Xian

{"title":"Animal models of Alzheimer’s disease: preclinical insights and challenges","authors":"Qing-Qing Xu, Wen Yang, Mei Zhong, Zhi-xiu Lin, Nora E. Gray, Yan-Fang Xian","doi":"10.15212/amm-2023-0001","DOIUrl":"https://doi.org/10.15212/amm-2023-0001","url":null,"abstract":"Alzheimer’s disease (AD), an irreversible neurodegenerative disease that progressively impairs memory and cognitive judgment, severely affects the quality of life and imposes a heavy burden on the healthcare system. No cure is currently available for AD, in part because the pathogenesis of this disease has not been established. Animal models are essential for investigating AD pathogenesis and evaluating potential therapeutic strategies for AD. Some phenotypic and neuropathologic changes in AD patients can be recapitulated with genetic and pharmacologic approaches in animals. This article systematically reviews the animal models available for AD research, including transgenic, chemical- or drug-induced, and spontaneous animal models, and the characteristics of these animal models. In this review we also discuss the challenges and constraints when using AD animal models. Although no single animal model can reproduce all pathologic aspects and behavioral features in AD patients, the currently available AD models are valuable tools for deciphering the pathogenic mechanisms underlying AD and developing new anti-AD therapeutics.","PeriodicalId":72055,"journal":{"name":"Acta materia medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67303321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5