ACS polymers Au最新文献

{"title":"Low-Cost, Disposable Biosensor for Detection of the Brain-Derived Neurotrophic Factor Biomarker in Noninvasively Collected Saliva toward Diagnosis of Mental Disorders","authors":"Nathalia O. Gomes,&nbsp;Marcelo L. Calegaro,&nbsp;Luiz Henrique C. Mattoso,&nbsp;Sergio A. S. Machado,&nbsp;Osvaldo N. Oliveira Jr. and Paulo A. Raymundo-Pereira*,&nbsp;","doi":"10.1021/acspolymersau.5c00038","DOIUrl":"https://doi.org/10.1021/acspolymersau.5c00038","url":null,"abstract":"<p >The importance of early detection of neurodegenerative disorder biomarkers has grown since these biomarkers are essential for timely diagnosis, treatment, healthcare, and wellness applications. We present a cost-effective and disposable electrochemical immunosensing strip for rapid, decentralized detection of brain-derived neurotrophic factor (BDNF)─one of the major neurotrophins (NTs) associated with neurological and psychiatric disorders─in human saliva. The salivary BDNF immunosensor strip is made on a screen-printed carbon electrode functionalized with carbon spherical shells (CSSs), polyethylenimine (PEI), and glutaraldehyde to enhance sensitivity. Through systematic optimization, the sensor achieved excellent analytical performance, with a wide dynamic detection range from 1.0 × 10^–20 to 1.0 × 10^–10 g mL^–1, a rapid response time of under 3 min, and an ultralow detection limit of 1.0 × 10^–20 g mL^–1 for BDNF in human saliva. The BDNF immunosensor demonstrated high selectivity, reproducibility, robustness, stability, and long-term storage capability. At a cost of less than US$ 2.19 per unit, this disposable sensor also enabled rapid BDNF detection in saliva samples collected from healthy volunteers without interference from other salivary constituents. The environmental impact was assessed using the Analytical Eco-Scale (AES), the Analytical GREEnness Metric Approach (AGREE), and the Blue Applicability Grade Index (BAGI), which evaluates the practicality (“blueness”) of the device. These assessments confirmed the sustainability of the disposable BDNF immunosensor strip. This device provides a rapid, efficient, cost-effective, and reliable method for the decentralized, noninvasive salivary analysis of BDNF, enabling broader applications in healthcare, wellness monitoring, and medical diagnostics related to the neurotrophin family of biomarkers.</p>","PeriodicalId":72049,"journal":{"name":"ACS polymers Au","volume":"5 4","pages":"420–431"},"PeriodicalIF":6.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acspolymersau.5c00038","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144826107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced Antifungal Efficacy through Controlled Delivery of Amphotericin B Loaded in Polyetheramine-Epoxide Nanogels","authors":"Julia S. Reinaldi,&nbsp;Heber E. Andrada,&nbsp;Ana F. A. P. Cunha,&nbsp;Bruno A. Fico,&nbsp;Felipe B. Alves,&nbsp;Renato P. Orenha,&nbsp;Renato L. T. Parreira,&nbsp;Regina H. Pires,&nbsp;Fabián Vaca Chávez,&nbsp;Carolina E. Tissera,&nbsp;O. Fernando Silva,&nbsp;Mariana A. Fernandez,&nbsp;Aline R. Passos and Eduardo F. Molina*,&nbsp;","doi":"10.1021/acspolymersau.5c00037","DOIUrl":"https://doi.org/10.1021/acspolymersau.5c00037","url":null,"abstract":"<p >Polymeric nanomaterials have emerged as promising carriers for drug delivery systems, offering improved therapeutic efficacy and reduced toxicity. In this study, we present an environmentally friendly and scalable approach for engineering nanogels as an innovative delivery platform for Amphotericin B (AmB), which is a potent antifungal agent. The nanogel system, named NanoT, was synthesized via an amine–epoxide reaction, enabling effective encapsulation and sustained release of AmB. Comprehensive physicochemical characterization was conducted using transmission electron microscopy (TEM), dynamic light scattering (DLS), ζ potential analysis, proton nuclear magnetic resonance (1H-NMR), atomic force microscopy (AFM), Fourier transform infrared spectroscopy (FTIR), and synchrotron-based ultra-small angle X-ray scattering (USAXS). These analyses confirmed the successful formation of spherical nanogels and provided insights into their structural features. Additionally, molecular simulations indicated noncovalent interactions between AmB and the nanogel particles, supporting polymer-drug interactions. The NanoT system achieved an AmB loading capacity of approximately 55%. Notably, encapsulation promoted the formation of AmB superaggregates, which facilitated a controlled release of the active drug, leading to a 4-fold enhancement in antifungal activity. Mechanistic studies suggest that the antifungal efficacy of NanoT is attributed to both the sustained release of AmB and the electrostatic interactions with fungal cell surfaces. Overall, this study demonstrates the potential of amine–epoxide-based nanogels as effective carriers for antifungal therapeutics and contributes significantly to the development of advanced polymer-based drug delivery systems.</p>","PeriodicalId":72049,"journal":{"name":"ACS polymers Au","volume":"5 4","pages":"406–419"},"PeriodicalIF":6.9,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acspolymersau.5c00037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144826159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Introducing the Tutorial Manuscript Type at the ACS Au Community Journals","authors":"Squire J. Booker,&nbsp;Stephanie L. Brock,&nbsp;Xiangdong Li,&nbsp;Géraldine Masson,&nbsp;Sébastien Perrier,&nbsp;Vivek V. Ranade,&nbsp;Raymond E. Schaak,&nbsp;Gemma C. Solomon and Shelley D. Minteer*,&nbsp;","doi":"10.1021/acspolymersau.5c00054","DOIUrl":"https://doi.org/10.1021/acspolymersau.5c00054","url":null,"abstract":"","PeriodicalId":72049,"journal":{"name":"ACS polymers Au","volume":"5 4","pages":"323–324"},"PeriodicalIF":6.9,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acspolymersau.5c00054","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144826218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PVDF Nanofiber Membranes for Dissolved Methane Recovery from Water Prepared by Combining Electrospinning and Hot-Pressing Methods","authors":"Félix Montero-Rocca,&nbsp;Jose D. Badia-Valiente,&nbsp;Ramón Jiménez-Robles,&nbsp;Vicente Martínez-Soria and Marta Izquierdo*,&nbsp;","doi":"10.1021/acspolymersau.5c00021","DOIUrl":"https://doi.org/10.1021/acspolymersau.5c00021","url":null,"abstract":"<p >Polyvinylidene fluoride (PVDF) electrospun nanofiber membranes (ENMs) could potentially be used in membrane contactors (MCs) for environmental applications, such as the removal of dissolved CH₄ from anaerobic effluents. In this work, a PVDF flat-sheet ENM fabrication protocol, including the electrospinning processing and the subsequent hot-pressing treatment (HP), has been developed to produce hydrophobic membranes with suitable integrity and pore size distribution for gas–liquid separations in MCs. The HP study explored the effects of pressure (1, 10, and 20 MPa), temperature (25, 60, 80, and 120 °C), and time (2, 4, 6, and 10 min) on the morphological properties and hydrophobicity of the membranes. Our research revealed that fibers in the PVDF ENMs began to sinter at temperatures above 60 °C when hot-pressed between 1 and 20 MPa. ENM samples were prepared at different dope compositions (10–15% PVDF, 0.00–0.043% LiCl). After HP (≥1 MPa, ≥60 °C, and 6 min), the membrane thickness and water contact angle (WCA) decreased considerably, and lower pore sizes with narrower distributions were obtained. At higher pressure (10 MPa), a noticeable decrease in thickness (from 270 to 38 μm) and WCA (from 139 to 110°) was observed. Additionally, pore size distribution shifted toward a predominant narrow peak of around 0.40 μm. HP enhanced the uniformity of the PVDF crystalline structure without altering its overall crystallinity degree (40–42%). The HP ENM exhibited a comparable dissolved CH₄ recovery performance to a commercial PVDF membrane and demonstrated sufficient mechanical integrity to endure operating conditions, maintaining a stable performance for at least 80 h.</p>","PeriodicalId":72049,"journal":{"name":"ACS polymers Au","volume":"5 4","pages":"353–368"},"PeriodicalIF":6.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acspolymersau.5c00021","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144826116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoscale Structure–Property Relationships of Cyanate Ester as a Function of Extent of Cure","authors":"Khatereh Kashmari,&nbsp;Josh Kemppainen,&nbsp;Sagar U. Patil,&nbsp;Julieta Barroeta Robles,&nbsp;Pascal Hubert and Gregory M. Odegard*,&nbsp;","doi":"10.1021/acspolymersau.5c00022","DOIUrl":"https://doi.org/10.1021/acspolymersau.5c00022","url":null,"abstract":"<p >Cyanate esters are key thermosetting resins for composite materials that require structural integrity and resistance to elevated temperatures. Because cyanate ester composites require relatively high processing temperatures, they are susceptible to the formation of process-induced residual stresses, which compromise their overall strength and durability. Process modeling is a key strategy for optimizing processing parameters to minimize such residual stresses. A necessary component of effective and efficient process modeling of composites is computationally established resin property evolution relationships for a range of processing parameters. In this study, the physical, mechanical, and thermal properties of a cyanate ester resin are established as a function of processing time and temperature using experimentally validated molecular dynamics modeling. The results show that the properties are strongly dependent on the processing temperature. At processing temperatures above 160 °C, the properties quickly approach their fully cured values, whereas at processing temperatures below 140 °C, the chemical cross-linking is significantly inhibited, and processing times to complete cure are relatively long. The evolution of the physical, mechanical, and thermal properties as a function of processing time is established, which is critical data needed as input into multiscale process modeling and optimization of cyanate ester composites for computationally driven composite design.</p>","PeriodicalId":72049,"journal":{"name":"ACS polymers Au","volume":"5 4","pages":"369–378"},"PeriodicalIF":6.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acspolymersau.5c00022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144826131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Brittany K. Roopnarine,&nbsp;Adediwura Deborah Adedeji,&nbsp;Sujata Dhakal,&nbsp;Sneha Suresh and Svetlana Morozova*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":72049,"journal":{"name":"ACS polymers Au","volume":"5 3","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.7,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acspolymersau.4c00099","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144423132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Magdalena A. Beres,&nbsp;Cyrille Boyer,&nbsp;Matthias Hartlieb,&nbsp;Dominik Konkolewicz,&nbsp;Greg G. Qiao,&nbsp;Brent S. Sumerlin and Sébastien Perrier*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":72049,"journal":{"name":"ACS polymers Au","volume":"5 3","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.7,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acspolymersau.4c00101","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144423137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Yanpu Yao,&nbsp;Xiaofan Yang,&nbsp;Cansu Aydogan,&nbsp;James Town,&nbsp;William Pointer and David M. Haddleton*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":72049,"journal":{"name":"ACS polymers Au","volume":"5 3","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.7,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acspolymersau.5c00020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144356750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Ioana Luca,&nbsp;Mădălina Georgiana Albu Kaya*,&nbsp;Irina Titorencu*,&nbsp;Cristina-Elena Dinu-Pîrvu,&nbsp;Maria Minodora Marin,&nbsp;Lăcrămioara Popa,&nbsp;Ana-Maria Rosca,&nbsp;Aurora Antoniac,&nbsp;Valentina Anuta,&nbsp;Răzvan Mihai Prisada,&nbsp;Durmus Alpaslan Kaya and Mihaela Violeta Ghica,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":72049,"journal":{"name":"ACS polymers Au","volume":"5 3","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.7,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acspolymersau.5c00010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144423130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Pilar A. Haro Gutiérrez,&nbsp;Samuele Colombi,&nbsp;Jordi Casanovas,&nbsp;Leonor Resina,&nbsp;Jordi Sans,&nbsp;Elisabeth Engel,&nbsp;Hamidreza Enshaei*,&nbsp;José García-Torres*,&nbsp;Maria M. Pérez-Madrigal* and Carlos Alemán*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":72049,"journal":{"name":"ACS polymers Au","volume":"5 3","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.7,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acspolymersau.4c00097","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144423134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}