ACS polymers Au最新文献

{"title":"Molecular Design of Thermoresponsive Poly(oligoethylene glycol)vinyl Esters for the Generation of Polymer Brush-Based Biointerfaces","authors":"Francesco M. Ara,&nbsp;Rachele Foladore,&nbsp;Alessandro Magro,&nbsp;Nicola Scapin,&nbsp;Daniele Rizzi,&nbsp;Alessandro Bertolo,&nbsp;Francesca Lorandi,&nbsp;Edmondo M. Benetti","doi":"10.1021/acspolymersau.6c00053","DOIUrl":"https://doi.org/10.1021/acspolymersau.6c00053","url":null,"abstract":"<p>Vinyl polymers bearing oligoethylene glycol (OEG) sidechains haveemerged as starting materials for the generation of biointerfacesand thermoresponsive systems. Here, we report the molecular designof thermoresponsive poly(oligoethylene glycol)vinyl esters (POEGVEs)and evaluate their behavior in solution as well as their performanceas surface-grafted polymer brushes. POEGVEs bearing one and two ethyleneglycol units were synthesized via RAFT/MADIX polymerization and directlycompared to the corresponding polyacrylate analogues. Despite theirclosely related compositions, POEGVEs exhibited markedly higher LCSTvalues in water, indicating stronger polymer–water interactionsassociated with the higher polarity of the vinyl ester backbone. Whenassembled as polymer brush layers on model Au surfaces, POEGVEs displayedenhanced hydration, higher swelling ratios, and lower water contactangles relative to those of the corresponding poly(oligoethylene glycol)acrylate(POEGA) brushes. This increased hydration translated into significantlyimproved resistance to nonspecific protein adsorption from full humanserum (FHS). Collectively, these findings identify OEG-functionalpoly(vinyl ester)s as a promising and previously overlooked platformfor the design of thermoresponsive and antifouling polymer biointerfaces.</p>","PeriodicalId":72049,"journal":{"name":"ACS polymers Au","volume":"6 4","pages":"1116–1123"},"PeriodicalIF":6.7,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148709933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ROMP-Derived Coumarin–Tyrosine Polymeric Chemosensors: A Biomolecule-Inspired Metal-Ion-Free Approach for Arginine Sensing in Artificial Saliva","authors":"Sirilak Wangngae,&nbsp;Theerada Khunpiluek,&nbsp;Sukanya Thisan,&nbsp;Sarawut Kumphune,&nbsp;Sutthira Sutthasupa","doi":"10.1021/acspolymersau.6c00062","DOIUrl":"https://doi.org/10.1021/acspolymersau.6c00062","url":null,"abstract":"<p>The development ofnoninvasive diagnostic platforms for biomarkerdetection in complex biological fluids remains a significant challenge.Herein, we report a biomolecule-inspired, metal-ion-free polymericfluorescence chemosensor in which polymer architecture governs molecularrecognition and photophysical response, enabling ultrasensitive detectionof arginine (Arg), a clinically relevant biomarker for metabolic andrenal disorders. Based on a coumarin–tyrosine-functionalizedpolynorbornene synthesized via ring-opening metathesis polymerization(ROMP), the system integrates recognition sites within a well-definedmacromolecular framework. UV–vis studies reveal a bathochromicshift (350–442 nm) with an isosbestic point at 392 nm uponArg binding. Both <strong>Poly-Cou-Tyr-Boc</strong> and <strong>Poly-Cou-Tyr-NH</strong>_{<strong>2</strong>} exhibit ratiometric fluorescence behaviorin DMSO. The polymeric architecture affords enhanced signal amplificationover monomeric analogues, achieving a limit of detection (LOD) of71.42 nM and 103.64 nM, respectively. Systematic evaluation establishedartificial saliva as the optimal medium due to negligible matrix interference.In this environment, the probes demonstrated matrix-dependent fluorescencesensing. <strong>Poly-Cou-Tyr-Boc</strong> maintained ratiometric performance,while the deprotected <strong>Poly-Cou-Tyr-NH</strong>_{<strong>2</strong>} functioned via high-sensitivity intensity-based quenchingat 411 nm. This dual-mode capability yielded exceptional LODs of 33.09nM and 32.45 nM in saliva, respectively. Mechanistic studies, including ¹H NMR titration and Job’s plot, confirmed a 1:1 interactionmediated by cooperative hydrogen bonding. This work establishes astructure–property-driven polymer design strategy, providinga versatile metal-ion-free platform for next-generation noninvasivediagnostics and real-time metabolic monitoring.</p>","PeriodicalId":72049,"journal":{"name":"ACS polymers Au","volume":"6 4","pages":"1157–1174"},"PeriodicalIF":6.7,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148710008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structurally Engineered Cu(II)–4-Chloro-2-nitrobenzoate–Picoline Complexes Immobilized in PVA/Cellulose Composite Films for Sustainable Catalytic and Antimicrobial Applications","authors":"Chetan Chauhan,&nbsp;Rajesh Kumar,&nbsp;Subhash Sharma,&nbsp;Thammarat Aree,&nbsp;Santosh Kumar","doi":"10.1021/acspolymersau.5c00204","DOIUrl":"https://doi.org/10.1021/acspolymersau.5c00204","url":null,"abstract":"<p>Herein, sustainable facile immobilization of two newCu(II) complexesinto poly(vinyl alcohol)–cellulose (PVA–CE) matricesfor their potential dip-catalytic and antibacterial applications isreported. In particular, structurally isomeric complexes [Cu(4C2N-Bz)₂(β-pic)₂(H₂O)₂] (<strong>1</strong>) and [Cu(4C2N-Bz)₂(γ-pic)₂(H₂O)₂] (<strong>2</strong>), where 4C2N-Bz = 4-chloro-2-nitrobenzoateand β-/γ-pic = 3-/4-methylpyridine, were isolated at roomtemperature and structurally evaluated by single-crystal X-ray diffraction(SCXRD). Distinct coordination geometries and the role of variousnoncovalent interactions that influence the overall electronic andreactivity characteristics were validated by packing analysis, Hirshfeldsurface (HS) mapping, and DFT calculations. Immobilization of complexes <strong>1</strong> and <strong>2</strong> into PVA–CE matrices via solutioncasting yielded hybrid blends PC<strong>1</strong> and PC<strong>2</strong>. Comprehensive characterization (UV–Vis, FT-IR, PXRD, SEM,and AFM) unveiled uniform dispersion and strong interfacial interactions,indicating that the complexes were successfully integrated as fillerswithin the matrix. Besides, both PC<strong>1</strong> and PC<strong>2</strong> exhibited an enhanced tensile strength and negligible Cu leaching,suggesting excellent mechanical stability and recyclability. For applicationaspects, catalytic evaluations revealed significant oxidase-mimeticactivity with <em>K</em>_cat values of 1913.4 and1947.6 h^–1 in a 30 min period for the hybrid blendsPC<strong>1</strong> and PC<strong>2</strong>, comparable to impregnated complexes <strong>1</strong> and <strong>2</strong> alone. Antibacterial assays demonstratedpotent inhibition efficiency of both polymeric blends. These findingsestablished a direct correlation between the structural features ofthe Cu(II) centers and the functional performance of hybrid materials,highlighting their potential as robust, reusable systems for sustainabledip-catalytic and antimicrobial applications.</p>","PeriodicalId":72049,"journal":{"name":"ACS polymers Au","volume":"6 4","pages":"1047–1061"},"PeriodicalIF":6.7,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148709664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Time-Gated Raman Spectroscopy and Mass Spectrometry Comparative Chemical Analysis of Plasticizers","authors":"Julie M. Rieland,&nbsp;Yamil Simón-Manso,&nbsp;Adam Zuber,&nbsp;Anthony P. Kotula,&nbsp;Kalman B. Migler,&nbsp;William E. Wallace,&nbsp;Kathryn L. Beers","doi":"10.1021/acspolymersau.6c00065","DOIUrl":"https://doi.org/10.1021/acspolymersau.6c00065","url":null,"abstract":"<p>Quantitativechemical characterization of postconsumer plasticsis challenging because of the large number of polymer chemistriesand additives used in formulating plastic products. Plasticizers arean important family of additives used to lower the glass transitiontemperature and enhance flexibility in polymer formulations. However,their identification and quantification are difficult in recyclingand end-of-life processes. This study critically assesses two analyticaltechniques for their suitability in plasticizer identification: massspectrometry (high resolution, selectivity, and sensitivity) and time-gatedRaman spectroscopy (nondestructive, quicker, and minimal sample preparation).Here, we generate searchable libraries for the identification of 91common plasticizers using these two techniques, along with the developmentof reliable tools to measure their spectral similarity. We then analyzethe reliability of identifications based on time-gated Raman and/orliquid chromatography–mass spectrometry with atmospheric pressurechemical ionization, explicitly highlighting the advantages and disadvantagesof each technique for a given plasticizer chemical family. We haveapplied these tools to identify and quantify plasticizers in a NISTStandard Reference Material (SRM 2860, Phthalates in Polyvinyl Chloride).</p>","PeriodicalId":72049,"journal":{"name":"ACS polymers Au","volume":"6 4","pages":"1134–1146"},"PeriodicalIF":6.7,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148709775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-Linked Poly(Ethylene Carbonate/Ethylene Oxide) Electrolyte for Solid-State Li-Ion Batteries Exploiting Membrane-Electrode Assembly","authors":"Nantapat Soontornnon,&nbsp;Edoardo Barcaro,&nbsp;Shuto Takayama,&nbsp;Kento Kimura,&nbsp;Yoichi Tominaga,&nbsp;Jusef Hassoun","doi":"10.1021/acspolymersau.6c00006","DOIUrl":"https://doi.org/10.1021/acspolymersau.6c00006","url":null,"abstract":"<p>Safety concerns of flammable liquid electrolytes as wellas challengesrelated to the use of high-capacity anodes, such as silicon-basedones, are among the bottlenecks for achieving next-generation Li-ionbatteries. Herein, we synergistically blend poly(ethylene carbonate)and poly(ethylene oxide) copolymers with complementary molecular weightsand cross-linking densities into membranes with lithium bis(fluorosulfonyl)imide(LiFSI) salt concentrated up to 140 mol %. The process leads to membraneswithout any electrochemical performance-enhancing additive, denotedas additive-free in this work. The thin, mechanically robust, andself-standing cross-linked polymer electrolyte membrane (CP-EM) isusedin an all-solid-state battery (ASSB), with scalable LiFePO₄ membrane-electrode assembly (LFP-MEA), and a prelithiated siliconoxide-carbon (Li_<em>y</em>SiO_<em>x</em>C) anode. Electrochemical characterization reveals a CP-EMwith a high lithium-ion transference number (<em>t</em>⁺) of 0.61, a low activation energy (<em>E</em>_a) of 0.110 eV, anodic stability exceeding 4.0 V, and a suitableinterphase with the lithium metal. The integration of the CP-EM intothe proof-of-concept full cell with the LFP-MEA and Li_<em>y</em>SiO_<em>x</em> is conducted witha practical N/P ratio of 1.16. The full cell delivers an initial reversiblecapacity of ∼140 mAh g^–1 at 70 °C, withan average working voltage of 3.2 V and limited polarization. Despitestability and rate capability still needing further improvements,this study offers a synergic design for blending distinct macromoleculararchitectures, with a specific balance between segmental flexibilityfor ion transport and structural integrity. The outcomes demonstratethe practical viability of the integrated MEA in scalable full cellsoperating at relatively high temperatures.</p>","PeriodicalId":72049,"journal":{"name":"ACS polymers Au","volume":"6 4","pages":"1072–1087"},"PeriodicalIF":6.7,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148710007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glycerol as a Sustainable Source for Nonisocyanate Polyurethanes: Green Chemistry and Applications","authors":"Marzieh Akrami,&nbsp;James Sternberg","doi":"10.1021/acspolymersau.6c00002","DOIUrl":"https://doi.org/10.1021/acspolymersau.6c00002","url":null,"abstract":"<p>The growing demandfor more sustainable polymeric materials hasdriven significant interest in renewable sources. In this context,nonisocyanate polyurethanes (NIPUs) represent a promising alternativeto conventional polyurethanes , as they eliminate the use of toxicisocyanates. Different synthetic routes for polyurethanes withoutisocyanate have been developed in recent years. Among them, the polyadditionof cyclic carbonates (CCs) and diamines has attracted particular attention.The availability of various biobased feedstocks for cyclic carbonatesynthesis has led to growing research in this area. Biobased feedstocksfor the preparation of cyclic carbonates (CCs) can be broadly categorizedinto four main groups: (i) vegetable-oil-derived feedstocks (e.g.,triglycerides and unsaturated fatty acids); (ii) lignocellulosic-biomass-derivedphenolic compounds, including lignin derivatives (e.g., vanillin andguaiacol), tannins, and cardanol; (iii) carbohydrates and polyols,such as glucose, sucrose, starch, cellulose, glycerol, sorbitol, andmannitol; and (iv) terpene-derived compounds, such as limonene androsin (a diterpene-based natural resin mainly composed of abietane-typeresin acids). Glycerol, a renewable, abundant, and low-cost byproductof industrial processes such as biodiesel production, is an attractivecandidate for cyclic carbonate synthesis. This review provides acomprehensive overview of the conversion of glycerol into cyclic carbonateprecursors, especially glycerol carbonate and diglycerol dicarbonate,and their role in NIPU synthesis. Particular emphasis is placed onthe application of NIPUs derived from these cyclic carbonates in foams,adhesives, and coatings. This article highlights the advancementsin the synthesis, properties, and performance of glycerol-based NIPUsover the past decade. By showing the progress and challenges of usingthese biobased feedstocks, this review contributes to the ongoingresearch toward sustainable NIPUs.</p>","PeriodicalId":72049,"journal":{"name":"ACS polymers Au","volume":"6 4","pages":"987–1028"},"PeriodicalIF":6.7,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148709764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustainable Polylactic Acid-Derived Polyurethane/MXene Microneedles for Stimulus-Responsive Transdermal Delivery","authors":"Oceu D. Putri,&nbsp;Atitsa Petchsuk,&nbsp;Kensuke Asukabe,&nbsp;Nagi Yamashita,&nbsp;Eijiro Miyako,&nbsp;Pakorn Opaprakasit,&nbsp;Kazuaki Matsumura","doi":"10.1021/acspolymersau.6c00060","DOIUrl":"https://doi.org/10.1021/acspolymersau.6c00060","url":null,"abstract":"<p>The convergence of sustainability and advanced functionalityiscritical in the design of next-generation biomedical materials. Here,we report a biodegradable microneedle (MN) platform composed of polyurethane(PU) synthesized by the chemical recycling of polylactic acid (PLA).This green strategy upcycles PLA waste to produce a flexible, mechanicallyrobust matrix suitable for transdermal applications. Incorporationof a trace amount (∼0.005 wt %) of delaminated Ti₃C₂T_<em>x</em> MXene imparts photothermalresponsiveness under near-infrared (NIR) irradiation, antioxidantcapacity (demonstrated using <em>in vitro</em> radical-scavengingassays), and improved mechanical strength. These features enable heat-triggeredmodel drug release and suggest the potential for managing local oxidativestress in wound environments. <em>In vitro</em> assessmentsconfirmed effective skin penetration, photothermal cycling stability,and acceptable cytocompatibility. This proof-of-concept study establishesa sustainable, multifunctional MN platform that integrates circularpolymer design with stimuli-responsive performance, supporting futuredevelopment for advanced transdermal drug delivery applications.</p>","PeriodicalId":72049,"journal":{"name":"ACS polymers Au","volume":"6 4","pages":"1175–1191"},"PeriodicalIF":6.7,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148709935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic Arrest and Tunable Gelation of Immunogenically Inert POEGMA Nanoparticles","authors":"Parul Sirohi,&nbsp;Max R. Ney,&nbsp;Yulia Shmidov,&nbsp;Brooke E. Silverstein,&nbsp;Anurag Singh,&nbsp;Gable Wadsworth,&nbsp;Sonal Deshpande,&nbsp;Yvonne Y. Ma,&nbsp;Lixin Fan,&nbsp;Priya R. Banerjee,&nbsp;Ashutosh Chilkoti","doi":"10.1021/acspolymersau.6c00033","DOIUrl":"https://doi.org/10.1021/acspolymersau.6c00033","url":null,"abstract":"<p>Physically cross-linked hydrogels formed through noncovalentinteractionsoffer reversible gelation, injectability, and shear-thinning behavior,making them ideal for biomedical applications. Temperature-responsivesystems are particularly attractive, as they enable injection as asolution, and at physiological temperature for minimally invasivedelivery. Poly(oligo(ethylene glycol) methacrylate) (POEGMA) is apromising nonimmunogenic polymer that combines PEG-like hydrationand protein resistance with tunable thermal responsiveness that doesnot bind pre-existing anti-PEG antibodies that are ubiquitous andelicits a minimal antibody response against itself. Here, we showthat diblock POEGMA copolymers─composed solely of short ethyleneglycol side chains─spontaneously self-assemble into nanoparticlesand form physically cross-linked hydrogels above a controllable transitiontemperature, without chemical modification. Using fluorescence recoveryafter photobleaching and video particle tracking nanorheology, weidentify a thermally induced transition from dynamically arrestedviscoelastic hydrogels to dynamically arrested liquid coacervates.These results establish a new class of single-component, nonimmunogenicPOEGMA hydrogels with tunable phase behavior and mechanical properties,offering a versatile platform for localized drug delivery, sustainedrelease, and regenerative medicine.</p>","PeriodicalId":72049,"journal":{"name":"ACS polymers Au","volume":"6 4","pages":"1096–1109"},"PeriodicalIF":6.7,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148703631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantifying the Miscibility of Biobased Resins in Binary Polyisoprene Systems","authors":"Johannes Rochau,&nbsp;Jürgen E. K. Schawe,&nbsp;Jorge Lacayo-Pineda","doi":"10.1021/acspolymersau.6c00038","DOIUrl":"https://doi.org/10.1021/acspolymersau.6c00038","url":null,"abstract":"<p>The miscibility ofpolymer–resin systems is akey factorfor processing behavior and performance of elastomer compounds, yetit is commonly assessed only indirectly. In this work, a quantitativeapproach for evaluating experimental characterization of the molecularinteraction of amorphous polymer filler composites is introduced basedon glass transition measurements by differential scanning calorimetry(DSC). Binary mixtures of isoprene rubber (IR) with three distinctbiobased resins, a terpene resin, a rosin ester, and a maleic-modifiedrosin ester, were investigated over the entire composition range.The molecular interaction is expressed by an interaction parameterwhich reveals stronger repulsive interactions between IR and the rosinester compared to the other resins of investigation. Mechanical investigationby torque measurements during mixing and transmission electron microscopy(TEM) indicates a correlation between the interaction parameter measuredby DSC and the miscibility of the components of the composites.</p>","PeriodicalId":72049,"journal":{"name":"ACS polymers Au","volume":"6 4","pages":"1110–1115"},"PeriodicalIF":6.7,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148710002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reversible Cationic Glycopolymer Hydrogels for RNA Delivery in Ticks","authors":"Zoe A. B. Lequeux,&nbsp;Kundu Thapa,&nbsp;Musa Rabiu,&nbsp;Alec N. Simmons,&nbsp;Laila C. W. Peery,&nbsp;John F. Searles,&nbsp;Shahid Karim,&nbsp;Sarah E. Morgan","doi":"10.1021/acspolymersau.6c00064","DOIUrl":"https://doi.org/10.1021/acspolymersau.6c00064","url":null,"abstract":"<p>RNA interference (RNAi) offers a promising approach forvectorcontrol in species such as the lone star tick (Amblyomma americanum),but current delivery methods, including microinjection and soaking,are invasive and inefficient for large-scale application. In thiswork, we developed a series of novel physically cross-linked cationicglycopolymer hydrogels for noninvasive double-stranded RNA (dsRNA)delivery and evaluated their rheological properties, release behavior,and in vivo performance. Rheological characterization demonstratedshear-thinning and self-healing behavior conducive to sprayable applications,while release studies revealed tunable cargo delivery dependent onglycomonomer stereochemistry and cationic content. In vivo studiesshowed that cationic terpolymer hydrogels successfully traversed theperitrophic membrane and enabled tissue-specific gene silencing, includingin ovarian tissue. These findings establish a promising platform forsprayable RNAi delivery and provide a framework for the design oftargeted gene delivery systems.</p>","PeriodicalId":72049,"journal":{"name":"ACS polymers Au","volume":"6 4","pages":"1200–1210"},"PeriodicalIF":6.7,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148710003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}